proglumide (BioDeep_00000386340)
代谢物信息卡片
proglumide
化学式: C18H26N2O4 (334.18924760000004)
中文名称: 丙谷胺
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCCN(CCC)C(=O)C(CCC(=O)O)NC(=O)C1=CC=CC=C1
InChI: InChI=1S/C18H26N2O4/c1-3-12-20(13-4-2)18(24)15(10-11-16(21)22)19-17(23)14-8-6-5-7-9-14/h5-9,15H,3-4,10-13H2,1-2H3,(H,19,23)(H,21,22)
描述信息
A racemate composed of equal amounts of (R)- and (S)-proglumide. A non-selective CCK antagonist that was used primarily for treatment of stomach ulcers, but has been replaced by newer drugs.
A - Alimentary tract and metabolism > A02 - Drugs for acid related disorders > A02B - Drugs for peptic ulcer and gastro-oesophageal reflux disease (gord)
C78276 - Agent Affecting Digestive System or Metabolism > C29701 - Anti-ulcer Agent
C78272 - Agent Affecting Nervous System > C28197 - Antianxiety Agent
D005765 - Gastrointestinal Agents > D000897 - Anti-Ulcer Agents
Proglumide is a nonpeptide and orally active cholecystokinin (CCK)-A/B receptors antagonist. Proglumide selective blocks CCK’s effects in the central nervous system (CNS). Proglumide has ability to inhibit gastric secretion and to protect the gastroduodenal mucosa. Proglumide also has antiepileptic and antioxidant activities[1][2][3][4][5].
同义名列表
1 个代谢物同义名
数据库引用编号
14 个数据库交叉引用编号
- ChEBI: CHEBI:32058
- ChEBI: CHEBI:76266
- KEGGdrug: D01818
- PubChem: 4922
- Metlin: METLIN43472
- DrugBank: DB13431
- ChEMBL: CHEMBL316561
- MeSH: Proglumide
- CAS: 25727-74-6
- CAS: 24485-90-3
- CAS: 6620-60-6
- PMhub: MS000236189
- MetaboLights: MTBLC32058
- medchemexpress: HY-B1330
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
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文献列表
- Jianming Yue, Dawei Guo, Xiuge Gao, Jiacai Wang, Eugenie Nepovimova, Wenda Wu, Kamil Kuca. Deoxynivalenol (Vomitoxin)-Induced Anorexia Is Induced by the Release of Intestinal Hormones in Mice.
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Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas.
1997 Nov; 30(11):1359-61. doi:
10.1590/s0100-879x1997001100016. [PMID: 9532247] - K Hayashi, S Kishimoto, M Kannbe. Endogenous CCK inhibits colonic contractions in unrestrained conscious rats.
Regulatory peptides.
1997 Oct; 72(2-3):131-7. doi:
10.1016/s0167-0115(97)01051-3. [PMID: 9652972] - I Arai, Y Komatsu, Y Hirai, K Shingu, Y Ida, H Yamaura, T Yamamoto, Y Kuroiwa, K Sasaki, S Taguchi. Stimulative effects of saponin from kikyo-to, a Japanese herbal medicine, on pancreatic exocrine secretion of conscious rats.
Planta medica.
1997 Oct; 63(5):419-24. doi:
10.1055/s-2006-957725. [PMID: 9342945] - M A Mesquita, D G Thompson, L E Troncon, M D'Amato, L C Rovati, J Barlow. Effect of cholecystokinin-A receptor blockade on lipid-induced gastric relaxation in humans.
The American journal of physiology.
1997 Jul; 273(1 Pt 1):G118-23. doi:
10.1152/ajpgi.1997.273.1.g118. [PMID: 9252517] - C Niederau, K Meereis-Schwanke, H Klonowski-Stumpe, L Herberg. CCK-resistance in Zucker obese versus lean rats.
Regulatory peptides.
1997 Jun; 70(2-3):97-104. doi:
10.1016/s0167-0115(97)00014-1. [PMID: 9272621] - A Pusztai, G Grant, S Bardocz, K Baintner, E Gelencsér, S W Ewen. Both free and complexed trypsin inhibitors stimulate pancreatic secretion and change duodenal enzyme levels.
The American journal of physiology.
1997 Feb; 272(2 Pt 1):G340-50. doi:
10.1152/ajpgi.1997.272.2.g340. [PMID: 9124359] - L Czakó, M Yamamoto, M Otsuki. Pancreatic fluid hypersecretion in rats after acute pancreatitis.
Digestive diseases and sciences.
1997 Feb; 42(2):265-72. doi:
10.1023/a:1018893230319. [PMID: 9052504] - H Taniguchi, E Yomota, E Kume, T Shikano, T Endo, M Nagasaki. Effect of T-0632, a cholecystokininA receptor antagonist, on experimental acute pancreatitis.
Japanese journal of pharmacology.
1997 Feb; 73(2):105-12. doi:
10.1254/jjp.73.105. [PMID: 9074944] - I Koop, M Schindler, A Bosshammer, J Scheibner, E Stange, H Koop. Physiological control of cholecystokinin release and pancreatic enzyme secretion by intraduodenal bile acids.
Gut.
1996 Nov; 39(5):661-7. doi:
10.1136/gut.39.5.661. [PMID: 9026479] - S Teyssen, E Niebergall-Roth, A Rausch, C Beglinger, R L Riepl, S Chari, M V Singer. Comparison of the effects of the M1-receptor antagonist telenzepine and the CCK-receptor antagonist loxiglumide on the pancreatic secretory response to intraduodenal tryptophan in dogs.
Pancreas.
1996 Nov; 13(4):407-16. doi:
10.1097/00006676-199611000-00011. [PMID: 8899802] - C Niederau, F Borchard, R Lüthen, M Niederau. Early development of experimental biliary pancreatitis and its amelioration by CCK-receptor blockade.
Hepato-gastroenterology.
1996 Nov; 43(12):1442-53. doi:
NULL. [PMID: 8975946] - A J Hirsh, R Tsang, S Kammila, C I Cheeseman. Effect of cholecystokinin and related peptides on jejunal transepithelial hexose transport in the Sprague-Dawley rat.
The American journal of physiology.
1996 Nov; 271(5 Pt 1):G755-61. doi:
10.1152/ajpgi.1996.271.5.g755. [PMID: 8944688] - M O Urban, M C Jiang, G F Gebhart. Participation of central descending nociceptive facilitatory systems in secondary hyperalgesia produced by mustard oil.
Brain research.
1996 Oct; 737(1-2):83-91. doi:
10.1016/0006-8993(96)00631-2. [PMID: 8930354] - K Tsubo, M Arai, H Omachi, K Mitamura. Effect of a cholecystokinin receptor antagonist (loxiglumide) on gallbladder contractile function in guinea pigs.
Journal of gastroenterology.
1996 Aug; 31(4):578-81. doi:
10.1007/bf02355060. [PMID: 8844481] - E Niebergall-Roth, S Teyssen, D Wetzel, M Hartel, C Beglinger, R L Riepl, M V Singer. Comparison of the effects of two cholecystokinin-receptor antagonists, loxiglumide and L-364,718, on the pancreatic secretory response to intraduodenal tryptophan in dogs.
Scandinavian journal of gastroenterology.
1996 Jul; 31(7):723-32. doi:
10.3109/00365529609009157. [PMID: 8819225] - M Katschinski, J Schirra, C Begliner, S Langbein, U Wank, M D'Amato, R Arnold. Intestinal phase of human antro-pyloro-duodenal motility: cholinergic and CCK-mediated regulation.
European journal of clinical investigation.
1996 Jul; 26(7):574-83. doi:
10.1046/j.1365-2362.1996.1790522.x. [PMID: 8864420] - C Feinle, M D'Amato, N W Read. Cholecystokinin-A receptors modulate gastric sensory and motor responses to gastric distension and duodenal lipid.
Gastroenterology.
1996 May; 110(5):1379-85. doi:
10.1053/gast.1996.v110.pm8613041. [PMID: 8613041] - J W Konturek, W Bielański, S J Konturek, W Domschke. Eradication of Helicobacter pylori and gastrin-somatostatin link in duodenal ulcer patients.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society.
1996 Mar; 47(1):161-75. doi:
NULL. [PMID: 8777296] - H Hasegawa, H Shirohara, Y Okabayashi, T Nakamura, M Fujii, M Koide, M Otsuki. Oral glucose ingestion stimulates cholecystokinin release in normal subjects and patients with non-insulin-dependent diabetes mellitus.
Metabolism: clinical and experimental.
1996 Feb; 45(2):196-202. doi:
10.1016/s0026-0495(96)90053-0. [PMID: 8596489] - W Song, H Yamaguchi, I Nakano, T Kimura, H Nawata. Role of endogenous cholecystokinin in the regeneration of pancreatic tissue after acute hemorrhagic pancreatitis in rats.
Fukuoka igaku zasshi = Hukuoka acta medica.
1996 Jan; 87(1):14-22. doi:
NULL. [PMID: 8820983] - N Sazaki, K Miyasaka, M Matsumoto, A Funakoshi. Effects of intraduodenal administration of a low dose of cholecystokinin (CCK) antagonist (CR-1505) on plasma CCK concentration, intestinal CCK content, and levels of CCK mRNA.
Journal of gastroenterology.
1995 Oct; 30(5):599-606. doi:
10.1007/bf02367785. [PMID: 8574331] - K Miyasaka, A Funakoshi, E Nakamura, H Teraoka. Regulation of gene expression of pancreatic secretory trypsin inhibitor-61 and -56 by bile and pancreatic juice in rats.
Pancreas.
1995 Oct; 11(3):246-55. doi:
10.1097/00006676-199510000-00006. [PMID: 8577678] - J W Konturek, A Gillessen, S J Konturek, W Domschke. Eradication of Helicobacter pylori restores the inhibitory effect of cholecystokinin on postprandial gastrin release in duodenal ulcer patients.
Gut.
1995 Oct; 37(4):482-7. doi:
10.1136/gut.37.4.482. [PMID: 7489932] - S Tachibana, T Onaga, H Mineo, S Kato. Role of endogenous CCK in regulation of interdigestive pancreatic exocrine secretion in sheep (Ovis aries).
Comparative biochemistry and physiology. Part A, Physiology.
1995 Sep; 112(1):103-9. doi:
10.1016/0300-9629(95)00083-j. [PMID: 7553326] - J W Konturek, S J Konturek, W Domschke. Cholecystokinin in the control of gastric acid secretion and gastrin release in response to a meal at low and high pH in healthy subjects and duodenal ulcer patients.
Scandinavian journal of gastroenterology.
1995 Aug; 30(8):738-44. doi:
10.3109/00365529509096321. [PMID: 7481540] - C Niederau, M Niederau, H Klonowski, R Lüthen, L D Ferrell. Effect of hypergastrinemia and blockade of gastrin-receptors on pancreatic growth in the mouse.
Hepato-gastroenterology.
1995 Jul; 42(4):423-31. doi:
NULL. [PMID: 8586382] - M Karaus, C Niederau. Effects of CCK-receptor antagonist on colonic motor activity in dogs.
Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.
1995 Jun; 7(2):63-71. doi:
10.1111/j.1365-2982.1995.tb00210.x. [PMID: 7621322] - Y Nakae, S Naruse, M Kitagawa, S Hirao, R Yamamoto, T Hayakawa. Activation of trypsinogen in experimental models of acute pancreatitis in rats.
Pancreas.
1995 Apr; 10(3):306-13. doi:
10.1097/00006676-199504000-00014. [PMID: 7542773] - C D Kim, K Y Lee, T M Chang, W Y Chey. Negative feedback regulation of pancreatic exocrine secretion in guinea pigs.
Pancreas.
1995 Mar; 10(2):173-9. doi:
10.1097/00006676-199503000-00011. [PMID: 7716142] - J W Konturek, A Gabryelewicz, E Kulesza, S J Konturek, W Domschke. Cholecystokinin (CCK) in the amino acid uptake and enzyme protein secretion by the pancreas in humans.
International journal of pancreatology : official journal of the International Association of Pancreatology.
1995 Feb; 17(1):55-61. doi:
10.1007/bf02788359. [PMID: 8568335] - R J Lieverse, J B Jansen, M C Jebbink, A A Masclee, L C Rovati, C B Lamers. Effects of somatostatin and loxiglumide on gallbladder motility.
European journal of clinical pharmacology.
1995; 47(6):489-92. doi:
10.1007/bf00193699. [PMID: 7768249] - J W Konturek. Cholecystokinin in the control of gastric acid and plasma gastrin and somatostatin secretion in healthy subjects and duodenal ulcer patients before and after eradication of Helicobacter pylori.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society.
1994 Dec; 45(4 Suppl 1):3-66. doi:
NULL. [PMID: 7787215] - W E Schmidt, S Schenk, R Nustede, J J Holst, U R Fölsch, W Creutzfeldt. Cholecystokinin is a negative regulator of gastric acid secretion and postprandial release of gastrin in humans.
Gastroenterology.
1994 Dec; 107(6):1610-20. doi:
10.1016/0016-5085(94)90799-4. [PMID: 7958670] - H O Jin, K Y Lee, T M Chang, W Y Chey, A Dubois. Physiological role of cholecystokinin on gastric emptying and acid output in dogs.
Digestive diseases and sciences.
1994 Nov; 39(11):2306-14. doi:
10.1007/bf02087643. [PMID: 7956596] - M L Verhulst, H A Gielkens, W P Hopman, A van Schaik, A Tangerman, L C Rovati, J B Jansen. Loxiglumide inhibits cholecystokinin stimulated somatostatin secretion and simultaneously enhances gastric acid secretion in humans.
Regulatory peptides.
1994 Oct; 53(3):185-93. doi:
10.1016/0167-0115(94)90167-8. [PMID: 7846294] - K Shimizu, K Shiratori, S Watanabe, T Takeuchi, T M Chang, W Y Chey. Effect of protein derivatives on pancreatic secretion and release of secretin and CCK in rats.
The American journal of physiology.
1994 Oct; 267(4 Pt 1):G508-14. doi:
10.1152/ajpgi.1994.267.4.g508. [PMID: 7943315] - K Okubo, K Miyasaka, M Matsumoto, A Funakoshi. Mechanisms of stimulatory effect of neuromedin C on pancreatic exocrine secretion in conscious rats.
Pancreas.
1994 Sep; 9(5):585-90. doi:
10.1097/00006676-199409000-00008. [PMID: 7809013] - H Tomita, K Miyasaka, A Jimi, Y Mishima, A Funakoshi. Lack of effect of cholecystokinin receptor antagonist (CR1505) on recovery of experimental pancreatitis after pancreatic duct occlusion in rats.
Pancreas.
1994 Sep; 9(5):638-45. doi:
10.1097/00006676-199409000-00015. [PMID: 7809019] - M Otsuki, S Nakano, I Tachibana. Treatment with cholecystokinin receptor antagonist loxiglumide enhances insulin response to intravenous glucose stimulation in postpancreatitic rats.
Regulatory peptides.
1994 Jul; 52(2):85-95. doi:
10.1016/0167-0115(94)90041-8. [PMID: 7972939]