Fluoroform (BioDeep_00000384499)
代谢物信息卡片
Trifluoromethane
化学式: CHF3 (70.003)
中文名称: 三氟甲烷
谱图信息:
最多检出来源 Arabidopsis thaliana(not specific) 50%
分子结构信息
SMILES: C(F)(F)F
InChI: InChI=1S/CHF3/c2-1(3)4/h1H
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Jayaraman Jayabharathi, Venugopal Thanikachalam, Marimuthu Venkatesh Perumal. Studies on interaction between an imidazole derivative and bovine serum by spectral methods.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.
2012 Sep; 95(?):622-6. doi:
10.1016/j.saa.2012.04.064. [PMID: 22584126] - Jian Wu, Shenghong Kang, Baoan Song, Deyu Hu, Ming He, Linhong Jin, Song Yang. Synthesis and antibacterial activity against ralstonia solanacearum for novel hydrazone derivatives containing a pyridine moiety.
Chemistry Central journal.
2012 Apr; 6(?):28. doi:
10.1186/1752-153x-6-28. [PMID: 22483270] - Andy J Liedtke, Brenda C Crews, Cristina M Daniel, Anna L Blobaum, Philip J Kingsley, Kebreab Ghebreselasie, Lawrence J Marnett. Cyclooxygenase-1-selective inhibitors based on the (E)-2'-des-methyl-sulindac sulfide scaffold.
Journal of medicinal chemistry.
2012 Mar; 55(5):2287-300. doi:
10.1021/jm201528b. [PMID: 22263894] - Lucy M Elphick, Nadine Pawolleck, Irina A Guschina, Leila Chaieb, Daniel Eikel, Heinz Nau, John L Harwood, Nick J Plant, Robin S B Williams. Conserved valproic-acid-induced lipid droplet formation in Dictyostelium and human hepatocytes identifies structurally active compounds.
Disease models & mechanisms.
2012 Mar; 5(2):231-40. doi:
10.1242/dmm.008391. [PMID: 22003123] - Hisashi Shinkai. Cholesteryl ester transfer-protein modulator and inhibitors and their potential for the treatment of cardiovascular diseases.
Vascular health and risk management.
2012; 8(?):323-31. doi:
10.2147/vhrm.s25238. [PMID: 22661899] - M Sanjeeva Gandhi, Y S Mok. Decomposition of trifluoromethane in a dielectric barrier discharge non-thermal plasma reactor.
Journal of environmental sciences (China).
2012; 24(7):1234-9. doi:
10.1016/s1001-0742(11)60935-2. [PMID: 23513444] - Tatsuya Homma, Koji Harano, Hiroyuki Isobe, Eiichi Nakamura. Preparation and properties of vesicles made of nonpolar/polar/nonpolar fullerene amphiphiles.
Journal of the American Chemical Society.
2011 Apr; 133(16):6364-70. doi:
10.1021/ja200498g. [PMID: 21456527] - Susan Yeyeodu, Nailya Gilyazova, Eun Young Huh, Srinivasa R Dandepally, Carla Oldham, Alfred Williams, Gordon Ibeanu. A trifluoromethyl analog of verbenachalcone promotes neurite outgrowth and cell proliferation of NeuroScreen-1 cells.
Cellular and molecular neurobiology.
2011 Jan; 31(1):145-53. doi:
10.1007/s10571-010-9563-3. [PMID: 20848307] - Salim Abdulla, Baraka Amuri, Abdunoor M Kabanywanyi, David Ubben, Christine Reynolds, Steve Pascoe, Serge Fitoussi, Ching-Ming Yeh, Marja Nuortti, Romain Séchaud, Günther Kaiser, Gilbert Lefèvre. Early clinical development of artemether-lumefantrine dispersible tablet: palatability of three flavours and bioavailability in healthy subjects.
Malaria journal.
2010 Sep; 9(?):253. doi:
10.1186/1475-2875-9-253. [PMID: 20815879] - Ru-Liang Xie, Tao Zhang, Ao-Cheng Cao, Xiang-Dong Mei. 4-(4-Chloro-5-methyl-3-trifluoro-meth-yl-1H-pyrazol-1-yl)-6-(prop-2-ynyl-oxy)pyrimidine.
Acta crystallographica. Section E, Structure reports online.
2010 Aug; 66(Pt 9):o2307. doi:
10.1107/s1600536810031740. [PMID: 21588656] - Aishen Gong, Xiaoyan Chen, Pan Deng, Dafang Zhong. Metabolism of flumatinib, a novel antineoplastic tyrosine kinase inhibitor, in chronic myelogenous leukemia patients.
Drug metabolism and disposition: the biological fate of chemicals.
2010 Aug; 38(8):1328-40. doi:
10.1124/dmd.110.032326. [PMID: 20478851] - Benjamin C Buer, Jeetender Chugh, Hashim M Al-Hashimi, E Neil G Marsh. Using fluorine nuclear magnetic resonance to probe the interaction of membrane-active peptides with the lipid bilayer.
Biochemistry.
2010 Jul; 49(27):5760-5. doi:
10.1021/bi100605e. [PMID: 20527804] - Yongchao Su, William F DeGrado, Mei Hong. Orientation, dynamics, and lipid interaction of an antimicrobial arylamide investigated by 19F and 31P solid-state NMR spectroscopy.
Journal of the American Chemical Society.
2010 Jul; 132(26):9197-205. doi:
10.1021/ja103658h. [PMID: 20536141] - Sang Hwui Lee, Jian-Qiang Lu. Nano-ring-shape growth of fluorocarbon macromolecules during SiO2 etching.
Nanotechnology.
2010 Apr; 21(15):155303. doi:
10.1088/0957-4484/21/15/155303. [PMID: 20332556] - Christopher P Thomas, Lloyd T Morgan, Benjamin H Maskrey, Robert C Murphy, Hartmut Kühn, Stanley L Hazen, Alison H Goodall, Hassan A Hamali, Peter W Collins, Valerie B O'Donnell. Phospholipid-esterified eicosanoids are generated in agonist-activated human platelets and enhance tissue factor-dependent thrombin generation.
The Journal of biological chemistry.
2010 Mar; 285(10):6891-903. doi:
10.1074/jbc.m109.078428. [PMID: 20061396] - Yong-Hong Li, Tao Zhang, Xiang-Dong Mei, Jun Ning. 4,6-Bis[5-methyl-3-(trifluoro-meth-yl)pyrazol-1-yl]pyrimidine.
Acta crystallographica. Section E, Structure reports online.
2009 Oct; 65(Pt 11):o2865. doi:
10.1107/s1600536809043657. [PMID: 21578452] - Hong-Ju Ma, Qian-Fei Zhao, Xiang-Dong Mei, Jun Ning. 4-Bromo-5-[(5,5-dimethyl-4,5-dihydro-isoxazol-3-yl)sulfonyl-meth-yl]-3-methyl-1-(2,2,2-trifluoro-ethyl)-1H-pyrazole.
Acta crystallographica. Section E, Structure reports online.
2009 Oct; 65(Pt 11):o2702-3. doi:
10.1107/s1600536809040380. [PMID: 21578303] - Sara Montanaro, Virginie Lhiaubet-Vallet, M Consuelo Jiménez, Miguel Blanca, Miguel Angel Miranda. Photonucleophilic addition of the epsilon-amino group of lysine to a triflusal metabolite as a mechanistic key to photoallergy mediated by the parent drug.
ChemMedChem.
2009 Jul; 4(7):1196-202. doi:
10.1002/cmdc.200900066. [PMID: 19462393] - Shaogang Chu, Robert J Letcher. Linear and branched perfluorooctane sulfonate isomers in technical product and environmental samples by in-port derivatization-gas chromatography-mass spectrometry.
Analytical chemistry.
2009 Jun; 81(11):4256-62. doi:
10.1021/ac8027273. [PMID: 19402680] - Ethel A Wilhelm, Cristiano R Jesse, Cristina W Nogueira, Lucielli Savegnago. Introduction of trifluoromethyl group into diphenyl diselenide molecule alters its toxicity and protective effect against damage induced by 2-nitropropane in rats.
Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie.
2009 May; 61(3):197-203. doi:
10.1016/j.etp.2008.08.003. [PMID: 18818063] - Stefan Balaz. Modeling kinetics of subcellular disposition of chemicals.
Chemical reviews.
2009 May; 109(5):1793-899. doi:
10.1021/cr030440j. [PMID: 19265398] - Toshiyuki Harada, Yoshiaki Nakagawa, Randy M Wadkins, Philip M Potter, Craig E Wheelock. Comparison of benzil and trifluoromethyl ketone (TFK)-mediated carboxylesterase inhibition using classical and 3D-quantitative structure-activity relationship analysis.
Bioorganic & medicinal chemistry.
2009 Jan; 17(1):149-64. doi:
10.1016/j.bmc.2008.11.008. [PMID: 19062296] - Lorraine M Deck, Lucy A Hunsaker, Amanda M Gonzales, Robert A Orlando, David L Vander Jagt. Substituted trans-stilbenes can inhibit or enhance the TPA-induced up-regulation of activator protein-1.
BMC pharmacology.
2008 Nov; 8(?):19. doi:
10.1186/1471-2210-8-19. [PMID: 19000313] - Hiroyuki Miyachi, Yuichi Hashimoto. Structural Development Studies of Subtype-Selective Ligands for Peroxisome Proliferator-Activated Receptors (PPARs) Based on the 3,4-Disubstituted Phenylpropanoic Acid Scaffold as a Versatile Template.
PPAR research.
2008; 2008(?):689859. doi:
10.1155/2008/689859. [PMID: 18566690] - Sergii Afonin, Pavel K Mikhailiuk, Igor V Komarov, Anne S Ulrich. Evaluating the amino acid CF3-bicyclopentylglycine as a new label for solid-state 19 F-NMR structure analysis of membrane-bound peptides.
Journal of peptide science : an official publication of the European Peptide Society.
2007 Sep; 13(9):614-23. doi:
10.1002/psc.854. [PMID: 17694569] - A Rehorek, P Hoffmann, A Kandelbauer, G M Gübitz. Sonochemical substrate selectivity and reaction pathway of systematically substituted azo compounds.
Chemosphere.
2007 Apr; 67(8):1526-32. doi:
10.1016/j.chemosphere.2006.12.044. [PMID: 17270236] - Ya-Fen Wang, Minliang Shih, Cheng-Hsien Tsai, Perng-Jy Tsai. Total toxicity equivalents emissions of SF6, CHF3, and CCl2F2 decomposed in a RF plasma environment.
Chemosphere.
2006 Mar; 62(10):1681-8. doi:
10.1016/j.chemosphere.2005.06.036. [PMID: 16084562] - Sijia Xue, Shaoyong Ke, Lin Yan, Zhijuan Cai, Yongge Wei. A trifluoromethyl substituted organoimido derivative of the hexametalate cluster: synthesis, crystal structure and bioactivity of [Mo6O17(NAr)2]2- (Ar=o-CF3C6H4).
Journal of inorganic biochemistry.
2005 Dec; 99(12):2276-81. doi:
10.1016/j.jinorgbio.2005.08.006. [PMID: 16213023] - Alemayehu Asfaw, Grethe Wibetoe. Freon (CHF3)-assisted atomization for the determination of titanium using ultrasonic slurry sampling-graphite furnace atomic absorption spectrometry (USS-GFAAS): a simple and advantageous method for solid samples.
Analytical and bioanalytical chemistry.
2004 Jun; 379(3):526-31. doi:
10.1007/s00216-004-2588-z. [PMID: 15071714] - Michihiro Ohno, Zhan-Guo Gao, Philippe Van Rompaey, Susanna Tchilibon, Soo-Kyung Kim, Brian A Harris, Ariel S Gross, Heng T Duong, Serge Van Calenbergh, Kenneth A Jacobson. Modulation of adenosine receptor affinity and intrinsic efficacy in adenine nucleosides substituted at the 2-position.
Bioorganic & medicinal chemistry.
2004 Jun; 12(11):2995-3007. doi:
10.1016/j.bmc.2004.03.031. [PMID: 15142558] - Grégori Gerebtzoff, Xiaochun Li-Blatter, Holger Fischer, Adrian Frentzel, Anna Seelig. Halogenation of drugs enhances membrane binding and permeation.
Chembiochem : a European journal of chemical biology.
2004 May; 5(5):676-84. doi:
10.1002/cbic.200400017. [PMID: 15122640] - Agnieszka Sekowska, Antoine Danchin. The methionine salvage pathway in Bacillus subtilis.
BMC microbiology.
2002 Apr; 2(?):8. doi:
10.1186/1471-2180-2-8. [PMID: 12022921] - Toshiaki Mori, Ming Li, Atsushi Kobayashi, Yoshio Okahata. Reversible control of enzymatic transglycosylations in supercritical fluoroform using a lipid-coated beta-D-galactosidase.
Journal of the American Chemical Society.
2002 Feb; 124(7):1188-9. doi:
10.1021/ja0169522. [PMID: 11841285] - Maurizio Bettinelli, Sandro Spezia, Cesarina Terni, Anna Ronchi, Claudio Balducci, Claudio Minoia. Determination of rare earth elements in urine by electrothermal vaporization inductively coupled plasma mass spectrometry.
Rapid communications in mass spectrometry : RCM.
2002; 16(6):579-84. doi:
10.1002/rcm.609. [PMID: 11870895] - A K Khatua, M Bhattacharyya. NADPH-induced oxidative damage of rat liver microsomes: protective role of chlorpromazine and trifluoperazine.
Polish journal of pharmacology.
2001 Nov; 53(6):629-34. doi:
". [PMID: 11985337] - T Mori, M Funasaki, A Kobayashi, Y Okhata. Reversible activity changes of lipid-coated lipase for enantioselective esterification in supercritical fluoroform.
Chemical communications (Cambridge, England).
2001 Sep; ?(18):1832-3. doi:
10.1039/b104913p. [PMID: 12240337] - K C Friese, U Wätjen, K H Grobecker. Analyte transport efficiencies in electrothermal vaporization for inductively coupled plasma mass spectrometry.
Fresenius' journal of analytical chemistry.
2001 Aug; 370(7):843-9. doi:
10.1007/s002160100865. [PMID: 11569862] - F Boscá, M C Cuquerella, M L Marín, M A Miranda. Photochemistry of 2-hydroxy-4-trifluoromethylbenzoic acid, major metabolite of the photosensitizing platelet antiaggregant drug triflusal.
Photochemistry and photobiology.
2001 May; 73(5):463-8. doi:
10.1562/0031-8655(2001)0730463pohtam2.0.co2. [PMID: 11367565]
