Alanosine (BioDeep_00000381343)

   


代谢物信息卡片


[(2S)-2-amino-2-carboxyethyl]-hydroxyimino-oxidoazanium

化学式: C3H7N3O4 (149.0436542)
中文名称: L-丙氨酸, 3-(羟基亚硝基氨基)丙氨酸
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C(C(C(=O)O)N)[N+](=NO)[O-]
InChI: InChI=1S/C3H7N3O4/c4-2(3(7)8)1-6(10)5-9/h2,9H,1,4H2,(H,7,8)/b6-5-

描述信息

D064449 - Sequestering Agents > D002614 - Chelating Agents
D000970 - Antineoplastic Agents
C274 - Antineoplastic Agent > C186664 - Cytotoxic Chemotherapeutic Agent > C272 - Antimetabolite
C471 - Enzyme Inhibitor > C2168 - Adenylosuccinate Synthetase Inhibitor

同义名列表

4 个代谢物同义名

[(2S)-2-amino-2-carboxyethyl]-hydroxyimino-oxidoazanium; Alanosine; DL-Alanosine; 3-(Hydroxynitrosoamino)alanine



数据库引用编号

11 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • Alex Gantverg, Gary Elliott, Jean Pineault, Roger Demers. Determination of derivatized l-alanosine in plasma by liquid chromatography-tandem mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2004 Apr; 803(2):311-5. doi: 10.1016/j.jchromb.2004.01.003. [PMID: 15063341]
  • P C Dagher. Modeling ischemia in vitro: selective depletion of adenine and guanine nucleotide pools. American journal of physiology. Cell physiology. 2000 Oct; 279(4):C1270-7. doi: 10.1152/ajpcell.2000.279.4.c1270. [PMID: 11003607]
  • J Yu, A Batova, L Shao, C J Carrera, A L Yu. Presence of methylthioadenosine phosphorylase (MTAP) in hematopoietic stem/progenitor cells: its therapeutic implication for MTAP (-) malignancies. Clinical cancer research : an official journal of the American Association for Cancer Research. 1997 Mar; 3(3):433-8. doi: . [PMID: 9815702]
  • O M Guicherit, B F Cooper, F B Rudolph, R E Kellems. Amplification of an adenylosuccinate synthetase gene in alanosine-resistant murine T-lymphoma cells. Molecular cloning of a cDNA encoding the 'non-muscle' isozyme. The Journal of biological chemistry. 1994 Feb; 269(6):4488-96. doi: 10.1016/s0021-9258(17)41805-9. [PMID: 8308018]
  • B Ramachandran, K Houben, Y Y Rozenberg, J R Haigh, A Varpetian, B D Howard. Differential expression of transporters for norepinephrine and glutamate in wild type, variant, and WNT1-expressing PC12 cells. The Journal of biological chemistry. 1993 Nov; 268(32):23891-7. doi: 10.1016/s0021-9258(20)80469-4. [PMID: 8226929]
  • J C Pang, R P Du, H Bingham, P Juranka, V L Chan. Imbalance of purine nucleotides in alanosine-resistant baby hamster kidney cells. Somatic cell and molecular genetics. 1989 Mar; 15(2):101-11. doi: 10.1007/bf01535070. [PMID: 2538926]
  • P J Elson, L K Kvols, S E Vogl, D J Glover, R G Hahn, D L Trump, P P Carbone, J D Earle, T E Davis. Phase II trials of 5-day vinblastine infusion (NSC 49842), L-alanosine (NSC 153353), acivicin (NSC 163501), and aminothiadiazole (NSC 4728) in patients with recurrent or metastatic renal cell carcinoma. Investigational new drugs. 1988 Jun; 6(2):97-103. doi: 10.1007/bf00195367. [PMID: 3170135]
  • R Daniels, T Gerbracht, R A Flickinger. Cell growth and division in relation to differentiation of mouse erythroleukemia cells. Cell biology international reports. 1988 Apr; 12(4):299-303. doi: 10.1016/0309-1651(88)90074-4. [PMID: 3165307]
  • G Powis. Dose-dependent metabolism, therapeutic effect, and toxicity of anticancer drugs in man. Drug metabolism reviews. 1983; 14(6):1145-63. doi: 10.3109/03602538308991425. [PMID: 6373208]
  • G Powis, M M Ames. Determination of L-alanosine in plasma and urine by reversed-phase high-performance liquid chromatography of the Dns derivative. Journal of chromatography. 1979 Feb; 170(1):195-201. doi: 10.1016/s0021-9673(00)84251-x. [PMID: 544618]
  • J M Kelley, R H Adamson, D A Cooney, H N Jayaram, S Anandaraj. Pharmacologic disposition of DL-alanosine in mice, rats, dogs, and monkeys. Cancer treatment reports. 1977 Nov; 61(8):1471-84. doi: NULL. [PMID: 411570]