Cyclosporine metabolite M17 (BioDeep_00000379083)

   


代谢物信息卡片


33-[(E)-1,6-dihydroxy-2-methylhex-4-enyl]-30-ethyl-1,4,7,10,12,15,19,25,28-nonamethyl-6,9,18,24-tetrakis(2-methylpropyl)-3,21-di(propan-2-yl)-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotritriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone

化学式: C62H111N11O13 (1217.8362396)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CCC1C(=O)N(CC(=O)N(C(C(=O)NC(C(=O)N(C(C(=O)NC(C(=O)NC(C(=O)N(C(C(=O)N(C(C(=O)N(C(C(=O)N(C(C(=O)N1)C(C(C)CC=CCO)O)C)C(C)C)C)CC(C)C)C)CC(C)C)C)C)C)CC(C)C)C)C(C)C)CC(C)C)C)C
InChI: InChI=1S/C62H111N11O13/c1-24-43-58(82)67(17)33-48(75)68(18)44(29-34(2)3)55(79)66-49(38(10)11)61(85)69(19)45(30-35(4)5)54(78)63-41(15)53(77)64-42(16)57(81)70(20)46(31-36(6)7)59(83)71(21)47(32-37(8)9)60(84)72(22)50(39(12)13)62(86)73(23)51(56(80)65-43)52(76)40(14)27-25-26-28-74/h25-26,34-47,49-52,74,76H,24,27-33H2,1-23H3,(H,63,78)(H,64,77)(H,65,80)(H,66,79)/b26-25+

描述信息

D007155 - Immunologic Factors > D007166 - Immunosuppressive Agents > D003524 - Cyclosporins

同义名列表

2 个代谢物同义名

Cyclosporine metabolite M17; 33-[(E)-1,6-dihydroxy-2-methylhex-4-enyl]-30-ethyl-1,4,7,10,12,15,19,25,28-nonamethyl-6,9,18,24-tetrakis(2-methylpropyl)-3,21-di(propan-2-yl)-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotritriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone



数据库引用编号

7 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • G I Kirchner, M Winkler, L Mueller, C Vidal, W Jacobsen, A Franzke, S Wagner, S Blick, M P Manns, K F Sewing. Pharmacokinetics of SDZ RAD and cyclosporin including their metabolites in seven kidney graft patients after the first dose of SDZ RAD. British journal of clinical pharmacology. 2000 Nov; 50(5):449-54. doi: 10.1046/j.1365-2125.2000.00293.x. [PMID: 11069439]
  • G Khoschsorur, T Auer, G Lanzer, P Petritsch, H Holzer, K H Tscheliessnigg. The determination of metabolite M17 and its meaning for immunosuppressive cyclosporin therapy. Angiology. 1998 Apr; 49(4):307-14. doi: 10.1177/000331979804900409. [PMID: 9555934]
  • V F Quesniaux, D Schmitter, M H Schreier, M H Van Regenmortel. Monoclonal antibodies to cyclosporin are representative of the major antibody populations present in antisera of immunized mice. Molecular immunology. 1990 Mar; 27(3):227-36. doi: 10.1016/0161-5890(90)90134-l. [PMID: 2342487]
  • K Copeland, M Lukowski, R Yatscoff, J Thliveris, N Honcharik. Pharmacokinetics and biotransformation of the cyclosporine metabolite M-17 in the rabbit. Drug metabolism and disposition: the biological fate of chemicals. 1990 Mar; 18(2):226-30. doi: NULL. [PMID: 1971578]
  • E Cole, K Skorecki, F Cheung, P Y Wong, L S Fung, G A Levy. Cyclosporine A in contrast to a cyclosporine metabolite (OL-17) specifically inhibits growth of renal cells in culture. Transplantation proceedings. 1988 Jun; 20(3 Suppl 3):732-7. doi: NULL. [PMID: 3388511]
  • K SCHUBERT, G FRANKENBERG, G BACIGALUPO. [ON THE APPEARANCE OF DELTA-4-ANDROSTENE-3,17-DIONE AND TESTOSTERONE IN THE URINE AFTER INFUSION OF DELTA-5-ANDROSTENE-3-BETA-OL-17-ONE PHOSPHATE]. Hoppe-Seyler's Zeitschrift fur physiologische Chemie. 1964; 336(?):96-9. doi: 10.1515/bchm2.1964.336.1.96. [PMID: 14214326]
  • G W OERTEL, K B EIK-NES. Isolation and identification of etiocholan-3 alpha-ol-17-one and etiocholane-3 alpha, 11 beta-diol-17-one from human blood plasma. Archives of biochemistry and biophysics. 1961 Jan; 92(?):150-3. doi: 10.1016/0003-9861(61)90229-6. [PMID: 13730351]
  • M NEEMAN, W R SLAUNWHITE, L M NEELY, J G COLSON, A A SANDBERG. 3,5-androstadiene-11beta-ol-17-one: a new metabolic product of 4-androstene-11beta-ol-3,17-dione in man. The Journal of biological chemistry. 1960 Nov; 235(?):PC58. doi: 10.1016/s0021-9258(20)81366-0. [PMID: 13728126]
  • E E BAULIEU. [Ester sulfates of steroid hormones. Isolation and characterization in urines of the ester sulfate of 5 beta-androstane 3 alpha-ol-17-one after administration of 5 beta-androstane 3 alpha-ol 17 one (etiocholanolone) to a child]. Comptes rendus hebdomadaires des seances de l'Academie des sciences. 1960 Jun; 250(?):4219-21. doi: NULL. [PMID: 13797694]
  • E DINGEMANSE, L G HUIS IN'T VELD. Isolation of i-androstan-6-ol-17-one from urine of patients with adrenal neoplasm. The Journal of biological chemistry. 1952 Apr; 195(2):827-35. doi: 10.1016/s0021-9258(18)55793-8. [PMID: 14946194]