Ubiquinone Q0 (BioDeep_00000368893)

   


代谢物信息卡片


2,3-Dimethoxy-5-methyl-1,4-benzoquinone

化学式: C9H10O4 (182.057906)
中文名称: 2,3-二甲氧基-5-甲基-1,4-苯醌
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC1=CC(=O)C(=C(C1=O)OC)OC
InChI: InChI=1S/C9H10O4/c1-5-4-6(10)8(12-2)9(13-3)7(5)11/h4H,1-3H3

描述信息

Coenzyme Q0 (CoQ0) is a potent, oral active ubiquinone compound can be derived from Antrodia cinnamomea. Coenzyme Q0 induces apoptosis and autophagy, suppresses of HER-2/AKT/mTOR signaling to potentiate the apoptosis and autophagy mechanisms. Coenzyme Q0 regulates NFκB/AP-1 activation and enhances Nrf2 stabilization in attenuation of inflammation and redox imbalance. Coenzyme Q0 has anti-angiogenic activity through downregulation of MMP-9/NF-κB and upregulation of HO-1 signaling[1][2][3].

同义名列表

5 个代谢物同义名

2,3-Dimethoxy-5-methyl-1,4-benzoquinone; Ubiquinone Q0; CoQ0; Coenzyme Q0; 2,3-Dimethoxy-5-methyl-1,4-benzoquinone



数据库引用编号

6 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(2)

PlantCyc(0)

代谢反应

4 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(4)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Ju-Hyun Jeon, Ji-Yeon Yang, Hoi-Seon Lee. Acaricidal activities of materials derived from Pyrus ussuriensis fruits against stored food mites. Journal of food protection. 2012 Jul; 75(7):1258-62. doi: 10.4315/0362-028x.jfp-12-040. [PMID: 22980009]
  • Gabriel Scalliet, Judith Bowler, Torsten Luksch, Lucy Kirchhofer-Allan, Diana Steinhauer, Keith Ward, Michael Niklaus, Andreas Verras, Michael Csukai, Antoine Daina, Raymonde Fonné-Pfister. Mutagenesis and functional studies with succinate dehydrogenase inhibitors in the wheat pathogen Mycosphaerella graminicola. PloS one. 2012; 7(4):e35429. doi: 10.1371/journal.pone.0035429. [PMID: 22536383]
  • Ming-Der Wu, Ming-Jen Cheng, Wei-Yi Wang, Hui-Chun Huang, Gwo-Fang Yuan, Jih-Jung Chen, Ih-Sheng Chen, Bor-Cheh Wang. Antioxidant activities of extracts and metabolites isolated from the fungus Antrodia cinnamomea. Natural product research. 2011 Sep; 25(16):1488-96. doi: 10.1080/14786410903132563. [PMID: 21337253]
  • Pedro Sanchez-Cruz, Carmelo Garcia, Antonio E Alegria. Role of quinones in the ascorbate reduction rates of S-nitrosoglutathione. Free radical biology & medicine. 2010 Nov; 49(9):1387-94. doi: 10.1016/j.freeradbiomed.2010.07.022. [PMID: 20691779]
  • Vitaly A Roginsky, Vadim N Tashlitsky, Vladimir P Skulachev. Chain-breaking antioxidant activity of reduced forms of mitochondria-targeted quinones, a novel type of geroprotectors. Aging. 2009 May; 1(5):481-9. doi: 10.18632/aging.100049. [PMID: 20195487]
  • Muralikrishnan Dhanasekaran, Jun Ren. The emerging role of coenzyme Q-10 in aging, neurodegeneration, cardiovascular disease, cancer and diabetes mellitus. Current neurovascular research. 2005 Dec; 2(5):447-59. doi: 10.2174/156720205774962656. [PMID: 16375724]
  • Petr Galuszka, Jitka Frébortová, Tomás Werner, Mamoru Yamada, Miroslav Strnad, Thomas Schmülling, Ivo Frébort. Cytokinin oxidase/dehydrogenase genes in barley and wheat: cloning and heterologous expression. European journal of biochemistry. 2004 Oct; 271(20):3990-4002. doi: 10.1111/j.1432-1033.2004.04334.x. [PMID: 15479228]
  • Jason W Cooley, Arthur G Roberts, Michael K Bowman, David M Kramer, Fevzi Daldal. The raised midpoint potential of the [2Fe2S] cluster of cytochrome bc1 is mediated by both the Qo site occupants and the head domain position of the Fe-S protein subunit. Biochemistry. 2004 Mar; 43(8):2217-27. doi: 10.1021/bi035938u. [PMID: 14979718]
  • Yong Deng, Ji-Yu Ye, Hua-Ling Mi, Yun-Gang Shen. [Separation of hydrophobic NAD(P)H dehydrogenase subcomplexes from cyanobacterium Synechocystis PCC6803]. Sheng wu hua xue yu sheng wu wu li xue bao Acta biochimica et biophysica Sinica. 2003 Aug; 35(8):723-7. doi: . [PMID: 12897967]
  • S F Martín, F Navarro, N Forthoffer, P Navas, J M Villalba. Neutral magnesium-dependent sphingomyelinase from liver plasma membrane: purification and inhibition by ubiquinol. Journal of bioenergetics and biomembranes. 2001 Apr; 33(2):143-53. doi: 10.1023/a:1010704715979. [PMID: 11456220]
  • P Galuszka, I Frébort, M Sebela, P Sauer, S Jacobsen, P Pec. Cytokinin oxidase or dehydrogenase? Mechanism of cytokinin degradation in cereals. European journal of biochemistry. 2001 Jan; 268(2):450-61. doi: 10.1046/j.1432-1033.2001.01910.x. [PMID: 11168382]
  • V E Kagan, A Arroyo, V A Tyurin, Y Y Tyurina, J M Villalba, P Navas. Plasma membrane NADH-coenzyme Q0 reductase generates semiquinone radicals and recycles vitamin E homologue in a superoxide-dependent reaction. FEBS letters. 1998 May; 428(1-2):43-6. doi: 10.1016/s0014-5793(98)00482-7. [PMID: 9645471]
  • V A Roginsky, G Bruchelt, O Bartuli. Ubiquinone-0 (2,3-dimethoxy-5-methyl-1,4-benzoquinone) as effective catalyzer of ascorbate and epinephrine oxidation and damager of neuroblastoma cells. Biochemical pharmacology. 1998 Jan; 55(1):85-91. doi: 10.1016/s0006-2952(97)00434-6. [PMID: 9413934]