Thymidine glycol (BioDeep_00000036572)

   

human metabolite Endogenous


代谢物信息卡片


4,5,6-trihydroxy-1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-methyl-1,2,5,6-tetrahydropyrimidin-2-one

化学式: C10H16N2O7 (276.0957466)
中文名称:
谱图信息: 最多检出来源 Bos taurus(endogenous) 50%

分子结构信息

SMILES: CC1(C(N(C(=O)NC1=O)C2CC(C(O2)CO)O)O)O
InChI: InChI=1S/C10H16N2O7/c1-10(18)7(15)11-9(17)12(8(10)16)6-2-4(14)5(3-13)19-6/h4-6,8,13-14,16,18H,2-3H2,1H3,(H,11,15,17)/t4-,5+,6+,8?,10?/m0/s1

描述信息

Thymidine glycol belongs to the family of Pyrimidine 2-deoxyribonucleosides and Analogues. These are compounds consisting of a pyrimidine linked to a ribose which lacks an hydroxyl group at position 2.

同义名列表

13 个代谢物同义名

4,5,6-trihydroxy-1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-methyl-1,2,5,6-tetrahydropyrimidin-2-one; 4,5,6-trihydroxy-1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-methyl-6H-pyrimidin-2-one; 5,6-Dihydro-5,6-dihydroxythymidine; 5,6-Dihydroxy-5,6-dihydrothymidine; Thymidine glycol, (5R*,6S*)-isomer; Thymidine glycol, (5S,6R)-isomer; Thymidine glycol, (5S,6S)-isomer; Thymidine glycol, (trans)-isomer; Thymidine glycol, (5R,6R)-isomer; Thymidine glycol, (5R,6S)-isomer; Thymidine glycol, (cis)-isomer; Thymidine glycol; Glycolthymidine



数据库引用编号

6 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Antonio Mancini, Francesco Guidi, Carmine Bruno, Flavia Angelini, Edoardo Vergani, Paola Lanza, Alvaro Mordente, Elisabetta Meucci, Andrea Silvestrini. Can plasma antioxidants prevent DNA damage in oxidative stress condition induced by growth hormone deficiency? A pilot study. PloS one. 2021; 16(4):e0248971. doi: 10.1371/journal.pone.0248971. [PMID: 33793606]
  • Frazer J Lowe, Karsta Luettich, Evan O Gregg. Lung cancer biomarkers for the assessment of modified risk tobacco products: an oxidative stress perspective. Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals. 2013 May; 18(3):183-95. doi: 10.3109/1354750x.2013.777116. [PMID: 23530763]
  • Frazer J Lowe, Evan O Gregg, Michael McEwan. Evaluation of biomarkers of exposure and potential harm in smokers, former smokers and never-smokers. Clinical chemistry and laboratory medicine. 2009; 47(3):311-20. doi: 10.1515/cclm.2009.069. [PMID: 19676143]
  • W Makropoulos, K Kocher, B Heintz, E R Schwarz, P R Mertens, I Stefanidis. Urinary thymidine glycol as a biomarker for oxidative stress after kidney transplantation. Renal failure. 2000; 22(4):499-510. doi: 10.1081/jdi-100100891. [PMID: 10901187]
  • R Thier, T Brüning, K Kocher, M Blaszkewicz, V Makropoulos, A Sundberg, H M Bolt. Determination of urinary thymidine glycol using affinity chromatography, HPLC and post-column reaction detection: a biomarker of oxidative DNA damage upon kidney transplantation. Archives of toxicology. 1999 Nov; 73(8-9):479-84. doi: 10.1007/s002040050638. [PMID: 10650920]
  • E H Cao, J J Wang. Oxidative damage to DNA: levels of thymine glycol and thymidine glycol in neoplastic human urines. Carcinogenesis. 1993 Jul; 14(7):1359-62. doi: 10.1093/carcin/14.7.1359. [PMID: 8330350]
  • K Frenkel. Oxidation of DNA bases by tumor promoter-activated processes. Environmental health perspectives. 1989 May; 81(?):45-54. doi: 10.1289/ehp.898145. [PMID: 2667984]
  • D S Bergtold, M G Simic. Background levels of DNA damage. Free radical research communications. 1989; 6(2-3):195-7. doi: 10.3109/10715768909073469. [PMID: 2744602]
  • R Adelman, R L Saul, B N Ames. Oxidative damage to DNA: relation to species metabolic rate and life span. Proceedings of the National Academy of Sciences of the United States of America. 1988 Apr; 85(8):2706-8. doi: 10.1073/pnas.85.8.2706. [PMID: 3128794]
  • D S Bergtold, M G Simic, H Alessio, R G Cutler. Urine biomarkers for oxidative DNA damage. Basic life sciences. 1988; 49(?):483-9. doi: 10.1007/978-1-4684-5568-7_75. [PMID: 3250507]
  • K Frenkel, K Chrzan, W Troll, G W Teebor, J J Steinberg. Radiation-like modification of bases in DNA exposed to tumor promoter-activated polymorphonuclear leukocytes. Cancer research. 1986 Nov; 46(11):5533-40. doi: NULL. [PMID: 3756901]
  • R Cathcart, E Schwiers, R L Saul, B N Ames. Thymine glycol and thymidine glycol in human and rat urine: a possible assay for oxidative DNA damage. Proceedings of the National Academy of Sciences of the United States of America. 1984 Sep; 81(18):5633-7. doi: 10.1073/pnas.81.18.5633. [PMID: 6592579]