Thiodiglycol (BioDeep_00000036571)

   

human metabolite Endogenous


代谢物信息卡片


2-[(2-Hydroxyethyl)sulphanyl]ethan-1-ol

化学式: C4H10O2S (122.040148)
中文名称: 硫双乙醇
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C(CSCCO)O
InChI: InChI=1S/C4H10O2S/c5-1-3-7-4-2-6/h5-6H,1-4H2

描述信息

Thiodiglycol, or bis(2-hydroxyethyl)sulfide (also known as 2,2-thiodiethanol or TDE), is a viscous, clear to pale-yellow liquid used as a solvent. Its chemical formula is C4H10O2S, or HOCH2CH2SCH2CH2OH. It is miscible with acetone, alcohols, and chloroform. It is soluble in benzene, ether, and tetrachloromethane.
C274 - Antineoplastic Agent > C186664 - Cytotoxic Chemotherapeutic Agent > C2842 - DNA Binding Agent
D004791 - Enzyme Inhibitors

同义名列表

79 个代谢物同义名

2-[(2-Hydroxyethyl)sulphanyl]ethan-1-ol; 2-[(2-Hydroxyethyl)sulfanyl]ethan-1-ol; beta,Beta-dihydroxydiethyl sulphide; beta,Beta-dihydroxydiethyl sulfide; beta,Beta-dihydroxyethyl sulphide; beta,Beta-dihydroxyethyl sulfide; b,Beta-dihydroxydiethyl sulphide; Β,beta-dihydroxydiethyl sulphide; beta-Bis(hydroxyethyl) sulphide; b,Beta-dihydroxydiethyl sulfide; Β,beta-dihydroxydiethyl sulfide; Bis(beta-hydroxyethyl) sulphide; b,Beta-dihydroxyethyl sulphide; Bis(beta-hydroxyethyl) sulfide; Bis(beta-hydroxyethyl)sulphide; beta-Bis(hydroxyethyl) sulfide; Β,beta-dihydroxyethyl sulphide; Bis(beta-hydroxyethyl)sulfide; Bis(2-hydroxyethyl) thioether; b,Beta-dihydroxyethyl sulfide; Β,beta-dihydroxyethyl sulfide; Bis(2-hydroxyethyl) sulphide; Sulfide, bis(2-hydroxyethyl); Bis(b-hydroxyethyl) sulphide; Bis(β-hydroxyethyl) sulphide; Β-bis(hydroxyethyl) sulphide; b-Bis(hydroxyethyl) sulphide; Di(2-hydroxyethyl) sulphide; Bis(2-hydroxyethyl) sulfide; Bis(β-hydroxyethyl) sulfide; Bis(b-hydroxyethyl) sulfide; Β-bis(hydroxyethyl) sulfide; b-Bis(hydroxyethyl) sulfide; Bis(2-hydroxyethyl)sulphide; Bis(β-hydroxyethyl)sulphide; Bis(b-hydroxyethyl)sulphide; Bis(β-hydroxyethyl)sulfide; Bis(b-hydroxyethyl)sulfide; beta-Hydroxyethyl sulphide; Di(2-hydroxyethyl) sulfide; Bis(2-hydroxyethyl)sulfide; beta-Hydroxyethyl sulfide; Bis(hydroxyethyl)sulphide; beta-Hydroxyethyl sulphid; Bis(hydroxyethyl)sulfide; beta-Hydroxyethyl sulfid; b-Hydroxyethyl sulphide; Dihydroxyethyl sulphide; Β-hydroxyethyl sulphide; Β-hydroxyethyl sulfide; b-Hydroxyethyl sulfide; 3-Thiapentane-1,5-diol; Β-hydroxyethyl sulphid; Dihydroxyethyl sulfide; b-Hydroxyethyl sulphid; Thiodiethylene glycol; b-Hydroxyethyl sulfid; Β-hydroxyethyl sulfid; 2,2-Thiobis[ethanol]; 2,2-Thiobis-ethanol; 2,2-Sulfobisethanol; 2,2-Thiodi-ethanol; Diethanol sulphide; 2,2-Thiobisethanol; beta-Thiodiglycol; Diethanol sulfide; 2,2-Thiodiethanol; 2,2-Thiodiglycol; Kromfax@ solvent; Kromfax solvent; b-Thiodiglycol; Β-thiodiglycol; Thiodiglycolum; Thiodiethanol; Tiodiglicolo; thiodiglycol; Tiodiglicol; Glyecine a; Tedegyl



数据库引用编号

9 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

2 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Qichao Ye, Chen Men, Lili Tian, Yuxin Liu, Lei Zhan, Yuan Fang Li, Cheng Zhi Huang, Shu Jun Zhen. Preparation of a molecularly imprinted test strip for point-of-care detection of thiodiglycol, a sulfur mustard poisoning metabolic marker. Talanta. 2021 Nov; 234(?):122701. doi: 10.1016/j.talanta.2021.122701. [PMID: 34364498]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Chang-Cai Liu, Shi-Lei Liu, Hai-Ling Xi, Hui-Lan Yu, Shi-Kun Zhou, Gui-Lan Huang, Long-Hui Liang, Jing-Quan Liu. Simultaneous quantification of four metabolites of sulfur mustard in urine samples by ultra-high performance liquid chromatography-tandem mass spectrometry after solid phase extraction. Journal of chromatography. A. 2017 Apr; 1492(?):41-48. doi: 10.1016/j.chroma.2017.02.056. [PMID: 28284764]
  • Daniel Slane, Patrick Bürgel, Martin Bayer. Staining and Clearing of Arabidopsis Reproductive Tissue for Imaging of Fluorescent Proteins. Methods in molecular biology (Clifton, N.J.). 2017; 1669(?):87-94. doi: 10.1007/978-1-4939-7286-9_8. [PMID: 28936652]
  • Alessandro Sassolini, Giampaolo Brinchi, Antonio Di Gennaro, Simone Dionisi, Carola Dominici, Luca Fantozzi, Giorgio Onofri, Rosario Piazza, Maurizio Guidotti. Evaluation of Molecular Markers and Analytical Methods Documenting the Occurrence of Mustard Gas and Arsenical Warfare Agents in Soil. Bulletin of environmental contamination and toxicology. 2016 Sep; 97(3):432-8. doi: 10.1007/s00128-016-1860-1. [PMID: 27385368]
  • Jin Young Lee, Yong Han Lee. Solid-Phase Extraction of Sulfur Mustard Metabolites Using an Activated Carbon Fiber Sorbent. Journal of analytical toxicology. 2016 Jan; 40(1):64-71. doi: 10.1093/jat/bkv112. [PMID: 26364317]
  • Thomas J Musielak, Daniel Slane, Christian Liebig, Martin Bayer. A Versatile Optical Clearing Protocol for Deep Tissue Imaging of Fluorescent Proteins in Arabidopsis thaliana. PloS one. 2016; 11(8):e0161107. doi: 10.1371/journal.pone.0161107. [PMID: 27517463]
  • Richard A Angerhofer, Mark W Michie, Glenn J Leach, Mark S Johnson, Gunda Reddy. Oral toxicity evaluation of thiodiglycol in Sprague-Dawley rats. International journal of toxicology. 2014 Sep; 33(5):393-402. doi: 10.1177/1091581814547541. [PMID: 25163473]
  • Zhiyong Nie, Yajiao Zhang, Jia Chen, Ying Lin, Bidong Wu, Yuan Dong, Jianlin Feng, Qin Liu, Jianwei Xie. Monitoring urinary metabolites resulting from sulfur mustard exposure in rabbits, using highly sensitive isotope-dilution gas chromatography-mass spectrometry. Analytical and bioanalytical chemistry. 2014 Aug; 406(21):5203-12. doi: 10.1007/s00216-014-7916-3. [PMID: 24924210]
  • Meehir Palit, Gary Mallard. Dispersive derivatization liquid-liquid extraction of degradation products/precursors of mustards and V-agents from aqueous samples. Journal of chromatography. A. 2011 Aug; 1218(32):5393-400. doi: 10.1016/j.chroma.2011.06.008. [PMID: 21737081]
  • Valérie Carraro, Anne-Catherine Maurin, Sarah Lambert-Langlais, Julien Averous, Cédric Chaveroux, Laurent Parry, Céline Jousse, Daima Ord, Tõnis Ord, Pierre Fafournoux, Alain Bruhat. Amino acid availability controls TRB3 transcription in liver through the GCN2/eIF2α/ATF4 pathway. PloS one. 2010 Dec; 5(12):e15716. doi: 10.1371/journal.pone.0015716. [PMID: 21203563]
  • Henry Daniell, Gricel Ruiz, Bela Denes, Laurence Sandberg, William Langridge. Optimization of codon composition and regulatory elements for expression of human insulin like growth factor-1 in transgenic chloroplasts and evaluation of structural identity and function. BMC biotechnology. 2009 Apr; 9(?):33. doi: 10.1186/1472-6750-9-33. [PMID: 19344517]
  • Karolin K Kroening, Douglas D Richardson, Scott Afton, Joseph A Caruso. Screening hydrolysis products of sulfur mustard agents by high-performance liquid chromatography with inductively coupled plasma mass spectrometry detection. Analytical and bioanalytical chemistry. 2009 Apr; 393(8):1949-56. doi: 10.1007/s00216-009-2642-y. [PMID: 19214483]
  • Benedict R Capacio, J Richard Smith, Richard J Lawrence, Brian L Boyd, Alicia M Witriol, Michele L Conti, Jennifer L Collins, Alfred M Sciuto. Gas chromatographic-mass spectrometric analysis of sulfur mustard-plasma protein adducts: validation and use in a rat inhalation model. Journal of analytical toxicology. 2008 Jan; 32(1):37-43. doi: 10.1093/jat/32.1.37. [PMID: 18269791]
  • Richard J Lawrence, J Richard Smith, Brian L Boyd, Benedict R Capacio. Improvements in the methodology of monitoring sulfur mustard exposure by gas chromatography-mass spectrometry analysis of cleaved and derivatized blood protein adducts. Journal of analytical toxicology. 2008 Jan; 32(1):31-6. doi: 10.1093/jat/32.1.31. [PMID: 18269790]
  • John R Barr, Carrie L Pierce, J Richard Smith, Benedict R Capacio, Adrian R Woolfitt, Maria I Solano, Joe V Wooten, Sharon W Lemire, Jerry D Thomas, Doris H Ash, David L Ashley. Analysis of urinary metabolites of sulfur mustard in two individuals after accidental exposure. Journal of analytical toxicology. 2008 Jan; 32(1):10-6. doi: 10.1093/jat/32.1.10. [PMID: 18269787]
  • Victor Paromov, Zacharias Suntres, Milton Smith, William L Stone. Sulfur mustard toxicity following dermal exposure: role of oxidative stress, and antioxidant therapy. Journal of burns and wounds. 2007 Oct; 7(?):e7. doi: ". [PMID: 18091984]
  • James Riches, Robert W Read, Robin M Black. Analysis of the sulphur mustard metabolites thiodiglycol and thiodiglycol sulphoxide in urine using isotope-dilution gas chromatography-ion trap tandem mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2007 Jan; 845(1):114-20. doi: 10.1016/j.jchromb.2006.07.065. [PMID: 16965944]
  • Gunda Reddy, Michael A Major, Glenn J Leach. Toxicity assessment of thiodiglycol. International journal of toxicology. 2005 Nov; 24(6):435-42. doi: 10.1080/10915810500368878. [PMID: 16393936]
  • Isaac Ohsawa, Mieko Kanamori-Kataoka, Kouichiro Tsuge, Yasuo Seto. Determination of thiodiglycol, a mustard gas hydrolysis product by gas chromatography-mass spectrometry after tert-butyldimethylsilylation. Journal of chromatography. A. 2004 Dec; 1061(2):235-41. doi: 10.1016/j.chroma.2004.10.087. [PMID: 15641367]
  • Benedict R Capacio, J R Smith, Michael T DeLion, Dana R Anderson, John S Graham, Gennady E Platoff, William D Korte. Monitoring sulfur mustard exposure by gas chromatography-mass spectrometry analysis of thiodiglycol cleaved from blood proteins. Journal of analytical toxicology. 2004 Jul; 28(5):306-10. doi: 10.1093/jat/28.5.306. [PMID: 15239847]
  • Anne E Boyer, Doris Ash, Dana B Barr, Carrie L Young, W J Driskell, Ralph D Whitehead, Maria Ospina, Kerry E Preston, Adrian R Woolfitt, Rodolfo A Martinez, L A Pete Silks, John R Barr. Quantitation of the sulfur mustard metabolites 1,1'-sulfonylbis[2-(methylthio)ethane] and thiodiglycol in urine using isotope-dilution Gas chromatography-tandem mass spectrometry. Journal of analytical toxicology. 2004 Jul; 28(5):327-32. doi: 10.1093/jat/28.5.327. [PMID: 15239851]
  • J S Graham, F M Reid, J R Smith, R R Stotts, E S Tucker, S M Shumaker, N A Niemuth, S J Janny. A cutaneous full-thickness liquid sulfur mustard burn model in weanling swine: clinical pathology and urinary excretion of thiodiglycol. Journal of applied toxicology : JAT. 2000 Dec; 20 Suppl 1(?):S161-72. doi: 10.1002/1099-1263(200012)20:1+<::aid-jat681>3.0.co;2-t. [PMID: 11428630]
  • R M Black, R W Read. Improved methodology for the detection and quantitation of urinary metabolites of sulphur mustard using gas chromatography-tandem mass spectrometry. Journal of chromatography. B, Biomedical applications. 1995 Mar; 665(1):97-105. doi: 10.1016/0378-4347(94)00522-7. [PMID: 7795806]
  • R M Black, R W Read. Biological fate of sulphur mustard, 1,1'-thiobis(2-chloroethane): identification of beta-lyase metabolites and hydrolysis products in human urine. Xenobiotica; the fate of foreign compounds in biological systems. 1995 Feb; 25(2):167-73. doi: 10.3109/00498259509061842. [PMID: 7618344]
  • R M Black, K Brewster, R J Clarke, J L Hambrook, J M Harrison, D J Howells. Metabolism of thiodiglycol (2,2'-thiobis-ethanol): isolation and identification of urinary metabolites following intraperitoneal administration to rat. Xenobiotica; the fate of foreign compounds in biological systems. 1993 May; 23(5):473-81. doi: 10.3109/00498259309059388. [PMID: 8342295]
  • R M Black, K Brewster, R J Clarke, J L Hambrook, J M Harrison, D J Howells. Biological fate of sulphur mustard, 1,1'-thiobis(2-chloroethane): isolation and identification of urinary metabolites following intraperitoneal administration to rat. Xenobiotica; the fate of foreign compounds in biological systems. 1992 Apr; 22(4):405-18. doi: 10.3109/00498259209046652. [PMID: 1523861]
  • E M Jakubowski, C L Woodard, M M Mershon, T W Dolzine. Quantification of thiodiglycol in urine by electron ionization gas chromatography-mass spectrometry. Journal of chromatography. 1990 Jun; 528(1):184-90. doi: 10.1016/s0378-4347(00)82374-9. [PMID: 2384552]
  • R M Black, R W Read. Detection of trace levels of thiodiglycol in blood, plasma and urine using gas chromatography-electron-capture negative-ion chemical ionisation mass spectrometry. Journal of chromatography. 1988 Sep; 449(1):261-70. doi: 10.1016/s0021-9673(00)94385-1. [PMID: 3235580]
  • E R Wils, A G Hulst, J van Laar. Analysis of thiodiglycol in urine of victims of an alleged attack with mustard gas, Part II. Journal of analytical toxicology. 1988 Jan; 12(1):15-9. doi: 10.1093/jat/12.1.15. [PMID: 3352237]
  • E R Wils, A G Hulst, A L de Jong, A Verweij, H L Boter. Analysis of thiodiglycol in urine of victims of an alleged attack with mustard gas. Journal of analytical toxicology. 1985 Nov; 9(6):254-7. doi: 10.1093/jat/9.6.254. [PMID: 4079337]
  • K Reiss, Z Pietrzykowski, J Kajstura, W Korohoda. Stimulation of myogenesis by 2,2'-thiodiethanol in suboptimal tissue culture conditions. Folia histochemica et cytobiologica. 1985; 23(3):109-16. doi: NULL. [PMID: 4065379]
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