Pinazepam (BioDeep_00000036562)

   

human metabolite Chemicals and Drugs


代谢物信息卡片


7-chloro-5-phenyl-1-(prop-2-yn-1-yl)-2,3-dihydro-1H-1,4-benzodiazepin-2-one

化学式: C18H13ClN2O (308.0716)
中文名称: 匹那西泮
谱图信息: 最多检出来源 Homo sapiens(not specific) 10.97%

分子结构信息

SMILES: C#CCN1C(=O)CN=C(C2=C1C=CC(=C2)Cl)C3=CC=CC=C3
InChI: InChI=1S/C18H13ClN2O/c1-2-10-21-16-9-8-14(19)11-15(16)18(20-12-17(21)22)13-6-4-3-5-7-13/h1,3-9,11H,10,12H2

描述信息

Pinazepam (marketed under the brand name Domar and Duna) is a drug which is a benzodiazepine. It possesses anxiolytic, anticonvulsant, sedative and skeletal muscle relaxant properties.
D002492 - Central Nervous System Depressants > D014149 - Tranquilizing Agents > D014151 - Anti-Anxiety Agents
D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D014149 - Tranquilizing Agents
N - Nervous system > N05 - Psycholeptics > N05B - Anxiolytics > N05BA - Benzodiazepine derivatives
C78272 - Agent Affecting Nervous System > C29756 - Sedative and Hypnotic > C1012 - Benzodiazepine
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants
C78272 - Agent Affecting Nervous System > C28197 - Antianxiety Agent

同义名列表

9 个代谢物同义名

7-chloro-5-phenyl-1-(prop-2-yn-1-yl)-2,3-dihydro-1H-1,4-benzodiazepin-2-one; 7-Chloro-1-propargyl-5-phenyl-2H-1,4-benzodiazepin-2-one; 7-Chloro-5-phenyl-1-propargyl-1,4-benzodiazepin-2- one; Tedec meiji brand OF pinazepam; Propazepam; pinazepam; Domar; Duna; Pinazepam



数据库引用编号

8 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • G Frison, L Tedeschi, S Maietti, S D Ferrara. Determination of midazolam in human plasma by solid-phase microextraction and gas chromatography/mass spectrometry. Rapid communications in mass spectrometry : RCM. 2001; 15(24):2497-501. doi: 10.1002/rcm.536. [PMID: 11746922]
  • D Altunkaya, R N Smith. 7-[125I]iodoclonazepam: purification by high-performance liquid chromatography for use in a very sensitive benzodiazepine radioimmunoassay of broad specificity. Forensic science international. 1988 Oct; 39(1):23-37. doi: 10.1016/0379-0738(88)90115-6. [PMID: 2905318]
  • G M Pacifici, L Cuoci, M Guarneri, P Fornaro, G Arcidiacono, N Cappelli, G Moggi, G F Placidi. Placental transfer of pinazepam and its metabolite N-desmethyldiazepam in women at term. European journal of clinical pharmacology. 1984; 27(3):307-10. doi: 10.1007/bf00542165. [PMID: 6150857]
  • J M Janbroers. Pinazepam: review of pharmacological properties and therapeutic efficacy. Clinical therapeutics. 1984; 6(4):434-50. doi: NULL. [PMID: 6147192]
  • G M Pacifici, L Cuoci, G F Placidi. Disposition, distribution, plasma protein binding and biliary excretion of pinazepam after i.p. administration to rat. European journal of drug metabolism and pharmacokinetics. 1983 Jul; 8(3):209-17. doi: 10.1007/bf03188750. [PMID: 6418547]
  • G M Pacifici, G F Placidi, P Fornaro, R Gomeni. Pharmacokinetics of pinazepam in healthy volunteers. International journal of clinical pharmacology research. 1983; 3(5):331-7. doi: NULL. [PMID: 6147314]
  • G M Pacifici, L Cuoci, G F Placidi. Disposition, distribution, and liver first-pass effect of pinazepam in the rat. Drug metabolism and disposition: the biological fate of chemicals. 1982 Mar; 10(2):180-2. doi: NULL. [PMID: 6124406]
  • G M Pacifici, G F Placidi, P Fornaro, R Gomeni. Pinazepam: a precursor of N-desmethyldiazepam. European journal of clinical pharmacology. 1982; 22(3):225-8. doi: 10.1007/bf00545219. [PMID: 6809477]
  • G M Pacifici, G F Placidi. First pass effect of pinazepam in the rabbit liver. European journal of drug metabolism and pharmacokinetics. 1982; 7(2):119-22. doi: 10.1007/bf03188728. [PMID: 6126360]
  • G M Pacifici, L Cuoci, G F Placidi, P Fornaro, R Gomeni. Elimination kinetics of desmethyldiazepam in two young and two elderly subjects. European journal of drug metabolism and pharmacokinetics. 1982 Jan; 7(1):69-72. doi: 10.1007/bf03189546. [PMID: 6802645]
  • E Grassi, G L Passetti, A Trebbi. Quantitative determination of pinazepam and its metabolites in blood and urine by high-performance liquid chromatography. Journal of chromatography. 1977 Nov; 144(1):132-5. doi: 10.1016/0021-9673(77)80017-4. [PMID: 914958]
  • G M Pacifici, G F Placidi. Rapid and sensitive electron-capture gas chromatographic method for the determination of pinazepam and its metabolites in human plasma, urine and milk. Journal of chromatography. 1977 May; 135(1):133-9. doi: 10.1016/s0021-9673(00)86309-8. [PMID: 16030]
  • A C Buck. Disorders of micturition in bacterial prostatitis. Proceedings of the Royal Society of Medicine. 1975 Aug; 68(8):508-11. doi: NULL. [PMID: 681]
  • A Trebbi, G B Gervasi, V Comi. Determination of pinazepam and its metabolites in serum, urine and brain by gas-liquid chromatography and mass spectrometry. Journal of chromatography. 1975 Jul; 110(2):309-19. doi: 10.1016/0021-9673(75)85011-4. [PMID: 1150839]