Oltipraz (BioDeep_00000036559)

   

human metabolite


代谢物信息卡片


4-methyl-5-(pyrazin-2-yl)-3H-1,2-dithiole-3-thione

化学式: C8H6N2S3 (225.96931160000003)
中文名称: 吡噻硫酮
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC1=C(SSC1=S)C1=CN=CC=N1
InChI: InChI=1S/C8H6N2S3/c1-5-7(12-13-8(5)11)6-4-9-2-3-10-6/h2-4H,1H3

描述信息

Oltipraz is a dithiole derivative and a schistosomicide. The studies have show oltipraz is also a chemoprotector, an antocarcinogen and possibly an antimutagen. [PubMed: 9593327]
D000890 - Anti-Infective Agents > D000998 - Antiviral Agents > D018894 - Reverse Transcriptase Inhibitors
D000890 - Anti-Infective Agents > D000977 - Antiparasitic Agents > D000871 - Anthelmintics
D004791 - Enzyme Inhibitors > D019384 - Nucleic Acid Synthesis Inhibitors
C1892 - Chemopreventive Agent > C54629 - Phase I Enzymes Inhibitor
C1892 - Chemopreventive Agent > C54630 - Phase II Enzymes Inducer
D020011 - Protective Agents > D016588 - Anticarcinogenic Agents
C274 - Antineoplastic Agent > C1742 - Angiogenesis Inhibitor
D000970 - Antineoplastic Agents
Oltipraz has an inhibitory effect on HIF-1α activation in a time-dependent manner, completely abrogating HIF-1α induction at ≥10 μM concentrations, the IC50 of Oltipraz for HIF-1α inhibition is 10 μM. Oltipraz is a potent Nrf2 activator.

同义名列表

11 个代谢物同义名

4-methyl-5-(pyrazin-2-yl)-3H-1,2-dithiole-3-thione; 5-(2-Pyrazinyl)-4-methyl-1,2-dithiole-3-thione; 4-Methyl-5-pyrazinyl-3H-1,2-dithiole-3-thione; 5-(2-Pyrazinyl)-4-methyl-1,2-dithiol-3-thione; 4-Methyl-PDT; 35 972 R.P.; Oltiprazum; RP-35,972; Oltipraz; RP 35972; NSC 347901



数据库引用编号

9 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Yuan-Qing Dai, Yao Bai, Jie Gu, Ben-Yi Fan. Stanniocalcin1 knockdown induces ferroptosis and suppresses glycolysis in prostate cancer via the Nrf2 pathway. Neoplasma. 2022 Dec; 69(6):1396-1405. doi: 10.4149/neo_2022_220626n665. [PMID: 36591803]
  • Yuanyuan Zhang, Bingke Ma, Shuangshuang Hao, Jiaqi Wang, Ruichen Zhang, Muhammad Ishfaq, Chenxi Shi, Liang Yuan, Rui Li, Changwen Li, Fangping Liu. Drug-induced liver injury: Oltipraz and C2-ceramide intervene HNF-1α/GSTA1 expression via JNK signaling pathway. Journal of applied toxicology : JAT. 2021 12; 41(12):2011-2020. doi: 10.1002/jat.4181. [PMID: 33959992]
  • Zhiqing Huang, Eiji Kondoh, Zachary R Visco, Tsukasa Baba, Noriomi Matsumura, Emma Dolan, Regina S Whitaker, Ikuo Konishi, Shingo Fujii, Andrew Berchuck, Susan K Murphy. Targeting Dormant Ovarian Cancer Cells In Vitro and in an In Vivo Mouse Model of Platinum Resistance. Molecular cancer therapeutics. 2021 01; 20(1):85-95. doi: 10.1158/1535-7163.mct-20-0119. [PMID: 33037137]
  • Zengxin Jiang, Mengxuan Bian, Jingping Wu, Defang Li, Lei Ding, Qingmin Zeng. Oltipraz Prevents High Glucose-Induced Oxidative Stress and Apoptosis in RSC96 Cells through the Nrf2/NQO1 Signalling Pathway. BioMed research international. 2020; 2020(?):5939815. doi: 10.1155/2020/5939815. [PMID: 32685505]
  • Hang Yu, Tingsheng Lin, Wei Chen, Wenmin Cao, Chengwei Zhang, Tianwei Wang, Meng Ding, Sheng Zhao, Hui Wei, Hongqian Guo, Xiaozhi Zhao. Size and temporal-dependent efficacy of oltipraz-loaded PLGA nanoparticles for treatment of acute kidney injury and fibrosis. Biomaterials. 2019 10; 219(?):119368. doi: 10.1016/j.biomaterials.2019.119368. [PMID: 31349200]
  • Y Tang, M Guo, X-Y Ma, W-P Sun, M-H Hao, H-Y Zhu. Oltipraz attenuates the progression of heart failure in rats through inhibiting oxidative stress and inflammatory response. European review for medical and pharmacological sciences. 2018 12; 22(24):8918-8923. doi: 10.26355/eurrev_201812_16661. [PMID: 30575935]
  • Emre Can Polat, Huseyin Besiroglu, Levent Ozcan, Alper Otunctemur, Ahmet Tugrul Eruyar, Adnan Somay, Nurver Ozbay, Mustafa Cekmen, Ceyla Eraldemir, Emin Ozbek. Beneficial effects of Oltipraz, nuclear factor - erythroid - 2 - related factor 2 (Nrf2), on renal damage in unilateral ureteral obstruction rat model. International braz j urol : official journal of the Brazilian Society of Urology. 2018 Nov; 44(6):1243-1251. doi: 10.1590/s1677-5538.ibju.2018.0232. [PMID: 30130014]
  • Shuiling Zhao, Anindya Ghosh, Chao-Sheng Lo, Isabelle Chenier, James W Scholey, Janos G Filep, Julie R Ingelfinger, Shao-Ling Zhang, John S D Chan. Nrf2 Deficiency Upregulates Intrarenal Angiotensin-Converting Enzyme-2 and Angiotensin 1-7 Receptor Expression and Attenuates Hypertension and Nephropathy in Diabetic Mice. Endocrinology. 2018 02; 159(2):836-852. doi: 10.1210/en.2017-00752. [PMID: 29211853]
  • S Y Wang, J Lin. Letter: the efficacy of oltipraz in patients with non-alcoholic fatty liver disease has not been confirmed. Alimentary pharmacology & therapeutics. 2017 07; 46(2):209. doi: 10.1111/apt.14122. [PMID: 28621072]
  • Amandla Atilano-Roque, Xia Wen, Lauren M Aleksunes, Melanie S Joy. Nrf2 activators as potential modulators of injury in human kidney cells. Toxicology reports. 2016; 3(?):153-159. doi: 10.1016/j.toxrep.2016.01.006. [PMID: 28959534]
  • Barbara A Roggenbeck, Michael W Carew, Gregory J Charrois, Donna N Douglas, Norman M Kneteman, Xiufen Lu, X Chris Le, Elaine M Leslie. Characterization of arsenic hepatobiliary transport using sandwich-cultured human hepatocytes. Toxicological sciences : an official journal of the Society of Toxicology. 2015 Jun; 145(2):307-20. doi: 10.1093/toxsci/kfv051. [PMID: 25752797]
  • Keiyu Oshida, Naresh Vasani, Russell S Thomas, Dawn Applegate, Mitch Rosen, Barbara Abbott, Christopher Lau, Grace Guo, Lauren M Aleksunes, Curtis Klaassen, J Christopher Corton. Identification of modulators of the nuclear receptor peroxisome proliferator-activated receptor α (PPARα) in a mouse liver gene expression compendium. PloS one. 2015; 10(2):e0112655. doi: 10.1371/journal.pone.0112655. [PMID: 25689681]
  • Shaaban Abdo, Yixuan Shi, Abouzar Otoukesh, Anindya Ghosh, Chao-Sheng Lo, Isabelle Chenier, Janos G Filep, Julie R Ingelfinger, Shao Ling Zhang, John S D Chan. Catalase overexpression prevents nuclear factor erythroid 2-related factor 2 stimulation of renal angiotensinogen gene expression, hypertension, and kidney injury in diabetic mice. Diabetes. 2014 Oct; 63(10):3483-96. doi: 10.2337/db13-1830. [PMID: 24812425]
  • Tae Hyun Kim, Jeong Sik Eom, Chan Gyu Lee, Yoon Mee Yang, Yong Sup Lee, Sang Geon Kim. An active metabolite of oltipraz (M2) increases mitochondrial fuel oxidation and inhibits lipogenesis in the liver by dually activating AMPK. British journal of pharmacology. 2013 Apr; 168(7):1647-61. doi: 10.1111/bph.12057. [PMID: 23145499]
  • William W Li, Vincent W Li, Michelle Hutnik, Albert S Chiou. Tumor angiogenesis as a target for dietary cancer prevention. Journal of oncology. 2012; 2012(?):879623. doi: 10.1155/2012/879623. [PMID: 21977033]
  • Joan Smith Sonneborn. Alternative strategy for Alzheimer's disease: stress response triggers. International journal of Alzheimer's disease. 2012; 2012(?):684283. doi: 10.1155/2012/684283. [PMID: 22655213]
  • Jong-Hwa Lee, Hwanmi Lim, Do-Geun Kim, Dae-Hun Park, Young-Ah Woo, Hyun-Jung Noh, Qing-Ri Jin, Kyeong-Ryoon Lee, Gye-Won Lee, Choong-Yong Kim. Quantification of oltipraz using liquid chromatography-tandem mass spectrometry and its application to a pharmacokinetic study in rat plasma. Journal of pharmaceutical and biomedical analysis. 2011 Nov; 56(3):623-6. doi: 10.1016/j.jpba.2011.06.014. [PMID: 21757314]
  • Ebenezer O Farombi, Olatunde Owoeye. Antioxidative and chemopreventive properties of Vernonia amygdalina and Garcinia biflavonoid. International journal of environmental research and public health. 2011 06; 8(6):2533-55. doi: 10.3390/ijerph8062533. [PMID: 21776245]
  • Sang Geon Kim, Young Mi Kim, Jong Young Choi, Joon-Yeol Han, Jeong Won Jang, Se-Hyun Cho, Soon Ho Um, Chae Yoon Chon, Dong Hoo Lee, Ja-June Jang, Eunsil Yu, Young Sok Lee. Oltipraz therapy in patients with liver fibrosis or cirrhosis: a randomized, double-blind, placebo-controlled phase II trial. The Journal of pharmacy and pharmacology. 2011 May; 63(5):627-35. doi: 10.1111/j.2042-7158.2011.01259.x. [PMID: 21492164]
  • Z Yu, W Shao, Y Chiang, W Foltz, Z Zhang, W Ling, I G Fantus, T Jin. Oltipraz upregulates the nuclear factor (erythroid-derived 2)-like 2 [corrected](NRF2) antioxidant system and prevents insulin resistance and obesity induced by a high-fat diet in C57BL/6J mice. Diabetologia. 2011 Apr; 54(4):922-34. doi: 10.1007/s00125-010-2001-8. [PMID: 21161163]
  • Z Zhang, Xf Liang, Mq Su, Q Liang, Lp Li, Xh Zhang, Xm Wang, X Zhu. Pharmacokinetics of dl-praeruptorin A after single-dose intravenous administration to rats with liver cirrhosis. Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences. 2011; 19(3):210-5. doi: NULL. [PMID: 22615659]
  • S G Kim, Y M Kim, Y H Choi, M G Lee, J Y Choi, J Y Han, S H Cho, J W Jang, S H Um, C Y Chon, D H Lee, J J Jang, E S Yu, Y S Lee. Pharmacokinetics of oltipraz and its major metabolite (RM) in patients with liver fibrosis or cirrhosis: relationship with suppression of circulating TGF-beta1. Clinical pharmacology and therapeutics. 2010 Sep; 88(3):360-8. doi: 10.1038/clpt.2010.89. [PMID: 20664537]
  • Lauren M Aleksunes, Scott A Reisman, Ronnie L Yeager, Michael J Goedken, Curtis D Klaassen. Nuclear factor erythroid 2-related factor 2 deletion impairs glucose tolerance and exacerbates hyperglycemia in type 1 diabetic mice. The Journal of pharmacology and experimental therapeutics. 2010 Apr; 333(1):140-51. doi: 10.1124/jpet.109.162271. [PMID: 20086057]
  • Quynh T Tran, Lijing Xu, Vinhthuy Phan, Shirlean B Goodwin, Mostafizur Rahman, Victor X Jin, Carrie H Sutter, Bill D Roebuck, Thomas W Kensler, E Olusegun George, Thomas R Sutter. Chemical genomics of cancer chemopreventive dithiolethiones. Carcinogenesis. 2009 Mar; 30(3):480-6. doi: 10.1093/carcin/bgn292. [PMID: 19126641]
  • Christopher D Mann, Christopher P Neal, Giuseppe Garcea, Margaret M Manson, Ashley R Dennison, David P Berry. Phytochemicals as potential chemopreventive and chemotherapeutic agents in hepatocarcinogenesis. European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP). 2009 Feb; 18(1):13-25. doi: 10.1097/cej.0b013e3282f0c090. [PMID: 19077560]
  • Haitao Chu, Lei Nie, Thomas W Kensler. A Bayesian approach estimating treatment effects on biomarkers containing zeros with detection limits. Statistics in medicine. 2008 Jun; 27(13):2497-508. doi: 10.1002/sim.3170. [PMID: 18167630]
  • Yazen Alnouti, Curtis D Klaassen. Tissue distribution, ontogeny, and regulation of aldehyde dehydrogenase (Aldh) enzymes mRNA by prototypical microsomal enzyme inducers in mice. Toxicological sciences : an official journal of the Society of Toxicology. 2008 Jan; 101(1):51-64. doi: 10.1093/toxsci/kfm280. [PMID: 17998271]
  • Suryakant K Niture, Chinavenmani S Velu, Quentin R Smith, G Jayarama Bhat, Kalkunte S Srivenugopal. Increased expression of the MGMT repair protein mediated by cysteine prodrugs and chemopreventative natural products in human lymphocytes and tumor cell lines. Carcinogenesis. 2007 Feb; 28(2):378-89. doi: 10.1093/carcin/bgl155. [PMID: 16950796]
  • Mitchell P Fink. Bench-to-bedside review: High-mobility group box 1 and critical illness. Critical care (London, England). 2007; 11(5):229. doi: 10.1186/cc6088. [PMID: 17903310]
  • Bente Glintborg, Allan Weimann, Thomas W Kensler, Henrik E Poulsen. Oltipraz chemoprevention trial in Qidong, People's Republic of China: unaltered oxidative biomarkers. Free radical biology & medicine. 2006 Sep; 41(6):1010-4. doi: 10.1016/j.freeradbiomed.2006.06.015. [PMID: 16934685]
  • Haitao Chu, Lei Nie, Stephen R Cole. Sample size and statistical power assessing the effect of interventions in the context of mixture distributions with detection limits. Statistics in medicine. 2006 Aug; 25(15):2647-57. doi: 10.1002/sim.2503. [PMID: 16456897]
  • Soo K Bae, Hee E Kang, Min K Kang, Jin W Kim, Taekrho Kim, Myung G Lee. Pharmacokinetics of oltipraz in mutant Nagase analbuminemic rats. Journal of pharmaceutical sciences. 2006 May; 95(5):998-1005. doi: 10.1002/jps.20602. [PMID: 16544321]
  • Ian Stewart, Philip J Schluter, Glen R Shaw. Cyanobacterial lipopolysaccharides and human health - a review. Environmental health : a global access science source. 2006 Mar; 5(?):7. doi: 10.1186/1476-069x-5-7. [PMID: 16563160]
  • Sunita B Jones, James D Brooks. Modest induction of phase 2 enzyme activity in the F-344 rat prostate. BMC cancer. 2006 Mar; 6(?):62. doi: 10.1186/1471-2407-6-62. [PMID: 16539699]
  • Eduardo Azziz-Baumgartner, Kimberly Lindblade, Karen Gieseker, Helen Schurz Rogers, Stephanie Kieszak, Henry Njapau, Rosemary Schleicher, Leslie F McCoy, Ambrose Misore, Kevin DeCock, Carol Rubin, Laurence Slutsker. Case-control study of an acute aflatoxicosis outbreak, Kenya, 2004. Environmental health perspectives. 2005 Dec; 113(12):1779-83. doi: 10.1289/ehp.8384. [PMID: 16330363]
  • Soo K Bae, Jin W Kim, Young H Kim, Yoon G Kim, Sang G Kim, Myung G Lee. Hepatic and intestinal first-pass effects of oltipraz in rats. Biopharmaceutics & drug disposition. 2005 May; 26(4):129-34. doi: 10.1002/bdd.439. [PMID: 15744718]
  • Soo K Bae, Shin J Lee, Yoon G Kim, So H Kim, Jin W Kim, Taekrho Kim, Myung G Lee. Interspecies pharmacokinetic scaling of oltipraz in mice, rats, rabbits and dogs, and prediction of human pharmacokinetics. Biopharmaceutics & drug disposition. 2005 Apr; 26(3):99-115. doi: 10.1002/bdd.437. [PMID: 15723427]
  • Michael J Kelley, Elizabeth M Glaser, James E Herndon, Frank Becker, Rajesh Bhagat, Yu-Jing Zhang, Regina M Santella, Steven G Carmella, Stephen S Hecht, Lilia Gallot, Lawrence Schilder, James A Crowell, Marjorie Perloff, Rodney J Folz, Raymond C Bergan. Safety and efficacy of weekly oral oltipraz in chronic smokers. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 2005 Apr; 14(4):892-9. doi: 10.1158/1055-9965.epi-04-0585. [PMID: 15824161]
  • Soo K Bae, Shin J Lee, Jin W Kim, Young H Kim, Sang G Kim, Myung G Lee. Pharmacokinetics of oltipraz after intravenous and oral administration in rats with dehydration for 72 hours. Biopharmaceutics & drug disposition. 2005 Mar; 26(2):77-83. doi: 10.1002/bdd.433. [PMID: 15617135]
  • Murugesan Velayutham, Frederick A Villamena, James C Fishbein, Jay L Zweier. Cancer chemopreventive oltipraz generates superoxide anion radical. Archives of biochemistry and biophysics. 2005 Mar; 435(1):83-8. doi: 10.1016/j.abb.2004.11.028. [PMID: 15680910]
  • Soo K Bae, Shin J Lee, Jin W Kim, Young H Kim, Sang G Kim, Myung G Lee. Effects of acute renal failure on the pharmacokinetics of oltipraz in rats. Journal of pharmaceutical sciences. 2004 Sep; 93(9):2353-63. doi: 10.1002/jps.20141. [PMID: 15295795]
  • Soo K Bae, Shin J Lee, Jang Y Lee, Youngsoo Lee, Inchul Lee, Sang G Kim, Myung G Lee. Pharmacokinetic changes of oltipraz after intravenous and oral administration to rats with liver cirrhosis induced by dimethylnitrosamine. International journal of pharmaceutics. 2004 May; 275(1-2):227-38. doi: 10.1016/j.ijpharm.2004.02.004. [PMID: 15081153]
  • E A El-Bassiouni, M H Helmy, M A Abdel-Hamid, M A Shohayeb, S S Ismail. In vitro effect of low concentrations of oltipraz on the antioxidant defence of mouse hepatocytes and Schistosoma mansoni worms. British journal of biomedical science. 2004; 61(1):15-21. doi: 10.1080/09674845.2004.11732640. [PMID: 15058738]
  • A L Slitt, N J Cherrington, J M Maher, C D Klaassen. Induction of multidrug resistance protein 3 in rat liver is associated with altered vectorial excretion of acetaminophen metabolites. Drug metabolism and disposition: the biological fate of chemicals. 2003 Sep; 31(9):1176-86. doi: 10.1124/dmd.31.9.1176. [PMID: 12920174]
  • Soo Kyung Bae, Eun Jung Kim, Suk Jae Chung, Sang Geon Kim, Myung Gull Lee. Pharmacokinetic interaction between oltipraz and dimethyl-4,4'-dimethoxy-5,6,5',6'-dimethylene dioxybiphenyl-2,2'-dicarboxylate (DDB) after single intravenous and oral administration to rats. The Journal of pharmacy and pharmacology. 2003 Sep; 55(9):1241-9. doi: 10.1211/0022357021648. [PMID: 14604467]
  • Keon Wook Kang, Yoon Gyoon Kim, Choon Won Kim, Sang Geon Kim. The anti-fibrogenic effect of a pharmaceutical composition of [5-(2-pyrazinyl)-4-methyl-1,2-dithiol-3-thione] (oltipraz) and dimethyl-4,4'-dimethoxy-5,6,5',6'-dimethylene dioxybiphenyl-2,2'-dicarboxylate (DDB). Archives of pharmacal research. 2002 Oct; 25(5):655-63. doi: 10.1007/bf02976940. [PMID: 12433201]
  • Eric Le Ferrec, Dominique Lagadic-Gossmann, Claudine Rauch, Caroline Bardiau, Karine Maheo, Frederic Massiere, Marc Le Vee, Andre Guillouzo, Fabrice Morel. Transcriptional induction of CYP1A1 by oltipraz in human Caco-2 cells is aryl hydrocarbon receptor- and calcium-dependent. The Journal of biological chemistry. 2002 Jul; 277(27):24780-7. doi: 10.1074/jbc.m111319200. [PMID: 11959854]
  • James M Brady, Nathan J Cherrington, Dylan P Hartley, Susan C Buist, Ning Li, Curtis D Klaassen. Tissue distribution and chemical induction of multiple drug resistance genes in rats. Drug metabolism and disposition: the biological fate of chemicals. 2002 Jul; 30(7):838-44. doi: 10.1124/dmd.30.7.838. [PMID: 12065443]
  • Swati Biswas, C Gary Gairola, Salil K Das. Oltipraz protects the passive smoke induced changes in renal glyoxalase system of rats. Molecular and cellular biochemistry. 2002 Apr; 233(1-2):27-30. doi: 10.1023/a:1015530130048. [PMID: 12083376]
  • Hideaki Nakamura, Akiyoshi Nishikawa, Fumio Furukawa, Ken-Ichiro Kasahara, Makoto Miyauchi, Kazushi Okazaki, Takayoshi Imazawa, Koji Uchida, Masao Hirose. Enhancing effects of oltipraz on the development of spontaneous hepatic lesions in LEC rats. Toxicologic pathology. 2002 Mar; 30(2):173-7. doi: 10.1080/019262302753559506. [PMID: 11950160]
  • Fay K Kessler, Marissa R Kessler, Diana J Auyeung, Joseph K Ritter. Glucuronidation of acetaminophen catalyzed by multiple rat phenol UDP-glucuronosyltransferases. Drug metabolism and disposition: the biological fate of chemicals. 2002 Mar; 30(3):324-30. doi: 10.1124/dmd.30.3.324. [PMID: 11854153]
  • Keon Wook Kang, Sung Hee Choi, Jong Ryul Ha, Choon Won Kim, Sang Geon Kim. Inhibition of dimethylnitrosamine-induced liver fibrosis by [5-(2-pyrazinyl)-4-methyl-1,2-dithiol-3-thione] (oltipraz) in rats: suppression of transforming growth factor-beta1 and tumor necrosis factor-alpha expression. Chemico-biological interactions. 2002 Jan; 139(1):61-77. doi: 10.1016/s0009-2797(01)00286-1. [PMID: 11803029]
  • Bruce A Ruggeri, Candy Robinson, Thelma Angeles, John Wilkinson, Margie L Clapper. The chemopreventive agent oltipraz possesses potent antiangiogenic activity in vitro, ex vivo, and in vivo and inhibits tumor xenograft growth. Clinical cancer research : an official journal of the American Association for Cancer Research. 2002 Jan; 8(1):267-74. doi: NULL. [PMID: 11801568]
  • M K Kwak, P A Egner, P M Dolan, M Ramos-Gomez, J D Groopman, K Itoh, M Yamamoto, T W Kensler. Role of phase 2 enzyme induction in chemoprotection by dithiolethiones. Mutation research. 2001 Sep; 480-481(?):305-15. doi: 10.1016/s0027-5107(01)00190-7. [PMID: 11506823]
  • S K Bae, S C Bu, E J Kim, S H Kim, S G Kim, M G Lee. Determination of a chemopreventive agent, Oltipraz, in rat plasma and urine by high-performance liquid chromatography. Research communications in molecular pathology and pharmacology. 2001 Jul; 110(1-2):133-8. doi: NULL. [PMID: 12090351]
  • A Camoirano, M Bagnasco, C Bennicelli, C Cartiglia, J B Wang, B C Zhang, Y R Zhu, G S Qian, P A Egner, L P Jacobson, T W Kensler, S De Flora. Oltipraz chemoprevention trial in Qidong, People's Republic of China: results of urine genotoxicity assays as related to smoking habits. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 2001 Jul; 10(7):775-83. doi: NULL. [PMID: 11440963]
  • D J Auyeung, F K Kessler, J K Ritter. An alternative promoter contributes to tissue- and inducer-specific expression of the rat UDP-glucuronosyltransferase 1A6 gene. Toxicology and applied pharmacology. 2001 Jul; 174(1):60-8. doi: 10.1006/taap.2001.9191. [PMID: 11437649]
  • M Walton, P Egner, P F Scholl, J Walker, T W Kensler, J D Groopman. Liquid chromatography electrospray-mass spectrometry of urinary aflatoxin biomarkers: characterization and application to dosimetry and chemoprevention in rats. Chemical research in toxicology. 2001 Jul; 14(7):919-26. doi: 10.1021/tx010063a. [PMID: 11453740]
  • G G Sofowora, E F Choo, G Mayo, Y Shyr, G R Wilkinson. In vivo inhibition of human CYP1A2 activity by oltipraz. Cancer chemotherapy and pharmacology. 2001 Jun; 47(6):505-10. doi: 10.1007/s002800000245. [PMID: 11459203]
  • N V Dimitrov, C M Leece, E R Tompkins, E Seymour, M Bennink, J Gardiner, J Crowell, E Hawk, M Nashawaty, J L Bennett. Oltipraz concentrations in plasma, buccal mucosa cells, and lipids: pharmacological studies. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 2001 Mar; 10(3):201-7. doi: NULL. [PMID: 11303588]
  • L Pendyala, G Schwartz, W Bolanowska-Higdon, S Hitt, J Zdanowicz, M Murphy, D Lawrence, P J Creaven. Phase I/pharmacodynamic study of N-acetylcysteine/oltipraz in smokers: early termination due to excessive toxicity. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 2001 Mar; 10(3):269-72. doi: NULL. [PMID: 11303598]
  • E Elmore, T T Luc, V E Steele, J L Redpath. Comparative tissue-specific toxicities of 20 cancer preventive agents using cultured cells from 8 different normal human epithelia. In vitro & molecular toxicology. 2001; 14(3):191-207. doi: 10.1089/109793301753407957. [PMID: 11846992]
  • S C Bu, E J Kim, S H Kim, S G Kim, M G Lee. Stability, blood partition and protein binding of an antifibrotic agent, oltipraz. Research communications in molecular pathology and pharmacology. 2001; 109(5-6):333-44. doi: NULL. [PMID: 12889516]
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