N,N'-dinitrosopiperazine (BioDeep_00000036554)
human metabolite Endogenous
代谢物信息卡片
化学式: C4H8N4O2 (144.0647228)
中文名称: 1,4-二亞硝哌
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1CN(CCN1N=O)N=O
InChI: InChI=1S/C4H8N4O2/c9-5-7-1-2-8(6-10)4-3-7/h1-4H2
描述信息
N,n-dinitrosopiperazine belongs to the family of Piperazines. These are compounds containing a piperazine ring, which is a saturated aliphatic six-member heterocyclic with two nitrogen atoms at positions 1 and 4, as well as four carbon atoms.
D009676 - Noxae > D002273 - Carcinogens
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代谢反应
0 个相关的代谢反应过程信息。
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1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Yuejin Li, Na Liu, Damao Huang, Zhenlin Zhang, Zhengke Peng, Chaojun Duan, Xiaowei Tang, Gongjun Tan, Guangrong Yan, Wenhua Mei, Faqing Tang. Proteomic analysis on N, N'-dinitrosopiperazine-mediated metastasis of nasopharyngeal carcinoma 6-10B cells.
BMC biochemistry.
2012 11; 13(?):25. doi:
10.1186/1471-2091-13-25. [PMID: 23157228] - Faqing Tang, Feiyan Zou, Zhengke Peng, Damao Huang, Yuan Wu, Yu Chen, Chaojun Duan, Ya Cao, Wenhua Mei, Xiaowei Tang, Zigang Dong. N,N'-dinitrosopiperazine-mediated ezrin protein phosphorylation via activation of Rho kinase and protein kinase C is involved in metastasis of nasopharyngeal carcinoma 6-10B cells.
The Journal of biological chemistry.
2011 Oct; 286(42):36956-67. doi:
10.1074/jbc.m111.259234. [PMID: 21878630] - F Q Tang, D F Tian, Z H Chen. [Inhibitory effect of yiqijiedu powder to telomerase and telomerase RNA in nasopharyngeal tumorigenesis of rats].
Hunan yi ke da xue xue bao = Hunan yike daxue xuebao = Bulletin of Hunan Medical University.
2001 Aug; 26(4):301-4. doi:
". [PMID: 12536718] - A R Tricker, T Kälble, R Preussmann. Comparative metabolism and urinary excretion of N-mononitrosopiperazine and N,N'-dinitrosopiperazine in the rat.
Cancer letters.
1991 Aug; 59(2):165-9. doi:
10.1016/0304-3835(91)90182-h. [PMID: 1884373] - S S Hecht, J B Morrison, R Young. N-Nitroso(2-hydroxyethyl)glycine, a urinary metabolite of N,N-dinitrosopiperazine with potential utility as a monitor for its formation in vivo from piperazine.
Carcinogenesis.
1984 Jul; 5(7):979-81. doi:
10.1093/carcin/5.7.979. [PMID: 6733859] - P Hevia, C R Truex, P B Imrey, S K Clinton, H J Mangian, W J Visek. Plasma amino acids and excretion of protein end products by mice fed 10 or 40\% soybean protein diets with or without dietary 2-acetylaminofluorene or N,N-dinitrosopiperazine.
The Journal of nutrition.
1984 Mar; 114(3):555-64. doi:
10.1093/jn/114.3.555. [PMID: 6538229] - B T Bellander, L Hagmar, B G Osterdahl. Nitrosation of piperazine in man.
IARC scientific publications.
1984; ?(57):171-8. doi:
NULL. [PMID: 6533004] - B G Osterdahl, B T Bellander. Determination of N-mononitrosopiperazine and N,N'-dinitrosopiperazine in human urine, gastric juice and blood.
Journal of chromatography.
1983 Nov; 278(1):71-80. doi:
NULL. [PMID: 6662887]