Ketophenylbutazone (BioDeep_00000036549)

   

human metabolite


代谢物信息卡片


1,2-Diphenyl-4-(gamma-ketobutyl)-3,5-pyrazolidinedione

化学式: C19H18N2O3 (322.1317)
中文名称: 酮基保泰松
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(=O)CCC1C(=O)N(N(C1=O)C1=CC=CC=C1)C1=CC=CC=C1
InChI: InChI=1S/C19H18N2O3/c1-14(22)12-13-17-18(23)20(15-8-4-2-5-9-15)21(19(17)24)16-10-6-3-7-11-16/h2-11,17H,12-13H2,1H3

描述信息

M - Musculo-skeletal system > M01 - Antiinflammatory and antirheumatic products > M01A - Antiinflammatory and antirheumatic products, non-steroids > M01AA - Butylpyrazolidines
Ketophenylbutazone belongs to the family of Pyrazolones. These are compounds containing a pyrazole ring which bears a ketone.
C78272 - Agent Affecting Nervous System > C241 - Analgesic Agent > C2198 - Nonnarcotic Analgesic
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
D002491 - Central Nervous System Agents > D000700 - Analgesics
D000893 - Anti-Inflammatory Agents
D018501 - Antirheumatic Agents

同义名列表

18 个代谢物同义名

1,2-Diphenyl-4-(gamma-ketobutyl)-3,5-pyrazolidinedione; 1,2-Diphenyl-4-(γ-ketobutyl)-3,5-pyrazolidinedione; 1,2-Diphenyl-4-(g-ketobutyl)-3,5-pyrazolidinedione; 4-(3-Oxobutyl)-1,2-diphenyl-3,5-pyrazolidinedione; 4-(3-oxobutyl)-1,2-diphenylpyrazolidine-3,5-dione; Ketophenylbutazonum; Ketophenylbutazone; Chetofenilbutazone; Chetofenilbutazon; Phloguron; Quebuzona; Kebuzonum; Kebuzone; Chebutan; Copirene; Racheton; Ketazon; Kebuzon



数据库引用编号

8 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • H H Maurer, F X Tauvel, T Kraemer. Screening procedure for detection of non-steroidal anti-inflammatory drugs and their metabolites in urine as part of a systematic toxicological analysis procedure for acidic drugs and poisons by gas chromatography-mass spectrometry after extractive methylation. Journal of analytical toxicology. 2001 May; 25(4):237-44. doi: 10.1093/jat/25.4.237. [PMID: 11386636]
  • Z D Zhivkova, V N Russeva. Binding of kebuzone to human serum albumin studied by high performance liquid affinity chromatography. Arzneimittel-Forschung. 2000 Mar; 50(3):272-5. doi: 10.1055/s-0031-1300198. [PMID: 10758780]
  • M H Rahman, K Yamasaki, Y H Shin, C C Lin, M Otagiri. Characterization of high affinity binding sites of non-steroidal anti-inflammatory drugs with respect to site-specific probes on human serum albumin. Biological & pharmaceutical bulletin. 1993 Nov; 16(11):1169-74. doi: 10.1248/bpb.16.1169. [PMID: 8312878]
  • A Vyskocil, M Tusl, V Chmelar. The effect of pretreatment with ketazon on the inflammatory changes in lung and concentration of corticosterone in serum of rats after nitrogen dioxide inhalation. Sbornik vedeckych praci Lekarske fakulty Karlovy university v Hradci Kralove. 1986; 29(4-5):511-6. doi: NULL. [PMID: 3481654]
  • G Heidelmann, G Burck, W Dauterstedt, J J Heinrich, R Ohlmer. [Indications for and methods of allopurinol-benzbromarone combination therapy in the treatment of hyperuricemic metabolic disorders]. Zeitschrift fur arztliche Fortbildung. 1982 Mar; 76(5):177-81. doi: NULL. [PMID: 6896252]
  • T Fukushima. [Monoamine oxidase (XXXVI). Characteristics of benzylamine oxidase in the dog serum]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica. 1975 Jul; 71(5):457-62. doi: . [PMID: 280]
  • O SIBLIKOVA, M CERNA, I M HAIS. [Contribution to the metabolism of ketophenylbutazone. II. Ketophenylbutazone metabolites in urine]. Ceskoslovenska farmacie. 1962 Mar; 11(?):123-6. doi: NULL. [PMID: 13912486]
  • O SIBLIKOVA, J LAVICKA, G VACHEK, B TESAREK, O VITULOVA, M CERNA. [Ketophenylbutazone, its metabolism and its effect on the uric acid content in the blood and urine]. Arzneimittel-Forschung. 1961 Dec; 11(?):1106-8. doi: NULL. [PMID: 13912488]