Dihydrodigoxin (BioDeep_00000036539)
human metabolite Endogenous
代谢物信息卡片
化学式: C41H66O14 (782.4452)
中文名称:
谱图信息:
最多检出来源 Homo sapiens(not specific) 25%
分子结构信息
SMILES: CC1C(C(CC(O1)OC2C(OC(CC2O)OC3C(OC(CC3O)OC4CCC5(C(C4)CCC6C5CC(C7(C6(CCC7C8CC(=O)OC8)O)C)O)C)C)C)O)O
InChI: InChI=1S/C41H66O14/c1-19-36(47)28(42)15-34(50-19)54-38-21(3)52-35(17-30(38)44)55-37-20(2)51-33(16-29(37)43)53-24-8-10-39(4)23(13-24)6-7-26-27(39)14-31(45)40(5)25(9-11-41(26,40)48)22-12-32(46)49-18-22/h19-31,33-38,42-45,47-48H,6-18H2,1-5H3
描述信息
Dihydrodigoxin belongs to the family of Terpene Glycosides. These are prenol lipids containing a carbohydrate moiety glycosidically bound to a terpene backbone.
D020011 - Protective Agents > D002316 - Cardiotonic Agents > D004071 - Digitalis Glycosides
D020011 - Protective Agents > D002316 - Cardiotonic Agents > D002301 - Cardiac Glycosides
同义名列表
数据库引用编号
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
|---|
文献列表
- Mohammad Al-Ghoul, Roland Valdes. Mammalian cardenolides in cancer prevention and therapeutics.
Therapeutic drug monitoring.
2008 Apr; 30(2):234-8. doi:
10.1097/ftd.0b013e31816b90ff. [PMID: 18367987] - H M Qazzaz, S A Jortani, J M Poole, R Valdes. Evidence for presence of a reduced form of digoxin-like immunoreactive factor (dihydro-DLIF) in mammalian tissues.
Clinical chemistry.
1996 Jul; 42(7):1092-9. doi:
NULL. [PMID: 8674194] - J A Stone, S J Soldin. Improved liquid chromatographic/immunoassay of digoxin in serum.
Clinical chemistry.
1988 Dec; 34(12):2547-51. doi:
NULL. [PMID: 3197300] - L W Robertson, A Chandrasekaran, R H Reuning, J Hui, B D Rawal. Reduction of digoxin to 20R-dihydrodigoxin by cultures of Eubacterium lentum.
Applied and environmental microbiology.
1986 Jun; 51(6):1300-3. doi:
10.1128/aem.51.6.1300-1303.1986. [PMID: 3729400] - E Kwong, K M McErlane. Development of a high-performance liquid chromatographic assay for digoxin using post-column fluorogenic derivatization.
Journal of chromatography.
1986 Apr; 377(?):233-42. doi:
10.1016/s0378-4347(00)80778-1. [PMID: 3711213] - T Akera, Y C Ng, I S Shieh, E Bero, T M Brody, W E Braselton. Effects of K+ on the interaction between cardiac glycosides and Na,K-ATPase.
European journal of pharmacology.
1985 May; 111(2):147-57. doi:
10.1016/0014-2999(85)90751-4. [PMID: 2990948] - R H Reuning, T A Shepard, B E Morrison, H N Bockbrader. Formation of [20R]-dihydrodigoxin from digoxin in humans.
Drug metabolism and disposition: the biological fate of chemicals.
1985 Jan; 13(1):51-7. doi:
NULL. [PMID: 2858377] - H N Bockbrader, R H Reuning. Digoxin and metabolites in urine: a derivatization--high-performance liquid chromatographic method capable of quantitating individual epimers of dihydrodigoxin.
Journal of chromatography.
1984 Sep; 310(1):85-95. doi:
10.1016/0378-4347(84)80070-5. [PMID: 6501524] - R Valdes, B A Brown, S W Graves. Variable cross-reactivity of digoxin metabolites in digoxin immunoassays.
American journal of clinical pathology.
1984 Aug; 82(2):210-3. doi:
10.1093/ajcp/82.2.210. [PMID: 6380268] - J O Magnusson, B Bergdahl, C Bogentoft, S Gustafsson, U E Jonsson. Increased metabolism to dihydrodigoxin after intake of a microencapsulated formulation of digoxin.
European journal of clinical pharmacology.
1984; 27(2):197-202. doi:
10.1007/bf00544045. [PMID: 6499898] - J O Magnusson, B Bergdahl, C Bogentoft, U E Jonsson. Metabolism of digoxin and absorption site.
British journal of clinical pharmacology.
1982 Aug; 14(2):284-5. doi:
10.1111/j.1365-2125.1982.tb01976.x. [PMID: 7104181] - J O Magnusson, B Bergdahl, C Bogentoft, U E Jonsson, L Tekenbergs. Excretion of digoxin and its metabolites in urine after a single oral dose in healthy subjects.
Biopharmaceutics & drug disposition.
1982 Jul; 3(3):211-8. doi:
10.1002/bdd.2510030304. [PMID: 7139062] - V P Butler, D Tse-Eng, J Lindenbraum, S M Kalman, J J Preibisz, D G Rund, P S Wissel. The development and application of a radioimmunoassay for dihydrodigoxin, a digoxin metabolite.
The Journal of pharmacology and experimental therapeutics.
1982 Apr; 221(1):123-31. doi:
NULL. [PMID: 7062278] - J Lindenbaum, D Tse-Eng, V P Butler, D G Rund. Urinary excretion of reduced metabolites of digoxin.
The American journal of medicine.
1981 Jul; 71(1):67-74. doi:
10.1016/0002-9343(81)90260-6. [PMID: 7246583] - B M Eriksson, L Tekenbergs, J O Magnusson, L Molin. Determination of tritiated digoxin and metabolites in urine by liquid chromatography.
Journal of chromatography.
1981 May; 223(2):401-8. doi:
10.1016/s0378-4347(00)80113-9. [PMID: 7251795] - W G Kramer, N L Kinnear, H K Morgan. Variability among commercially available digoxin radioimmunoassay kits in cross reactivity to dihydrodigoxin.
Clinical chemistry.
1978 Jan; 24(1):155-7. doi:
10.1093/clinchem/24.1.155. [PMID: 618648] - D Sugden, M Ahmed, M H Gault. Fractionation of tritiated digoxin and dihydrodigoxin with DEAE-sephadex LH-20.
Journal of chromatography.
1976 Jun; 121(2):401-4. doi:
10.1016/s0021-9673(00)85041-4. [PMID: 932155]
