Desacetylcefotaxime (BioDeep_00000036535)
human metabolite Endogenous blood metabolite
代谢物信息卡片
(6R,7R)-7-{[(2Z)-1-hydroxy-2-(2-imino-2,3-dihydro-1,3-thiazol-4-yl)-2-(methoxyimino)ethylidene]amino}-3-(hydroxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
化学式: C14H15N5O6S2 (413.046373)
中文名称: 3-去乙酰头孢噻肟, 3-去乙酰基头孢噻肟
谱图信息:
最多检出来源 Homo sapiens(blood) 5.56%
分子结构信息
SMILES: CON=C(C1=CSC(=N1)N)C(=O)NC2C3N(C2=O)C(=C(CS3)CO)C(=O)O
InChI: InChI=1S/C14H15N5O6S2/c1-25-18-7(6-4-27-14(15)16-6)10(21)17-8-11(22)19-9(13(23)24)5(2-20)3-26-12(8)19/h4,8,12,20H,2-3H2,1H3,(H2,15,16)(H,17,21)(H,23,24)/b18-7-/t8-,12-/m1/s1
描述信息
Desacetylcefotaxime belongs to the family of Cephems. These are organic compounds containing the 5-thia-1-azabicyclo[4.2.0]oct-2-en-8-one nucleus[1].
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D002511 - Cephalosporins
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D047090 - beta-Lactams
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D007769 - Lactams
同义名列表
8 个代谢物同义名
(6R,7R)-7-{[(2Z)-1-hydroxy-2-(2-imino-2,3-dihydro-1,3-thiazol-4-yl)-2-(methoxyimino)ethylidene]amino}-3-(hydroxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid; (6R,7R)-7-{[(2Z)-1-hydroxy-2-(2-imino-2,3-dihydro-1,3-thiazol-4-yl)-2-(methoxyimino)ethylidene]amino}-3-(hydroxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate; (6R,7R)-7-{[(2Z)-1-hydroxy-2-(2-imino-3H-1,3-thiazol-4-yl)-2-(methoxyimino)ethylidene]amino}-3-(hydroxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid; Desacetylcefotaxime, monosodium salt, (6R-trans)-isomer; Desacetylcefotaxime, monosodium salt; 3-Desacetyl Cefotaxime; Desacetylcefotaxime; Deacetylcefotaxime
数据库引用编号
分类词条
相关代谢途径
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代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Yarmarly C Guerra Valero, Tavey Dorofaeff, Jason A Roberts, Jeffrey Lipman, Mark G Coulthard, Louise Sparkes, Steven C Wallis, Suzanne L Parker. Development and validation of a UHPLC-MS/MS method to measure cefotaxime and metabolite desacetylcefotaxime in blood plasma: a pilot study suitable for capillary microsampling in critically ill children.
Analytical and bioanalytical chemistry.
2021 Jul; 413(17):4483-4491. doi:
10.1007/s00216-021-03411-7. [PMID: 34041575] - Joost B Koedijk, Corinne G H Valk-Swinkels, Tom A Rijpstra, Daan J Touw, Paul G H Mulder, Peter H J van der Voort, Nils E van 't Veer, Nardo J M van der Meer. Pilot Study of the Pharmacokinetics of Cefotaxime in Critically Ill Patients with Acute Kidney Injury Treated with Continuous Renal Replacement Therapy.
Antimicrobial agents and chemotherapy.
2016 06; 60(6):3587-90. doi:
10.1128/aac.02888-15. [PMID: 27021325] - Maurice J Ahsman, Enno D Wildschut, Dick Tibboel, Ron A Mathot. Pharmacokinetics of cefotaxime and desacetylcefotaxime in infants during extracorporeal membrane oxygenation.
Antimicrobial agents and chemotherapy.
2010 May; 54(5):1734-41. doi:
10.1128/aac.01696-09. [PMID: 20176908] - Philippe Seguin, Marie Clémence Verdier, Charles Chanavaz, Charlotte Engrand, Bruno Laviolle, Pierre-Yves Donnio, Yannick Mallédant. Plasma and peritoneal concentration following continuous infusion of cefotaxime in patients with secondary peritonitis.
The Journal of antimicrobial chemotherapy.
2009 Mar; 63(3):564-7. doi:
10.1093/jac/dkn522. [PMID: 19168542] - Maurice J Ahsman, Enno D Wildschut, Dick Tibboel, Ron A Mathot. Microanalysis of beta-lactam antibiotics and vancomycin in plasma for pharmacokinetic studies in neonates.
Antimicrobial agents and chemotherapy.
2009 Jan; 53(1):75-80. doi:
10.1128/aac.00636-08. [PMID: 18955527] - Mara M Aleksić, Vera Kapetanović, Jasmina Atanacković, Biljana Jocić, Mira Zecević. Simultaneous determination of cefotaxime and desacetylcefotaxime in real urine sample using voltammetric and high-performance liquid chromatographic methods.
Talanta.
2008 Oct; 77(1):131-7. doi:
10.1016/j.talanta.2008.05.047. [PMID: 18804610] - M T Rosseel, K H Vandewoude. Liquid chromatographic determination of the plasma concentrations of cefotaxime and desacetylcefotaxime in plasma of critically ill patients.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2004 Nov; 811(2):159-63. doi:
10.1016/j.jchromb.2004.08.040. [PMID: 15522715] - S Urien, N Laurent, J Barre, M Druguet, M Bouvier D'yvoire, P Maire. Pharmacokinetic modelling of cefotaxime and desacetylcefotaxime--a population study in 25 elderly patients.
European journal of clinical pharmacology.
2004 Mar; 60(1):11-6. doi:
10.1007/s00228-003-0725-9. [PMID: 14767629] - Jane Freeman, Fiona J O'Neill, Mark H Wilcox. Effects of cefotaxime and desacetylcefotaxime upon Clostridium difficile proliferation and toxin production in a triple-stage chemostat model of the human gut.
The Journal of antimicrobial chemotherapy.
2003 Jul; 52(1):96-102. doi:
10.1093/jac/dkg267. [PMID: 12775682] - T Scanes, A F Hundt, K J Swart, H K Hundt. Simultaneous determination of cefotaxime and desacetylcefotaxime in human plasma and cerebrospinal fluid by high-performance liquid chromatography.
Journal of chromatography. B, Biomedical sciences and applications.
2001 Jan; 750(1):171-6. doi:
10.1016/s0378-4347(00)00417-5. [PMID: 11204218] - H J Kraemer, R Gehrke, A Breithaupt, H Breithaupt. Simultaneous quantification of cefotaxime, desacetylcefotaxime, ofloxacine and ciprofloxacine in ocular aqueous humor and in plasma by high-performance liquid chromatography.
Journal of chromatography. B, Biomedical sciences and applications.
1997 Oct; 700(1-2):147-53. doi:
10.1016/s0378-4347(97)00323-x. [PMID: 9390724] - I R Friedland, K P Klugman. Cerebrospinal fluid bactericidal activity against cephalosporin-resistant Streptococcus pneumoniae in children with meningitis treated with high-dosage cefotaxime.
Antimicrobial agents and chemotherapy.
1997 Sep; 41(9):1888-91. doi:
10.1128/aac.41.9.1888. [PMID: 9303379] - G Castaneda Penalvo, M Kelly, H Maillols, H Fabre. Evaluation of capillary zone electrophoresis and micellar electrokinetic capillary chromatography with direct injection of plasma for the determination of cefotaxime and its metabolite.
Analytical chemistry.
1997 Apr; 69(7):1364-9. doi:
10.1021/ac9605049. [PMID: 9105177] - K B Patel, D P Nicolau, C H Nightingale, R Quintiliani. Pharmacokinetics of cefotaxime in healthy volunteers and patients.
Diagnostic microbiology and infectious disease.
1995 May; 22(1-2):49-55. doi:
10.1016/0732-8893(95)00072-i. [PMID: 7587050] - J D Turnidge. Pharmacodynamic (kinetic) considerations in the treatment of moderately severe infections with cefotaxime.
Diagnostic microbiology and infectious disease.
1995 May; 22(1-2):57-69. doi:
10.1016/0732-8893(95)00071-h. [PMID: 7587052] - R N Jones. Cefotaxime and desacetylcefotaxime antimicrobial interactions. The clinical relevance of enhanced activity: a review.
Diagnostic microbiology and infectious disease.
1995 May; 22(1-2):19-33. doi:
10.1016/0732-8893(95)00043-a. [PMID: 7587039] - S K Nath, G A Foster, L A Mandell, C Rotstein. Antimicrobial activity of ceftriaxone versus cefotaxime: negative effect of serum albumin binding of ceftriaxone.
The Journal of antimicrobial chemotherapy.
1994 Jun; 33(6):1239-43. doi:
10.1093/jac/33.6.1239. [PMID: 7928818] - S Y Gardner, R W Sweeney, T J Divers. Pharmacokinetics of cefotaxime in neonatal pony foals.
American journal of veterinary research.
1993 Apr; 54(4):576-9. doi:
NULL. [PMID: 8484578] - C M Paap, M C Nahata. The relation between type of renal disease and renal drug clearance in children.
European journal of clinical pharmacology.
1993; 44(2):195-7. doi:
10.1007/bf00315480. [PMID: 8453966] - P M Arnow, K Furmaga, J P Flaherty, D George. Microbiological efficacy and pharmacokinetics of prophylactic antibiotics in liver transplant patients.
Antimicrobial agents and chemotherapy.
1992 Oct; 36(10):2125-30. doi:
10.1128/aac.36.10.2125. [PMID: 1444292] - C M Paap, M C Nahata, M A Mentser, J D Mahan, S K Puri, J A Hubbard. Cefotaxime and metabolite disposition in two pediatric continuous ambulatory peritoneal dialysis patients.
The Annals of pharmacotherapy.
1992 Mar; 26(3):341-3. doi:
10.1177/106002809202600307. [PMID: 1554953] - J Sjölin, N Eriksson, P Arneborn, O Cars. Penetration of cefotaxime and desacetylcefotaxime into brain abscesses in humans.
Antimicrobial agents and chemotherapy.
1991 Dec; 35(12):2606-10. doi:
10.1128/aac.35.12.2606. [PMID: 1810195] - Iu V Kamnev, K K Manuĭlov, V A Orlov, V I Sokolova. [Pharmacokinetics of cefotaxime and desacetylcefotaxime in the blood serum and bronchial secretion in patients with chronic bronchitis after administration of a single 24-hour dose].
Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic].
1991 Oct; 36(10):42-4. doi:
NULL. [PMID: 1805696] - M B Kays, R L White, L V Friedrich, V E Del Bene. Evaluation of cephalosporins/cephamycins with antianaerobic activity by integrating microbiologic and pharmacokinetic properties.
Clinical therapeutics.
1991 Sep; 13(5):596-605. doi:
NULL. [PMID: 1799917] - C M Paap, M C Nahata, M A Mentser, J D Mahan, S K Puri, J W Hubbard. Pharmacokinetics of cefotaxime and its active metabolite in children with renal dysfunction.
Antimicrobial agents and chemotherapy.
1991 Sep; 35(9):1879-83. doi:
10.1128/aac.35.9.1879. [PMID: 1952862] - L A Mandell, M Afnan. Synergistic killing of gram-negative bacilli by cefotaxime, its desacetyl metabolite and human polymorphonuclear neutrophils.
The Journal of antimicrobial chemotherapy.
1991 Jun; 27(6):817-28. doi:
10.1093/jac/27.6.817. [PMID: 1938688] - J B Gouyon, A Pechinot, C Safran, P Chretien, D Sandre, A Kazmierczak. Pharmacokinetics of cefotaxime in preterm infants.
Developmental pharmacology and therapeutics.
1990; 14(1):29-34. doi:
10.1159/000480936. [PMID: 2311478] - L Hakim, D W Bourne, E J Triggs. Disposition of cefotaxime and its metabolite, desacetylcefotaxime, in rat: application of a pharmacokinetic-protein binding model.
Xenobiotica; the fate of foreign compounds in biological systems.
1989 Jul; 19(7):743-54. doi:
10.3109/00498258909042312. [PMID: 2773510] - G L Kearns, R F Jacobs, B R Thomas, T L Darville, J M Trang. Cefotaxime and desacetylcefotaxime pharmacokinetics in very low birth weight neonates.
The Journal of pediatrics.
1989 Mar; 114(3):461-7. doi:
10.1016/s0022-3476(89)80573-6. [PMID: 2921690] - M D Blanchin, M L Rondot-Dudragne, H Fabre, B Mandrou. Determination of cefotaxime, desacetylcefotaxime, cefmenoxime and ceftizoxime in biological samples by fluorescence detection after separation by thin-layer chromatography.
The Analyst.
1988 Jun; 113(6):899-902. doi:
10.1039/an9881300899. [PMID: 3218764] - S Kobayashi, S Arai, S Hayashi, T Sakaguchi, R Kawana. [In vitro synergy between cefotaxime and its main metabolite, desacetylcefotaxime].
The Japanese journal of antibiotics.
1988 May; 41(5):594-601. doi:
NULL. [PMID: 3216482] - F Demotes-Mainard, H Albin, J M Ragnaud, H Gin, G Vincon, J Aubertin. [Influence of fever on cefotaxime pharmacokinetics].
Pathologie-biologie.
1988 Feb; 36(2):155-8. doi:
NULL. [PMID: 3279384] - H C Goodpasture, E H Gerlach, R N Jones, J D Peterie. Optimal cefotaxime dosing for gram-negative bacteremia: effective trough serum bactericidal titers and drug concentrations 8 and 12 hr after 1- or 2-gm infusions.
Diagnostic microbiology and infectious disease.
1988 Feb; 9(2):97-103. doi:
10.1016/0732-8893(88)90102-2. [PMID: 3383550] - L Hakim, D W Bourne, E J Triggs. High-performance liquid chromatographic assay of cefotaxime, desacetylcefotaxime and ceftriaxone in rat plasma.
Journal of chromatography.
1988 Jan; 424(1):111-7. doi:
10.1016/s0378-4347(00)81081-6. [PMID: 3366822] - K Tago, N Yabusaki, A Ueno. Serum and renal tissue concentrations of cefotaxime in urinary tract obstruction in rabbits.
Drugs.
1988; 35 Suppl 2(?):65-71. doi:
10.2165/00003495-198800352-00015. [PMID: 3396491] - K Oizumi, I Hayashi, S Aonuma, K Konno. In vitro activity of desacetylcefotaxime and the interaction with its parent compound, cefotaxime.
Drugs.
1988; 35 Suppl 2(?):57-61. doi:
10.2165/00003495-198800352-00013. [PMID: 3135170] - F Jehl, J D Peter, A Picard, J P Dupeyron, J Marescaux, A Sibilly, H Monteil. Investigation of the biliary clearances of cefotaxime and desacetylcefotaxime by an original procedure in cholecystectomised patients.
Infection.
1987 Nov; 15(6):450-4. doi:
10.1007/bf01647231. [PMID: 3436677] - F Jehl, J D Peter, A Picard, J P Dupeyron, J Marescaux, A Sibilly, H Monteil. [Biliary excretion of cefotaxime and desacetylcefotaxime].
La Revue de medecine interne.
1987 Nov; 8(5):487-92. doi:
10.1016/s0248-8663(87)80198-4. [PMID: 3445030] - C R Marchbanks, R L Yost, R L White. Cefotaxime stability during in vitro microbiological testing.
Antimicrobial agents and chemotherapy.
1987 Sep; 31(9):1375-8. doi:
10.1128/aac.31.9.1375. [PMID: 3314698] - D R Guay, G R Matzke, K L Heim, C E Halstenson, P A Abraham, W F Keane. Influence of gender on the disposition of cefotaxime and desacetylcefotaxime.
Therapeutic drug monitoring.
1987 Sep; 9(3):259-62. doi:
10.1097/00007691-198709000-00002. [PMID: 3672567] - L Hary, M Andrejak. [Analysis of serum cefotaxime and desacetylcefotaxime by high performance liquid ion exchange chromatography].
Journal of chromatography.
1987 Aug; 419(?):396-400. doi:
NULL. [PMID: 3667798] - R N Jones, A L Barry. Antimicrobial activity of ceftriaxone, cefotaxime, desacetylcefotaxime, and cefotaxime-desacetylcefotaxime in the presence of human serum.
Antimicrobial agents and chemotherapy.
1987 May; 31(5):818-20. doi:
10.1128/aac.31.5.818. [PMID: 3606081] - R B Fick, M R Alexander, R A Prince, J E Kasik. Penetration of cefotaxime into respiratory secretions.
Antimicrobial agents and chemotherapy.
1987 May; 31(5):815-7. doi:
10.1128/aac.31.5.815. [PMID: 3606080] - E Beyssac, J M Cardot, G Colnet, J Sirot, J M Aiache. Pharmacokinetics of cefotaxime and its desacetyl metabolite in plasma and in cerebrospinal fluid.
European journal of drug metabolism and pharmacokinetics.
1987 Apr; 12(2):91-102. doi:
10.1007/bf03189882. [PMID: 3691581] - W D Welch, R E Bawdon. Cefotaxime metabolism by hemolyzed blood: quantitation and inhibition of the deacetylation reaction.
Diagnostic microbiology and infectious disease.
1986 Feb; 4(2):119-24. doi:
10.1016/0732-8893(86)90145-8. [PMID: 3082581] - R L Yost, H Derendorf. Disposition of cefotaxime and its desacetyl metabolite in morbidly obese male and female subjects.
Therapeutic drug monitoring.
1986; 8(2):189-94. doi:
10.1097/00007691-198606000-00011. [PMID: 3726933] - S Selwyn, M Bakhtiar. Comparative in vitro studies on cefotaxime and desacetylcefotaxime.
Drugs under experimental and clinical research.
1986; 12(12):953-65. doi:
NULL. [PMID: 3494587] - J M Trang, R F Jacobs, G L Kearns, A L Brown, T G Wells, F L Underwood, R B Kluza. Cefotaxime and desacetylcefotaxime pharmacokinetics in infants and children with meningitis.
Antimicrobial agents and chemotherapy.
1985 Dec; 28(6):791-5. doi:
10.1128/aac.28.6.791. [PMID: 4083862] - H C Albin, F M Demotes-Mainard, J L Bouchet, G A Vincon, C Martin-Dupont. Pharmacokinetics of intravenous and intraperitoneal cefotaxime in chronic ambulatory peritoneal dialysis.
Clinical pharmacology and therapeutics.
1985 Sep; 38(3):285-9. doi:
10.1038/clpt.1985.172. [PMID: 4028623] - G R Matzke, P A Abraham, C E Halstenson, W F Keane. Cefotaxime and desacetyl cefotaxime kinetics in renal impairment.
Clinical pharmacology and therapeutics.
1985 Jul; 38(1):31-6. doi:
10.1038/clpt.1985.130. [PMID: 4006373] - R L Yost, H Derendorf. Rapid chromatographic determination of cefotaxime and its metabolite in biological fluids.
Journal of chromatography.
1985 May; 341(1):131-8. doi:
10.1016/s0378-4347(00)84017-7. [PMID: 3894403] - R M Ings, D S Reeves, L O White, R P Bax, M J Bywater, H A Holt. The human pharmacokinetics of cefotaxime and its metabolites and the role of renal tubular secretion on their elimination.
Journal of pharmacokinetics and biopharmaceutics.
1985 Apr; 13(2):121-42. doi:
10.1007/bf01059394. [PMID: 4057054] - J Petersen, R D Stewart, G R Catto, N Edward. Pharmacokinetics of intraperitoneal cefotaxime treatment of peritonitis in patients on continuous ambulatory peritoneal dialysis.
Nephron.
1985; 40(1):79-82. doi:
10.1159/000183433. [PMID: 4000338] - F M Demotes-Mainard, G A Vinçon, C H Jarry, H C Albin. Micromethod for the determination of cefotaxime and desacetylcefotaxime in plasma and urine by high-performance liquid chromatography.
Journal of chromatography.
1984 Dec; 336(2):438-45. doi:
10.1016/s0378-4347(00)85174-9. [PMID: 6099369] - J Crooks, L O White, L J Burville, B D Speidel, D S Reeves. Pharmacokinetics of cefotaxime and desacetyl-cefotaxime in neonates.
The Journal of antimicrobial chemotherapy.
1984 Sep; 14 Suppl B(?):97-101. doi:
10.1093/jac/14.suppl_b.97. [PMID: 6094467] - H Hasegawa, A Imada, A Horiuchi, Y Nishii, M Fukushima, E Kurokawa. Pharmacokinetics of cefotaxime in patients undergoing haemodialysis and continuous ambulatory peritoneal dialysis.
The Journal of antimicrobial chemotherapy.
1984 Sep; 14 Suppl B(?):135-42. doi:
10.1093/jac/14.suppl_b.135. [PMID: 6094432] - W Graninger, M Uihlein, P Ferenci, C Moser, A Georgopoulos. Cefotaxime and desacetyl-cefotaxime blood levels in hepatic dysfunction.
The Journal of antimicrobial chemotherapy.
1984 Sep; 14 Suppl B(?):143-6. doi:
10.1093/jac/14.suppl_b.143. [PMID: 6094433] - E M Hammond, M Legge, A B MacLean. Determination of Cefotaxime in plasma by high pressure liquid chromatography.
Medical laboratory sciences.
1984 Jul; 41(3):299-301. doi:
NULL. [PMID: 6090858] - R Quintiliani, C H Nightingale, R Tilton. Comparative pharmacokinetics of cefotaxime and ceftizoxime and the role of desacetylcefotaxime in the antibacterial activity of cefotaxime.
Diagnostic microbiology and infectious disease.
1984 Jun; 2(3 Suppl):63S-70S. doi:
NULL. [PMID: 6086220] - H B Lassman, J D Coombes. Metabolism of cefotaxime: a review.
Diagnostic microbiology and infectious disease.
1984 Jun; 2(3 Suppl):3S-12S. doi:
NULL. [PMID: 6086216] - L B Reller. Interaction of cefotaxime and desacetylcefotaxime against pathogenic bacteria. Assessment with the serum bactericidal test.
Diagnostic microbiology and infectious disease.
1984 Jun; 2(3 Suppl):55S-61S. doi:
NULL. [PMID: 6086219] - G Humbert, A Leroy, S R Nair, C E Cherubin. Concentrations of cefotaxime and the desacetyl metabolite in serum and CSF of patients with meningitis.
The Journal of antimicrobial chemotherapy.
1984 May; 13(5):487-94. doi:
10.1093/jac/13.5.487. [PMID: 6330021] - M Boyer, J Sirot, R Cluzel. [Technic for assaying cefotaxime and desacetylcefotaxime in serum by high performance liquid chromatography].
Pathologie-biologie.
1984 Apr; 32(4):285-8. doi:
NULL. [PMID: 6326023] - G Höffken, H Lode, P Koeppe, M Ruhnke, K Borner. Pharmacokinetics of cefotaxime and desacetyl-cefotaxime in cirrhosis of the liver.
Chemotherapy.
1984; 30(1):7-17. doi:
10.1159/000238238. [PMID: 6319092] - F Demotes-Mainard, G Vinçon, J L Bouchet, C Jarry, H Albin. [Assay of cefotaxime and desacetylcefotaxime in plasma and urine by high performance liquid chromatography].
Annales de biologie clinique.
1984; 42(4):301-5. doi:
NULL. [PMID: 6093635] - R Krausse, U Ullmann, G Brandstetter, P Kratochvil. Investigation of human bile and serum levels by high pressure liquid chromatography after administration of latamoxef or cefotaxime.
Arzneimittel-Forschung.
1984; 34(12):1787-91. doi:
NULL. [PMID: 6099130] - D M Baer, R N Jones, J P Mullooly, W Horner. Protocol for the study of drug interferences in laboratory tests: cefotaxime interference in 24 clinical tests.
Clinical chemistry.
1983 Oct; 29(10):1736-40. doi:
10.1093/clinchem/29.10.1736. [PMID: 6311458] - M Ohkawa, A Okasho, I Motoi, S Tokunaga, R Shoda, S Kawaguchi, M Sawaki, M Shimamura, S Hirano, K Kuroda, S Awazu. Elimination kinetics of cefotaxime and desacetyl cefotaxime in patients with renal insufficiency and during hemodialysis.
Chemotherapy.
1983; 29(1):4-12. doi:
10.1159/000238166. [PMID: 6299656] - W Mühlberg, D Platt. [Elimination of desacetyl cefotaxime in geriatric patients with multiple diseases].
Klinische Wochenschrift.
1982 Dec; 60(24):1497-500. doi:
10.1007/bf01716101. [PMID: 6300510] - C M Nolan, C Ulmer. Penetration of cefotaxime and moxalactam into cerebrospinal fluid of rabbits with experimentally induced Escherichia coli meningitis.
Reviews of infectious diseases.
1982 Sep; 4 Suppl(?):S396-400. doi:
10.1093/clinids/4.supplement_2.s396. [PMID: 6294789] - R M Ings, J P Fillastre, M Godin, A Leroy, G Humbert. The pharmacokinetics of cefotaxime and its metabolites in subjects with normal and impaired renal function.
Reviews of infectious diseases.
1982 Sep; 4 Suppl(?):S379-91. doi:
10.1093/clinids/4.supplement_2.s379. [PMID: 6294787] - R N Jones, H W Wilson. Comparative beta-lactamase hydrolysis of and inhibition by 7-aminothiazolyl alpha-methoxyimino cephalosporins.
Infection.
1982 Sep; 10(5):303-6. doi:
10.1007/bf01640880. [PMID: 6293977] - J B Lecaillon, M C Rouan, C Souppart, N Febvre, F Juge. Determination of cefsulodin, cefotiam, cephalexin, cefotaxime, desacetyl-cefotaxime, cefuroxime and cefroxadin in plasma and urine by high-performance liquid chromatography.
Journal of chromatography.
1982 Mar; 228(?):257-67. doi:
10.1016/s0378-4347(00)80438-7. [PMID: 6281285] - D Dell, J Chamberlain, F Coppin. Determination of cefotaxime and desacetylcefotaxime in plasma and urine by high-performance liquid chromatography.
Journal of chromatography.
1981 Dec; 226(2):431-40. doi:
10.1016/s0378-4347(00)86077-6. [PMID: 6274890] - I Yamazaki, Y Shirakawa, T Fugono. Comparison of the renal excretory mechanisms of cefmenoxime and other cephalosporins: effect of para-aminohippurate on renal clearance and intrarenal distribution of cephalosporins in rabbits.
The Journal of antibiotics.
1981 Nov; 34(11):1476-85. doi:
10.7164/antibiotics.34.1476. [PMID: 6274834] - R Wise, N Wright, P J Wills. Pharmacology of cefotaxime and its desacetyl metabolite in renal and hepatic disease.
Antimicrobial agents and chemotherapy.
1981 Apr; 19(4):526-31. doi:
10.1128/aac.19.4.526. [PMID: 6264849] - F Kees, E Strehl, K Seeger, G Seidel, P Dominiak, H Grobecker. Comparative determination of cefotaxime and desacetyl cefotaxime in serum and bile by bioassay and high-performance liquid chromatography.
Arzneimittel-Forschung.
1981; 31(2):362-5. doi:
NULL. [PMID: 6261772]