Clobenzorex (BioDeep_00000036533)

   

human metabolite Chemicals and Drugs


代谢物信息卡片


Benzenemethanamine, 2-chloro, N-(1-methyl-2-phenylethyl)

化学式: C16H18ClN (259.1128)
中文名称: 氯苄雷司
谱图信息: 最多检出来源 Mus musculus(not specific) 14%

分子结构信息

SMILES: CC(CC1=CC=CC=C1)NCC1=CC=CC=C1Cl
InChI: InChI=1S/C16H18ClN/c1-13(11-14-7-3-2-4-8-14)18-12-15-9-5-6-10-16(15)17/h2-10,13,18H,11-12H2,1H3

描述信息

Chemically, clobenzorex is an N-substituted amphetamine analog that is converted to d-amphetamine soon after ingestion. In commercial production, clobenzorex is supplied in 30 mg doses as the hydrochloride salt in green-tinted capsules. The drug gained use as a prescription anorectic in the 1970s; however, adverse reactions were eventually observed, which led to the prohibition of clobenzorex in the United States and certain other countries. Clobenzorex (Asenlix, Dinintel, Finedal, Rexigen) is a stimulant drug of the phenethylamine and amphetamine chemical classes used as an appetite suppressant. The drug is legally distributed in Mexico under the trade name Asenlix by Aventis.
A - Alimentary tract and metabolism > A08 - Antiobesity preparations, excl. diet products > A08A - Antiobesity preparations, excl. diet products > A08AA - Centrally acting antiobesity products

同义名列表

11 个代谢物同义名

Benzenemethanamine, 2-chloro, N-(1-methyl-2-phenylethyl); [(2-chlorophenyl)methyl](1-phenylpropan-2-yl)amine; (+)-N-(O-Chlorobenzyl)-alpha-methylphenethylamine; N-[(2-chlorophenyl)methyl]-1-phenylpropan-2-amine; Clobenzorex hydrochloride; Clobenzorex, (+-)-isomer; (+-)-clobenzorex; Clobenzorex; Dinintel; Asenlix; Finedal



数据库引用编号

7 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

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Plant Reactome(0)

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1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • J T Cody, S Valtier. Amphetamine, clobenzorex, and 4-hydroxyclobenzorex levels following multidose administration of clobenzorex. Journal of analytical toxicology. 2001 Apr; 25(3):158-65. doi: 10.1093/jat/25.3.158. [PMID: 11327347]
  • S Valtier, J T Cody. Differentiation of clobenzorex use from amphetamine abuse using the metabolite 4-hydroxyclobenzorex. Journal of analytical toxicology. 2000 Oct; 24(7):606-13. doi: 10.1093/jat/24.7.606. [PMID: 11043667]
  • J T Cody, S Valtier. A gas chromatography-mass spectrometry method for the quantitation of clobenzorex. Journal of analytical toxicology. 1999 Nov; 23(7):603-8. doi: 10.1093/jat/23.7.603. [PMID: 10595847]
  • K L Baden, S Valtier, J T Cody. Metabolic production of amphetamine following multidose administration of clobenzorex. Journal of analytical toxicology. 1999 Oct; 23(6):511-7. doi: 10.1093/jat/23.6.511. [PMID: 10517559]
  • S Valtier, J T Cody. Metabolic production of amphetamine following administration of clobenzorex. Journal of forensic sciences. 1999 Jan; 44(1):17-22. doi: NULL. [PMID: 9987865]
  • H H Maurer, T Kraemer, O Ledvinka, C J Schmitt, A A Weber. Gas chromatography-mass spectrometry (GC-MS) and liquid chromatography-mass spectrometry (LC-MS) in toxicological analysis. Studies on the detection of clobenzorex and its metabolites within a systematic toxicological analysis procedure by GC-MS and by immunoassay and studies on the detection of alpha- and beta-amanitin in urine by atmospheric pressure ionization electrospray LC-MS. Journal of chromatography. B, Biomedical sciences and applications. 1997 Feb; 689(1):81-9. doi: 10.1016/s0378-4347(96)00348-9. [PMID: 9061484]
  • R de la Torre, R Badia, G Gonzàlez, M García, M J Pretel, M Farré, J Segura. Cross-reactivity of stimulants found in sports drug testing by two fluorescence polarization immunoassays. Journal of analytical toxicology. 1996 May; 20(3):165-70. doi: 10.1093/jat/20.3.165. [PMID: 8735197]
  • J A Tarver. Amphetamine-positive drug screens from use of clobenzorex hydrochlorate. Journal of analytical toxicology. 1994 May; 18(3):183. doi: 10.1093/jat/18.3.183. [PMID: 8065131]
  • A Franceschini, J M Duthel, J J Vallon. [Specific detection of urinary sympathomimetic amines for control of anti-doping by gas chromatography-mass spectroscopy]. Journal of chromatography. 1991 Mar; 541(1-2):109-20. doi: 10.1016/s0021-9673(01)95988-6. [PMID: 2037649]