Lactitol (BioDeep_00000036257)

   

human metabolite Endogenous


代谢物信息卡片


(2S,3R,4R,5R)-4-{[(2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}hexane-1,2,3,5,6-pentol

化学式: C12H24O11 (344.13185539999995)
中文名称: 乳糖醇
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C(C1C(C(C(C(O1)OC(C(CO)O)C(C(CO)O)O)O)O)O)O
InChI: InChI=1S/C12H24O11/c13-1-4(16)7(18)11(5(17)2-14)23-12-10(21)9(20)8(19)6(3-15)22-12/h4-21H,1-3H2/t4-,5+,6+,7+,8-,9-,10+,11+,12-/m0/s1

描述信息

Lactitol is found in herbs and spices. Artificial sweetener used in foods. Sweetness 0.4 x sucrose.Lactitol is a sugar alcohol used as a replacement bulk sweetener for low calorie foods with approximately 40\\% of the sweetness of sugar. Lactitol is produced by two manufacturers, Danisco and Purac Biochem
A - Alimentary tract and metabolism > A06 - Drugs for constipation > A06A - Drugs for constipation > A06AD - Osmotically acting laxatives
Artificial sweetener used in foods. Sweetness 0.4 x sucrose
D000074385 - Food Ingredients > D005503 - Food Additives
D010592 - Pharmaceutic Aids > D005421 - Flavoring Agents
D005765 - Gastrointestinal Agents > D002400 - Cathartics

同义名列表

12 个代谢物同义名

(2S,3R,4R,5R)-4-{[(2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}hexane-1,2,3,5,6-pentol; WURCS=2.0/2,2,1/[H2122H][a2112h-1b_1-5]/1-2/a4-b1; 4-O-beta-D-Galactopyranosyl-D-glucitol; 4-O-β-D-Galactopyranosyl-D-glucitol; Neda lactiv importal; D-Lactitol; Lactitolum; Importal; Emportal; Lactitol; Pizensy; Oponaf



数据库引用编号

11 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Xiao Qing Li, Xu Min Zhang, Xi Wu, Yu Lan, Le Xu, Xiang Chen Meng, Jing Nan Li. Beneficial effects of lactitol on the composition of gut microbiota in constipated patients. Journal of digestive diseases. 2020 Aug; 21(8):445-453. doi: 10.1111/1751-2980.12912. [PMID: 32483935]
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  • Ya-Nan Wang, Xiang-Chen Meng, Yi-Fan Dong, Xin-Hua Zhao, Jia-Ming Qian, Hong-Ying Wang, Jing-Nan Li. Effects of probiotics and prebiotics on intestinal microbiota in mice with acute colitis based on 16S rRNA gene sequencing. Chinese medical journal. 2019 Aug; 132(15):1833-1842. doi: 10.1097/cm9.0000000000000308. [PMID: 31268903]
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  • Mario Del Piano, Marco Balzarini, Stefania Carmagnola, Michela Pagliarulo, Roberto Tari, Stefania Nicola, Francesca Deidda, Marco Pane. Assessment of the capability of a gelling complex made of tara gum and the exopolysaccharides produced by the microorganism Streptococcus thermophilus ST10 to prospectively restore the gut physiological barrier: a pilot study. Journal of clinical gastroenterology. 2014 Nov; 48 Suppl 1(?):S56-61. doi: 10.1097/mcg.0000000000000254. [PMID: 25291130]
  • Chunlei Chen, Xiuli Yu, Haifeng Lu, Dangsheng Xiao, Weiling Mao, Lanjuan Li. Antioxidant protective effects of lactitol against endotoxemia in patients with chronic viral hepatitis. Molecular medicine reports. 2013 Feb; 7(2):401-5. doi: 10.3892/mmr.2012.1188. [PMID: 23165913]
  • Daniel J Warner, Hongming Chen, Louis-David Cantin, J Gerry Kenna, Simone Stahl, Clare L Walker, Tobias Noeske. Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification. Drug metabolism and disposition: the biological fate of chemicals. 2012 Dec; 40(12):2332-41. doi: 10.1124/dmd.112.047068. [PMID: 22961681]
  • M Eugenia Giorgi, Laura Ratier, Rosalía Agusti, Alberto C C Frasch, Rosa M de Lederkremer. Improved bioavailability of inhibitors of Trypanosoma cruzi trans-sialidase: PEGylation of lactose analogs with multiarm polyethyleneglycol. Glycobiology. 2012 Oct; 22(10):1363-73. doi: 10.1093/glycob/cws091. [PMID: 22653661]
  • Hiroshi Sakagami, Tomohiko Matsuta, Kazue Satoh, Sumiko Ohtsuki, Chiyako Shimada, Taisei Kanamoto, Shigemi Terakubo, Hideki Nakashima, Yurika Morita, Atsuko Ohkubo, Tadashi Tsuda, Katsuyoshi Sunaga, Jun Maki, Tomoko Sugiura, Madoka Kitajima, Hiroshi Oizumi, Takaaki Oizumi. Biological activity of SE-10, granulated powder of Sasa senanensis Rehder leaf extract. In vivo (Athens, Greece). 2012 May; 26(3):411-8. doi: ". [PMID: 22523293]
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  • Saori Kadoya, Kahori Fujii, Ken-ichi Izutsu, Etsuo Yonemochi, Katsuhide Terada, Chikako Yomota, Toru Kawanishi. Freeze-drying of proteins with glass-forming oligosaccharide-derived sugar alcohols. International journal of pharmaceutics. 2010 Apr; 389(1-2):107-13. doi: 10.1016/j.ijpharm.2010.01.027. [PMID: 20097277]
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  • Arthur C Ouwehand, Kirsti Tiihonen, Markku Saarinen, Heli Putaala, Nina Rautonen. Influence of a combination of Lactobacillus acidophilus NCFM and lactitol on healthy elderly: intestinal and immune parameters. The British journal of nutrition. 2009 Feb; 101(3):367-75. doi: 10.1017/s0007114508003097. [PMID: 18634707]
  • A Piva, E Grilli, L Fabbri, V Pizzamiglio, P P Gatta, F Galvano, M Bognanno, L Fiorentini, J Woliński, R Zabielski, J A Patterson. Intestinal metabolism of weaned piglets fed a typical United States or European diet with or without supplementation of tributyrin and lactitol. Journal of animal science. 2008 Nov; 86(11):2952-61. doi: 10.2527/jas.2007-0402. [PMID: 18502885]
  • Ryukichi Kumashiro. Treatment of minimal hepatic encephalopathy. Hepatology research : the official journal of the Japan Society of Hepatology. 2008 Nov; 38 Suppl 1(?):S128-31. doi: 10.1111/j.1872-034x.2008.00438.x. [PMID: 19125944]
  • Iu V Perevalova, P I Tsapok. [Influence of the bifidobacteria and lactitol containing products on lypoperoxidation processes and intestinal microflora]. Voprosy pitaniia. 2008; 77(2):36-9. doi: ". [PMID: 18505097]
  • Anne Hafer, Sigrid Krämer, Swantje Duncker, Martin Krüger, Michael P Manns, Stephan C Bischoff. Effect of oral lactulose on clinical and immunohistochemical parameters in patients with inflammatory bowel disease: a pilot study. BMC gastroenterology. 2007 Sep; 7(?):36. doi: 10.1186/1471-230x-7-36. [PMID: 17784949]
  • Michelle Finney, Joanne Smullen, Howard A Foster, Saskia Brokx, David M Storey. Effects of low doses of lactitol on faecal microflora, pH, short chain fatty acids and gastrointestinal symptomology. European journal of nutrition. 2007 Sep; 46(6):307-14. doi: 10.1007/s00394-007-0666-7. [PMID: 17623227]
  • S Nakamura, R Hongo, K Moji, T Oku. Suppressive effect of partially hydrolyzed guar gum on transitory diarrhea induced by ingestion of maltitol and lactitol in healthy humans. European journal of clinical nutrition. 2007 Sep; 61(9):1086-93. doi: 10.1038/sj.ejcn.1602623. [PMID: 17251924]
  • Chunlei Chen, Lanjuan Li, Zhongwen Wu, Huguang Chen, Shuzhen Fu. Effects of lactitol on intestinal microflora and plasma endotoxin in patients with chronic viral hepatitis. The Journal of infection. 2007 Jan; 54(1):98-102. doi: 10.1016/j.jinf.2005.11.013. [PMID: 17049992]
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  • Jennifer M Gee, Ian T Johnson. Dietary lactitol fermentation increases circulating peptide YY and glucagon-like peptide-1 in rats and humans. Nutrition (Burbank, Los Angeles County, Calif.). 2005 Oct; 21(10):1036-43. doi: 10.1016/j.nut.2005.03.002. [PMID: 16157241]
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  • Tsuneyuki Oku, Sadako Nakamura, Makoto Ichinose. Maximum permissive dosage of lactose and lactitol for transitory diarrhea, and utilizable capacity for lactose in Japanese female adults. Journal of nutritional science and vitaminology. 2005 Apr; 51(2):51-7. doi: 10.3177/jnsv.51.51. [PMID: 16022189]
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