tritriacontanoic acid (BioDeep_00000361413)

   

natural product


代谢物信息卡片


tritriacontanoic acid

化学式: C33H66O2 (494.5062536)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC(=O)O
InChI: InChI=1S/C33H66O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-26-27-28-29-30-31-32-33(34)35/h2-32H2,1H3,(H,34,35)

描述信息

D005765 - Gastrointestinal Agents > D002400 - Cathartics

同义名列表

1 个代谢物同义名

tritriacontanoic acid



数据库引用编号

7 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

17 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • Daniela Pop, Radu Samuel Pop, Dorin Farcău. The Use of Fibers, Herbal Medicines and Spices in Children with Irritable Bowel Syndrome: A Narrative Review. Nutrients. 2023 Oct; 15(20):. doi: 10.3390/nu15204351. [PMID: 37892426]
  • Michał Majewski, Leszek Gromadziński, Ewelina Cholewińska, Katarzyna Ognik, Bartosz Fotschki, Jerzy Juśkiewicz. The Interaction of Dietary Pectin, Inulin, and Psyllium with Copper Nanoparticle Induced Changes to the Cardiovascular System. Nutrients. 2023 Aug; 15(16):. doi: 10.3390/nu15163557. [PMID: 37630746]
  • Lina Herliana, Julian G Schwerdt, Tycho R Neumann, Anita Severn-Ellis, Jana L Phan, James M Cowley, Neil J Shirley, Matthew R Tucker, Tina Bianco-Miotto, Jacqueline Batley, Nathan S Watson-Haigh, Rachel A Burton. A chromosome-level genome assembly of Plantago ovata. Scientific reports. 2023 01; 13(1):1528. doi: 10.1038/s41598-022-25078-5. [PMID: 36707685]
  • Xiaoqiang Zou, Xiuli Xu, Zhonghao Chao, Xuan Jiang, Lei Zheng, Bangzhi Jiang. Properties of plant-derived soluble dietary fibers for fiber-enriched foods: A comparative evaluation. International journal of biological macromolecules. 2022 Dec; 223(Pt A):1196-1207. doi: 10.1016/j.ijbiomac.2022.11.008. [PMID: 36347374]
  • Mohamed Eltorki, Russell Leong, Elyanne M Ratcliffe. Kiwifruit and Kiwifruit Extracts for Treatment of Constipation: A Systematic Review and Meta-Analysis. Canadian journal of gastroenterology & hepatology. 2022; 2022(?):7596920. doi: 10.1155/2022/7596920. [PMID: 36247043]
  • K A H T Kodithuwakku, H Owada, H Miura, D Maruyama, K Hirano, Y Suzuki, Y Kobayashi, S Koike. Effects of oral administration of timothy hay and psyllium on the growth performance and fecal microbiota of preweaning calves. Journal of dairy science. 2021 Dec; 104(12):12472-12485. doi: 10.3168/jds.2021-20259. [PMID: 34538491]
  • Zhe Ren, Ruihong Yu, Zhen Meng, Mengke Sun, Yongyuan Huang, Ting Xu, Qiong Guo, Tao Qin. Spiky titanium dioxide nanoparticles-loaded Plantaginis Semen polysaccharide as an adjuvant to enhance immune responses. International journal of biological macromolecules. 2021 Nov; 191(?):1096-1104. doi: 10.1016/j.ijbiomac.2021.09.184. [PMID: 34610351]
  • Harsha Suresh, Jerry Zhou, Vincent Ho. The Short-Term Effects and Tolerability of Low-Viscosity Soluble Fibre on Gastroparesis Patients: A Pilot Clinical Intervention Study. Nutrients. 2021 Nov; 13(12):. doi: 10.3390/nu13124298. [PMID: 34959850]
  • Matthew G Pontifex, Aleena Mushtaq, Gwenaëlle Le Gall, Ildefonso Rodriguez-Ramiro, Britt Anne Blokker, Mara E M Hoogteijling, Matthew Ricci, Michael Pellizzon, David Vauzour, Michael Müller. Differential Influence of Soluble Dietary Fibres on Intestinal and Hepatic Carbohydrate Response. Nutrients. 2021 Nov; 13(12):. doi: 10.3390/nu13124278. [PMID: 34959832]
  • Carlos A Montoya, Sharon J Henare, Erin M O'Donoghue, Douglas Rosendale, Patrick Edwards, Paul J Moughan. Kiwifruit (Actinidia deliciosa), compared with cellulose and psyllium, influences the histology and mucus layer of the gastrointestinal tract in the growing pig. Food & function. 2021 Sep; 12(17):8007-8016. doi: 10.1039/d0fo02920c. [PMID: 34269359]
  • Xin Zhang, Ya Zhao, Qilong Shi, Yuexiang Zhang, Jing Liu, Xiaotian Wu, Zhongxiang Fang. Development and characterization of active and pH-sensitive films based on psyllium seed gum incorporated with free and microencapsulated mulberry pomace extracts. Food chemistry. 2021 Aug; 352(?):129333. doi: 10.1016/j.foodchem.2021.129333. [PMID: 33662916]
  • Fei Yang, Wenjun Shi, Liting Wang, Nankun Qin, Chengxiang Wang, Yuying Guo, Guang Xu, Jie Fang, Xue Yu, Qun Ma. Lipidomics study of the therapeutic mechanism of Plantaginis Semen in potassium oxonate-induced hyperuricemia rat. BMC complementary medicine and therapies. 2021 Jun; 21(1):175. doi: 10.1186/s12906-021-03350-x. [PMID: 34172058]
  • J C Alves, A Santos, P Jorge, A Pitães. The use of soluble fibre for the management of chronic idiopathic large-bowel diarrhoea in police working dogs. BMC veterinary research. 2021 Mar; 17(1):100. doi: 10.1186/s12917-021-02809-w. [PMID: 33653329]
  • Crystal R Rivers, Mark A Kantor. Psyllium husk intake and risk of type 2 diabetes: an evidence-based scientific and regulatory review of a qualified health claim conducted by the US Food and Drug Administration. Nutrition reviews. 2020 10; 78(10):787-797. doi: 10.1093/nutrit/nuz103. [PMID: 31968119]
  • Marzena Helena Zając. The properties of poultry batters depending on the amount of water and Plantago ovata husk. Acta scientiarum polonorum. Technologia alimentaria. 2020 Oct; 19(4):475-482. doi: 10.17306/j.afs.0824. [PMID: 33179487]
  • Michael J Mienaltowski, Ashley Belt, John D Henderson, Tannah N Boyd, Nicole Marter, Elizabeth A Maga, Edward J DePeters. Psyllium supplementation is associated with changes in the fecal microbiota of horses. BMC research notes. 2020 Sep; 13(1):459. doi: 10.1186/s13104-020-05305-w. [PMID: 32993781]
  • Harsha Suresh, Vincent Ho, Jerry Zhou. Rheological Characteristics of Soluble Fibres during Chemically Simulated Digestion and their Suitability for Gastroparesis Patients. Nutrients. 2020 Aug; 12(8):. doi: 10.3390/nu12082479. [PMID: 32824535]
  • Mekky M Abouzied, Shaymaa M Mahmoud, Ahmed Wahid, Amr E Ahmed, Ahmed M Okasha, Hanan A Soliman, Sultan S Al Thagfan, Eman Z Attia. A study of the hepatoprotective effect of Plantago psyllium L. seed extract against Carbon tetrachloride induced hepatic injury in rats. Journal of applied biomedicine. 2020 Aug; 18(2-3):80-86. doi: 10.32725/jab.2020.006. [PMID: 34907729]
  • Xin Zhang, Ya Zhao, Yuanyuan Li, Lanlan Zhu, Zhongxiang Fang, Qilong Shi. Physicochemical, mechanical and structural properties of composite edible films based on whey protein isolate/psyllium seed gum. International journal of biological macromolecules. 2020 Jun; 153(?):892-901. doi: 10.1016/j.ijbiomac.2020.03.018. [PMID: 32142843]
  • Zhifang Xiao, Hui Chen, Yu Zhang, Hui Deng, KunWei Wang, Akshaya Srikanth Bhagavathula, Shamma Jauaan Almuhairi, Paul M Ryan, Jamal Rahmani, Minyan Dang, Vasileios Kontogiannis, Andrew Vick, Yuhe Wei. The effect of psyllium consumption on weight, body mass index, lipid profile, and glucose metabolism in diabetic patients: A systematic review and dose-response meta-analysis of randomized controlled trials. Phytotherapy research : PTR. 2020 Jun; 34(6):1237-1247. doi: 10.1002/ptr.6609. [PMID: 31919936]
  • Somaye Beigi, Majid Azizi, Marcello Iriti. Application of Super Absorbent Polymer and Plant Mucilage Improved Essential Oil Quantity and Quality of Ocimum basilicum var. Keshkeni Luvelou. Molecules (Basel, Switzerland). 2020 May; 25(11):. doi: 10.3390/molecules25112503. [PMID: 32481510]
  • Mohammad Ali Hesarinejad, Elhamalsadat Shekarforoush, Farnaz Rezayian Attar, Sajad Ghaderi. The dependency of rheological properties of Plantago lanceolata seed mucilage as a novel source of hydrocolloid on mono- and di-valent salts. International journal of biological macromolecules. 2020 Mar; 147(?):1278-1284. doi: 10.1016/j.ijbiomac.2019.10.093. [PMID: 31751715]
  • Johnson W McRorie, George C Fahey, Roger D Gibb, William D Chey. Laxative effects of wheat bran and psyllium: Resolving enduring misconceptions about fiber in treatment guidelines for chronic idiopathic constipation. Journal of the American Association of Nurse Practitioners. 2020 Jan; 32(1):15-23. doi: 10.1097/jxx.0000000000000346. [PMID: 31764399]
  • Jixian Zhang, Chaoting Wen, Haihui Zhang, Yuqing Duan. Review of isolation, structural properties, chain conformation, and bioactivities of psyllium polysaccharides. International journal of biological macromolecules. 2019 Oct; 139(?):409-420. doi: 10.1016/j.ijbiomac.2019.08.014. [PMID: 31381918]
  • Sakshi Sukhija, Sukhcharn Singh, Charanjit S Riar. Development and characterization of biodegradable films from whey protein concentrate, psyllium husk and oxidized, crosslinked, dual-modified lotus rhizome starch composite. Journal of the science of food and agriculture. 2019 May; 99(7):3398-3409. doi: 10.1002/jsfa.9557. [PMID: 30609039]
  • Noureddin Soltanian, Mohsen Janghorbani. Effect of flaxseed or psyllium vs. placebo on management of constipation, weight, glycemia, and lipids: A randomized trial in constipated patients with type 2 diabetes. Clinical nutrition ESPEN. 2019 02; 29(?):41-48. doi: 10.1016/j.clnesp.2018.11.002. [PMID: 30661699]
  • Jonna Jalanka, Giles Major, Kathryn Murray, Gulzar Singh, Adam Nowak, Caroline Kurtz, Inmaculada Silos-Santiago, Jeffrey M Johnston, Willem M de Vos, Robin Spiller. The Effect of Psyllium Husk on Intestinal Microbiota in Constipated Patients and Healthy Controls. International journal of molecular sciences. 2019 Jan; 20(2):. doi: 10.3390/ijms20020433. [PMID: 30669509]
  • Sarah L Eady, Alison J Wallace, Christine A Butts, Duncan Hedderley, Lynley Drummond, Juliet Ansell, Richard B Gearry. The effect of 'Zesy002' kiwifruit (Actinidia chinensis var. chinensis) on gut health function: a randomised cross-over clinical trial. Journal of nutritional science. 2019; 8(?):e18. doi: 10.1017/jns.2019.14. [PMID: 31080591]
  • Monica Jane, Jenny McKay, Sebely Pal. Effects of daily consumption of psyllium, oat bran and polyGlycopleX on obesity-related disease risk factors: A critical review. Nutrition (Burbank, Los Angeles County, Calif.). 2019 01; 57(?):84-91. doi: 10.1016/j.nut.2018.05.036. [PMID: 30153584]
  • Elena Jovanovski, Shahen Yashpal, Allison Komishon, Andreea Zurbau, Sonia Blanco Mejia, Hoang Vi Thanh Ho, Dandan Li, John Sievenpiper, Lea Duvnjak, Vladimir Vuksan. Effect of psyllium (Plantago ovata) fiber on LDL cholesterol and alternative lipid targets, non-HDL cholesterol and apolipoprotein B: a systematic review and meta-analysis of randomized controlled trials. The American journal of clinical nutrition. 2018 11; 108(5):922-932. doi: 10.1093/ajcn/nqy115. [PMID: 30239559]
  • Soltanian Noureddin, Janghorbani Mohsen, Adibi Payman. Effects of psyllium vs. placebo on constipation, weight, glycemia, and lipids: A randomized trial in patients with type 2 diabetes and chronic constipation. Complementary therapies in medicine. 2018 Oct; 40(?):1-7. doi: 10.1016/j.ctim.2018.07.004. [PMID: 30219432]
  • Lubobo-Claude Kazadi, Janine Fletcher, Paul A Barrow. Gastric cooling and menthol cause an increase in cardiac parasympathetic efferent activity in healthy adult human volunteers. Experimental physiology. 2018 10; 103(10):1302-1308. doi: 10.1113/ep087058. [PMID: 30070742]
  • Mahdieh Kamalpour, Hamid Ghalandari, Javad Nasrollahzadeh. Short-Term Supplementation of a Moderate Carbohydrate Diet with Psyllium Reduces Fasting Plasma Insulin and Tumor Necrosis Factor-α in Patients with Type 2 Diabetes Mellitus. Journal of dietary supplements. 2018 Jul; 15(4):507-515. doi: 10.1080/19390211.2017.1358791. [PMID: 28956658]
  • E V Onuchina. A new look at dietary fibers in metabolic syndrome. Terapevticheskii arkhiv. 2018 Apr; 90(4):85-90. doi: 10.26442/terarkh201890485-90. [PMID: 30701880]
  • Ryan M Pace, Amanda L Prince, Jun Ma, Benjamin D W Belfort, Alexia S Harvey, Min Hu, Karalee Baquero, Peter Blundell, Diana Takahashi, Tyler Dean, Paul Kievit, Elinor L Sullivan, Jacob E Friedman, Kevin Grove, Kjersti M Aagaard. Modulations in the offspring gut microbiome are refractory to postnatal synbiotic supplementation among juvenile primates. BMC microbiology. 2018 04; 18(1):28. doi: 10.1186/s12866-018-1169-9. [PMID: 29621980]
  • Sean R Llewellyn, Graham J Britton, Eduardo J Contijoch, Olivia H Vennaro, Arthur Mortha, Jean-Frederic Colombel, Ari Grinspan, Jose C Clemente, Miriam Merad, Jeremiah J Faith. Interactions Between Diet and the Intestinal Microbiota Alter Intestinal Permeability and Colitis Severity in Mice. Gastroenterology. 2018 03; 154(4):1037-1046.e2. doi: 10.1053/j.gastro.2017.11.030. [PMID: 29174952]
  • Miyuki Ogata, Tasuku Ogita, Hiroyuki Tari, Teruaki Arakawa, Takuya Suzuki. Supplemental psyllium fibre regulates the intestinal barrier and inflammation in normal and colitic mice. The British journal of nutrition. 2017 Nov; 118(9):661-672. doi: 10.1017/s0007114517002586. [PMID: 29185927]
  • Ruijian Zhong, Yan Yu, Yangbing Zheng, Weikang Chen, Guoping Zhou, Jianhong Ding, Mingming Yuan. A simple and selective UHPLC-MS/MS method for quantification of plantagoguanidinic acid in rat plasma and its application to a pharmacokinetic study. Biomedical chromatography : BMC. 2017 Aug; 31(8):. doi: 10.1002/bmc.3929. [PMID: 28054363]
  • Yukihiro Okuda, Kojiro Taura, Kenji Yoshino, Yoshinobu Ikeno, Takahiro Nishio, Gen Yamamoto, Kazutaka Tanabe, Yukinori Koyama, Etsuro Hatano, Shiro Tanaka, Shinji Uemoto. Usefulness of Mac-2 Binding Protein Glycosylation Isomer for Prediction of Posthepatectomy Liver Failure in Patients With Hepatocellular Carcinoma. Annals of surgery. 2017 06; 265(6):1201-1208. doi: 10.1097/sla.0000000000001836. [PMID: 27355265]
  • Pankaj Garg. Psyllium Husk Should Be Taken at Higher Dose with Sufficient Water to Maximize Its Efficacy. Journal of the Academy of Nutrition and Dietetics. 2017 05; 117(5):681. doi: 10.1016/j.jand.2017.03.001. [PMID: 28449791]
  • Javed Yakoob, Wasim Jafri, Malik Hassan Mehmood, Zaigham Abbas, Kanwal Tariq. Cytokine changes in gastric and colonic epithelial cell in response to Planta ovata extract. Journal of complementary & integrative medicine. 2017 Mar; 14(2):. doi: 10.1515/jcim-2015-0075. [PMID: 28333654]
  • Emma P Halmos. When the low FODMAP diet does not work. Journal of gastroenterology and hepatology. 2017 Mar; 32 Suppl 1(?):69-72. doi: 10.1111/jgh.13701. [PMID: 28244666]
  • Johnson W McRorie, Nicola M McKeown. Understanding the Physics of Functional Fibers in the Gastrointestinal Tract: An Evidence-Based Approach to Resolving Enduring Misconceptions about Insoluble and Soluble Fiber. Journal of the Academy of Nutrition and Dietetics. 2017 02; 117(2):251-264. doi: 10.1016/j.jand.2016.09.021. [PMID: 27863994]
  • Sebely Pal, Suleen Ho, Roland J Gahler, Simon Wood. Effect on Insulin, Glucose and Lipids in Overweight/Obese Australian Adults of 12 Months Consumption of Two Different Fibre Supplements in a Randomised Trial. Nutrients. 2017 Jan; 9(2):. doi: 10.3390/nu9020091. [PMID: 28146065]
  • André Álvares Monge Neto, Rita de Cássia Bergamasco, Flávio Faria de Moraes, Antônio Medina Neto, Rosane Marina Peralta. Development of a technique for psyllium husk mucilage purification with simultaneous microencapsulation of curcumin. PloS one. 2017; 12(8):e0182948. doi: 10.1371/journal.pone.0182948. [PMID: 28817614]
  • Stefan A Schmidt, Julia A Baumann, Nora Stanescu-Siegmund, Eckhart Froehlich, Hans-Juergen Brambs, Markus S Juchems. Oral distension methods for small bowel MRI: comparison of different agents to optimize bowel distension. Acta radiologica (Stockholm, Sweden : 1987). 2016 Dec; 57(12):1460-1467. doi: 10.1177/0284185116631183. [PMID: 26868172]
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  • Javed Yakoob, Wasim Jafri, Malik Hassan Mehmood, Zaigham Abbas, Kanwal Tariq. Immunomodulatory Effects of Psyllium Extract on Helicobacter pylori Interaction With Gastric Epithelial Cells. Journal of evidence-based complementary & alternative medicine. 2016 Oct; 21(4):NP18-24. doi: 10.1177/2156587215611517. [PMID: 26474925]
  • M A Jimoh, W MacNaughtan, H E L Williams, D Greetham, R L Linforth, I D Fisk. Sodium ion interaction with psyllium husk (Plantago sp.). Food & function. 2016 Sep; 7(9):4041-4047. doi: 10.1039/c6fo00785f. [PMID: 27722358]
  • Monica R P Rao, Deepa U Warrier, Snehal R Gaikwad, Prachi M Shevate. Phosphorylation of psyllium seed polysaccharide and its characterization. International journal of biological macromolecules. 2016 Apr; 85(?):317-26. doi: 10.1016/j.ijbiomac.2015.12.043. [PMID: 26769088]
  • Zhaleh Sadat Ladjevardi, Seyed Mohammad Taghi Gharibzahedi, Mohammad Mousavi. Development of a stable low-fat yogurt gel using functionality of psyllium (Plantago ovata Forsk) husk gum. Carbohydrate polymers. 2015 Jul; 125(?):272-80. doi: 10.1016/j.carbpol.2015.02.051. [PMID: 25857984]
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  • Sílvia A Steiner, Marcia R F Torres, Francisco J Penna, Barbara F Gazzinelli, Caroline G A Corradi, Aline S Costa, Isabela G Ribeiro, Eugênio G de Andrade, Maria do Carmo Barros de Melo. Chronic functional constipation in children: adherence and factors associated with drug treatment. Journal of pediatric gastroenterology and nutrition. 2014 May; 58(5):598-602. doi: 10.1097/mpg.0000000000000255. [PMID: 24345842]
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  • Naoyuki Togawa, Rumiko Takahashi, Shizuka Hirai, Tatsunobu Fukushima, Yukari Egashira. Gene expression analysis of the liver and skeletal muscle of psyllium-treated mice. The British journal of nutrition. 2013 Feb; 109(3):383-93. doi: 10.1017/s0007114512001250. [PMID: 22874121]
  • Jing Yang, Hai-Peng Wang, Li Zhou, Chun-Fang Xu. Effect of dietary fiber on constipation: a meta analysis. World journal of gastroenterology. 2012 Dec; 18(48):7378-83. doi: 10.3748/wjg.v18.i48.7378. [PMID: 23326148]
  • Sebely Pal, Simone Radavelli-Bagatini. Effects of psyllium on metabolic syndrome risk factors. Obesity reviews : an official journal of the International Association for the Study of Obesity. 2012 Nov; 13(11):1034-47. doi: 10.1111/j.1467-789x.2012.01020.x. [PMID: 22863407]
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  • Sung Chul Jun, Eun Young Jung, Yang Hee Hong, Yooheon Park, Duk ho Kang, Un Jae Chang, Hyung Joo Suh. Anti-obesity effects of chitosan and psyllium husk with L-ascorbic acid in guinea pigs. International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition. 2012 Apr; 82(2):113-20. doi: 10.1024/0300-9831/a000100. [PMID: 23065836]
  • I A Komissarenko, S V Levchenko, S Iu Sil'vestrova, T A Kosacheva, K K Noskova. [Multipurpose psyllium monotherapy in patients with diverticular disease]. Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology. 2012; ?(3):62-7. doi: NULL. [PMID: 22830226]
  • Martin de Bock, José G B Derraik, Christine M Brennan, Janene B Biggs, Greg C Smith, David Cameron-Smith, Clare R Wall, Wayne S Cutfield. Psyllium supplementation in adolescents improves fat distribution & lipid profile: a randomized, participant-blinded, placebo-controlled, crossover trial. PloS one. 2012; 7(7):e41735. doi: 10.1371/journal.pone.0041735. [PMID: 22848584]
  • Zhong Q Wang, Yongmei Yu, Xian H Zhang, Z Elizabeth Floyd, Anik Boudreau, Kun Lian, William T Cefalu. Comparing the effects of nano-sized sugarcane fiber with cellulose and psyllium on hepatic cellular signaling in mice. International journal of nanomedicine. 2012; 7(?):2999-3012. doi: 10.2147/ijn.s30887. [PMID: 22787396]
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