Tilivalline (BioDeep_00000356299)
Toxin
代谢物信息卡片
化学式: C20H19N3O2 (333.1477194)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1CC2C(NC3=C(C=CC=C3O)C(=O)N2C1)C4=CNC5=CC=CC=C54
InChI: InChI=1S/C20H19N3O2/c24-17-9-3-6-13-19(17)22-18(16-8-4-10-23(16)20(13)25)14-11-21-15-7-2-1-5-12(14)15/h1-3,5-7,9,11,16,18,21-22,24H,4,8,10H2/t16-,18-/m0/s1
描述信息
A pyrrolobenzodiazepine that is (11aS)-2,3,5,10,11,11a-hexahydro-1H-pyrrolo[2,1-c][1,4]benzodiazepine substituted by an oxo group at position 5, by a hydroxy group at position 9, and by a 1H-indol-3-yl group at position 11S. It is a natural product discovered in Klebsiella oxytoca which is the causative toxin in antibiotic associated hemorrhagic colitis. It exhibits a microtubule-stabilizing activity that leads to mitotic arrest in the host cells.
同义名列表
1 个代谢物同义名
数据库引用编号
6 个数据库交叉引用编号
- ChEBI: CHEBI:156292
- PubChem: 128363
- PubChem: 14314372
- CAS: 80279-24-9
- PMhub: MS000166590
- MetaboLights: MTBLC156292
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
- 573 - Klebsiella pneumoniae: 10.1016/0040-4020(82)85058-8
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Ronald A Glabonjat, Maksym Kitsera, Katrin Unterhauser, Christian Lembacher-Fadum, Christoph Högenauer, Georg Raber, Rolf Breinbauer, Ellen L Zechner. Simultaneous quantification of enterotoxins tilimycin and tilivalline in biological matrices using HPLC high resolution ESMS2 based on isotopically 15N-labeled internal standards.
Talanta.
2021 Jan; 222(?):121677. doi:
10.1016/j.talanta.2020.121677. [PMID: 33167283] - Majid Validi, Mohammad Mehdi Soltan-Dallal, Masoumeh Douraghi, Jalil Fallah-Mehrabadi, Abbas Rahimi-Foroushani, Homa Frohesh-Tehrani. Identification of cytotoxin-producing Klebsiella oxytoca strains isolated from clinical samples with cell culture assays.
Microbial pathogenesis.
2017 Dec; 113(?):1-4. doi:
10.1016/j.micpath.2017.09.063. [PMID: 28970173] - Ines Zollner-Schwetz, Kathrin A T Herzog, Gebhard Feierl, Eva Leitner, Georg Schneditz, Hanna Sprenger, Jürgen Prattes, Wolfgang Petritsch, Heimo Wenzl, Patrizia Kump, Gregor Gorkiewicz, Ellen Zechner, Christoph Högenauer. The Toxin-Producing Pathobiont Klebsiella oxytoca Is Not Associated with Flares of Inflammatory Bowel Diseases.
Digestive diseases and sciences.
2015 Nov; 60(11):3393-8. doi:
10.1007/s10620-015-3765-y. [PMID: 26091802] - Alison Darby, Kvin Lertpiriyapong, Ujjal Sarkar, Uthpala Seneviratne, Danny S Park, Eric R Gamazon, Chara Batchelder, Cheryl Cheung, Ellen M Buckley, Nancy S Taylor, Zeli Shen, Steven R Tannenbaum, John S Wishnok, James G Fox. Cytotoxic and pathogenic properties of Klebsiella oxytoca isolated from laboratory animals.
PloS one.
2014; 9(7):e100542. doi:
10.1371/journal.pone.0100542. [PMID: 25057966]