Thymine dimer (BioDeep_00000356088)

   


代谢物信息卡片


Thymine dimer

化学式: C10H12N4O4 (252.0859)
中文名称: 胸腺嘧啶二聚体
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC12C(=O)NC(O)=NC1C1N=C(O)NC(=O)C12C
InChI: InChI=1S/C10H12N4O4/c1-9-3(11-7(17)13-5(9)15)4-10(9,2)6(16)14-8(18)12-4/h3-4H,1-2H3,(H2,11,13,15,17)(H2,12,14,16,18)

描述信息

同义名列表

2 个代谢物同义名

Thymine dimer; Thymine dimer



数据库引用编号

5 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Momo Otake, Mika Teranishi, Chiharu Komatsu, Mamoru Hara, Kaoru Okamoto Yoshiyama, Jun Hidema. Poaceae plants transfer cyclobutane pyrimidine dimer photolyase to chloroplasts for ultraviolet-B resistance. Plant physiology. 2024 Apr; 195(1):326-342. doi: 10.1093/plphys/kiae060. [PMID: 38345835]
  • Sezgi Kaya, Dugcar Ebrar Erdogan, Aziz Sancar, Ogun Adebali, Onur Oztas. Global repair is the primary nucleotide excision repair subpathway for the removal of pyrimidine-pyrimidone (6-4) damage from the Arabidopsis genome. Scientific reports. 2024 02; 14(1):3308. doi: 10.1038/s41598-024-53472-8. [PMID: 38332020]
  • Monireh Saeid Nia, Christine Desel, Frauke Pescheck, Karin Krupinska, Wolfgang Bilger. WHIRLY1-deficient chloroplasts display enhanced formation of cyclobutane pyrimidine dimers during exposure to UV-B radiation. Physiologia plantarum. 2023 Sep; 175(5):e14049. doi: 10.1111/ppl.14049. [PMID: 37882276]
  • Gideon S Mmbando, Sugihiro Ando, Hideki Takahashi, Jun Hidema. High ultraviolet-B sensitivity due to lower CPD photolyase activity is needed for biotic stress response to the rice blast fungus, Magnaporthe oryzae. Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology. 2023 Jun; 22(6):1309-1321. doi: 10.1007/s43630-023-00379-4. [PMID: 36729358]
  • Sezgi Kaya, Ogun Adebali, Onur Oztas, Aziz Sancar. Genome-wide Excision Repair Map of Cyclobutane Pyrimidine Dimers in Arabidopsis and the Roles of CSA1 and CSA2 Proteins in Transcription-coupled Repair. Photochemistry and photobiology. 2022 05; 98(3):707-712. doi: 10.1111/php.13519. [PMID: 34525225]
  • Huijuan Wang, Hongwei Liu, Qian Yu, Fenghua Fan, Shenghao Liu, Guihua Feng, Pengying Zhang. A CPD photolyase gene PnPHR1 from Antarctic moss Pohlia nutans is involved in the resistance to UV-B radiation and salinity stress. Plant physiology and biochemistry : PPB. 2021 Oct; 167(?):235-244. doi: 10.1016/j.plaphy.2021.08.005. [PMID: 34385002]
  • Munehisa Nakamura, Tatsuo Nunoshiba, Keiichiro Hiratsu. Detection and analysis of UV-induced mutations in the chromosomal DNA of Arabidopsis. Biochemical and biophysical research communications. 2021 05; 554(?):89-93. doi: 10.1016/j.bbrc.2021.03.087. [PMID: 33784511]
  • Wojciech Strzałka, Piotr Zgłobicki, Ewa Kowalska, Aneta Bażant, Dariusz Dziga, Agnieszka Katarzyna Banaś. The Dark Side of UV-Induced DNA Lesion Repair. Genes. 2020 12; 11(12):. doi: 10.3390/genes11121450. [PMID: 33276692]
  • Eusebio Navarro, Nils Niemann, Dennis Kock, Tamila Dadaeva, Gabriel Gutiérrez, Timo Engelsdorf, Stephan Kiontke, Luis M Corrochano, Alfred Batschauer, Victoriano Garre. The DASH-type Cryptochrome from the Fungus Mucor circinelloides Is a Canonical CPD-Photolyase. Current biology : CB. 2020 11; 30(22):4483-4490.e4. doi: 10.1016/j.cub.2020.08.051. [PMID: 32946746]
  • Agnieszka Katarzyna Banaś, Piotr Zgłobicki, Ewa Kowalska, Aneta Bażant, Dariusz Dziga, Wojciech Strzałka. All You Need Is Light. Photorepair of UV-Induced Pyrimidine Dimers. Genes. 2020 11; 11(11):. doi: 10.3390/genes11111304. [PMID: 33158066]
  • Gideon Sadikiel Mmbando, Mika Teranishi, Jun Hidema. Very high sensitivity of African rice to artificial ultraviolet-B radiation caused by genotype and quantity of cyclobutane pyrimidine dimer photolyase. Scientific reports. 2020 02; 10(1):3158. doi: 10.1038/s41598-020-59720-x. [PMID: 32081870]
  • Yutong Song, Hirotaka Tajima, Tomoyuki Sato, Keizo Ito, Tsutomu Okuno, Masaaki Kurasaki. Zweigelt and Niagara skin extracts suppress cyclobutane pyrimidine dimer formation due to UV irradiation in NHEK cells: first attempt. Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes. 2020; 55(7):593-598. doi: 10.1080/03601234.2020.1745544. [PMID: 32241220]
  • Francesca Tedeschi, Paride Rizzo, Bui Thi Mai Huong, Andreas Czihal, Twan Rutten, Lothar Altschmied, Sarah Scharfenberg, Ivo Grosse, Claude Becker, Detlef Weigel, Helmut Bäumlein, Markus Kuhlmann. EFFECTOR OF TRANSCRIPTION factors are novel plant-specific regulators associated with genomic DNA methylation in Arabidopsis. The New phytologist. 2019 01; 221(1):261-278. doi: 10.1111/nph.15439. [PMID: 30252137]
  • J Narbutt, P A Philipsen, A Lesiak, T Sandberg Liljendahl, D Segerbäck, J Heydenreich, D Chlebna-Sokol, P Olsen, G I Harrison, A Pearson, K Baczynska, M Rogowski-Tylman, H C Wulf, A R Young. Children sustain high levels of skin DNA photodamage, with a modest increase of serum 25-hydroxyvitamin D3 , after a summer holiday in Northern Europe. The British journal of dermatology. 2018 10; 179(4):940-950. doi: 10.1111/bjd.16668. [PMID: 29691848]
  • Marioly Vernhes Tamayo, André Passaglia Schuch, Teiti Yagura, Luis Baly Gil, Carlos Frederico Martins Menck, Angel Sánchez-Lamar. Genoprotective Effect of Phyllanthus orbicularis Extract Against UVA, UVB, and Solar Radiation. Photochemistry and photobiology. 2018 09; 94(5):1026-1031. doi: 10.1111/php.12939. [PMID: 29768722]
  • Serena Di Francesco, Monica Savio, Nora Bloise, Giovanni Borroni, Lucia Anna Stivala, Riccardo G Borroni. Red grape (Vitis vinifera L.) flavonoids down-regulate collagen type III expression after UV-A in primary human dermal blood endothelial cells. Experimental dermatology. 2018 09; 27(9):973-980. doi: 10.1111/exd.13682. [PMID: 29742305]
  • Friedrich G Kapp, Julie R Perlin, Elliott J Hagedorn, John M Gansner, Daniel E Schwarz, Lauren A O'Connell, Nicholas S Johnson, Chris Amemiya, David E Fisher, Ute Wölfle, Eirini Trompouki, Charlotte M Niemeyer, Wolfgang Driever, Leonard I Zon. Protection from UV light is an evolutionarily conserved feature of the haematopoietic niche. Nature. 2018 06; 558(7710):445-448. doi: 10.1038/s41586-018-0213-0. [PMID: 29899448]
  • Jeong-Ju Lee, Ki Bbeum Kim, Jina Heo, Dae-Hyun Cho, Hee-Sik Kim, Song Hee Han, Kyu Joong Ahn, In-Sook An, Sungkwan An, Seunghee Bae. Protective effect of Arthrospira platensis extracts against ultraviolet B-induced cellular senescence through inhibition of DNA damage and matrix metalloproteinase-1 expression in human dermal fibroblasts. Journal of photochemistry and photobiology. B, Biology. 2017 Aug; 173(?):196-203. doi: 10.1016/j.jphotobiol.2017.05.042. [PMID: 28595074]
  • Paola Torricelli, Milena Fini, Pier Alessandro Fanti, Emi Dika, Massimo Milani. Protective effects of Polypodium leucotomos extract against UVB-induced damage in a model of reconstructed human epidermis. Photodermatology, photoimmunology & photomedicine. 2017 May; 33(3):156-163. doi: 10.1111/phpp.12297. [PMID: 28140474]
  • Catherine Schalk, Valérie Cognat, Stéfanie Graindorge, Timothée Vincent, Olivier Voinnet, Jean Molinier. Small RNA-mediated repair of UV-induced DNA lesions by the DNA DAMAGE-BINDING PROTEIN 2 and ARGONAUTE 1. Proceedings of the National Academy of Sciences of the United States of America. 2017 04; 114(14):E2965-E2974. doi: 10.1073/pnas.1618834114. [PMID: 28325872]
  • S J Felton, M S Cooke, R Kift, J L Berry, A R Webb, P M W Lam, F R de Gruijl, A Vail, L E Rhodes. Concurrent beneficial (vitamin D production) and hazardous (cutaneous DNA damage) impact of repeated low-level summer sunlight exposures. The British journal of dermatology. 2016 Dec; 175(6):1320-1328. doi: 10.1111/bjd.14863. [PMID: 27411377]
  • Cheng-Che E Lan, Ching-Shuang Wu, Shu-Mei Huang, Chin-Han Wu, Hsiao-Chi Lai, Yu-Ting Peng, Pao-Sheng Hou, Hui-Jun Yang, Gwo-Shing Chen. Irradiance-dependent UVB Photocarcinogenesis. Scientific reports. 2016 11; 6(?):37403. doi: 10.1038/srep37403. [PMID: 27869214]
  • Changxun Fang, Weisi Chen, Chengxun Li, Xin Jian, Yingzhe Li, Hongmei Lin, Wenxiong Lin. Methyl-CpG binding domain protein acts to regulate the repair of cyclobutane pyrimidine dimers on rice DNA. Scientific reports. 2016 10; 6(?):34569. doi: 10.1038/srep34569. [PMID: 27694845]
  • Vasilissa Manova, Ralitsa Georgieva, Borislav Borisov, Lubomir Stoilov. Efficient removal of cyclobutane pyrimidine dimers in barley: differential contribution of light-dependent and dark DNA repair pathways. Physiologia plantarum. 2016 Oct; 158(2):236-53. doi: 10.1111/ppl.12446. [PMID: 27021252]
  • Qing-Wei Wang, Chiho Kamiyama, Jun Hidema, Kouki Hikosaka. Ultraviolet-B-induced DNA damage and ultraviolet-B tolerance mechanisms in species with different functional groups coexisting in subalpine moorlands. Oecologia. 2016 08; 181(4):1069-82. doi: 10.1007/s00442-016-3644-z. [PMID: 27139425]
  • Jiana Chen, Mingcai Zhang, A Egrinya Eneji, Jianmin Li. Influence of exogenous silicon on UV-B radiation-induced cyclobutane pyrimidine dimmers in soybean leaves and its alleviation mechanism. Journal of plant physiology. 2016 Jun; 196-197(?):20-7. doi: 10.1016/j.jplph.2016.01.019. [PMID: 27019132]
  • Fazile Canturk, Muhammet Karaman, Christopher P Selby, Michael G Kemp, Gulnihal Kulaksiz-Erkmen, Jinchuan Hu, Wentao Li, Laura A Lindsey-Boltz, Aziz Sancar. Nucleotide excision repair by dual incisions in plants. Proceedings of the National Academy of Sciences of the United States of America. 2016 Apr; 113(17):4706-10. doi: 10.1073/pnas.1604097113. [PMID: 27071131]
  • Ajeet K Srivastav, Syed Faiz Mujtaba, Ashish Dwivedi, Saroj K Amar, Shruti Goyal, Ankit Verma, Hari N Kushwaha, Rajnish K Chaturvedi, Ratan Singh Ray. Photosensitized rose Bengal-induced phototoxicity on human melanoma cell line under natural sunlight exposure. Journal of photochemistry and photobiology. B, Biology. 2016 Mar; 156(?):87-99. doi: 10.1016/j.jphotobiol.2015.12.001. [PMID: 26866294]
  • Victor G Tagua, Marcell Pausch, Maike Eckel, Gabriel Gutiérrez, Alejandro Miralles-Durán, Catalina Sanz, Arturo P Eslava, Richard Pokorny, Luis M Corrochano, Alfred Batschauer. Fungal cryptochrome with DNA repair activity reveals an early stage in cryptochrome evolution. Proceedings of the National Academy of Sciences of the United States of America. 2015 Dec; 112(49):15130-5. doi: 10.1073/pnas.1514637112. [PMID: 26578805]
  • Patrick Scheerer, Fan Zhang, Jacqueline Kalms, David von Stetten, Norbert Krauß, Inga Oberpichler, Tilman Lamparter. The class III cyclobutane pyrimidine dimer photolyase structure reveals a new antenna chromophore binding site and alternative photoreduction pathways. The Journal of biological chemistry. 2015 May; 290(18):11504-14. doi: 10.1074/jbc.m115.637868. [PMID: 25784552]
  • Vishalsingh R Chaudhari, Aniket Vyawahare, Swapan K Bhattacharjee, Basuthkar J Rao. Enhanced excision repair and lack of PSII activity contribute to higher UV survival of Chlamydomonas reinhardtii cells in dark. Plant physiology and biochemistry : PPB. 2015 Mar; 88(?):60-9. doi: 10.1016/j.plaphy.2015.02.001. [PMID: 25660990]
  • Sarvajeet S Gill, Naser A Anjum, Ritu Gill, Manoranjan Jha, Narendra Tuteja. DNA damage and repair in plants under ultraviolet and ionizing radiations. TheScientificWorldJournal. 2015; 2015(?):250158. doi: 10.1155/2015/250158. [PMID: 25729769]
  • Bibi Petersen, Hans C Wulf, Margarita Triguero-Mas, Peter A Philipsen, Elisabeth Thieden, Peter Olsen, Jakob Heydenreich, Payam Dadvand, Xavier Basagaña, Tove S Liljendahl, Graham I Harrison, Dan Segerbäck, Alois W Schmalwieser, Antony R Young, Mark J Nieuwenhuijsen. Sun and ski holidays improve vitamin D status, but are associated with high levels of DNA damage. The Journal of investigative dermatology. 2014 Nov; 134(11):2806-2813. doi: 10.1038/jid.2014.223. [PMID: 24844860]
  • Victor M Cubillos, Miles D Lamare, Barrie M Peake, David J Burritt. Cellular changes associated with the acclimation of the intertidal sea anemone Actinia tenebrosa to ultraviolet radiation. Photochemistry and photobiology. 2014 Nov; 90(6):1314-23. doi: 10.1111/php.12310. [PMID: 25041232]
  • Sayaka Takahashi, Mika Teranishi, Masanori Izumi, Masaaki Takahashi, Fumio Takahashi, Jun Hidema. Transport of rice cyclobutane pyrimidine dimer photolyase into mitochondria relies on a targeting sequence located in its C-terminal internal region. The Plant journal : for cell and molecular biology. 2014 Sep; 79(6):951-63. doi: 10.1111/tpj.12598. [PMID: 24947012]
  • Jarah A Meador, Amy J Baldwin, J Dean Pakulski, Wade H Jeffrey, David L Mitchell, Thierry Douki. The significance of the Dewar valence photoisomer as a UV radiation-induced DNA photoproduct in marine microbial communities. Environmental microbiology. 2014 Jun; 16(6):1808-20. doi: 10.1111/1462-2920.12414. [PMID: 24517516]
  • Shuta Kunihiro, Hikaru Kowata, Youichi Kondou, Shinya Takahashi, Minami Matsui, Thomas Berberich, Shohab Youssefian, Jun Hidema, Tomonobu Kusano. Overexpression of rice OsREX1-S, encoding a putative component of the core general transcription and DNA repair factor IIH, renders plant cells tolerant to cadmium- and UV-induced damage by enhancing DNA excision repair. Planta. 2014 May; 239(5):1101-11. doi: 10.1007/s00425-014-2042-1. [PMID: 24563249]
  • Qing-Wei Wang, Jun Hidema, Kouki Hikosaka. Is UV-induced DNA damage greater at higher elevation?. American journal of botany. 2014 05; 101(5):796-802. doi: 10.3732/ajb.1400010. [PMID: 24748608]
  • Runa Masuma, Tsutomu Okuno, Mohammad Shahabuddin Kabir Choudhuri, Takeshi Saito, Masaaki Kurasaki. Effect of Tinospora cordifolia on the reduction of ultraviolet radiation-induced cytotoxicity and DNA damage in PC12 cells. Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes. 2014; 49(6):416-21. doi: 10.1080/03601234.2014.894777. [PMID: 24762179]
  • Vishalsingh Chaudhari, Vandana Raghavan, Basuthkar J Rao. Preparation of efficient excision repair competent cell-free extracts from C. reinhardtii cells. PloS one. 2014; 9(10):e109160. doi: 10.1371/journal.pone.0109160. [PMID: 25299516]
  • Shou-Cheng Wang, Sue-Fung Chen, Yi-Min Lee, Chin-Liang Chuang, Da-Tian Bau, Song-Shei Lin. Baicalin scavenges reactive oxygen species and protects human keratinocytes against UVC-induced cytotoxicity. In vivo (Athens, Greece). 2013 Nov; 27(6):707-14. doi: ". [PMID: 24292572]
  • Sreemanti Das, Jayeeta Das, Avijit Paul, Asmita Samadder, Anisur Rahman Khuda-Bukhsh. Apigenin, a bioactive flavonoid from Lycopodium clavatum, stimulates nucleotide excision repair genes to protect skin keratinocytes from ultraviolet B-induced reactive oxygen species and DNA damage. Journal of acupuncture and meridian studies. 2013 Oct; 6(5):252-62. doi: 10.1016/j.jams.2013.07.002. [PMID: 24139463]
  • Tove Sandberg Liljendahl, Anna Blomqvist, Eva M Andersson, Lars Barregard, Dan Segerbäck. Urinary levels of thymine dimer as a biomarker of exposure to ultraviolet radiation in humans during outdoor activities in the summer. Mutagenesis. 2013 May; 28(3):249-56. doi: 10.1093/mutage/ges077. [PMID: 23339196]
  • Mika Teranishi, Kentaro Nakamura, Haruya Furukawa, Jun Hidema. Identification of a phosphorylation site in cyclobutane pyrimidine dimer photolyase of rice. Plant physiology and biochemistry : PPB. 2013 Feb; 63(?):24-9. doi: 10.1016/j.plaphy.2012.11.003. [PMID: 23220084]
  • Seoung Woo Shin, Eunsun Jung, Seungbeom Kim, Jang-Hyun Kim, Eui-Gyun Kim, Jongsung Lee, Deokhoon Park. Antagonizing effects and mechanisms of afzelin against UVB-induced cell damage. PloS one. 2013; 8(4):e61971. doi: 10.1371/journal.pone.0061971. [PMID: 23626759]
  • Marioly Vernhes, Maribel González-Pumariega, Luciana Andrade, Andre Passaglia Schuch, Keronninn Moreno de Lima-Bessa, Carlos Frederico Martins Menck, Angel Sánchez-Lamar. Protective effect of a Phyllanthus orbicularis aqueous extract against UVB light in human cells. Pharmaceutical biology. 2013 Jan; 51(1):1-7. doi: 10.3109/13880209.2012.695800. [PMID: 23249398]
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  • Sarah Wagener, Tanja Völker, Silke De Spirt, Hansgeorg Ernst, Wilhelm Stahl. 3,3'-Dihydroxyisorenieratene and isorenieratene prevent UV-induced DNA damage in human skin fibroblasts. Free radical biology & medicine. 2012 Aug; 53(3):457-63. doi: 10.1016/j.freeradbiomed.2012.05.022. [PMID: 22634149]
  • Mika Teranishi, Taku Taguchi, Taiichi Ono, Jun Hidema. Augmentation of CPD photolyase activity in japonica and indica rice increases their UVB resistance but still leaves the difference in their sensitivities. Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology. 2012 May; 11(5):812-20. doi: 10.1039/c2pp05392f. [PMID: 22362193]
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  • Gennady Rosenblat, Shai Meretski, Joseph Segal, Mark Tarshis, Avi Schroeder, Alexandra Zanin-Zhorov, Gilead Lion, Arieh Ingber, Malka Hochberg. Polyhydroxylated fatty alcohols derived from avocado suppress inflammatory response and provide non-sunscreen protection against UV-induced damage in skin cells. Archives of dermatological research. 2011 May; 303(4):239-46. doi: 10.1007/s00403-010-1088-6. [PMID: 20978772]
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  • Lei Jiang, Yan Wang, Lars Olof Björn, Shaoshan Li. UV-B-induced DNA damage mediates expression changes of cell cycle regulatory genes in Arabidopsis root tips. Planta. 2011 Apr; 233(4):831-41. doi: 10.1007/s00425-010-1340-5. [PMID: 21221633]
  • Inga Oberpichler, Antonio J Pierik, Janine Wesslowski, Richard Pokorny, Ran Rosen, Michal Vugman, Fan Zhang, Olivia Neubauer, Eliora Z Ron, Alfred Batschauer, Tilman Lamparter. A photolyase-like protein from Agrobacterium tumefaciens with an iron-sulfur cluster. PloS one. 2011; 6(10):e26775. doi: 10.1371/journal.pone.0026775. [PMID: 22066008]
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  • Julia Moldt, Richard Pokorny, Christian Orth, Uwe Linne, Yann Geisselbrecht, Mohamed A Marahiel, Lars-Oliver Essen, Alfred Batschauer. Photoreduction of the folate cofactor in members of the photolyase family. The Journal of biological chemistry. 2009 Aug; 284(32):21670-83. doi: 10.1074/jbc.m109.018697. [PMID: 19531478]
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