Roxarsone (BioDeep_00000034505)
human metabolite
代谢物信息卡片
As-(4-hydroxy-3-nitrophenyl)-arsonic acid
化学式: C6H6AsNO6 (262.9411076)
中文名称: 4-羟基-3-硝基苯胂酸
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1=CC(=C(C=C1[As](=O)(O)O)[N+](=O)[O-])O
InChI: InChI=1S/C6H6AsNO6/c9-6-2-1-4(7(10,11)12)3-5(6)8(13)14/h1-3,9H,(H2,10,11,12)
描述信息
Roxarsone is used to control enteric infections in chicken and to improve growth and feed efficiency. Roxarsone is a fda approved additive for chicken, turkey and swine feeds.
It is used to control enteric infections in chicken and to improve growth and feed efficiency. FDA approved additive for chicken, turkey and swine feeds.
D000890 - Anti-Infective Agents > D000977 - Antiparasitic Agents > D000981 - Antiprotozoal Agents
C254 - Anti-Infective Agent > C276 - Antiparasitic Agent > C277 - Antiprotozoal Agent
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents
同义名列表
42 个代谢物同义名
As-(4-hydroxy-3-nitrophenyl)-arsonic acid; 2-Nitro-1-hydroxybenzene-4-arsonic acid; (4-Hydroxy-3-nitrophenyl)-arsonic acid; (4-Hydroxy-3-nitrobenzene)arsonic acid; 4-HYDROXY-3-nitro-benzenearsonIC ACID; (4-hydroxy-3-nitrophenyl)arsonic acid; 4-Hydroxy-3-nitrophenyl arsonic acid; 3-Nitro-4-hydroxybenzenearsonic acid; Acid, 3-nitro-4-hydroxyphenylarsonic; 4-Hydroxy-3-nitrobenzenearsonic acid; 3-Nitro-4-hydroxyphenylarsonic acid; 2-Nitro-1-hydroxybenzene-4-arsonate; 3 nitro 4 Hydroxyphenylarsonic acid; 4-Hydroxy-3-nitrophenylarsonic acid; 4-Hydroxy-3-nitrobenzenearsonate; 3-Nitro-4-hydroxybenzenearsonate; 4-Hydroxy-3-nitrophenylarsonate; 3-Nitro-4-hydroxyphenylarsonate; 2-Nitrophenol-4-arsonic acid; Roxarsone, ban, inn, usan; Nitrophenoloarsonic acid; Nitrophenolarsonic acid; nitro acid 100 per cent; Roxarsone(usan); Roxarsonum; 3-nitro-20; 3 nitro 10; 3-nitro-10; 3-nitro-50; 3-nitro-80; Ren O-sal; Ren-O-sal; Aklomix-3; C6H6AsNO6; Roxarsone; 3Nitro10; NSC-2101; NSC 2101; Roxarson; 3-Nitro; Ristat; 3n4HPa
数据库引用编号
10 个数据库交叉引用编号
- ChEBI: CHEBI:35817
- PubChem: 5104
- HMDB: HMDB0033205
- DrugBank: DB11458
- ChEMBL: CHEMBL1321154
- Wikipedia: Roxarsone
- MeSH: Roxarsone
- foodb: FDB011218
- chemspider: 4925
- CAS: 121-19-7
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Ting-Ting Li, Xiao-Wei Su, Lin-Lin Chen, Wan-Nian Zhang, Jun-Ping Zhang, Yan Wang, Wei-Heng Xu. Roxarsone inhibits hepatic stellate cell activation and ameliorates liver fibrosis by blocking TGF-β1/Smad signaling pathway.
International immunopharmacology.
2023 Jan; 114(?):109527. doi:
10.1016/j.intimp.2022.109527. [PMID: 36700762] - Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
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Environmental science & technology.
2021 02; 55(3):2037-2047. doi:
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Molecular pharmacology.
2019 11; 96(5):629-640. doi:
10.1124/mol.119.115964. [PMID: 31515284] - Ke Huang, Hanyong Peng, Fan Gao, QingQing Liu, Xiufen Lu, Qirong Shen, X Chris Le, Fang-Jie Zhao. Biotransformation of arsenic-containing roxarsone by an aerobic soil bacterium Enterobacter sp. CZ-1.
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Ecotoxicology and environmental safety.
2018 Sep; 159(?):232-239. doi:
10.1016/j.ecoenv.2018.05.012. [PMID: 29753825] - Qing-Long Fu, Lee Blaney, Dong-Mei Zhou. Identifying Plant Stress Responses to Roxarsone in Soybean Root Exudates: New Insights from Two-Dimensional Correlation Spectroscopy.
Journal of agricultural and food chemistry.
2018 Jan; 66(1):53-62. doi:
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Environmental pollution (Barking, Essex : 1987).
2016 Dec; 219(?):210-218. doi:
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The Science of the total environment.
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Ecotoxicology and environmental safety.
2016 Aug; 130(?):4-10. doi:
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Environmental science & technology.
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Journal of hazardous materials.
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Huan jing ke xue= Huanjing kexue.
2015 Aug; 36(8):3068-73. doi:
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Journal of hazardous materials.
2015 Apr; 286(?):171-8. doi:
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Chemosphere.
2014 Apr; 100(?):57-62. doi:
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Journal of hazardous materials.
2013 Jun; 254-255(?):270-276. doi:
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Huan jing ke xue= Huanjing kexue.
2013 Feb; 34(2):732-9. doi:
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Journal of agricultural and food chemistry.
2013 Jan; 61(2):320-4. doi:
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Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment.
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2012 Dec; 40(12):2332-41. doi:
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Journal of agricultural and food chemistry.
2012 Sep; 60(37):9394-404. doi:
10.1021/jf302366a. [PMID: 22897610] - Ross C Beier, Phelue N Anderson, Michael E Hume, Toni L Poole, Sara E Duke, Tawni L Crippen, Cynthia L Sheffield, David J Caldwell, James A Byrd, Robin C Anderson, David J Nisbet. Characterization of Salmonella enterica isolates from turkeys in commercial processing plants for resistance to antibiotics, disinfectants, and a growth promoter.
Foodborne pathogens and disease.
2011 May; 8(5):593-600. doi:
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Environmental science and pollution research international.
2010 Jun; 17(5):1167-73. doi:
10.1007/s11356-009-0281-7. [PMID: 20099042] - Lixian Yao, Guoliang Li, Zhi Dang, Baomei Yang, Zhaohuan He, Changmin Zhou. Uptake and transport of roxarsone and its metabolites in water spinach as affected by phosphate supply.
Environmental toxicology and chemistry.
2010 Apr; 29(4):947-51. doi:
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Journal of environmental quality.
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