Sisomicin (BioDeep_00000003422)

   


代谢物信息卡片


NCGC00181169-01

化学式: C19H37N5O7 (447.2692852)
中文名称:
谱图信息: 最多检出来源 Viridiplantae(plant) 55.56%

分子结构信息

SMILES: CC1(COC(C(C1NC)O)OC2C(CC(C(C2O)OC3C(CC=C(O3)CN)N)N)N)O
InChI: InChI=1S/C19H37N5O7/c1-19(27)7-28-18(13(26)16(19)24-2)31-15-11(23)5-10(22)14(12(15)25)30-17-9(21)4-3-8(6-20)29-17/h3,9-18,24-27H,4-7,20-23H2,1-2H3/t9-,10+,11-,12+,13-,14-,15+,16-,17-,18-,19+/m1/s1

描述信息

J - Antiinfectives for systemic use > J01 - Antibacterials for systemic use > J01G - Aminoglycoside antibacterials
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D005839 - Gentamicins
C784 - Protein Synthesis Inhibitor > C2363 - Aminoglycoside Antibiotic
D004791 - Enzyme Inhibitors > D011500 - Protein Synthesis Inhibitors
C254 - Anti-Infective Agent > C258 - Antibiotic
KEIO_ID S047; [MS3] KO009246
KEIO_ID S047; [MS2] KO009245
KEIO_ID S047

同义名列表

3 个代谢物同义名

Sisomicin; NCGC00181169-01; Antibiotic 6640



数据库引用编号

31 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

2 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • William Earle, Ramón G B Bonegio, Donald B Smith, Westyn Branch-Elliman. Plazomicin for the treatment of multidrug-resistant Klebsiella bacteraemia in a patient with underlying chronic kidney disease and acute renal failure requiring renal replacement therapy. BMJ case reports. 2021 Aug; 14(8):. doi: 10.1136/bcr-2021-243609. [PMID: 34413038]
  • Xiaotang Chen, Hui Zhang, Shaotong Zhou, Mingjun Bi, Shizhou Qi, Huiyuan Gao, Xianpu Ni, Huanzhang Xia. The bifunctional enzyme, GenB4, catalyzes the last step of gentamicin 3',4'-di-deoxygenation via reduction and transamination activities. Microbial cell factories. 2020 Mar; 19(1):62. doi: 10.1186/s12934-020-01317-0. [PMID: 32156271]
  • Louis D Saravolatz, Gary E Stein. Plazomicin: A New Aminoglycoside. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 2020 02; 70(4):704-709. doi: 10.1093/cid/ciz640. [PMID: 31328228]
  • Jonathan Gall, Taylor Choi, Valerie Riddle, Scott Van Wart, Jacqueline A Gibbons, Julie Seroogy. A Phase 1 Study of Intravenous Plazomicin in Healthy Adults to Assess Potential Effects on the QT/QTc Interval, Safety, and Pharmacokinetics. Clinical pharmacology in drug development. 2019 11; 8(8):1032-1041. doi: 10.1002/cpdd.653. [PMID: 30650259]
  • Tomefa E Asempa, Joseph L Kuti, Julie D Seroogy, Allison S Komirenko, David P Nicolau. Application of the Hartford Hospital Nomogram for Plazomicin Dosing Interval Selection in Patients with Complicated Urinary Tract Infection. Antimicrobial agents and chemotherapy. 2019 10; 63(10):. doi: 10.1128/aac.00148-19. [PMID: 31358580]
  • Taylor Choi, Allison S Komirenko, Valerie Riddle, Aryun Kim, Shyeilla V Dhuria. No Effect of Plazomicin on the Pharmacokinetics of Metformin in Healthy Subjects. Clinical pharmacology in drug development. 2019 08; 8(6):818-826. doi: 10.1002/cpdd.648. [PMID: 30605260]
  • Michael Trang, Julie D Seroogy, Scott A Van Wart, Sujata M Bhavnani, Aryun Kim, Jacqueline A Gibbons, Paul G Ambrose, Christopher M Rubino. Population Pharmacokinetic Analyses for Plazomicin Using Pooled Data from Phase 1, 2, and 3 Clinical Studies. Antimicrobial agents and chemotherapy. 2019 04; 63(4):. doi: 10.1128/aac.02329-18. [PMID: 30670433]
  • Allison S Komirenko, Valerie Riddle, Jacqueline A Gibbons, Scott Van Wart, Julie D Seroogy. A Phase 1 Study To Assess the Pharmacokinetics of Intravenous Plazomicin in Adult Subjects with Varying Degrees of Renal Function. Antimicrobial agents and chemotherapy. 2018 12; 62(12):. doi: 10.1128/aac.01128-18. [PMID: 30275092]
  • Lynn E Connolly, Valerie Riddle, Deborah Cebrik, Eliana S Armstrong, Loren G Miller. A Multicenter, Randomized, Double-Blind, Phase 2 Study of the Efficacy and Safety of Plazomicin Compared with Levofloxacin in the Treatment of Complicated Urinary Tract Infection and Acute Pyelonephritis. Antimicrobial agents and chemotherapy. 2018 04; 62(4):. doi: 10.1128/aac.01989-17. [PMID: 29378708]
  • George Louis Drusano, Weiguo Liu, Steven Fikes, Ryan Cirz, Nichole Robbins, Stephanie Kurhanewicz, Jaime Rodriquez, David Brown, Dodge Baluya, Arnold Louie. Interaction of drug- and granulocyte-mediated killing of Pseudomonas aeruginosa in a murine pneumonia model. The Journal of infectious diseases. 2014 Oct; 210(8):1319-24. doi: 10.1093/infdis/jiu237. [PMID: 24760199]
  • Yanfei Tao, Dongmei Chen, Huan Yu, Lingli Huang, Zhaoying Liu, Xiaoqin Cao, Caixia Yan, Yuanhu Pan, Zhenli Liu, Zonghui Yuan. Simultaneous determination of 15 aminoglycoside(s) residues in animal derived foods by automated solid-phase extraction and liquid chromatography-tandem mass spectrometry. Food chemistry. 2012 Nov; 135(2):676-83. doi: 10.1016/j.foodchem.2012.04.086. [PMID: 22868145]
  • Robert T Cass, Carter D Brooks, Nancy A Havrilla, Kenneth J Tack, Marie T Borin, Don Young, Jon B Bruss. Pharmacokinetics and safety of single and multiple doses of ACHN-490 injection administered intravenously in healthy subjects. Antimicrobial agents and chemotherapy. 2011 Dec; 55(12):5874-80. doi: 10.1128/aac.00624-11. [PMID: 21911572]
  • Ing-Marie Jonsson, Jarmo T Juuti, Patrice François, Rana AlMajidi, Milla Pietiäinen, Myriam Girard, Catharina Lindholm, Manfred J Saller, Arnold J M Driessen, Pentti Kuusela, Maria Bokarewa, Jacques Schrenzel, Vesa P Kontinen. Inactivation of the Ecs ABC transporter of Staphylococcus aureus attenuates virulence by altering composition and function of bacterial wall. PloS one. 2010 Dec; 5(12):e14209. doi: 10.1371/journal.pone.0014209. [PMID: 21151985]
  • Yiqiang Chen, Xiangmei Li, Lidong He, Shuheng Tang, Xilong Xiao. Immunoassays for the rapid detection of gentamicin and micronomicin in swine muscle. Journal of AOAC International. 2010 Jan; 93(1):335-42. doi: . [PMID: 20334196]
  • Xin Lu, Dan Zhang, Chengwei Liu, Qin Xu, Shulin Zhao. Development of a non-derivatization high-performance liquid chromatography method with resonance Rayleigh scattering detection for the detection of sisomicin in rat serum. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2009 Dec; 877(31):4022-6. doi: 10.1016/j.jchromb.2009.10.019. [PMID: 19889588]
  • Roberto Cabrera, Joaquím Ruiz, Javier Sánchez-Céspedes, Pilar Goñi, Rafael Gómez-Lus, M Teresa Jiménez de Anta, Joaquím Gascón, Jordi Vila. Characterization of the enzyme aac(3)-Id in a clinical isolate of Salmonella enterica serovar Haifa causing traveler's diarrhea. Enfermedades infecciosas y microbiologia clinica. 2009 Oct; 27(8):453-6. doi: 10.1016/j.eimc.2008.11.016. [PMID: 19403206]
  • Manthena V S Varma, Bo Feng, R Scott Obach, Matthew D Troutman, Jonathan Chupka, Howard R Miller, Ayman El-Kattan. Physicochemical determinants of human renal clearance. Journal of medicinal chemistry. 2009 Aug; 52(15):4844-52. doi: 10.1021/jm900403j. [PMID: 19445515]
  • R Scott Obach, Franco Lombardo, Nigel J Waters. Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals. 2008 Jul; 36(7):1385-405. doi: 10.1124/dmd.108.020479. [PMID: 18426954]
  • Brian G Keevil, Stephen J Lockhart, Donald P Cooper. Determination of tobramycin in serum using liquid chromatography-tandem mass spectrometry and comparison with a fluorescence polarisation assay. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2003 Sep; 794(2):329-35. doi: 10.1016/s1570-0232(03)00492-6. [PMID: 12954384]
  • T Osada, K Yamamura, K Yano, K Fujimoto, K Mizuno, T Sakurai, T Nabeshima. Distribution and serum concentration of sisomicin released from fibrin glue-sealed dacron graft in the rat and human. Journal of biomedical materials research. 2000 Oct; 52(1):53-7. doi: 10.1002/1097-4636(200010)52:1<53::aid-jbm7>3.0.co;2-i. [PMID: 10906674]
  • C Yuan, J Wang, Z Liang, N Xin. [Determination of sisomicin in body fluid by high performance liquid chromatography-indirect photometric detection method]. Se pu = Chinese journal of chromatography. 1998 Sep; 16(5):445-7. doi: NULL. [PMID: 11498926]
  • D A Stead, R M Richards. Sensitive high-performance liquid chromatographic assay for aminoglycosides in biological matrices enables the direct estimation of bacterial drug uptake. Journal of chromatography. B, Biomedical sciences and applications. 1997 Jun; 693(2):415-21. doi: 10.1016/s0378-4347(97)00032-7. [PMID: 9210447]
  • A A Firsov, M E Alekseeva, G I Lukomskiĭ, L V Umnova, L B Kashina. [Pharmacokinetic monitoring of aminoglycoside therapy: an optimal method of administration of individualized doses of gentamicin and sisomicin]. Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic]. 1991 Oct; 36(10):40-2. doi: . [PMID: 1805695]
  • C Sanchez-Bernal, M Vlitos, J A Cabezas, R G Price. Variation in the isoenzymes of N-acetyl-beta-D-glucosaminidase and protein excretion in aminoglycoside nephrotoxicity in the rat. Cell biochemistry and function. 1991 Jul; 9(3):209-14. doi: 10.1002/cbf.290090309. [PMID: 1752026]
  • A A Firsov. In vitro simulated pharmacokinetics profiles: forecasting antibiotic optimal dosage. European journal of drug metabolism and pharmacokinetics. 1991; Spec No 3(?):406-9. doi: NULL. [PMID: 1820913]
  • A A Firsov, L B Kashina, G I Lukomskiĭ, M E Alekseeva, K K Manuĭlov. [Individual schedule of administration of aminoglycosides with reference to anatomo-physiological and pathological factors]. Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic]. 1989 Sep; 34(9):687-91. doi: NULL. [PMID: 2610537]
  • R G Anufrieva, B A Shenderov. [Effect of sisomicin on intestinal microflora and colonization resistance in rats and their offspring]. Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic]. 1989 Aug; 34(8):596-601. doi: NULL. [PMID: 2589899]
  • I Viano, L Silvestro, L Giovannini, A A Bertelli, L Trombi, C Dianzani, R Ferro. Excretion of aminoglycosides in a rat kidney model. Drugs under experimental and clinical research. 1989; 15(3):137-40. doi: . [PMID: 2752914]
  • T Fujimoto, R Tawa, S Hirose. Determination of sisomicin in eluate from dried blood spot on filter paper disc for monitoring of blood level in rat, by reversed-phase high-performance liquid chromatography after pre-column fluorimetric derivatization. Chemical & pharmaceutical bulletin. 1989 Jan; 37(1):174-6. doi: 10.1248/cpb.37.174. [PMID: 2720847]
  • J P Mallie, C Billerey. [Experimental study of nephrotoxicity: effects, on the newborn rat kidney, of aminoglycoside administration during gestation]. Nephrologie. 1989; 10(1):27-31. doi: NULL. [PMID: 2716942]
  • R Tawa, K Koshide, S Hirose, T Fujimoto. Pre-column derivatization of sisomicin with o-phthalaldehyde-beta-mercaptopropionic acid and its application to sensitive high-performance liquid chromatographic determination with fluorimetric detection. Journal of chromatography. 1988 Mar; 425(1):143-52. doi: 10.1016/0378-4347(88)80014-8. [PMID: 3360865]
  • J Blaser, R Münch, R Lüthy. Human pharmacology of 5-epi-sisomicin (Sch 22591) following intramuscular administration. The Journal of antimicrobial chemotherapy. 1987 Feb; 19(2):233-8. doi: 10.1093/jac/19.2.233. [PMID: 3571044]
  • E V Gagaeva, A A Firsov, G G Egorenko, V I Danilova, L A Shtegel'man. [Interrelations in the changes in the pharmacokinetics and nephrotoxic effect of sisomycin as affected by cefazolin]. Antibiotiki i meditsinskaia biotekhnologiia = Antibiotics and medical biotechnology. 1986 Oct; 31(10):785-90. doi: . [PMID: 3789689]
  • W E Siegenthaler, A Bonetti, R Luthy. Aminoglycoside antibiotics in infectious diseases. An overview. The American journal of medicine. 1986 Jun; 80(6B):2-14. doi: 10.1016/0002-9343(86)90473-0. [PMID: 3524216]
  • D A Evans, J Buring, S Mayrent, B Rosner, T Colton, C Hennekens. Qualitative overview of randomized trials of aminoglycosides. The American journal of medicine. 1986 Jun; 80(6B):39-43. doi: 10.1016/0002-9343(86)90477-8. [PMID: 3524219]
  • H Lüllmann, B Schwarz. Effects of aminoglycoside antibiotics on bound calcium and contraction in guinea-pig atria. British journal of pharmacology. 1985 Dec; 86(4):799-803. doi: 10.1111/j.1476-5381.1985.tb11101.x. [PMID: 4075016]
  • K Suzuki, H Tamai. [Clinical evaluation of sisomicin in the treatment of complicated chronic urinary tract infections administered by intravenous infusion]. The Japanese journal of antibiotics. 1985 Nov; 38(11):3097-104. doi: . [PMID: 4094049]
  • K Koshide, R Tawa, S Hirose, T Fujimoto. Liquid-chromatographic determination of sisomicin in plasma, with fluorometric pre-column derivatization. Clinical chemistry. 1985 Nov; 31(11):1921-2. doi: 10.1093/clinchem/31.11.1921. [PMID: 4053377]
  • A A Firsov, G V Dolgova, V V Berezhinskaia, A A Eĭromdzhants. [Sisomycin pharmacokinetics in the perilymph and blood serum--an approach to predicting its ototoxic effect]. Antibiotiki i meditsinskaia biotekhnologiia = Antibiotics and medical biotechnology. 1985 Oct; 30(10):765-70. doi: . [PMID: 4091513]
  • K Tamura, R Iwakiri, T Amamoto, M Seita. Serum concentration of sisomicin by intravenous infusion and its clinical response as a single agent. The Japanese journal of antibiotics. 1985 Jun; 38(6):1552-6. doi: NULL. [PMID: 4046176]
  • O S Treskina, E N Levina, L M Slepchenko. [Laboratory methods of controlling the effectiveness of antibacterial therapy]. Antibiotiki i meditsinskaia biotekhnologiia = Antibiotics and medical biotechnology. 1985 Jun; 30(6):456-9. doi: NULL. [PMID: 4062272]
  • V P Pozdniakova, S M Kuznetsova, A N Lobuseva, I P Fomina. [Methods of evaluating the efficacy of combinations of aminoglycosides with penicillins and their value for the possibility of predicting the therapeutic effect in patients]. Antibiotiki i meditsinskaia biotekhnologiia = Antibiotics and medical biotechnology. 1985 May; 30(5):369-75. doi: NULL. [PMID: 3927835]
  • A A Firsov, O S Treskina, L V Umnova, V L Cherniakov, O N Vetchinnikova. [Pharmacokinetics of sisomicin during hemosorption and hemodialysis]. Antibiotiki i meditsinskaia biotekhnologiia = Antibiotics and medical biotechnology. 1985 May; 30(5):352-5. doi: NULL. [PMID: 4026255]
  • I D Amirak, R J Williams, M Chung, P Noone. The single-dose pharmacokinetics of 5-epi-sisomicin (Sch 22591) in human volunteers. The Journal of antimicrobial chemotherapy. 1985 May; 15(5):607-11. doi: 10.1093/jac/15.5.607. [PMID: 3839236]
  • E V Gagaeva, A A Firsov, G G Egorenko, E K Berezina, L A Shtegel'man. [Decrease of sisomicin nephrotoxicity as affected by cephalothin: pharmacokinetic evaluation]. Antibiotiki i meditsinskaia biotekhnologiia = Antibiotics and medical biotechnology. 1985 Mar; 30(3):190-6. doi: . [PMID: 4015061]
  • R Palla, M Marchitiello, M Tuoni, C Cirami, L Giovannini, A A Bertelli, A Bertelli. Enzymuria in aminoglycoside-induced kidney damage. Comparative study of gentamicin, amikacin, sisomicin and netilmicin. International journal of clinical pharmacology research. 1985; 5(5):351-5. doi: . [PMID: 2866167]
  • A E Guliaev, G Ia Kivman. [Quantitative indicators of gentamicin and sisomicin interaction with isolated subcellular fractions of the liver and kidneys and intracellular distribution of these antibiotics]. Antibiotiki i meditsinskaia biotekhnologiia = Antibiotics and medical biotechnology. 1985 Jan; 30(1):50-4. doi: . [PMID: 3994342]
  • J M Failler, R Farinotti, A Dauphin. [Immunological assay of sisomycin by fluorescence polarization]. Annales de biologie clinique. 1985; 43(4):341-5. doi: NULL. [PMID: 4091297]
  • H J Zeiler, K G Metzger, P Schacht, K Grohe. Assessment of the in vitro and in vivo activity of ciprofloxacin measured against current standards of therapy. Drugs under experimental and clinical research. 1985; 11(5):343-50. doi: NULL. [PMID: 2941263]
  • L Xerri, P Orsolini, R Broggio. In vitro evaluation of ceftazidime (GR 20263), amikacin and sisomicin, in a model simulating serum pharmacokinetics of therapeutic doses. Chemioterapia : international journal of the Mediterranean Society of Chemotherapy. 1984 Oct; 3(5):271-7. doi: NULL. [PMID: 6398124]
  • P Noone. Sisomicin, netilmicin and dibekacin. A review of their antibacterial activity and therapeutic use. Drugs. 1984 Jun; 27(6):548-78. doi: 10.2165/00003495-198427060-00003. [PMID: 6376062]
  • P Dri, R Menegazzi, F Pirotta, M R Soranzo, R Cramer. Effect of gentamicin and sisomicin on the generation of superoxide by human monocytes. Chemioterapia : international journal of the Mediterranean Society of Chemotherapy. 1984 Jun; 3(3):159-62. doi: . [PMID: 6099223]
  • T Nishimura, N Iwai, T Motohiro. [A pharmacokinetic investigation of sisomicin administered intramuscularly to children]. The Japanese journal of antibiotics. 1984 May; 37(5):835-46. doi: NULL. [PMID: 6481958]
  • T Kawamoto, I Mashimo, S Yamauchi, M Watanabe. Determination of sisomicin, netilmicin, astromicin and micronomicin in serum by high-performance liquid chromatography. Journal of chromatography. 1984 Feb; 305(2):373-9. doi: 10.1016/s0378-4347(00)83351-4. [PMID: 6707164]
  • S Kinura, M Nakazono, H Tazaki. [Electron microscopic evaluation of the renal tubular damage in rats after aminoglycoside administration]. Nihon Hinyokika Gakkai zasshi. The japanese journal of urology. 1984 Feb; 75(2):181-96. doi: 10.5980/jpnjurol1928.75.2_181. [PMID: 6748426]
  • A M Clausse, G Houin, J Barre, C J Soussy, J Duval, M Chousterman, J P Tillement. [Comparison of bacteriological and immunoenzyme methods for the serum determination of sisomicin. Pharmacokinetic application in the human]. Annales de biologie clinique. 1984; 42(1):15-9. doi: . [PMID: 6375471]
  • Y Noguchi, M Taguchi, M Takasugi, T Sakamoto, K Matsumoto. [Aerosol administration of dibekacin--the sputum concentration]. The Japanese journal of antibiotics. 1983 Dec; 36(12):3405-11. doi: NULL. [PMID: 6674552]
  • A A Firsov. [Graphic method of assessing the maximum cumulative excretion of a drug]. Antibiotiki. 1983 Dec; 28(12):904-8. doi: NULL. [PMID: 6660844]
  • A A Firsov, L V Umnova, I P Fomina. [Simulation of the pharmacokinetics of aminoglycosides in the kidneys: single and continuous intake of sisomicin and gentamicin by rats]. Antibiotiki. 1983 Nov; 28(11):826-34. doi: NULL. [PMID: 6651271]
  • A A Firsov, P S Navashin, L A Blatun, V I Danilova. [Pharmacokinetic prediction of the efficacy of using sisomicin in wound infections]. Antibiotiki. 1983 Oct; 28(10):772-8. doi: NULL. [PMID: 6651268]
  • G G Egorenko, E K Berezina, V V Berezhinskaia, G V Dolgova, L P Kovalenko. [General toxic and organotropic properties of sisomicin sulfate in chronic experiments on animals]. Antibiotiki. 1983 Sep; 28(9):678-82. doi: NULL. [PMID: 6605712]
  • S M Navashin, O S Treskina, A A Firsov, N S Bogomolova, O S Belorusov. [Pharmacokinetic basis for using tobramycin and sisomicin in treating pyelonephritis of the transplanted kidney]. Antibiotiki. 1983 Jul; 28(7):539-45. doi: . [PMID: 6354075]
  • D Kampf, R Schurig, A Bergs, D Förster. Interactions between mezlocillin and sisomicin in vitro and in patients with normal and various degrees of impaired renal function. Clinical nephrology. 1983 Jan; 19(1):37-44. doi: . [PMID: 6219847]
  • I Haller. The combined action of azlocillin and sisomicin in a model simulating the in vivo serum kinetics. Infection. 1983; 11 Suppl 2(?):S81-2. doi: 10.1007/bf01645291. [PMID: 6423547]
  • A A Firsov, G F Pankova. [Build up of a given concentration of tobramycin and sisomycin in the blood of young children by the intravenous infusion of the antibiotics according to a calculated regimen]. Antibiotiki. 1982 Nov; 27(11):830-5. doi: NULL. [PMID: 6758682]
  • A Tachibana, C Ikeda, K Yano. [Pharmacokinetics of cefotetan and an aminoglycoside preparation in combined administration. 1. Individual quantification of cefotetan and sisomicin by bioassay and their absorption, distribution, and excretion in rats when given together]. The Japanese journal of antibiotics. 1982 Jun; 35(6):1411-26. doi: . [PMID: 6957627]
  • C Ikeda, A Tachibana, K Yano. [Pharmacokinetics of a cefotetan and an aminoglycoside preparation in combined administration. 2. Absorption and exercise of cefotetan and sisomicin in dogs when the two are given together]. The Japanese journal of antibiotics. 1982 Jun; 35(6):1427-36. doi: NULL. [PMID: 6957628]
  • R R Bailey, B Peddie, C U McRae. Antibiotic concentrations in the urine from kidneys of unequal function. Clinical nephrology. 1982 May; 17(5):258-61. doi: NULL. [PMID: 7094442]
  • A A Firsov, G G Egorenko, E K Berezina, E V Gagaevea, V I Danilova. [Elaboration of the procedures for the pharmacokinetic interpretation of aminoglycoside nephrotoxicity: the experimental evaluation of the safety of repeated gentamycin administration]. Antibiotiki. 1982 Apr; 27(4):287-92. doi: NULL. [PMID: 7092200]
  • G Nicot, L Merle, J P Valette, J P Charmes, G Lachâtre. Gentamicin and sisomicin - induced renal tubular damage. European journal of clinical pharmacology. 1982; 23(2):161-6. doi: 10.1007/bf00545972. [PMID: 6128232]
  • D Dzierzanowska, J Patzer, J Jeljaszewicz. Pharmacokinetic studies of azlocillin, mezlocillin, cephalothin and sisomicin in rabbits. Infection. 1982; 10 Suppl 3(?):S217-20. doi: 10.1007/bf01640676. [PMID: 6218118]
  • E Magliulo, G Piantieri, A Cafarelli, M Cruciani. Therapy of Klebsiella pneumoniae septicaemia in neutropenic rats. Pharmatherapeutica. 1982; 3(2):114-8. doi: NULL. [PMID: 7048337]
  • I Haller. Combined action of decreasing concentrations of azlocillin and sisomicin on Pseudomonas aeruginosa as assessed in a dynamic in vitro model. Infection. 1982; 10 Suppl 3(?):S229-33. doi: 10.1007/bf01640679. [PMID: 6818155]
  • M Chung, J J Schrogie, S Symchowicz. Pharmacokinetic study of sisomicin in humans. Journal of pharmacokinetics and biopharmaceutics. 1981 Oct; 9(5):535-51. doi: 10.1007/bf01061025. [PMID: 7334458]
  • L V Umnova, V G Koroleva, T Ia Goncharskaia, A A Firsov, I P Fomina. [Sisomicin pharmacokinetics in rat tissues in single and long-term administration]. Antibiotiki. 1981 Aug; 26(8):612-7. doi: NULL. [PMID: 7294752]
  • T Ia Goncharskaia, V G Koroleva, L V Umnova, N S Bogomolova, O S Treskina. [Rapid microbiological method of determining the gentamicin, sisomicin and kanamycin concentrations in patients' serum]. Antibiotiki. 1981 May; 26(5):367-70. doi: NULL. [PMID: 6789763]
  • D M Barends, C L Zwaan, A Hulshoff. Improved microdetermination of gentamicin and sisomicin in serum by high-performance liquid chromatography with ultraviolet detection. Journal of chromatography. 1981 Feb; 222(2):316-23. doi: 10.1016/s0378-4347(00)81068-3. [PMID: 7251749]
  • S Bopp, R Marre, E Schulz, K Sack. [Animal experiments on the nephrotoxicity, pharmacokinetics and therapeutic efficacy of dibekacin]. Arzneimittel-Forschung. 1981; 31(3):473-7. doi: . [PMID: 7194672]
  • T Matsuzawa, M Nakata, C Ikeda, A Tachibana, K Yano. Transfer of sisomicin to unborn and suckling guinea pigs. Chemotherapy. 1981; 27(5):297-302. doi: 10.1159/000237995. [PMID: 7261685]
  • A A Firsov, G G Egorenko, A A Eĭromdzhants. [Pharmacokinetic analysis of the nephrotoxic effect of sisomycin]. Antibiotiki. 1981 Jan; 26(1):50-5. doi: NULL. [PMID: 7212683]
  • N Kardos, A Eichholz, C P Schaffner. Binding of aminocyclitol antibiotics to kidney and intestinal brush border membranes. The Journal of antibiotics. 1981 Jan; 34(1):103-13. doi: 10.7164/antibiotics.34.103. [PMID: 7251500]
  • J M Chennebault, B Thomas, A M Dumont, P Alquier. [Acute renal insufficiency during treatment with sisomycin]. Therapie. 1980 Jul; 35(4):556-8. doi: NULL. [PMID: 7466738]
  • A A Firsov, G G Egorenko, E K Berezina, V G Koroleva, L V Umnova. [Pharmacokinetic validation of the nephrotoxic action of sisomycin. The relationship between nephrotoxicity and sisomycin concentration in the blood serum of rats]. Antibiotiki. 1980 Apr; 25(4):275-80. doi: NULL. [PMID: 7369731]
  • T P Svinogeeva, E K Berezina. [Comparative study of sisomicin and gentamycin action on the cells in a tissue culture]. Antibiotiki. 1980 Apr; 25(4):271-4. doi: NULL. [PMID: 7369730]
  • E Faragó, I J Kiss, L Mihóczy. Data on sisomicin effect: human pharmacokinetic and bacteriological studies. International journal of clinical pharmacology, therapy, and toxicology. 1980 Mar; 18(3):128-32. doi: NULL. [PMID: 7380585]
  • N Iwai, A Sasaki, M Miyazu, T Osuga. [Fundamental and clinical studies on sisomicin in children (author's transl)]. The Japanese journal of antibiotics. 1980 Mar; 33(3):333-51. doi: NULL. [PMID: 6901786]
  • A A Firsov, V G Koroleva, T Ia Goncharskaia, L V Umnova, I P Fomina. [Pharmacokinetic basis of the nephrotoxic action of sisomycin. The pharmacokinetics of sisomycin in single and multiple administrations to rats]. Antibiotiki. 1980 Mar; 25(3):201-6. doi: NULL. [PMID: 7362226]
  • M Doerck, G Fricke, G Gruenwaldt, H M von Hattingberg, M Scheer. [Pharmacokinetic and clinical studies with sisomicin in paediatrics (author's transl)]. Infection. 1980; 8(3):107-14. doi: 10.1007/bf01641473. [PMID: 7419274]
  • C W Norden, E Keleti. Experimental osteomyelitis caused by Pseudomonas aeruginosa. The Journal of infectious diseases. 1980 Jan; 141(1):71-5. doi: 10.1093/infdis/141.1.71. [PMID: 6767790]
  • U Ullmann, R M Schmülling. Distribution of Pseudomonas aeruginosa serotypes in bacteriologic specimens and their aminoglycoside resistance. Zentralblatt fur Bakteriologie. 1. Abt. Originale. A: Medizinische Mikrobiologie, Infektionskrankheiten und Parasitologie. 1980; 247(2):241-7. doi: 10.1016/s0172-5599(80)80009-5. [PMID: 6775451]
  • T Orłowski, K Wierzba, J Lazowski, A Lypka. [Sisomicin dosage in renal failure]. Wiadomosci lekarskie (Warsaw, Poland : 1960). 1979 Nov; 32(22):1585-9. doi: NULL. [PMID: 538909]
  • J M Richmond, R G Walker, P Kincaid-Smith. Sisomicin in the treatment of urinary tract infections. The Medical journal of Australia. 1979 Oct; 2(7):375-6. doi: 10.5694/j.1326-5377.1979.tb104190.x. [PMID: 390345]
  • H Müssiggang. [Ambulatory treatment of urinary tract infections with sisomicin]. Therapie der Gegenwart. 1979 Aug; 118(8):1217-23. doi: NULL. [PMID: 494126]
  • M Yamamoto. [An experimental study on Pseudomonas osteomyelitis with special reference to the production of experimental osteomyelitis in mice (author's transl)]. Nihon Seikeigeka Gakkai zasshi. 1979 Jul; 53(7):777-92. doi: NULL. [PMID: 115949]
  • A Rodríquez Torres. [Sisomicin sulfate: its efficacy in the treatment of urologic infections]. Archivos espanoles de urologia. 1979 Jul; 32(4):387-96. doi: NULL. [PMID: 485572]
  • C Ikeda, A Tachibana, K Yano. [Absorption, distribution, metabolism and excretion of sisomicin in mice, rats and dogs (author's transl)]. The Japanese journal of antibiotics. 1979 Mar; 32(3):312-24. doi: NULL. [PMID: 439399]
  • E J Perea, C Gutierrez de la Pena, D A Oliver, G Solorzano, S Garcia-Diaz. Sisomicin in surgical infections. Laboratory and clinical studies. Arzneimittel-Forschung. 1979; 29(1):134-7. doi: . [PMID: 375945]
  • L Weingärtner, U Sitka, R Patsch, U Burchardt, I Richter. [Experience with sisomicin in pediatrics (author's transl)]. Infection. 1979; 7(3):119-27. doi: 10.1007/bf01641311. [PMID: 383623]
  • H Rosenkranz, D Förster. Comparative study of the binding of acylureidopenicillins and carbenicillin to human serum proteins. Infection. 1979; 7(3):102-8. doi: 10.1007/bf01641306. [PMID: 478650]