Anisodine (BioDeep_00000341729)

   

natural product


代谢物信息卡片


[(1R,2R,4S,5S)-9-methyl-3-oxa-9-azatricyclo[3.3.1.02,4]nonan-7-yl] (2S)-2,3-dihydroxy-2-phenylpropanoate

  化学式: C17H21NO5 (319.142)
中文名称:
  谱图信息: 最多检出来源 () %

分子结构信息

SMILES: CN1C2CC(C(=O)OC(O)(CO)c3ccccc3)CC1C1OC12
InChI: InChI=1S/C17H21NO5/c1-18-12-7-11(8-13(18)15-14(12)23-15)22-16(20)17(21,9-19)10-5-3-2-4-6-10/h2-6,11-15,19,21H,7-9H2,1H3/t11?,12-,13+,14-,15+,17-/m1/s1


描述信息

同义名列表

11 个代谢物同义名

Anisodine; .ALPHA.-HYDROXYSCOPOLAMINE; [(1R,2R,4S,5S)-9-methyl-3-oxa-9-azatricyclo[3.3.1.02,4]nonan-7-yl] (2S)-2,3-dihydroxy-2-phenylpropanoate; [(1S,2S,4R,5R)-9-Methyl-3-oxa-9-azatricyclo[3.3.1.02,4]nonan-7-yl] (2S)-2,3-dihydroxy-2-phenylpropanoate; 6.BETA.,7.BETA.-EPOXY-1.ALPHA.H,5.ALPHA.H-TROPAN-3.ALPHA.-YL (-)-2,3-DIHYDROXY-2-PHENYLPROPIONATE; ANISODINE [WHO-DD]; anisodine hydrobromide; anisodine hydrochloride; BENZENEACETIC ACID, .ALPHA.-HYDROXY-.ALPHA.-(HYDROXYMETHYL)-, 9-METHYL-3-OXA-9-AZATRICYCLO(3.3.1.02,4)NON-7-YL ESTER, (7(S)-(1.ALPHA.,2.BETA.,4.BETA.,5.ALPHA.,7.BETA.))-; Benzeneacetic acid, alpha-hydroxy-alpha-(hydroxymethyl)-, 9-methyl-3-oxa-9-azatricyclo(3.3.1.02,4)non-7-yl ester, (7(S)-(1alpha,2beta,4beta,5alpha,7beta))-; DATURAMINE



数据库引用编号

7 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome()

BioCyc()

PlantCyc()

代谢反应

个相关的代谢反应过程信息。

Reactome()

BioCyc()

WikiPathways()

Plant Reactome()

INOH()

PlantCyc()

COVID-19 Disease Map()

PathBank()

PharmGKB()

10 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Bo Wang, Chen Chen, Yuanming Xiao, Kaiyang Chen, Juan Wang, Lingling Wang, Jianan Li, Zongxiu Kang, Guoying Zhou. A core root bacteria contribute to plant growth and anisodine accumulation of Anisodus tanguticus. BMC plant biology. 2023 Dec; 23(1):655. doi: 10.1186/s12870-023-04690-1. [PMID: 38110871]
  • Feng Wan, Linlu Jin, Yixue Qin, Ye Zeng. Modulation of muscarinic receptors by anisodine hydrobromide in cerebral ischemia. Cellular and molecular biology (Noisy-le-Grand, France). 2023 Nov; 69(11):17-24. doi: 10.14715/cmb/2023.69.11.3. [PMID: 38015513]
  • Yunlu Liu, Lin Wang, Feng Wan, Na Yang. Effects of Anisodine Hydrobromide on the Cardiovascular and Respiratory Functions in Conscious Dogs. Drug design, development and therapy. 2020; 14(?):4263-4276. doi: 10.2147/dddt.s268113. [PMID: 33116414]
  • Jia-Yin Chen, Jürgen Brockmöller, Mladen V Tzvetkov, Li-Jun Wang, Xi-Jing Chen. An in vitro study on interaction of anisodine and monocrotaline with organic cation transporters of the SLC22 and SLC47 families. Chinese journal of natural medicines. 2019 Jul; 17(7):490-497. doi: 10.1016/s1875-5364(19)30070-6. [PMID: 31514980]
  • Dandan Chen, Cheng Peng, Xiaofang Xie, Qiuling Chen, Han Liu, Shiyang Zhang, Feng Wan, Hui Ao. Low Dose of Anisodine Hydrobromide Induced Neuroprotective Effects in Chronic Cerebral Hypoperfusion Rats. CNS & neurological disorders drug targets. 2017; 16(10):1111-1119. doi: 10.2174/1871527316666171026114043. [PMID: 29076436]
  • Fengjie Tian, Cuiyun Li, Xin Wang, Shuangxia Ren, Ning Li, Qi Liu, Sufeng Zhou, Yang Lu, Di Zhao, Xijing Chen. Comparative study on pharmacokinetics of a series of anticholinergics, atropine, anisodamine, anisodine, scopolamine and tiotropium in rats. European journal of drug metabolism and pharmacokinetics. 2015 Sep; 40(3):245-53. doi: 10.1007/s13318-014-0192-y. [PMID: 24748278]
  • Yun-bin Jiang, Yan Gou, Mao-hua Yuan, Yu-ying Ma, Juan Zhou, Pi-e Wu. [HPLC Fingerprint of Anisodus tanguticus Root]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials. 2015 May; 38(5):957-61. doi: . [PMID: 26767288]
  • Guoyin Kai, Ang Zhang, Yingying Guo, Li Li, Lijie Cui, Xiuqin Luo, Cong Liu, Jianbo Xiao. Enhancing the production of tropane alkaloids in transgenic Anisodus acutangulus hairy root cultures by over-expressing tropinone reductase I and hyoscyamine-6β-hydroxylase. Molecular bioSystems. 2012 Nov; 8(11):2883-90. doi: 10.1039/c2mb25208b. [PMID: 22955966]
  • Guoyin Kai, Sheng Yang, Xiuqin Luo, Wentao Zhou, Xueqing Fu, Ang Zhang, Yan Zhang, Jianbo Xiao. Co-expression of AaPMT and AaTRI effectively enhances the yields of tropane alkaloids in Anisodus acutangulus hairy roots. BMC biotechnology. 2011 Apr; 11(?):43. doi: 10.1186/1472-6750-11-43. [PMID: 21526999]
  • Run-sheng Wang, Pei-lin Lü, Yu-lei Zhnag, Cun-li Zhnag, Bin-ke Yu, Hong-yan Wang, Jian-zhou Wang, Hui-fang Wang. [Change of plasma endothelin-1 concentrations in photodynamic induced rat anterior ischemic optic neuropathy model and drug modulation]. [Zhonghua yan ke za zhi] Chinese journal of ophthalmology. 2010 Dec; 46(12):1079-83. doi: NULL. [PMID: 21211220]
  • Huaixia Chen, Yong Chen, Peng Du, Fengmei Han. Structural elucidation of in vivo and in vitro metabolites of anisodine by liquid chromatography-tandem mass spectrometry. Journal of pharmaceutical and biomedical analysis. 2007 Jul; 44(3):773-8. doi: 10.1016/j.jpba.2007.01.038. [PMID: 17433600]
  • Huai-Xia Chen, Peng Du, Feng-Mei Han, Yong Chen. [Analysis of anisodine and its metabolites in rat plasma by liquid chromatography-tandem mass spectrometry]. Yao xue xue bao = Acta pharmaceutica Sinica. 2006 Jun; 41(6):518-21. doi: NULL. [PMID: 16927825]
  • Junbiao Chang, Weilin Xie, Limin Wang, Nianchun Ma, Senxiang Cheng, Jingxi Xie. An efficient approach to the asymmetric total synthesis of (-)-anisodine. European journal of medicinal chemistry. 2006 Mar; 41(3):397-400. doi: 10.1016/j.ejmech.2005.12.001. [PMID: 16414152]
  • S Y Pan, Y F Han. Comparison of the inhibitory efficacy of four belladonna drugs on gastrointestinal movement and cognitive function in food-deprived mice. Pharmacology. 2004 Nov; 72(3):177-83. doi: 10.1159/000080102. [PMID: 15452366]
  • Shao-jie Shan, Qiu-ping Xu, Yukihiro Shoyama. Extract of Yi Zhi Fang improves learning and memory behaviours of mice and its possible mechanisms. Phytotherapy research : PTR. 2002 Aug; 16(5):449-54. doi: 10.1002/ptr.965. [PMID: 12203266]
  • S Y Pan, Y F Han. Learning deficits induced by 4 belladonna alkaloids are preferentially attenuated by tacrine. Acta pharmacologica Sinica. 2000 Feb; 21(2):124-30. doi: . [PMID: 11263258]
  • S Y Pan, Y F Han, Q P Xu, M Y Liu, H Z Ma, W J Ding, R L Zhu. Belladonna alkaloids-induced behavioral changes and amnesia on open-field and step-through in 18-, 28-, and 38-day-old mice. Zhongguo yao li xue bao = Acta pharmacologica Sinica. 1998 Mar; 19(2):112-6. doi: . [PMID: 10374631]
  • Z S Huang, M P Liu, C Z Chen. [Studies on improving the ability of learning and memories of yangshoudan]. Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine. 1997 Sep; 17(9):553-6. doi: ". [PMID: 10322880]
  • Z Liu, Z W Guo, J Zhang. [Clinical and experimental studies on zhikang oral liquid in treatment of hypophrenia]. Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine. 1996 Feb; 16(2):74-7. doi: ". [PMID: 8762417]
  • X Liu, S Cheng, S Wang, Z Xing, L Wang. [Manufacture of computer-based testing and analyzing system for measuring step-through performance]. Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae. 1995 Dec; 17(6):466-9. doi: ". [PMID: 9208576]
  • R B Chao, C Y Wu. [Study on separation and determination of four tropane alkaloids in crude drugs by micellar HPLC]. Yao xue xue bao = Acta pharmaceutica Sinica. 1991; 26(7):519-26. doi: ". [PMID: 1805510]
  • J F Zhang, C D Yan, Y Q Zhang, W Z Gao, X M Zhai. [Effect of scopolia drugs on the gastric mucosal lesion in rats]. Yao xue xue bao = Acta pharmaceutica Sinica. 1990; 25(2):90-4. doi: . [PMID: 2239328]
  • J X Xie, J H Yang, Y X Zhao, C Z Zhang. Absolute configuration of (-)anisodine (a new ganglio blocking agent) and (-)anisodinic acid. Scientia Sinica. Series B, Chemical, biological, agricultural, medical & earth sciences. 1983 Sep; 26(9):931-5. doi: ". [PMID: 6140755]
  • P G Kuang, F L Dai, F Y Chang, P Z Kuang, S S Chen. Effects of anisodine on memory. Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan. 1982 Dec; 2(4):277-84. doi: ". [PMID: 6765723]