Alanylglutamine (BioDeep_00000033393)
Secondary id: BioDeep_00001871323
human metabolite PANOMIX_OTCML-2023 Endogenous
代谢物信息卡片
(2S)-2-{[(2S)-2-amino-1-hydroxypropylidene]amino}-4-(C-hydroxycarbonimidoyl)butanoate
化学式: C8H15N3O4 (217.106251)
中文名称: L-丙氨酰-L-谷氨酸盐
谱图信息:
最多检出来源 Chinese Herbal Medicine(otcml) 20.64%
分子结构信息
SMILES: CC(C(=O)NC(CCC(=O)N)C(=O)O)N
InChI: InChI=1S/C8H15N3O4/c1-4(9)7(13)11-5(8(14)15)2-3-6(10)12/h4-5H,2-3,9H2,1H3,(H2,10,12)(H,11,13)(H,14,15)/t4-,5-/m0/s1
描述信息
Alanylglutamine is a dipeptide composed of alanine and glutamine. It is an incomplete breakdown product of protein digestion or protein catabolism. Some dipeptides are known to have physiological or cell-signaling effects although most are simply short-lived intermediates on their way to specific amino acid degradation pathways following further proteolysis.
B - Blood and blood forming organs > B05 - Blood substitutes and perfusion solutions > B05X - I.v. solution additives > B05XB - Amino acids
L-Alanyl-L-glutamine, a glutamine dipeptide, is benefit for the antioxidant system, attenuating inflammation, and may modulate the heat shock protein (HSP) response in catabolic situations[1].
L-Alanyl-L-glutamine, a glutamine dipeptide, is benefit for the antioxidant system, attenuating inflammation, and may modulate the heat shock protein (HSP) response in catabolic situations[1].
同义名列表
23 个代谢物同义名
(2S)-2-{[(2S)-2-amino-1-hydroxypropylidene]amino}-4-(C-hydroxycarbonimidoyl)butanoate; (2S)-2-[(2S)-2-aminopropanamido]-4-carbamoylbutanoic acid; Alanylglutamine, (D-glu)-isomer; Alanine-glutamine dipeptide; Alanine glutamine dipeptide; N(2)-L-Alanyl-L-glutamine; N2-L-Alanyl-L-glutamine; L-Alanyl-L-glutamine; N2-Alanylglutamine; Alanyl-glutamine; Alanylglutamine; a-Q Dipeptide; H-Ala-Gln-OH; AQ dipeptide; L-Ala-L-GLN; Dipeptamin; Dipeptiven; Glutamax I; Sustamine; GlutaMAX; Ala-GLN; AQ; Ala-Gln
数据库引用编号
10 个数据库交叉引用编号
- ChEBI: CHEBI:73788
- PubChem: 123935
- HMDB: HMDB0028685
- DrugBank: DB11876
- ChEMBL: CHEMBL3707366
- MetaCyc: CPD-13403
- foodb: FDB111745
- chemspider: 110464
- CAS: 39537-23-0
- medchemexpress: HY-W014102
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Yigang Zheng, Hanglu Ying, Jiayi Shi, Long Li, Yufen Zhao. Alanyl-Glutamine Dipeptide Attenuates Non-Alcoholic Fatty Liver Disease Induced by a High-Fat Diet in Mice by Improving Gut Microbiota Dysbiosis.
Nutrients.
2023 Sep; 15(18):. doi:
10.3390/nu15183988. [PMID: 37764772] - Jiaji Hu, Yigang Zheng, Hanglu Ying, Huabin Ma, Long Li, Yufen Zhao. Alanyl-Glutamine Protects Mice against Methionine- and Choline-Deficient-Diet-Induced Steatohepatitis and Fibrosis by Modulating Oxidative Stress and Inflammation.
Nutrients.
2022 Sep; 14(18):. doi:
10.3390/nu14183796. [PMID: 36145172] - Giovanni S Molinari, Michal Wojno, Vance J McCracken, Karolina Kwasek. The use of dipeptide supplementation as a means of mitigating the negative effects of dietary soybean meal on Zebrafish Danio rerio.
Comparative biochemistry and physiology. Part A, Molecular & integrative physiology.
2021 07; 257(?):110958. doi:
10.1016/j.cbpa.2021.110958. [PMID: 33865992] - Xiaolei Su, Yuemeng Li, Yan Zhang, Shiquan Han. Efficacy of alanyl glutamine in nutritional support therapy for patients with sepsis: A protocol for systematic review and meta-analysis.
Medicine.
2021 Mar; 100(11):e24861. doi:
10.1097/md.0000000000024861. [PMID: 33725958] - Marcos Soares, Analu B Dos Santos, Tainara M Weich, Gabriela Gomes Mânica, Paulo Ivo Homem de Bittencourt, Mirna Stela Ludwig, Thiago Gomes Heck. Heat shock response in noise-induced hearing loss: effects of alanyl-glutamine dipeptide supplementation on heat shock proteins status.
Brazilian journal of otorhinolaryngology.
2020 Nov; 86(6):703-710. doi:
10.1016/j.bjorl.2019.04.012. [PMID: 31255578] - Sean R Moore, Laura A Quinn, Elizabeth A Maier, Marjorie M Guedes, Josiane S Quetz, Madeline Perry, Chethan Ramprasad, Gabriela M L Lanzarini Lopes, Jordi Mayneris-Perxachs, Jonathan Swann, Alberto M Soares, José Q Filho, Francisco S Junior, Alexandre Havt, Noelia L Lima, Richard L Guerrant, Aldo A M Lima. Intervention and Mechanisms of Alanyl-glutamine for Inflammation, Nutrition, and Enteropathy: A Randomized Controlled Trial.
Journal of pediatric gastroenterology and nutrition.
2020 09; 71(3):393-400. doi:
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Oxidative medicine and cellular longevity.
2020; 2020(?):7101407. doi:
10.1155/2020/7101407. [PMID: 33456673] - Ahmed M El-Lekawy, Dalaal M Abdallah, Hanan S El-Abhar. Alanyl-glutamine Heals Indomethacin-induced Gastric Ulceration in Rats Via Antisecretory and Anti-apoptotic Mechanisms.
Journal of pediatric gastroenterology and nutrition.
2019 12; 69(6):710-718. doi:
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Animal : an international journal of animal bioscience.
2019 Sep; 13(9):1826-1833. doi:
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JPEN. Journal of parenteral and enteral nutrition.
2019 08; 43(6):726-733. doi:
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Annals of Saudi medicine.
2019 Jul; 39(4):251-257. doi:
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European journal of trauma and emergency surgery : official publication of the European Trauma Society.
2018 Dec; 44(6):869-876. doi:
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Kidney international.
2018 12; 94(6):1227-1237. doi:
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Kidney international.
2018 12; 94(6):1050-1052. doi:
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Comparative biochemistry and physiology. Toxicology & pharmacology : CBP.
2018 Nov; 213(?):55-61. doi:
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Molecular medicine reports.
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Molecular & cellular proteomics : MCP.
2018 03; 17(3):516-532. doi:
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Pharmacology.
2018; 101(3-4):156-162. doi:
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Molecular medicine reports.
2017 Sep; 16(3):2807-2813. doi:
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Clinical nutrition (Edinburgh, Scotland).
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The British journal of nutrition.
2016 08; 116(3):470-9. doi:
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Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition.
2016 Apr; 31(2):250-6. doi:
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Fish & shellfish immunology.
2016 Apr; 51(?):365-372. doi:
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Kidney international.
2016 Mar; 89(3):625-35. doi:
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Transplantation proceedings.
2015 Oct; 47(8):2478-82. doi:
10.1016/j.transproceed.2015.08.001. [PMID: 26518955] - Bolin Zhang, Changning Yu, Meng Lin, Ya'nan Fu, Lin Zhang, Meijuan Meng, Shen Xing, Jiaolong Li, Hui Sun, Feng Gao, Guanghong Zhou. Regulation of skeletal muscle protein synthetic and degradative signaling by alanyl-glutamine in piglets challenged with Escherichia coli lipopolysaccharide.
Nutrition (Burbank, Los Angeles County, Calif.).
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PloS one.
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The American journal of clinical nutrition.
2014 Nov; 100(5):1385-91. doi:
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Life sciences.
2014 Jan; 94(2):130-6. doi:
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Clinical nutrition (Edinburgh, Scotland).
2013 Jun; 32(3):331-7. doi:
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Heart, lung & circulation.
2013 May; 22(5):360-5. doi:
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European journal of nutrition.
2013 Apr; 52(3):1089-98. doi:
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East African medical journal.
2013 Feb; 90(2):59-66. doi:
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JPEN. Journal of parenteral and enteral nutrition.
2012 Sep; 36(5):556-61. doi:
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The Journal of nutritional biochemistry.
2012 Sep; 23(9):1092-9. doi:
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The Journal of infectious diseases.
2012 May; 205(9):1464-71. doi:
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Nutrition research (New York, N.Y.).
2012 Apr; 32(4):272-7. doi:
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Veterinary immunology and immunopathology.
2012 Jan; 145(1-2):134-42. doi:
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Nutricion hospitalaria.
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Yonsei medical journal.
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Nutrition & metabolism.
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BMC complementary and alternative medicine.
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The Journal of surgical research.
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Acta cirurgica brasileira.
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Animal reproduction science.
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Annals of vascular surgery.
2010 May; 24(4):461-7. doi:
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Journal of the International Society of Sports Nutrition.
2010 Feb; 7(?):8. doi:
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Cell biochemistry and function.
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Journal of physiology and pharmacology : an official journal of the Polish Physiological Society.
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Alimentary pharmacology & therapeutics.
2009 Sep; 30(5):452-8. doi:
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Anesthesia and analgesia.
2009 Aug; 109(2):502-5. doi:
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Amino acids.
2009 May; 37(1):131-42. doi:
10.1007/s00726-009-0243-x. [PMID: 19189199] - Vinicius Fernandes Cruzat, Julio Tirapegui. Effects of oral supplementation with glutamine and alanyl-glutamine on glutamine, glutamate, and glutathione status in trained rats and subjected to long-duration exercise.
Nutrition (Burbank, Los Angeles County, Calif.).
2009 Apr; 25(4):428-35. doi:
10.1016/j.nut.2008.09.014. [PMID: 19056244] - J M Engel, S Ruhs, J Mühling, C Katzer, M Müller, T Menges, T Langefeld, G Hempelmann. Perioperative application of L-alanyl-L-glutamine in cardiac surgery: effect on the polarized T cell cytokine expression.
Amino acids.
2009 Mar; 36(3):519-27. doi:
10.1007/s00726-008-0114-x. [PMID: 18563517] - Gisele P Oliveira, Mariana B G Oliveira, Raquel S Santos, Letícia D Lima, Cristina M Dias, Alexandre M Ab' Saber, Walcy R Teodoro, Vera L Capelozzi, Rachel N Gomes, Patricia T Bozza, Paolo Pelosi, Patricia R M Rocco. Intravenous glutamine decreases lung and distal organ injury in an experimental model of abdominal sepsis.
Critical care (London, England).
2009; 13(3):R74. doi:
10.1186/cc7888. [PMID: 19454012] - Jing-Chen Liu, Hai-Tang Wang, Wei Wang. Protective effects of alanyl-glutamine on acute lung injury induced by lipopolysaccharide in rats.
Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences.
2008 Dec; 33(12):1095-100. doi:
NULL. [PMID: 19141974] - Concepción F Estívariz, Daniel P Griffith, Menghua Luo, Elaina E Szeszycki, Niloofar Bazargan, Nisha Dave, Nicole M Daignault, Glen F Bergman, Therese McNally, Cindy H Battey, Celeste E Furr, Li Hao, James G Ramsay, Carolyn R Accardi, George A Cotsonis, Dean P Jones, John R Galloway, Thomas R Ziegler. Efficacy of parenteral nutrition supplemented with glutamine dipeptide to decrease hospital infections in critically ill surgical patients.
JPEN. Journal of parenteral and enteral nutrition.
2008 Jul; 32(4):389-402. doi:
10.1177/0148607108317880. [PMID: 18596310] - Clotilde Fuentes-Orozco, Gabino Cervantes-Guevara, Ivette Muciño-Hernández, Alejandro López-Ortega, Gabriela Ambriz-González, José Luis Gutiérrez-de-la-Rosa, Efraín Gómez-Herrera, José Manuel Hermosillo-Sandoval, Alejandro González-Ojeda. L-alanyl-L-glutamine-supplemented parenteral nutrition decreases infectious morbidity rate in patients with severe acute pancreatitis.
JPEN. Journal of parenteral and enteral nutrition.
2008 Jul; 32(4):403-11. doi:
10.1177/0148607108319797. [PMID: 18596311] - Frantisek Duska, Michal Fric, Petr Waldauf, Jaroslav Pazout, Michal Andel, Pavel Mokrejs, Petr Tůma, Jan Pachl. Frequent intravenous pulses of growth hormone together with glutamine supplementation in prolonged critical illness after multiple trauma: effects on nitrogen balance, insulin resistance, and substrate oxidation.
Critical care medicine.
2008 Jun; 36(6):1707-13. doi:
10.1097/ccm.0b013e318174d499. [PMID: 18496372] - Menghua Luo, Niloofar Bazargan, Daniel P Griffith, Concepción F Estívariz, Lorraine M Leader, Kirk A Easley, Nicole M Daignault, Li Hao, Jon B Meddings, John R Galloway, Jeffrey B Blumberg, Dean P Jones, Thomas R Ziegler. Metabolic effects of enteral versus parenteral alanyl-glutamine dipeptide administration in critically ill patients receiving enteral feeding: a pilot study.
Clinical nutrition (Edinburgh, Scotland).
2008 Apr; 27(2):297-306. doi:
10.1016/j.clnu.2007.12.003. [PMID: 18258342] - Frantisek Duska, Michal Fric, Jaroslav Pazout, Petr Waldauf, Petr Tůma, Jan Pachl. Frequent intravenous pulses of growth hormone together with alanylglutamine supplementation in prolonged critical illness after multiple trauma: effects on glucose control, plasma IGF-I and glutamine.
Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society.
2008 Feb; 18(1):82-7. doi:
10.1016/j.ghir.2007.07.003. [PMID: 17709266] - Piyawan Bunpo, Betty Murray, Judy Cundiff, Emma Brizius, Carla J Aldrich, Tracy G Anthony. Alanyl-glutamine consumption modifies the suppressive effect of L-asparaginase on lymphocyte populations in mice.
The Journal of nutrition.
2008 Feb; 138(2):338-43. doi:
10.1093/jn/138.2.338. [PMID: 18203901] - R F C Leitão, R A Ribeiro, A M S Lira, L R Silva, E A L Bellaguarda, F D B Macedo, R B Sousa, G A C Brito. Glutamine and alanyl-glutamine accelerate the recovery from 5-fluorouracil-induced experimental oral mucositis in hamster.
Cancer chemotherapy and pharmacology.
2008 Feb; 61(2):215-22. doi:
10.1007/s00280-007-0463-2. [PMID: 17426972] - Ping Xue, Li-Hui Deng, Qing Xia, Zhao-Da Zhang, Wei-Ming Hu, Xiao-Nan Yang, Bing Song, Zong-Wen Huang. Impact of alanyl-glutamine dipeptide on severe acute pancreatitis in early stage.
World journal of gastroenterology.
2008 Jan; 14(3):474-8. doi:
10.3748/wjg.14.474. [PMID: 18200673] - Menghua Luo, Concepcion Fernandez-Estivariz, Dean P Jones, Carolyn R Accardi, Birgit Alteheld, Niloofar Bazargan, Li Hao, Daniel P Griffith, Jeffrey B Blumberg, John R Galloway, Thomas R Ziegler. Depletion of plasma antioxidants in surgical intensive care unit patients requiring parenteral feeding: effects of parenteral nutrition with or without alanyl-glutamine dipeptide supplementation.
Nutrition (Burbank, Los Angeles County, Calif.).
2008 Jan; 24(1):37-44. doi:
10.1016/j.nut.2007.10.004. [PMID: 18065204] - Si-Qing Yang, Jian-Guo Xu. [Effect of glutamine on serum interleukin-8 and tumor necrosis factor-alpha levels in patients with severe pancreatitis].
Nan fang yi ke da xue xue bao = Journal of Southern Medical University.
2008 Jan; 28(1):129-31. doi:
NULL. [PMID: 18227044] - Attila Szijártó, Oszkár Hahn, Enkhjargal Batmunkh, Rita Stangl, András Kiss, Gábor Lotz, Zsuzsa Schaff, László Váli, Anna Blázovics, Domokos Gero, Csaba Szabó, Péter Kupcsulik, László Harsányi. Short-term alanyl-glutamine dipeptide pretreatment in liver ischemia-reperfusion model: effects on microcirculation and antioxidant status in rats.
Clinical nutrition (Edinburgh, Scotland).
2007 Oct; 26(5):640-8. doi:
10.1016/j.clnu.2007.06.011. [PMID: 17689840] - Zheng Zhang, Hai-dong Qin, Hai-bin Ni, Ying Xu, Hai-rong Wu, Hui Cheng, Shu-kui Wang. [Effect of early enriched parenteral alanyl-glutamine on heat shock protein 70 (HSP70) expression in critical patients].
Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue.
2007 Aug; 19(8):481-4. doi:
NULL. [PMID: 17708846] - M Oguz, M Kerem, A Bedirli, B B Mentes, O Sakrak, B Salman, H Bostanci. L-alanin-L-glutamine supplementation improves the outcome after colorectal surgery for cancer.
Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland.
2007 Jul; 9(6):515-20. doi:
10.1111/j.1463-1318.2006.01174.x. [PMID: 17573745] - Jason R Herrick, Jennifer B Bond, Genevieve M Magarey, Helen L Bateman, Rebecca L Krisher, Susan A Dunford, William F Swanson. Toward a feline-optimized culture medium: impact of ions, carbohydrates, essential amino acids, vitamins, and serum on development and metabolism of in vitro fertilization-derived feline embryos relative to embryos grown in vivo.
Biology of reproduction.
2007 May; 76(5):858-70. doi:
10.1095/biolreprod.106.058065. [PMID: 17267698] - A Berg, A Norberg, C-R Martling, L Gamrin, O Rooyackers, J Wernerman. Glutamine kinetics during intravenous glutamine supplementation in ICU patients on continuous renal replacement therapy.
Intensive care medicine.
2007 Apr; 33(4):660-6. doi:
10.1007/s00134-007-0547-9. [PMID: 17318498] - Noélia L Lima, Alberto M Soares, Rosa M S Mota, Helena S A Monteiro, Richard L Guerrant, Aldo A M Lima. Wasting and intestinal barrier function in children taking alanyl-glutamine-supplemented enteral formula.
Journal of pediatric gastroenterology and nutrition.
2007 Mar; 44(3):365-74. doi:
10.1097/mpg.0b013e31802eecdd. [PMID: 17325559] - Liang Jing, Qiong Wu, Fuzhou Wang. Glutamine induces heat-shock protein and protects against Escherichia coli lipopolysaccharide-induced vascular hyporeactivity in rats.
Critical care (London, England).
2007; 11(2):R34. doi:
10.1186/cc5717. [PMID: 17346354] - Yi-Liang Peng, Qian-Fen Gong, Zi-Qiang Wand. [The prospective study on application of parenteral nutrition with alanyl-glutamine dipeptide in chemotherapy of gastrointestinal neoplasms patients].
Ai zheng = Aizheng = Chinese journal of cancer.
2006 Aug; 25(8):1044-7. doi:
NULL. [PMID: 16965691] - Marcelo Macedo Rogero, Julio Tirapegui, Rogerio Graça Pedrosa, Inar Alves de Castro, Ivanir Santana de Oliveira Pires. Effect of alanyl-glutamine supplementation on plasma and tissue glutamine concentrations in rats submitted to exhaustive exercise.
Nutrition (Burbank, Los Angeles County, Calif.).
2006 May; 22(5):564-71. doi:
10.1016/j.nut.2005.11.002. [PMID: 16472983] - J Ockenga, K Borchert, E Stüber, H Lochs, M P Manns, S C Bischoff. Glutamine-enriched total parenteral nutrition in patients with inflammatory bowel disease.
European journal of clinical nutrition.
2005 Nov; 59(11):1302-9. doi:
10.1038/sj.ejcn.1602243. [PMID: 16077744] - A Berg, O Rooyackers, A Norberg, J Wernerman. Elimination kinetics of L-alanyl-L-glutamine in ICU patients.
Amino acids.
2005 Nov; 29(3):221-8. doi:
10.1007/s00726-005-0230-9. [PMID: 16049639] - Marcos Antonio Alves, Sérgio Botelho Guimarães, Daniel Aguiar Dias, Paulo Roberto Cavalcante de Vasconcelos, Vicente de Paulo Martins Coelho, Paulo Roberto Leitão de Vasconcelos. Effects of L-alanyl-glutamine upon the blood and kidney biochemical parameters in the rat hind limb model of ischemia/reperfusion.
Acta cirurgica brasileira.
2005 Nov; 20(6):445-9. doi:
10.1590/s0102-86502005000600009. [PMID: 16302080] - Petra G Boelens, Paul A M van Leeuwen, Cornelis H C Dejong, Nicolaas E P Deutz. Intestinal renal metabolism of L-citrulline and L-arginine following enteral or parenteral infusion of L-alanyl-L-[2,15N]glutamine or L-[2,15N]glutamine in mice.
American journal of physiology. Gastrointestinal and liver physiology.
2005 Oct; 289(4):G679-85. doi:
10.1152/ajpgi.00026.2005. [PMID: 15933220] - Gerdien C Melis, Petra G Boelens, Joost R M van der Sijp, Theodora Popovici, Jean-Pascal De Bandt, Luc Cynober, Paul A M van Leeuwen. The feeding route (enteral or parenteral) affects the plasma response of the dipetide Ala-Gln and the amino acids glutamine, citrulline and arginine, with the administration of Ala-Gln in preoperative patients.
The British journal of nutrition.
2005 Jul; 94(1):19-26. doi:
10.1079/bjn20051463. [PMID: 16115328] - Juan J Ortíz de Urbina, Francisco Jorquera, Jesús M Culebras, Carmen Villares, Javier González-Gallego, María J Tuñón. Effects of parenteral nutrition supplemented with alanyl-glutamine on nutrition status in rats.
JPEN. Journal of parenteral and enteral nutrition.
2005 Jul; 29(4):262-5. doi:
10.1177/0148607105029004262. [PMID: 15961682] - Clotilde Fuentes-Orozco, Roberto Anaya-Prado, Alejandro González-Ojeda, Humberto Arenas-Márquez, Carlos Cabrera-Pivaral, Gabino Cervantes-Guevara, Luis M Barrera-Zepeda. L-alanyl-L-glutamine-supplemented parenteral nutrition improves infectious morbidity in secondary peritonitis.
Clinical nutrition (Edinburgh, Scotland).
2004 Feb; 23(1):13-21. doi:
10.1016/s0261-5614(03)00055-4. [PMID: 14757388] - Jin Satoh, Tomoyuki Tsujikawa, Yoshihide Fujiyama, Tadao Bamba. Nutritional benefits of enteral alanyl-glutamine supplementation on rat small intestinal damage induced by cyclophosphamide.
Journal of gastroenterology and hepatology.
2003 Jun; 18(6):719-25. doi:
10.1046/j.1440-1746.2003.03042.x. [PMID: 12753156] - Yuko Tazuke, Masafumi Wasa, Yoshiyuki Shimizu, Hong-Sheng Wang, Akira Okada. Alanyl-glutamine-supplemented parenteral nutrition prevents intestinal ischemia-reperfusion injury in rats.
JPEN. Journal of parenteral and enteral nutrition.
2003 Mar; 27(2):110-5. doi:
10.1177/0148607103027002110. [PMID: 12665166] - Ruth Exner, Dietmar Tamandl, Peter Goetzinger, Martina Mittlboeck, Reinhold Fuegger, Thomas Sautner, Andreas Spittler, Erich Roth. Perioperative GLY-GLN infusion diminishes the surgery-induced period of immunosuppression: accelerated restoration of the lipopolysaccharide-stimulated tumor necrosis factor-alpha response.
Annals of surgery.
2003 Jan; 237(1):110-5. doi:
10.1097/00000658-200301000-00015. [PMID: 12496537] - Yeping Zhou, Yonghua Sun, Zhuming Jiang, Guizhen He, Naifa Yang. [The effects of glutamine dipeptide on the improvement of endotoxemia in severely burned patients].
Zhonghua shao shang za zhi = Zhonghua shaoshang zazhi = Chinese journal of burns.
2002 Dec; 18(6):343-5. doi:
NULL. [PMID: 12641984] - R Pytlík, P Benes, M Patorková, E Chocenská, E Gregora, B Procházka, T Kozák. Standardized parenteral alanyl-glutamine dipeptide supplementation is not beneficial in autologous transplant patients: a randomized, double-blind, placebo controlled study.
Bone marrow transplantation.
2002 Dec; 30(12):953-61. doi:
10.1038/sj.bmt.1703759. [PMID: 12476290] - P Benes, R Pytlík, E Chocenská, M Pat'orková, J Klepetár, B Procházka, E Gregora, T Kozák, M Andĕl. [Parenteral glutamine does not improve the nutritional status in patients during high-dose chemotherapy and autologous peripheral stem cell transplantation].
Vnitrni lekarstvi.
2002 Nov; 48(11):1039-48. doi:
NULL. [PMID: 12577455] - Christiane Goeters, Anke Wenn, Norbert Mertes, Carola Wempe, Hugo Van Aken, Peter Stehle, Hans-Georg Bone. Parenteral L-alanyl-L-glutamine improves 6-month outcome in critically ill patients.
Critical care medicine.
2002 Sep; 30(9):2032-7. doi:
10.1097/00003246-200209000-00013. [PMID: 12352037] - M-T Lin, S-P Kung, S-L Yeh, C Lin, T-H Lin, K-H Chen, K-Y Liaw, P-H Lee, K-J Chang, W-J Chen. The effect of glutamine-supplemented total parenteral nutrition on nitrogen economy depends on severity of diseases in surgical patients.
Clinical nutrition (Edinburgh, Scotland).
2002 Jun; 21(3):213-8. doi:
10.1054/clnu.2001.0528. [PMID: 12127929] - M Holecek, F Skopec, L Sprongl, J Mráz, H Skalská, M Pecka. Effect of alanyl-glutamine on leucine and protein metabolism in irradiated rats.
Amino acids.
2002; 22(1):95-108. doi:
10.1007/s726-002-8203-0. [PMID: 12025876] - M T Lin, H Saito, S Furukawa, R Fukushima, F Kazuhiko, P H Lee, K J Chang, W J Chen. Alanyl-glutamine enriched total parenteral nutrition improves local, systemic, and remote organ responses to intraperitoneal bacterial challenge.
JPEN. Journal of parenteral and enteral nutrition.
2001 Nov; 25(6):346-51. doi:
10.1177/0148607101025006346. [PMID: 11688940] - A Spittler, T Sautner, A Gornikiewicz, N Manhart, R Oehler, M Bergmann, R Függer, E Roth. Postoperative glycyl-glutamine infusion reduces immunosuppression: partial prevention of the surgery induced decrease in HLA-DR expression on monocytes.
Clinical nutrition (Edinburgh, Scotland).
2001 Feb; 20(1):37-42. doi:
10.1054/clnu.2000.0153. [PMID: 11161542] - N Mertes, C Schulzki, C Goeters, G Winde, S Benzing, K S Kuhn, H Van Aken, P Stehle, P Fürst. Cost containment through L-alanyl-L-glutamine supplemented total parenteral nutrition after major abdominal surgery: a prospective randomized double-blind controlled study.
Clinical nutrition (Edinburgh, Scotland).
2000 Dec; 19(6):395-401. doi:
10.1054/clnu.2000.0142. [PMID: 11104589] - H Yuzawa, T Azuma, R Tsutsumi, H Fujioka, J Furui, T Kanematsu. Alanylglutamine-enriched total parenteral nutrition prevents bacterial translocation after small bowel transplantation in pigs.
Transplantation proceedings.
2000 Nov; 32(7):1662. doi:
10.1016/s0041-1345(00)01430-5. [PMID: 11119880] - M Holecek, F Skopec, H Skalská, L Sprongl. Effect of alanyl-glutamine on leucine and protein metabolism in endotoxemic rats.
JPEN. Journal of parenteral and enteral nutrition.
2000 Jul; 24(4):215-22. doi:
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