Ticagrelor (BioDeep_00000033388)

   

human metabolite blood metabolite Chemicals and Drugs


代谢物信息卡片


(1S,2S,3R,5S)-3-(7-{[(1R,2S)-2-(3,4-difluorophenyl)cyclopropyl]amino}-5-(propylsulfanyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-5-(2-hydroxyethoxy)cyclopentane-1,2-diol

化学式: C23H28F2N6O4S (522.1860712)
中文名称: 替卡格雷
谱图信息: 最多检出来源 Homo sapiens(blood) 55.88%

分子结构信息

SMILES: CCCSC1=NC(=C2C(=N1)N(N=N2)C3CC(C(C3O)O)OCCO)NC4CC4C5=CC(=C(C=C5)F)F
InChI: InChI=1S/C23H28F2N6O4S/c1-2-7-36-23-27-21(26-15-9-12(15)11-3-4-13(24)14(25)8-11)18-22(28-23)31(30-29-18)16-10-17(35-6-5-32)20(34)19(16)33/h3-4,8,12,15-17,19-20,32-34H,2,5-7,9-10H2,1H3,(H,26,27,28)/t12-,15+,16+,17-,19-,20+/m0/s1

描述信息

Ticagrelor (trade name Brilinta in the US, Brilique and Possia in the EU) is a platelet aggregation inhibitor produced by AstraZeneca. The drug was approved for use in the European Union by the European Commission on December 3, 2010. The drug was approved by the US Food and Drug Administration on July 20, 2011.
B - Blood and blood forming organs > B01 - Antithrombotic agents > B01A - Antithrombotic agents > B01AC - Platelet aggregation inhibitors excl. heparin
C78275 - Agent Affecting Blood or Body Fluid > C1327 - Antiplatelet Agent > C190801 - P2Y12 Inhibitor
D018377 - Neurotransmitter Agents > D058905 - Purinergic Agents > D058914 - Purinergic Antagonists
COVID info from clinicaltrial, clinicaltrials, clinical trial, clinical trials
D006401 - Hematologic Agents > D010975 - Platelet Aggregation Inhibitors
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
Ticagrelor (AZD6140) is a reversible oral P2Y12 receptor antagonist for the treatment of platelet aggregation.

同义名列表

10 个代谢物同义名

(1S,2S,3R,5S)-3-(7-{[(1R,2S)-2-(3,4-difluorophenyl)cyclopropyl]amino}-5-(propylsulfanyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-5-(2-hydroxyethoxy)cyclopentane-1,2-diol; (1S,2S,3R,5S)-3-(7-((1R,2S)-2-(3,4-Difluorophenyl)cyclopropylamino)-5-(propylthio)-3H-(1,2,3)triazolo(4,5-D)pyrimidin-3-yl)-5-(2-hydroxyethoxy)cyclopentane-1,2-diol; 3-(7-((2-(3,4-Difluorophenyl)cyclopropyl)amino)-5-(propylthio)-3H-(1-3)-triazolo(4,5-D)pyrimidin-3-yl)-5-(2-hydroxyethoxy)cyclopentane-1,2-diol; Ticagrelor; AZD-6140; Brilinta; AZD 6140; Brilique; AZD6140; AR-C 126532XX



数据库引用编号

10 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • ShaoJun Zheng, Qiong Jie, NaiDong Chen, XiJing Chen, YuBing Zhu. Ticagrelor Steady-State Trough Concentration in Chinese Patients Undergoing Percutaneous Coronary Intervention. European journal of drug metabolism and pharmacokinetics. 2024 Jan; 49(1):33-42. doi: 10.1007/s13318-023-00867-z. [PMID: 37999873]
  • Jiafeng Zou, Rui Sun, Muye He, You Chen, Yi Cheng, Chuanhe Xia, Ying Ma, Shulei Zheng, Xiuzhi Fu, Zeting Yuan, Minbo Lan, Kaiyan Lou, Xianjun Chen, Feng Gao. Sequential Rocket-Mode Bioactivating Ticagrelor Prodrug Nanoplatform Combining Light-Switchable Diphtherin Transgene System for Breast Cancer Metastasis Inhibition. ACS applied materials & interfaces. 2023 Nov; 15(46):53198-53216. doi: 10.1021/acsami.3c11594. [PMID: 37942626]
  • Yinxue Guo, Pingyu Ge, Ziju Li, Jingxia Xiao, Lirui Xie. Ticagrelor or Clopidogrel as Antiplatelet Agents in Patients with Chronic Kidney Disease and Cardiovascular Disease: A Meta-analysis. American journal of cardiovascular drugs : drugs, devices, and other interventions. 2023 Sep; 23(5):533-546. doi: 10.1007/s40256-023-00600-w. [PMID: 37530990]
  • Cui-Cui Wang, Qing Zhao, Bing-Yan Guo, Jie Hao, Jia-Jia Zhao, Jia-Liang Ren, Ya-Qing Sun, Xiao-Rui Zhang, Xiu-Ling Yang, Jin-Ming Liu. The Plasma Concentration of Ticagrelor and Aspirin as a Predictor of Bleeding Complications in Chinese Acute Coronary Syndrome Patients With Dual Antiplatelet Therapy: A Prospective Observational Study. Journal of cardiovascular pharmacology. 2023 08; 82(2):148-156. doi: 10.1097/fjc.0000000000001442. [PMID: 37295072]
  • Miaohan Qiu, Kun Na, Zizhao Qi, He Zhou, Pengxiao Li, Kai Xu, Bin Wang, Haiwei Liu, Jing Li, Yi Li, Yaling Han. Contemporary Use of Ticagrelor vs Clopidogrel in Patients With Acute Coronary Syndrome Undergoing Percutaneous Coronary Intervention: A GRACE Risk Score Stratification-Based Analysis in a Large-Scale, Real-World Study From China. Mayo Clinic proceedings. 2023 Jul; 98(7):1021-1032. doi: 10.1016/j.mayocp.2023.02.004. [PMID: 37419570]
  • Ziwei Xi, Yong Wang, Qianhong Lu, Hong Qiu, Yanan Gao, Ang Gao, Runlin Gao. Implementation of CYP2C19 genotyping and clinical outcomes following percutaneous coronary intervention in East Asian patients treated with oral P2Y12 inhibitors. Thrombosis research. 2023 May; 228(?):85-93. doi: 10.1016/j.thromres.2023.05.023. [PMID: 37301117]
  • Minwoo Jung, Minki Jin, Woo-Jin Jeon, HaeSoo Lee, Haeun Kim, Jong-Hee Won, Hyelim Yoo, Hyoung-Woo Bai, Su-Cheol Han, Hearan Suh, Kyoung Un Kang, Hong-Ki Lee, Cheong-Weon Cho. Development of a long-acting tablet with ticagrelor high-loaded nanostructured lipid carriers. Drug delivery and translational research. 2023 05; 13(5):1212-1227. doi: 10.1007/s13346-022-01205-7. [PMID: 35794353]
  • Anxin Wang, Xia Meng, Xue Tian, Yingting Zuo, Philip M Bath, Hao Li, Xuewei Xie, Jing Jing, Jinxi Lin, Yilong Wang, Xingquan Zhao, Liping Liu, Zixiao Li, Yong Jiang, Jie Xu, Feng Wang, Weifeng Chen, Minghua Cao, Jianhua Li, Yongjun Wang. Ticagrelor Aspirin vs Clopidogrel Aspirin in CYP2C19 Loss-of-Function Carriers With Minor Stroke or TIA Stratified by Risk Profile. Neurology. 2023 01; 100(5):e497-e504. doi: 10.1212/wnl.0000000000201454. [PMID: 36535779]
  • Anxin Wang, Xia Meng, Xue Tian, S Claiborne Johnston, Hao Li, Philip M Bath, Yingting Zuo, Xuewei Xie, Jing Jing, Jinxi Lin, Yilong Wang, Xingquan Zhao, Zixiao Li, Yong Jiang, Liping Liu, Feng Wang, Yanxia Wang, Panbing Huang, Guofang Chen, Yongjun Wang. Effect of Hypertension on Efficacy and Safety of Ticagrelor-Aspirin Versus Clopidogrel-Aspirin in Minor Stroke or Transient Ischemic Attack. Stroke. 2022 09; 53(9):2799-2808. doi: 10.1161/strokeaha.122.038662. [PMID: 35656824]
  • Xiao-Yan Sheng, Hui-Jie An, Yong-Yang He, Yong-Feng Ye, Jia-Lan Zhao, Sai Li. High-Dose Clopidogrel versus Ticagrelor in CYP2C19 intermediate or poor metabolizers after percutaneous coronary intervention: A Meta-Analysis of Randomized Trials. Journal of clinical pharmacy and therapeutics. 2022 Aug; 47(8):1112-1121. doi: 10.1111/jcpt.13665. [PMID: 35396752]
  • Carol Anne Graham, Mary K Tan, Derek P Chew, Christopher P Gale, Keith A A Fox, Akshay Bagai, Mark A Henderson, Ata Ur Rehman Quraishi, Jean-Pierre Déry, Asim N Cheema, Harold Fisher, David Brieger, Sohrab R Lutchmedial, Shahar Lavi, Brian Y L Wong, Tomas Cieza, Shamir R Mehta, Neil Brass, Shaun G Goodman, Andrew T Yan. Use and outcomes of dual antiplatelet therapy for acute coronary syndrome in patients with chronic kidney disease: insights from the Canadian Observational Antiplatelet Study (COAPT). Heart and vessels. 2022 Aug; 37(8):1291-1298. doi: 10.1007/s00380-022-02029-8. [PMID: 35089380]
  • Yuesong Pan, Xia Meng, Aoming Jin, S Claiborne Johnston, Hao Li, Philip M Bath, Xuewei Xie, Jing Jing, Jinxi Lin, Yilong Wang, Xingquan Zhao, Zixiao Li, Yong Jiang, Liping Liu, Hongqin Yang, Jiwei Cheng, Zhimin Wang, Yongjun Wang. Time Course for Benefit and Risk With Ticagrelor and Aspirin in Individuals With Acute Ischemic Stroke or Transient Ischemic Attack Who Carry CYP2C19 Loss-of-Function Alleles: A Secondary Analysis of the CHANCE-2 Randomized Clinical Trial. JAMA neurology. 2022 08; 79(8):739-745. doi: 10.1001/jamaneurol.2022.1457. [PMID: 35727586]
  • Gjin Ndrepepa, Shqipdona Lahu, Alp Aytekin, Maria Scalamogna, John Joseph Coughlan, Senta Gewalt, Costanza Pellegrini, Katharina Mayer, Adnan Kastrati. One-Year Ischemic and Bleeding Events According to Renal Function in Patients With Non-ST-Segment Elevation Acute Coronary Syndromes Treated With Percutaneous Coronary Intervention and Third-Generation Antiplatelet Drugs. The American journal of cardiology. 2022 08; 176(?):15-23. doi: 10.1016/j.amjcard.2022.04.040. [PMID: 35606172]
  • Maan H Harbi, Christopher W Smith, Fawaz O Alenazy, Phillip L R Nicolson, Alok Tiwari, Steve P Watson, Mark R Thomas. Antithrombotic Effects of Fostamatinib in Combination with Conventional Antiplatelet Drugs. International journal of molecular sciences. 2022 Jun; 23(13):. doi: 10.3390/ijms23136982. [PMID: 35805988]
  • Chor-Cheung Frankie Tam, Yap-Hang Chan, Yuen-Kwun Wong, Zhen Li, Xiurui Zhu, Kuo-Jung Su, Anindita Ganguly, Kuoyuan Hwa, Xuefeng B Ling, Hung-Fat Tse. Multi-Omics Signatures Link to Ticagrelor Effects on Vascular Function in Patients With Acute Coronary Syndrome. Arteriosclerosis, thrombosis, and vascular biology. 2022 06; 42(6):789-798. doi: 10.1161/atvbaha.121.317513. [PMID: 35387483]
  • Stefan Heitmeier, Mayken Visser, Adrian Tersteegen, Julia Dietze-Torres, Julia Glunz, Christoph Gerdes, Volker Laux, Jan Stampfuss, Susanne Roehrig. Pharmacological profile of asundexian, a novel, orally bioavailable inhibitor of factor XIa. Journal of thrombosis and haemostasis : JTH. 2022 06; 20(6):1400-1411. doi: 10.1111/jth.15700. [PMID: 35289054]
  • Yu-Han Cao, Qian-Cheng Xu, Yu-Wei Wang, Yang Ling, Cong Fu. Ticagrelor Protects against Sepsis-Induced Acute Kidney Injury through an Adenosine Receptor-Dependent Pathway. Current medical science. 2022 Jun; 42(3):505-512. doi: 10.1007/s11596-022-2516-5. [PMID: 35678913]
  • Qian Xiang, Zhiyan Liu, Guangyan Mu, Qiufen Xie, Hanxu Zhang, Shuang Zhou, Zining Wang, Ninghong Guo, Jie Huang, Jie Jiang, Jian Li, Guoping Yang, Yimin Cui. Effect of Genetic Polymorphism Including NUP153 and SVEP1 on the Pharmacokinetics and Pharmacodynamics of Ticagrelor in Healthy Chinese Subjects. Clinical drug investigation. 2022 May; 42(5):447-458. doi: 10.1007/s40261-022-01154-6. [PMID: 35501592]
  • Xi Zhang, Xiaolin Zhang, Fangnian Tong, Yi Cai, Yujie Zhang, Haixu Song, Xiaoxiang Tian, Chenghui Yan, Yaling Han. Gut microbiota induces high platelet response in patients with ST segment elevation myocardial infarction after ticagrelor treatment. eLife. 2022 03; 11(?):. doi: 10.7554/elife.70240. [PMID: 35258452]
  • Suzan M Mansour, Sarah A Abd El-Aal, Hanan S El-Abhar, Kawkab A Ahmed, Magdy M Awny. Repositioning of Ticagrelor: Renoprotection mediated by modulating renin-angiotensin system, inflammation, autophagy and galectin-3. European journal of pharmacology. 2022 Mar; 918(?):174793. doi: 10.1016/j.ejphar.2022.174793. [PMID: 35104457]
  • Yannan Pan, Bing Liu, Junmeng Liu, Wei Zhuang, Qing He, Ming Lan. Clopidogrel-induced neutropenia in an 80-year-old patient with chronic kidney disease who underwent percutaneous coronary intervention: a case report and literature review. BMC cardiovascular disorders. 2022 02; 22(1):40. doi: 10.1186/s12872-022-02490-3. [PMID: 35148681]
  • Peng Wei, Shujiang Zhuo, Qiang Fu, Haibo Wang, Bin Zong, Bangming Cao, Liansheng Wang. The efficacy and safety of the short-term combination therapy with ticagrelor and PPIs or H2RA in patients with acute STEMI who underwent emergency PCI. Clinical and translational science. 2022 02; 15(2):477-489. doi: 10.1111/cts.13165. [PMID: 34670024]
  • Sigrid E Sandner, Heribert Schunkert, Adnan Kastrati, Milan Milojevic, Andreas Böning, Daniel Zimpfer, Stephan Zellmer, Dominik Wiedemann, Günther Laufer, Moritz von Scheidt. Ticagrelor or Aspirin After Coronary Artery Bypass in Patients With Chronic Kidney Disease. The Annals of thoracic surgery. 2022 02; 113(2):554-562. doi: 10.1016/j.athoracsur.2021.03.061. [PMID: 33819474]
  • Mohammed A Abosheasha, Afnan H El-Gowily, Abdo A Elfiky. Potential antiviral properties of antiplatelet agents against SARS-CoV-2 infection: an in silico perspective. Journal of thrombosis and thrombolysis. 2022 Feb; 53(2):273-281. doi: 10.1007/s11239-021-02558-5. [PMID: 34510337]
  • Jeffrey S Berger, Lucy Z Kornblith, Michelle N Gong, Harmony R Reynolds, Mary Cushman, Yu Cheng, Bryan J McVerry, Keri S Kim, Renato D Lopes, Bassel Atassi, Scott Berry, Grant Bochicchio, Murillo de Oliveira Antunes, Michael E Farkouh, Yonatan Greenstein, Erinn M Hade, Kristin Hudock, Robert Hyzy, Pooja Khatri, Andrei Kindzelski, Bridget-Anne Kirwan, Lisa Baumann Kreuziger, Patrick R Lawler, Eric Leifer, Jose Lopez-Sendon Moreno, Jose Lopez-Sendon, James F Luther, Lilia Nigro Maia, John Quigley, Robert Sherwin, Lana Wahid, Jennifer Wilson, Judith S Hochman, Matthew D Neal. Effect of P2Y12 Inhibitors on Survival Free of Organ Support Among Non-Critically Ill Hospitalized Patients With COVID-19: A Randomized Clinical Trial. JAMA. 2022 01; 327(3):227-236. doi: 10.1001/jama.2021.23605. [PMID: 35040887]
  • Anne H Tavenier, Renicus S Hermanides, Jan Paul Ottervanger, Rudolf Tolsma, Antony van Beurden, Robbert Jan Slingerland, Peter G J Ter Horst, A T Marcel Gosselink, Jan-Henk E Dambrink, Maarten A H van Leeuwen, Vincent Roolvink, Elvin Kedhi, Olaf H Klungel, Svetlana V Belitser, Dominick J Angiolillo, Tobias Pustjens, Saman Rasoul, Ben Gho, Mera Stein, Lex Ruiters, Arnoud W J van 't Hof. Impact of opioids on P2Y12 receptor inhibition in patients with ST-elevation myocardial infarction who are pre-treated with crushed ticagrelor: Opioids aNd crushed Ticagrelor In Myocardial infarction Evaluation (ON-TIME 3) trial. European heart journal. Cardiovascular pharmacotherapy. 2022 01; 8(1):4-12. doi: 10.1093/ehjcvp/pvaa095. [PMID: 32730628]
  • Nishank Jain, Milind A Phadnis, Bradley C Martin, Jawahar L Mehta. Potent Antiplatelet Therapy May Reduce Death from Sepsis in Patients on Chronic Dialysis. The American journal of cardiology. 2022 01; 162(?):209-211. doi: 10.1016/j.amjcard.2021.10.001. [PMID: 34740395]
  • Rui Peng, Feng Li. The Clinical Efficacy of Tirofiban Combined with Ticagrelor and Aspirin in Treating Acute Myocardial Infarction by Percutaneous Coronary Intervention and Its Effect on Patients' Cardiac Function. Journal of healthcare engineering. 2022; 2022(?):4708572. doi: 10.1155/2022/4708572. [PMID: 35186231]
  • Fang Li, Shuhui Wang, Lei Wang, Feng Liu, Zhen Meng, Jia Liu. The Effects of Ticagrelor Combined with Tirofiban on Coagulation Function, Serum Myocardial Injury Markers, and Inflammatory Factor Levels in Patients with Acute Myocardial Infarction after Percutaneous Coronary Intervention. Computational and mathematical methods in medicine. 2022; 2022(?):4217270. doi: 10.1155/2022/4217270. [PMID: 35529262]
  • Piotr Niezgoda, Malwina A Barańska, Joanna Sikora, Przemysław Sobczak, Katarzyna Buszko, Adam Sikora, Michał P Marszałł, Eliano P Navarese, Bernd Jilma, Jacek Kubica. Oral NAloxone to overcome the moRphine effect in acute COronary syndrome patients treated with TICagrelor - NARCOTIC trial. Cardiology journal. 2022; 29(3):432-440. doi: 10.5603/cj.a2020.0040. [PMID: 32207836]
  • Juan F Iglesias, Marco Valgimigli, Federico Carbone, Nathalie Lauriers, Pier-Giorgio Masci, Sophie Degrauwe. Comparative effects of fentanyl versus morphine on platelet inhibition induced by ticagrelor in patients with ST-segment elevation myocardial infarction: Full results of the PERSEUS randomized trial. Cardiology journal. 2022; 29(4):591-600. doi: 10.5603/cj.a2022.0049. [PMID: 35762079]
  • Elena Díaz-García, Sara García-Tovar, Enrique Alfaro, Ester Zamarrón, Alberto Mangas, Raúl Galera, José Juan Ruíz-Hernández, Jordi Solé-Violán, Carlos Rodríguez-Gallego, Ana Van-Den-Rym, Rebeca Pérez-de-Diego, Kapil Nanwani-Nanwani, Eduardo López-Collazo, Francisco García-Rio, Carolina Cubillos-Zapata. Role of CD39 in COVID-19 Severity: Dysregulation of Purinergic Signaling and Thromboinflammation. Frontiers in immunology. 2022; 13(?):847894. doi: 10.3389/fimmu.2022.847894. [PMID: 35173744]
  • Zahra Lotfollahi, Ana P Q Mello, Francisco A H Fonseca, Luciene O Machado, Andressa F Mathias, Maria C Izar, Nagila R T Damasceno, Cristiano L P Oliveira, Antônio M F Neto. Changes in lipoproteins associated with lipid-lowering and antiplatelet strategies in patients with acute myocardial infarction. PloS one. 2022; 17(8):e0273292. doi: 10.1371/journal.pone.0273292. [PMID: 36040917]
  • Mohammed Ahmed Akkaif, Mei Li Ng, Muhamad Ali Sk Abdul Kader, Nur Aizati Athirah Daud, Abubakar Sha'aban, Baharudin Ibrahim. A review of the effects of ticagrelor on adenosine concentration and its clinical significance. Pharmacological reports : PR. 2021 Dec; 73(6):1551-1564. doi: 10.1007/s43440-021-00309-0. [PMID: 34283374]
  • Judith Hsia, Sarah T Kavanagh, Charles W Hopley, Iris Baumgartner, Jeffrey S Berger, Gerry R Fowkes, W Schuyler Jones, Kenneth W Mahaffey, Lars Norgren, Manesh R Patel, Frank Rockhold, Juuso Blomster, Brian G Katona, William R Hiatt, Marc P Bonaca. Impact of chronic kidney disease on hemoglobin among patients with peripheral artery disease treated with P2Y12 inhibitors: Insights from the EUCLID trial. Vascular medicine (London, England). 2021 12; 26(6):608-612. doi: 10.1177/1358863x211017641. [PMID: 34082620]
  • Giulio G Stefanini, Carlo Briguori, Davide Cao, Usman Baber, Samantha Sartori, Zhongjie Zhang, George Dangas, Dominick J Angiolillo, Shamir Mehta, David J Cohen, Timothy Collier, Dariusz Dudek, Javier Escaned, C Michael Gibson, Robert Gil, Kurt Huber, Upendra Kaul, Ran Kornowski, Mitchell W Krucoff, Vijay Kunadian, David J Moliterno, E Magnus Ohman, Keith G Oldroyd, Gennaro Sardella, Samin K Sharma, Richard Shlofmitz, Giora Weisz, Bernhard Witzenbichler, Stuart Pocock, Roxana Mehran. Ticagrelor monotherapy in patients with chronic kidney disease undergoing percutaneous coronary intervention: TWILIGHT-CKD. European heart journal. 2021 12; 42(45):4683-4693. doi: 10.1093/eurheartj/ehab533. [PMID: 34423374]
  • Weijie Zhang, Yaxin Sun, Shuangyan Wei, Bo Wei, Xia Xu, Youcai Tang. Untargeted metabolomics reveals the mechanism of quercetin enhancing the bioavailability of ticagrelor. Biomedical chromatography : BMC. 2021 Dec; 35(12):e5206. doi: 10.1002/bmc.5206. [PMID: 34185878]
  • Li Deng, Hai-Zhen Jia, Mao-Chun Li, Wei Zhu. Comparison of the effect of ticagrelor combined with tirofiban versus clopidogrel combined with tirofiban on inflammation response and prognosis of patients with unstable angina pectoris in long term follow-up. The Kaohsiung journal of medical sciences. 2021 Nov; 37(11):1010-1015. doi: 10.1002/kjm2.12421. [PMID: 34338425]
  • Luke P Parish, Tate Cutshall, Benjamin Duhart. Acute kidney injury and rhabdomyolysis due to ticagrelor and rosuvastatin. The Nurse practitioner. 2021 11; 46(11):12-16. doi: 10.1097/01.npr.0000794540.96561.51. [PMID: 34695045]
  • Ying-Chang Tung, Chi-Jen Chang, Jia-Rou Liu, Shu-Hao Chang, Yi-Hsin Chan, Chi-Tai Kuo, Lai-Chu See. Outcomes after ticagrelor versus clopidogrel treatment in end-stage renal disease patients with acute myocardial infarction: a nationwide cohort study. Scientific reports. 2021 10; 11(1):20826. doi: 10.1038/s41598-021-00360-0. [PMID: 34675293]
  • Himawan Fernando, Thy Duong, Kevin Huynh, Jonathan Noonan, James Shaw, Stephen J Duffy, Ziad Nehme, Karen Smith, Paul S Myles, Peter J Meikle, Karlheinz Peter, Dion Stub. Effects of lignocaine vs. opioids on antiplatelet activity of ticagrelor: the LOCAL trial. European heart journal. 2021 10; 42(39):4025-4036. doi: 10.1093/eurheartj/ehab557. [PMID: 34423354]
  • Immaneni Sathyamurthy, M S Hiremath, Jitendra Pal Sawhney, Subhash Chandra, Hrudanand Mishra, C K Ponde, Shuvanan Ray, Suhas Hardas, Sunil Sathe, P C Rath, Bagirath R, Girish B Navasundi, Vilas Magarkar, C N Makhale, Suvro Banerjee, P R Vaidyanathan, Amal Kanti Sen, Pandey Bp, Swami Onkar C. Expert Opinion on P2Y12 Inhibitors Use in Management of Acute Coronary Syndromes: Focus on Ticagrelor. The Journal of the Association of Physicians of India. 2021 Oct; 69(10):11-12. doi: NULL. [PMID: 34781659]
  • Blanca Trejo-Velasco, Antonio Tello-Montoliu, Ignacio Cruz-González, Raul Moreno, Jose A Baz-Alonso, Pablo J Salvadores, Rafael Romaguera, Eduardo Molina-Navarro, Emilio Paredes-Galán, Saleta Fernández-Barbeira, Alberto Ortiz-Saez, Guillermo Bastos-Fernandez, Antonio De Miguel-Castro, Adolfo Figueiras-Guzman, Andres Iñiguez-Romo, Victor A Jimenez-Diaz. Impact of Comorbidities and Antiplatelet Regimen on Platelet Reactivity Levels in Patients Undergoing Transcatheter Aortic Valve Implantation. Journal of cardiovascular pharmacology. 2021 09; 78(3):463-473. doi: 10.1097/fjc.0000000000001075. [PMID: 34117181]
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