Alcaftadine (BioDeep_00000033377)

   

human metabolite blood metabolite Chemicals and Drugs


代谢物信息卡片


2-(1-methylpiperidin-4-ylidene)-4,7-diazatricyclo[8.4.0.0³,⁷]tetradeca-1(14),3,5,10,12-pentaene-6-carbaldehyde

化学式: C19H21N3O (307.1684536)
中文名称: 阿卡他定
谱图信息: 最多检出来源 Mus musculus(blood) 12.5%

分子结构信息

SMILES: CN1CCC(=C2C3=CC=CC=C3CCN4C2=NC=C4C=O)CC1
InChI: InChI=1S/C19H21N3O/c1-21-9-6-15(7-10-21)18-17-5-3-2-4-14(17)8-11-22-16(13-23)12-20-19(18)22/h2-5,12-13H,6-11H2,1H3

描述信息

Alcaftadine is only found in individuals that have used or taken this drug. It is a H1 histamine receptor antagonist indicated for the prevention of itching associated with allergic conjunctivitis. This drug was approved in July 2010.Alcaftadine is a H1 histamine receptor antagonist and inhibitor of the release of histamine from mast cells. Decreased chemotaxis and inhibition of eosinophil activation has also been demonstrated.
C78272 - Agent Affecting Nervous System > C241 - Analgesic Agent > C2198 - Nonnarcotic Analgesic
D018377 - Neurotransmitter Agents > D018494 - Histamine Agents > D006633 - Histamine Antagonists
S - Sensory organs > S01 - Ophthalmologicals > S01G - Decongestants and antiallergics
C308 - Immunotherapeutic Agent > C29578 - Histamine-1 Receptor Antagonist
Alcaftadine (R89674) is a histamine H1 receptor antagonist, which is used to prevent eye irritation brought on by allergic conjunctivitis. Alcaftadine is a broad-spectrum antihistamine displaying a high affinity for histamine H1 and H2 receptors and a lower affinity for H4 receptors. Alcaftadine also exhibits modulatory action on immune cell recruitment and mast cell stabilizing effects[1][2].

同义名列表

6 个代谢物同义名

2-(1-methylpiperidin-4-ylidene)-4,7-diazatricyclo[8.4.0.0³,⁷]tetradeca-1(14),3,5,10,12-pentaene-6-carbaldehyde; Alcaftadinum; Alcaftadine; Alcaftadina; Lastacaft; R89674



数据库引用编号

10 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

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1 个相关的物种来源信息

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  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

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文献列表

  • Sawsan A Abdel Razeq, Shimaa E Abdel Aziz, Nermin S Ahmed. Stability-indicating UPLC, TLC-densitometric and UV-spectrophotometric methods for alcaftadine determination. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2021 Jul; 1177(?):122804. doi: 10.1016/j.jchromb.2021.122804. [PMID: 34098180]
  • Hilde Bohets, Claude McGowan, Geert Mannens, Nathalie Schroeder, Kimberly Edwards-Swanson, Aron Shapiro. Clinical pharmacology of alcaftadine, a novel antihistamine for the prevention of allergic conjunctivitis. Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics. 2011 Apr; 27(2):187-95. doi: 10.1089/jop.2010.0153. [PMID: 21314437]