Enoximone (BioDeep_00000033347)
human metabolite blood metabolite Chemicals and Drugs
代谢物信息卡片
4-methyl-5-[4-(methylsulfanyl)benzoyl]-2,3-dihydro-1H-imidazol-2-one
化学式: C12H12N2O2S (248.0619452)
中文名称: 依诺昔酮
谱图信息:
最多检出来源 Homo sapiens(blood) 7.5%
分子结构信息
SMILES: CC1=C(NC(=O)N1)C(=O)C2=CC=C(C=C2)SC
InChI: InChI=1S/C12H12N2O2S/c1-7-10(14-12(16)13-7)11(15)8-3-5-9(17-2)6-4-8/h3-6H,1-2H3,(H2,13,14,16)
描述信息
Enoximone is a selective phosphodiesterase inhibitor with vasodilating and positive inotropic activity that does not cause changes in myocardial oxygen consumption. It is used in patients with congestive heart failure. Trials were halted in the U.S., but the drug is used in various countries.
C - Cardiovascular system > C01 - Cardiac therapy > C01C - Cardiac stimulants excl. cardiac glycosides > C01CE - Phosphodiesterase inhibitors
D004791 - Enzyme Inhibitors > D010726 - Phosphodiesterase Inhibitors > D058987 - Phosphodiesterase 3 Inhibitors
D002317 - Cardiovascular Agents > D014665 - Vasodilator Agents
C471 - Enzyme Inhibitor > C744 - Phosphodiesterase Inhibitor
D020011 - Protective Agents > D002316 - Cardiotonic Agents
同义名列表
数据库引用编号
9 个数据库交叉引用编号
- ChEBI: CHEBI:135010
- PubChem: 53708
- HMDB: HMDB0015599
- DrugBank: DB04880
- ChEMBL: CHEMBL249856
- Wikipedia: Enoximone
- MeSH: Enoximone
- chemspider: 48492
- CAS: 77671-31-9
分类词条
相关代谢途径
Reactome(0)
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代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
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- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
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文献列表
- Jan Beute, Alex KleinJan. Phosphodiesterase-3 Inhibitor Enoximone in SARS-CoV-2 Infection.
Journal of aerosol medicine and pulmonary drug delivery.
2021 09; 34(5):322-323. doi:
10.1089/jamp.2021.0042. [PMID: 34495768] - Baldassare Ferro, Roberta Cinelli, Lara Vegnuti, Anna Maria Piras, Paolo Roncucci. The Potential Role of Aerosolized Phosphodiesterase 3 Inhibitor Enoximone in the Management of Coronavirus Disease 2019 Hypoxemia: A Case Report.
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2021 08; 34(4):262-264. doi:
10.1089/jamp.2021.0024. [PMID: 34152840] - Jan Beute, Pieter Boermans, Bart Benraad, Jan Telman, Zuzana Diamant, Alex KleinJan. PDE3-inhibitor enoximone prevented mechanical ventilation in patients with SARS-CoV-2 pneumonia.
Experimental lung research.
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10.1080/01902148.2021.1881189. [PMID: 33544007] - Emiliano Angeloni, Giovanni Melina, Antonino Roscitano, Simone Refice, Fabio Capuano, Cosimo Comito, Umberto Benedetto, Riccardo Sinatra. Perioperative administration of enoximone and renal function after cardiac surgery: a propensity-matched analysis.
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Intensive care medicine.
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10.1007/s00134-002-1435-y. [PMID: 12373472] - H Kern, T Schröder, M Kaulfuss, M Martin, W J Kox, C D Spies. Enoximone in contrast to dobutamine improves hepatosplanchnic function in fluid-optimized septic shock patients.
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