Erythrityl Tetranitrate (BioDeep_00000033342)

   

human metabolite blood metabolite Chemicals and Drugs


代谢物信息卡片


(2R*,3S)-rel-1,2,3,4-butanetetroltetranitric acid

化学式: C4H6N4O12 (301.9982236)
中文名称: 四硝酸赤藻糖酯
谱图信息: 最多检出来源 Homo sapiens(blood) 0.79%

分子结构信息

SMILES: C(C(C(CO[N+](=O)[O-])O[N+](=O)[O-])O[N+](=O)[O-])O[N+](=O)[O-]
InChI: InChI=1S/C4H6N4O12/c9-5(10)17-1-3(19-7(13)14)4(20-8(15)16)2-18-6(11)12/h3-4H,1-2H2/t3-,4+

描述信息

Erythrityl Tetranitrate is only found in individuals that have used or taken this drug. It is a vasodilator with general properties similar to nitroglycerin. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1020)Similar to other nitrites and organic nitrates, erythrityl tetranitrate is converted to an active intermediate compound which activates the enzyme guanylate cyclase. This stimulates the synthesis of cyclic guanosine 3,5-monophosphate (cGMP) which then activates a series of protein kinase-dependent phosphorylations in the smooth muscle cells, eventually resulting in the dephosphorylation of the myosin light chain of the smooth muscle fiber. The subsequent release of calcium ions results in the relaxation of the smooth muscle cells and vasodilation.
C - Cardiovascular system > C01 - Cardiac therapy > C01D - Vasodilators used in cardiac diseases > C01DA - Organic nitrates
C78274 - Agent Affecting Cardiovascular System > C29707 - Vasodilating Agent
D002317 - Cardiovascular Agents > D014665 - Vasodilator Agents

同义名列表

29 个代谢物同义名

(2R*,3S)-rel-1,2,3,4-butanetetroltetranitric acid; (2S,3R)-1,3,4-tris(nitrooxy)butan-2-yl nitrate; (2R*,3S)-rel-1,2,3,4-butanetetroltetranitrate; 1,2,3,4-Butanetetralyl tetranitric acid; 1,2,3,4-Butanetetralyl tetranitrate; Meso-erythritol tetranitric acid; Tetranitric acid deritrityle; Meso-erythritol tetranitrate; Erythrityl tetranitric acid; Erythritol tetranitric acid; Eritrityl tetranitric acid; Tetranitrato de eritritilo; Erythrol tetranitric acid; Tetranitrate deritrityle; Tetranitrate, erythrityl; Eritritile tetranitrato; Erythrityl Tetranitrate; Erythritol tetranitrate; Eritrityli tetranitras; eritrityl tetranitrate; Erythrol tetranitrate; Nitroerythrite; Nitroerythrol; Cardilic acid; Nitroerythrit; Tetranitrin; Tetranitrol; Cardilate; ETN



数据库引用编号

9 个数据库交叉引用编号

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代谢反应

0 个相关的代谢反应过程信息。

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1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

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文献列表

  • A E Rigamonti, S G Cella, N Marazzi, E E Müller. Nitric oxide modulation of the growth hormone-releasing activity of Hexarelin in young and old dogs. Metabolism: clinical and experimental. 1999 Feb; 48(2):176-82. doi: 10.1016/s0026-0495(99)90030-6. [PMID: 10024078]
  • B Hinz, U Kuntze, H Schröder. Pentaerithrityl tetranitrate and its phase I metabolites are potent activators of cellular cyclic GMP accumulation. Biochemical and biophysical research communications. 1998 Dec; 253(3):658-61. doi: 10.1006/bbrc.1998.9845. [PMID: 9918783]