Pivmecillinam (BioDeep_00000033341)

   

human metabolite blood metabolite Chemicals and Drugs


代谢物信息卡片


[(2,2-Dimethylpropanoyl)oxy]methyl (2S,5R,6R)-6-[(azepan-1-ylmethylidene)amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid

化学式: C21H33N3O5S (439.2140808000001)
中文名称: 匹美西林
谱图信息: 最多检出来源 Mus musculus(blood) 50%

分子结构信息

SMILES: CC(C)(C)C(=O)OCOC(=O)[C@H]1C(C)(C)S[C@@H]2[C@@H](C(=O)N12)N=CN1CCCCCC1
InChI: InChI=1S/C21H33N3O5S/c1-20(2,3)19(27)29-13-28-18(26)15-21(4,5)30-17-14(16(25)24(15)17)22-12-23-10-8-6-7-9-11-23/h12,14-15,17H,6-11,13H2,1-5H3/t14-,15+,17-/m1/s1

描述信息

Pivmecillinam is only found in individuals that have used or taken this drug. It is a mecillinam prodrug, a pivaloyloxymethyl ester of amdinocillin that is well absorbed orally, but broken down to amdinocillin in the intestinal mucosa. It is active against gram-negative organisms and used as for amdinocillin. [PubChem]Pivmecillinam interferes with the biosynthesis of the bacterial cell wall however its activity is slightly different from that of other penicillins and cephalosporins
J - Antiinfectives for systemic use > J01 - Antibacterials for systemic use > J01C - Beta-lactam antibacterials, penicillins > J01CA - Penicillins with extended spectrum
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D047090 - beta-Lactams
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D010406 - Penicillins
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D007769 - Lactams
C254 - Anti-Infective Agent > C258 - Antibiotic > C260 - Beta-Lactam Antibiotic

同义名列表

16 个代谢物同义名

[(2,2-Dimethylpropanoyl)oxy]methyl (2S,5R,6R)-6-[(azepan-1-ylmethylidene)amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid; [(2,2-Dimethylpropanoyl)oxy]methyl (2S,5R,6R)-6-[(azepan-1-ylmethylidene)amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate; [(2S,5R,6R)-6-[(azepan-1-ylmethylidene)amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carbonyloxy]methyl 2,2-dimethylpropanoate; Leo brand OF pivmecillinam hydrochloride; Amdinocillin, pivaloyloxymethyl ester; Hydrochloride, pivmecillinam; Pivmecillinam hydrochloride; Pivaloyl ester, mecillinam; Mecillinam pivaloyl ester; Pivoxil, amdinocillin; Amdinocillin pivoxil; Pivmecillinamum; Pivamdinocillin; PIVMECILLINAM; Pivmecilinamo; Selexid



数据库引用编号

12 个数据库交叉引用编号

分类词条

相关代谢途径

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PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

3 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Karen Leth Nielsen, Katrine Hartung Hansen, Jesper Boye Nielsen, Jenny Dahl Knudsen, Kristian Schønning, Niels Frimodt-Møller, Frederik Boëtius Hertz, Filip Jansåker. Mutational change of CTX-M-15 to CTX-M-127 resulting in mecillinam resistant Escherichia coli during pivmecillinam treatment of a patient. MicrobiologyOpen. 2019 12; 8(12):e941. doi: 10.1002/mbo3.941. [PMID: 31573735]
  • Nadeem S Raja. Emerging clinical role of pivmecillinam in the treatment of urinary tract infections caused by Extended Spectrum βeta-lactamase (ESBL) producing Enterobacteriaceae. International journal of clinical practice. 2019 Sep; 73(9):1-5. doi: 10.1111/ijcp.13387. [PMID: 31243859]
  • C Duployez, C Loiez, C Cattoen, D Descamps, F Wallet, A Vachée. In vitro susceptibility to mecillinam of Escherichia coli strains isolated from the urine of pregnant women. Medecine et maladies infectieuses. 2016 Dec; 46(8):436-441. doi: 10.1016/j.medmal.2016.07.007. [PMID: 27609597]
  • Petra Salomonsson, Marie-Louise von Linstow, Jenny Dahl Knudsen, Ida Heiberg, Gylli Mola, Therese Ramstad Wenger, Dina Cortes, Ulrikka Nygaard. Best oral empirical treatment for pyelonephritis in children: Do we need to differentiate between age and gender?. Infectious diseases (London, England). 2016 Oct; 48(10):721-5. doi: 10.3109/23744235.2016.1168937. [PMID: 27300266]
  • Frederik Boëtius Hertz, Kristian Schønning, Steen Christian Rasmussen, Pia Littauer, Jenny Dahl Knudsen, Anders Løbner-Olesen, Niels Frimodt-Møller. Epidemiological factors associated with ESBL- and non ESBL-producing E. coli causing urinary tract infection in general practice. Infectious diseases (London, England). 2016; 48(3):241-5. doi: 10.3109/23744235.2015.1103895. [PMID: 26523346]
  • Tor J Monsen, Stig E Holm, Björn Magnus Ferry, Sven A Ferry. Mecillinam resistance and outcome of pivmecillinam treatment in uncomplicated lower urinary tract infection in women. APMIS : acta pathologica, microbiologica, et immunologica Scandinavica. 2014 Apr; 122(4):317-23. doi: 10.1111/apm.12147. [PMID: 24738161]
  • Filip Jansåker, Niels Frimodt-Møller, Ingegerd Sjögren, Jenny Dahl Knudsen. Clinical and bacteriological effects of pivmecillinam for ESBL-producing Escherichia coli or Klebsiella pneumoniae in urinary tract infections. The Journal of antimicrobial chemotherapy. 2014 Mar; 69(3):769-72. doi: 10.1093/jac/dkt404. [PMID: 24107388]
  • Emilia Titelman, Aina Iversen, Mats Kalin, Christian G Giske. Efficacy of pivmecillinam for treatment of lower urinary tract infection caused by extended-spectrum β-lactamase-producing Escherichia coli and Klebsiella pneumoniae. Microbial drug resistance (Larchmont, N.Y.). 2012 Apr; 18(2):189-92. doi: 10.1089/mdr.2011.0161. [PMID: 22204597]
  • Ditte Mølgaard-Nielsen, Anders Hviid. Maternal use of antibiotics and the risk of orofacial clefts: a nationwide cohort study. Pharmacoepidemiology and drug safety. 2012 Mar; 21(3):246-53. doi: 10.1002/pds.2179. [PMID: 22125260]
  • Yann Neuzillet, Kurt G Naber, Giancarlo Schito, Laura Gualco, Henry Botto. French results of the ARESC study: clinical aspects and epidemiology of antimicrobial resistance in female patients with cystitis. Implications for empiric therapy. Medecine et maladies infectieuses. 2012 Feb; 42(2):66-75. doi: 10.1016/j.medmal.2011.07.005. [PMID: 22264668]
  • Ha Vinh, Vo Thi Cuc Anh, Nguyen Duc Anh, James I Campbell, Nguyen Van Minh Hoang, Tran Vu Thieu Nga, Nguyen Thi Khanh Nhu, Pham Van Minh, Cao Thu Thuy, Pham Thanh Duy, Le Thi Phuong, Ha Thi Loan, Mai Thu Chinh, Nguyen Thi Thu Thao, Nguyen Thi Hong Tham, Bui Li Mong, Phan Van Be Bay, Jeremy N Day, Christiane Dolecek, Nguyen Phu Huong Lan, To Song Diep, Jeremy J Farrar, Nguyen Van Vinh Chau, Marcel Wolbers, Stephen Baker. A multi-center randomized trial to assess the efficacy of gatifloxacin versus ciprofloxacin for the treatment of shigellosis in Vietnamese children. PLoS neglected tropical diseases. 2011 Aug; 5(8):e1264. doi: 10.1371/journal.pntd.0001264. [PMID: 21829747]
  • Meher Rizvi, Fatima Khan, Indu Shukla, Abida Malik, Shaheen. Rising prevalence of antimicrobial resistance in urinary tract infections during pregnancy: necessity for exploring newer treatment options. Journal of laboratory physicians. 2011 Jul; 3(2):98-103. doi: 10.4103/0974-2727.86842. [PMID: 22219563]
  • Hiroshi Sakata. [Clinical efficacy of tebipenem pivoxil treatment in children with pneumonia, who had no relief despite having administered oral beta-lactam antibiotics]. The Japanese journal of antibiotics. 2011 Jun; 64(3):171-7. doi: NULL. [PMID: 21861308]
  • Karen Ejrnæs. Bacterial characteristics of importance for recurrent urinary tract infections caused by Escherichia coli. Danish medical bulletin. 2011 Apr; 58(4):B4187. doi: . [PMID: 21466767]
  • Daniele Minardi, Gianluca d'Anzeo, Daniele Cantoro, Alessandro Conti, Giovanni Muzzonigro. Urinary tract infections in women: etiology and treatment options. International journal of general medicine. 2011; 4(?):333-43. doi: 10.2147/ijgm.s11767. [PMID: 21674026]
  • Miika Bergman, Solja T Nyberg, Pentti Huovinen, Pirkko Paakkari, Antti J Hakanen. Association between antimicrobial consumption and resistance in Escherichia coli. Antimicrobial agents and chemotherapy. 2009 Mar; 53(3):912-7. doi: 10.1128/aac.00856-08. [PMID: 19104012]
  • Lars Bjerrum, Bente Gahrn-Hansen, Per Grinsted. Pivmecillinam versus sulfamethizole for short-term treatment of uncomplicated acute cystitis in general practice: a randomized controlled trial. Scandinavian journal of primary health care. 2009; 27(1):6-11. doi: 10.1080/02813430802535312. [PMID: 18991182]
  • David Sevillano, Lorenzo Aguilar, Luis Alou, María-José Giménez, Martha Torrico, Natalia González, Fabio Cafini, María-Teresa Relaño, Pilar Coronel, José Prieto. Urine bactericidal activity against Escherichia coli isolates exhibiting different resistance phenotypes/genotypes in an in vitro pharmacodynamic model simulating urine concentrations obtained after oral administration of a 400-milligram single dose of cefditoren-pivoxil. Antimicrobial agents and chemotherapy. 2008 Mar; 52(3):1184-6. doi: 10.1128/aac.01247-07. [PMID: 18160517]
  • M I Issack, H Y Yee Kin Tet, P Morlat. Antimicrobial resistance among enterobacteriaceae causing uncomplicated urinary tract infections in Mauritius: consequences of past misuse of antibiotics. Journal of chemotherapy (Florence, Italy). 2007 Apr; 19(2):222-5. doi: 10.1179/joc.2007.19.2.222. [PMID: 17434833]
  • Karen Ejrnaes, Dorthe Sandvang, Bettina Lundgren, Sven Ferry, Stig Holm, Tor Monsen, Rolf Lundholm, Niels Frimodt-Moller. Pulsed-field gel electrophoresis typing of Escherichia coli strains from samples collected before and after pivmecillinam or placebo treatment of uncomplicated community-acquired urinary tract infection in women. Journal of clinical microbiology. 2006 May; 44(5):1776-81. doi: 10.1128/jcm.44.5.1776-1781.2006. [PMID: 16672406]
  • Tom L Broderick. Hypocarnitinaemia induced by sodium pivalate in the rat is associated with left ventricular dysfunction and impaired energy metabolism. Drugs in R&D. 2006; 7(3):153-61. doi: 10.2165/00126839-200607030-00002. [PMID: 16752941]
  • O Pruvost, P Roumagnac, C Gaube, F Chiroleu, L Gagnevin. New media for the semiselective isolation and enumeration of Xanthomonas campestris pv. mangiferaeindicae, the causal agent of mango bacterial black spot. Journal of applied microbiology. 2005; 99(4):803-15. doi: 10.1111/j.1365-2672.2005.02681.x. [PMID: 16162231]
  • K Abelson Storby, A Osterlund, G Kahlmeter. Antimicrobial resistance in Escherichia coli in urine samples from children and adults: a 12 year analysis. Acta paediatrica (Oslo, Norway : 1992). 2004 Apr; 93(4):487-91. doi: 10.1080/08035250410023034. [PMID: 15188976]
  • C-M Lokrantz, B Eriksson, I Rosén, F Asztely. Hyperammonemic encephalopathy induced by a combination of valproate and pivmecillinam. Acta neurologica Scandinavica. 2004 Apr; 109(4):297-301. doi: 10.1046/j.1600-0404.2003.00227.x. [PMID: 15016014]
  • Malin André, Sigvard Mölstad, Cecilia Stålsby Lundborg, Inga Odenholt. Management of urinary tract infections in primary care: a repeated 1-week diagnosis-prescribing study in five counties in Sweden in 2000 and 2002. Scandinavian journal of infectious diseases. 2004; 36(2):134-8. doi: 10.1080/00365540410019075. [PMID: 15061669]
  • M B Kerrn, N Frimodt-Møller, F Espersen. Urinary concentrations and urine ex-vivo effect of mecillinam and sulphamethizole. Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases. 2004 Jan; 10(1):54-61. doi: 10.1111/j.1469-0691.2004.00737.x. [PMID: 14706087]
  • Sven A Ferry, Stig E Holm, Hans Stenlund, Rolf Lundholm, Tor J Monsen. The natural course of uncomplicated lower urinary tract infection in women illustrated by a randomized placebo controlled study. Scandinavian journal of infectious diseases. 2004; 36(4):296-301. doi: 10.1080/00365540410019642. [PMID: 15198188]
  • Lindsay Nicolle. Best pharmacological practice: urinary tract infections. Expert opinion on pharmacotherapy. 2003 May; 4(5):693-704. doi: 10.1517/14656566.4.5.693. [PMID: 12739995]
  • L E Nicolle, K S Madsen, G O Debeeck, E Blochlinger, N Borrild, J P Bru, C Mckinnon, B O'Doherty, W Spiegel, F A M Van Balen, P Menday. Three days of pivmecillinam or norfloxacin for treatment of acute uncomplicated urinary infection in women. Scandinavian journal of infectious diseases. 2002; 34(7):487-92. doi: 10.1080/00365540110080728. [PMID: 12195873]
  • H K Johansen, K Børch, F Espersen, C Koch, N Høiby. Randomised trial of pivampicillin plus pivmecillinam vs. pivampicillin in children and young adults with chronic obstructive pulmonary disease and infection with Haemophilus influenzae. Current medical research and opinion. 1999; 15(4):300-9. doi: 10.1185/03007999909116501. [PMID: 10640263]
  • M A Salam, U Dhar, W A Khan, M L Bennish. Randomised comparison of ciprofloxacin suspension and pivmecillinam for childhood shigellosis. Lancet (London, England). 1998 Aug; 352(9127):522-7. doi: 10.1016/s0140-6736(97)11457-x. [PMID: 9716056]
  • K Abrahamsson, B O Eriksson, E Holme, U Jodal, A Jönsson, S Lindstedt. Pivalic acid-induced carnitine deficiency and physical exercise in humans. Metabolism: clinical and experimental. 1996 Dec; 45(12):1501-7. doi: 10.1016/s0026-0495(96)90179-1. [PMID: 8969283]
  • K Abrahamsson, M Mellander, B O Eriksson, E Holme, U Jodal, A Jönsson, S Lindstedt. Transient reduction of human left ventricular mass in carnitine depletion induced by antibiotics containing pivalic acid. British heart journal. 1995 Dec; 74(6):656-9. doi: 10.1136/hrt.74.6.656. [PMID: 8541173]
  • K Abrahamsson, E Holme, U Jodal, S Lindstedt, I Nordin. Effect of short-term treatment with pivalic acid containing antibiotics on serum carnitine concentration--a risk irrespective of age. Biochemical and molecular medicine. 1995 Jun; 55(1):77-9. doi: 10.1006/bmme.1995.1036. [PMID: 7551831]
  • K Abrahamsson, B O Eriksson, E Holme, U Jodal, S Lindstedt, I Nordin. Impaired ketogenesis in carnitine depletion caused by short-term administration of pivalic acid prodrug. Biochemical medicine and metabolic biology. 1994 Jun; 52(1):18-21. doi: 10.1006/bmmb.1994.1028. [PMID: 7917463]
  • Q N Diep, T Bøhmer, O T Storrøsten, J I Holme, A Torvik, C W Loennecken, P Monstad, E Jellum. [Slow replenishment of carnitine level after long-term treatment with pivampicillin/pivmecillinam]. Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke. 1994 May; 114(14):1614-6. doi: . [PMID: 8079264]
  • Q N Diep, T Bøhmer, J I Holme, A Torvik, O T Storrøsten, C W Loennecken, P Monstad, E Jellum. Slow replenishment of carnitine deficiency after cessation of long-term treatment with pivaloyl-containing antibiotics. Pharmacy world & science : PWS. 1993 Oct; 15(5):225-9. doi: 10.1007/bf01880631. [PMID: 8257960]
  • E Holme, U Jodal, S Linstedt, I Nordin. Effects of pivalic acid-containing prodrugs on carnitine homeostasis and on response to fasting in children. Scandinavian journal of clinical and laboratory investigation. 1992 Sep; 52(5):361-72. doi: 10.3109/00365519209088371. [PMID: 1514015]
  • A Heikkilä, K Pyykkö, R Erkkola, E Iisalo. The pharmacokinetics of mecillinam and pivmecillinam in pregnant and non-pregnant women. British journal of clinical pharmacology. 1992 Jun; 33(6):629-33. doi: 10.1111/j.1365-2125.1992.tb04092.x. [PMID: 1389936]
  • E Holme, J Greter, C E Jacobson, S Lindstedt, I Nordin, B Kristiansson, U Jodal. Carnitine deficiency induced by pivampicillin and pivmecillinam therapy. Lancet (London, England). 1989 Aug; 2(8661):469-73. doi: 10.1016/s0140-6736(89)92086-2. [PMID: 2570185]
  • L D Bornemann, S Castellano, A H Lin, D Enthoven, I H Patel. Influence of food on bioavailability of amdinocillin pivoxil. Antimicrobial agents and chemotherapy. 1988 Apr; 32(4):592-4. doi: 10.1128/aac.32.4.592. [PMID: 3377469]
  • I R McFadyen, M Campbell-Brown, M Stephenson, D V Seal. Single-dose treatment of bacteriuria in pregnancy. European urology. 1987; 13 Suppl 1(?):22-5. doi: 10.1159/000472854. [PMID: 3552699]
  • M Grabe, A Forsgren. The effectiveness of a short perioperative course with pivampicillin/pivmecillinam in transurethral prostatic resection: bacteriological results. Scandinavian journal of infectious diseases. 1986; 18(6):575-81. doi: 10.3109/00365548609021665. [PMID: 3643648]
  • N L Carlsen, U Hesselbjerg, P Glenting. Comparison of long-term, low-dose pivmecillinam and nitrofurantoin in the control of recurrent urinary tract infection in children. An open, randomized, cross-over study. The Journal of antimicrobial chemotherapy. 1985 Oct; 16(4):509-17. doi: 10.1093/jac/16.4.509. [PMID: 4066562]
  • I Kabir, M M Rahaman, S M Ahmed, S Q Akhter, T Butler. Comparative efficacies of pivmecillinam and ampicillin in acute shigellosis. Antimicrobial agents and chemotherapy. 1984 May; 25(5):643-5. doi: 10.1128/aac.25.5.643. [PMID: 6329092]
  • D K Sommers, M Van Wyk, P E Williams, S M Harding. Pharmacokinetics and tolerance of cefuroxime axetil in volunteers during repeated dosing. Antimicrobial agents and chemotherapy. 1984 Mar; 25(3):344-7. doi: 10.1128/aac.25.3.344. [PMID: 6721467]
  • J K Møller, A Stenderup. The influence of long-term treatment with mecillinam on fecal Escherichia coli. Scandinavian journal of infectious diseases. 1984; 16(2):223-4. doi: 10.3109/00365548409087147. [PMID: 6330882]
  • E Ekwall, A Ljungh, B Selander. Asymptomatic urinary tract infection caused by Shigella sonnei. Scandinavian journal of infectious diseases. 1984; 16(1):121-2. doi: 10.3109/00365548409068417. [PMID: 6364325]
  • N Jeppesen, C Frimodt-Møller. Serum concentrations and penetration into prostate of mecillinam and ampicillin. Current medical research and opinion. 1984; 9(3):213-8. doi: 10.1185/03007998409109582. [PMID: 6499514]
  • A P Ball, A M Geddes. Management of enteric fever with amdinocillin. The American journal of medicine. 1983 Aug; 75(2A):130-3. doi: 10.1016/0002-9343(83)90108-0. [PMID: 6311001]
  • H C Neu, S Srinivasan, E L Francke, C Ortiz-Neu, J G Christenson. Pharmacokinetics of amdinocillin and pivamdinocillin in normal volunteers. The American journal of medicine. 1983 Aug; 75(2A):60-4. doi: 10.1016/0002-9343(83)90095-5. [PMID: 6311007]
  • M R Newby. An evaluation in general practice of the use of dip-slide urine cultures in combination with antimicrobial sensitivity testing in patients with symptoms of acute cystitis treated with pivmecillinam. The British journal of clinical practice. 1983 Jun; 37(6):217-22. doi: NULL. [PMID: 6309205]
  • C S Iosif, J Laurin, E B Möller, C A Bauer. Treatment of urinary tract infections in gynecological patients. A randomized study comparing pivampicillin-pivmecillinam with trimethoprim-sulphamethoxazole. Acta obstetricia et gynecologica Scandinavica. 1983; 62(5):515-8. doi: 10.3109/00016348309154228. [PMID: 6320580]
  • J N Bruun, A Digranes, J Bøe, A Maeland. Treatment of Salmonella carriers with pivmecillinam alone or in combination with pivampicillin: experience with three patients. Scandinavian journal of infectious diseases. 1983; 15(1):21-4. doi: 10.3109/inf.1983.15.issue-1.05. [PMID: 6302830]
  • J J Kjer. Serum estriol level during treatment with pivmecillinam. Acta obstetricia et gynecologica Scandinavica. 1983; 62(2):153-4. doi: 10.3109/00016348309155780. [PMID: 6306983]
  • NULL. A fixed combination of pivmecillinam and pivampicillin in complicated urinary tract infections. Double-blind comparison with pivmecillinam alone in hospitalized patients. Scandinavian journal of infectious diseases. 1983; 15(2):195-9. doi: 10.3109/inf.1983.15.issue-2.12. [PMID: 6308755]
  • I Helin. Pivmecillinam in the treatment of childhood pyelonephritis. The Journal of international medical research. 1983; 11(2):113-5. doi: 10.1177/030006058301100209. [PMID: 6303875]
  • H Hey, H J Frederiksen, J T Andersen. Gastroscopic and pharmacokinetic evaluation of a new pivmecillinam tablet. European journal of clinical pharmacology. 1982; 22(1):63-9. doi: 10.1007/bf00606427. [PMID: 6284518]
  • A Igesund, L Vorland. A fixed combination of pivmecillinam and pivampicillin in complicated urinary tract infections. A double-blind comparison with pivmecillinam. Scandinavian journal of infectious diseases. 1982; 14(2):159-60. doi: 10.3109/inf.1982.14.issue-2.20. [PMID: 6285450]
  • K Josefsson, T Bergan, L Magni, B G Pring, D Westerlund. Pharmacokinetics of bacmecillinam and pivmecillinam in volunteers. European journal of clinical pharmacology. 1982; 23(3):249-52. doi: 10.1007/bf00547563. [PMID: 6293834]
  • H Aratani, S Negita, H Tateishi, S Miyamoto. [Fundamental studies on excretion of pivmecillinam in bile (author's transl)]. The Japanese journal of antibiotics. 1981 Dec; 34(12):1540-8. doi: NULL. [PMID: 6278176]
  • P W Taylor, H Gaunt, F M Unger. Effect of subinhibitory concentrations of mecillinam on the serum susceptibility of Escherichia coli strains. Antimicrobial agents and chemotherapy. 1981 May; 19(5):786-8. doi: 10.1128/aac.19.5.786. [PMID: 6271047]
  • H Gippert, A Norberg, B Norberg, G Kahlmeter, N Bukh. Symptomatic bacteriuria in non-catheterized geriatric patients with urinary incontinence; the effect of short-term treatment with pivmecillinam or the combination pivmecillinam-pivampicillin. The Journal of antimicrobial chemotherapy. 1981 Feb; 7(2):185-91. doi: 10.1093/jac/7.2.185. [PMID: 6260728]
  • O S Nielsen, N Frimodt-Moeller, S Maigaard, U Hoyme, A Baumueller, P O Madsen. Penicillanic acid derivatives in the canine prostate. The Prostate. 1980; 1(1):79-85. doi: 10.1002/pros.2990010111. [PMID: 6269107]
  • B T Andersen, M Joergensen, J Lorenzen. Pivmecillinam in the treatment of therapy resistant urinary tract infections. A comparison with pivmecillinam, pivampicillin and their combination. Infection. 1980; 8(1):27-31. doi: 10.1007/bf01677395. [PMID: 6246005]
  • Y Shiraiwa, Y Takahashi, M Kobayashi, M Fujimura, M Takeuchi, I Imamura, J Yokoyama, S Hozumi, M Arai, T Hirai, K Miyata, H Ishiwata, M Nagasawa, M Saito, R Chiba. [Therapeutic effect of pivmecillinam for acute simple cystitis (author's transl)]. The Japanese journal of antibiotics. 1980 Jan; 33(1):82-6. doi: NULL. [PMID: 6246289]
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