Stepronin (BioDeep_00000033332)

   

human metabolite blood metabolite Chemicals and Drugs


代谢物信息卡片


2-[2-(thiophene-2-carbonylsulfanyl)propanamido]acetic acid

  化学式: C10H11NO4S2 (273.0129)
中文名称: 司替罗宁
  谱图信息: 最多检出来源 Homo sapiens(blood) 27.55%

分子结构信息

SMILES: CC(C(=O)NCC(=O)O)SC(=O)C1=CC=CS1
InChI: InChI=1S/C10H11NO4S2/c1-6(9(14)11-5-8(12)13)17-10(15)7-3-2-4-16-7/h2-4,6H,5H2,1H3,(H,11,14)(H,12,13)


描述信息

Strepronin is a mucolytic drug. A mucolytic agent is any agent which dissolves thick mucus usually used to help relieve respiratory difficulties. The viscosity of mucous secretions in the lungs is dependent upon the concentrations of mucoprotein as well as the presence of disulfide bonds between these macromolecules and DNA.
R - Respiratory system > R05 - Cough and cold preparations > R05C - Expectorants, excl. combinations with cough suppressants > R05CB - Mucolytics
C78273 - Agent Affecting Respiratory System > C74536 - Mucolytic Agent
D007155 - Immunologic Factors > D007166 - Immunosuppressive Agents
D019141 - Respiratory System Agents > D005100 - Expectorants
D000890 - Anti-Infective Agents > D000998 - Antiviral Agents

同义名列表

15 个代谢物同义名

2-[2-(thiophene-2-carbonylsulfanyl)propanamido]acetic acid; N-(1-oxo-2-((2-Thienylcarbonyl)thio)propyl)-glycine; 2-(alpha-Thenoylthio)propionylglycine; 2-(alpha-Theonyl)thiopropionylglycine; Stepronin monosodium salt; Stepronine lysine salt; Stepronin lysine salt; Stepronin sodium; Stepronin lysine; Prostenoglycine; Broncoplus; Stepronin; Tiofacic; Tiase; TTPG



数据库引用编号

8 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • H Y Kim, D Thomas, M R Hanley. Stimulation of Ca(2+)-dependent membrane currents in Xenopus oocytes by microinjection of pyrimidine nucleotide-glucose conjugates. Molecular pharmacology. 1996 Feb; 49(2):360-4. doi: . [PMID: 8632770]
  • A Marzo, G Bruno, D Nava, C Giubilei, E Arrigoni Martelli, M J Douin, D Chassard, A Mignot, J J Thebault. Pharmacokinetics of 2-(alpha-thenoylthio)-propionylglycine (TTPG) in healthy volunteers--an oral dose-proportionality investigation. Journal of pharmaceutical and biomedical analysis. 1992 Sep; 10(9):623-9. doi: 10.1016/0731-7085(92)80089-6. [PMID: 1286128]
  • A Marzo, E Arrigoni Martelli, G Bruno, D Nava, A Mignot, R Vidal, M A Lefebvre. High-performance liquid chromatographic evaluation of 2-(alpha-thenoylthio)propionylglycine and its two metabolites in biological fluids. Journal of chromatography. 1991 Jan; 536(1-2):327-35. doi: 10.1016/s0021-9673(01)89266-9. [PMID: 2050772]
  • M C Morale, A Fiumara, E Bousquet, M Matera, V Guarcello, V Rizza. The effects of 2-(alpha-Tenoyl) thiopropionylglycine (TTPG) on human lung mucus. International journal of tissue reactions. 1983; 5(2):231-5. doi: NULL. [PMID: 6618789]
  • M Bruno, B Fruttero, M Marangella, F Linari. [Cystinuria: clinical and therapeutic aspects]. Bollettino chimico farmaceutico. 1982 Feb; 121(2):1S-8S. doi: NULL. [PMID: 7126344]
  • G Zanolo, P Gnemi, A Mondino, S Silvestri, G Segre. [Serum kinetics and biotransformation of prostenoglycine in the rat, dog and monkey]. Bollettino chimico farmaceutico. 1981 Jan; 120(1):55-67. doi: NULL. [PMID: 7236372]