Bevantolol (BioDeep_00000033317)
human metabolite blood metabolite
代谢物信息卡片
化学式: C20H27NO4 (345.19399820000007)
中文名称: 贝凡洛尔
谱图信息:
最多检出来源 Homo sapiens(blood) 7.69%
分子结构信息
SMILES: CC1=CC(=CC=C1)OCC(CNCCC2=CC(=C(C=C2)OC)OC)O
InChI: InChI=1S/C20H27NO4/c1-15-5-4-6-18(11-15)25-14-17(22)13-21-10-9-16-7-8-19(23-2)20(12-16)24-3/h4-8,11-12,17,21-22H,9-10,13-14H2,1-3H3
描述信息
Bevantolol is a beta-1 adrenoceptor antagonist that has been shown to be as effective as other beta blockers for the treatment of angina pectoris and hypertension. Mechanism of Action Animal experiments confirm both agonist and antagonist effects on alpha-receptors, in addition to antagonist activity at beta-1 receptors.
C - Cardiovascular system > C07 - Beta blocking agents > C07A - Beta blocking agents > C07AB - Beta blocking agents, selective
C78272 - Agent Affecting Nervous System > C29747 - Adrenergic Agent > C72900 - Adrenergic Antagonist
D018377 - Neurotransmitter Agents > D018663 - Adrenergic Agents > D018674 - Adrenergic Antagonists
同义名列表
9 个代谢物同义名
1-((2-(3,4-Dimethoxyphenyl)ethyl)amino)-3-(3-methylphenoxy)-2-propanol; 1-{[2-(3,4-dimethoxyphenyl)ethyl]amino}-3-(3-methylphenoxy)propan-2-ol; 1-[2-(3,4-Dimethoxy-phenyl)-ethylamino]-3-m-tolyloxy-propan-2-ol; 1-(3,4-Dimethoxyphenethylamino)-3-(m-tolyloxy)-2-propanol; 1-(3,4-Dimethoxyphenethylamino)-3-m-tolyloxy-propan-2-ol; Bevantolol hydrochloride; (+-)-Bevantolol; Bevantololum; bevantolol
数据库引用编号
8 个数据库交叉引用编号
- ChEBI: CHEBI:238698
- PubChem: 2372
- HMDB: HMDB0015409
- DrugBank: DB01295
- ChEMBL: CHEMBL314010
- Wikipedia: Bevantolol
- chemspider: 2282
- CAS: 59170-23-9
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Juntong Zeng, Danwei Zhang, Shen Lin, Xiaoting Su, Peng Wang, Yan Zhao, Zhe Zheng. Comparative analysis of machine learning vs. traditional modeling approaches for predicting in-hospital mortality after cardiac surgery: temporal and spatial external validation based on a nationwide cardiac surgery registry.
European heart journal. Quality of care & clinical outcomes.
2024 Mar; 10(2):121-131. doi:
10.1093/ehjqcco/qcad028. [PMID: 37218710] - Li Ren, Zheng Wang, Yiceng Lou, Lu Zheng, Heng Zheng, Chunping Yin. Determination of bevantolol in human plasma using liquid chromatography-electrospray ionization tandem mass spectrometry and its application to a bioequivalence study.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2014 May; 959(?):16-21. doi:
10.1016/j.jchromb.2014.03.040. [PMID: 24747519] - Manthena V S Varma, Bo Feng, R Scott Obach, Matthew D Troutman, Jonathan Chupka, Howard R Miller, Ayman El-Kattan. Physicochemical determinants of human renal clearance.
Journal of medicinal chemistry.
2009 Aug; 52(15):4844-52. doi:
10.1021/jm900403j. [PMID: 19445515] - R Scott Obach, Franco Lombardo, Nigel J Waters. Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Drug metabolism and disposition: the biological fate of chemicals.
2008 Jul; 36(7):1385-405. doi:
10.1124/dmd.108.020479. [PMID: 18426954] - Takahiro Horinouchi, Shigeru Morishima, Takashi Tanaka, Fumiko Suzuki, Yoshio Tanaka, Katsuo Koike, Soichi Miwa, Ikunobu Muramatsu. Different changes of plasma membrane beta-adrenoceptors in rat heart after chronic administration of propranolol, atenolol and bevantolol.
Life sciences.
2007 Jul; 81(5):399-404. doi:
10.1016/j.lfs.2007.06.003. [PMID: 17628611] - Joung Weon Oh, Tran Quoc Trung, Kwan Seog Sin, Jong Seong Kang, Kyeong Ho Kim. Determination of bevantolol enantiomers in human plasma by coupled achiral-chiral high performance-liquid chromatography.
Chirality.
2007 Jul; 19(7):528-35. doi:
10.1002/chir.20410. [PMID: 17457831] - Tran Quoc Trung, Pham Hai Long, Ahmed M Al-Abd, Hyo Jeong Ku, Ho Yoon Lee, Sung Joo Hwang, Kyeong Ho Kim. Determination of bevantolol in human plasma by high performance liquid chromatography using solid phase extraction technique.
Archives of pharmacal research.
2007 Jul; 30(7):890-7. doi:
10.1007/bf02978842. [PMID: 17703743] - Yuji Hara, Mareomi Hamada, Yuji Shigematsu, Tomoaki Ohtsuka, Akiyoshi Ogimoto, Jitsuo Higaki. Effect of beta-blockers on insulin resistance in patients with dilated cardiomyopathy.
Circulation journal : official journal of the Japanese Circulation Society.
2003 Aug; 67(8):701-4. doi:
10.1253/circj.67.701. [PMID: 12890914] - Yuji Hara, Mareomi Hamada, Tomoaki Ohtsuka, Akiyoshi Ogimoto, Hideyuki Saeki, Tsuyoshi Matsunaka, Jun Suzuki, Yuji Shigematsu. Comparison of treatment effects of bevantolol and metoprolol on cardiac function and natriuretic peptides in patients with dilated cardiomyopathy.
Heart and vessels.
2002 Dec; 17(2):53-6. doi:
10.1007/s003800200043. [PMID: 12541094] - J Sasaki, G Kajiyama, R Kusukawa, H Mori, S Koga, R Takagi, N Tanaka, N Ogawa, K Arakawa. Effect of bevantolol and propranolol on serum lipids in patients with essential hypertension.
International journal of clinical pharmacology and therapeutics.
1994 Dec; 32(12):660-4. doi:
NULL. [PMID: 7881705] - H Y Aboul-Enein, V Serignese. Direct enantioselective separation of bevantolol by high-performance liquid chromatography on normal and reverse cellulose chiral stationary phases.
Biomedical chromatography : BMC.
1994 Jan; 8(1):22-5. doi:
10.1002/bmc.1130080106. [PMID: 8130628] - X Q Liu, X L Ye, H Q Zhu, S K Huang. Plasma bevantolol concentration and heart rate in rabbits.
Zhongguo yao li xue bao = Acta pharmacologica Sinica.
1993 May; 14(3):200-2. doi:
NULL. [PMID: 7901961] - S E Rose, E J Randinitis. A high-performance liquid chromatographic assay for the enantiomers of bevantolol in human plasma.
Pharmaceutical research.
1991 Jun; 8(6):758-62. doi:
10.1023/a:1015858219018. [PMID: 1676512] - P G Fernandez, W Snedden, S Vasdev, P Bolli. Bevantolol attenuates thiazide stimulated renin secretion and catecholamine release in diuretic resistant hypertensives.
The Canadian journal of cardiology.
1989 Mar; 5(2):93-7. doi:
NULL. [PMID: 2565158] - W Snedden, P G Fernandez, S Vasdev, P Bolli. Hemodynamic and adrenergic responses of bevantolol and propranolol in hypertensives.
The Canadian journal of cardiology.
1989 Jan; 5(1):37-41. doi:
NULL. [PMID: 2563955] - S Nattel, S Lawand, C Matthews, J McCans. Bevantolol disposition in patients with hepatic cirrhosis.
Journal of clinical pharmacology.
1987 Dec; 27(12):962-6. doi:
10.1002/j.1552-4604.1987.tb05597.x. [PMID: 2893814] - M Solimon, S G Massry, V M Campese. Renal hemodynamics and pharmacokinetics of bevantolol in patients with impaired renal function.
The American journal of cardiology.
1986 Nov; 58(12):21E-24E. doi:
10.1016/0002-9149(86)90593-x. [PMID: 2878596] - H R Kaplan. Pharmacology of bevantolol hydrochloride.
The American journal of cardiology.
1986 Nov; 58(12):3E-7E. doi:
10.1016/0002-9149(86)90590-4. [PMID: 2878599] - J J McNeil, O H Drummer, A I Anderson, W J Louis. Pharmacokinetics and concentration--effect relationships of bevantolol (CI-775) in normal volunteers.
Journal of cardiovascular pharmacology.
1986 Nov; 8(6):1201-7. doi:
10.1097/00005344-198611000-00016. [PMID: 2434747] - J R Latts. Clinical pharmacokinetics and metabolism of bevantolol.
Angiology.
1986 Mar; 37(3 Pt 2):221-5. doi:
10.1177/000331978603700313. [PMID: 2871781] - H R Kaplan. Bevantolol hydrochloride--preclinical pharmacologic profile.
Angiology.
1986 Mar; 37(3 Pt 2):254-62. doi:
10.1177/000331978603700319. [PMID: 2871786] - A Selen, A W Kinkel, A C Darke, D S Greene, P G Welling. Comparative single dose and steady-state pharmacokinetics of bevantolol in young and elderly subjects.
European journal of clinical pharmacology.
1986; 30(6):699-704. doi:
10.1007/bf00608218. [PMID: 2876899] - P Vermeij, P van Brummelen. Pharmacokinetic parameters of bevantolol in volunteers.
European journal of clinical pharmacology.
1986; 30(3):375-7. doi:
10.1007/bf00541549. [PMID: 2874033] - E J Randinitis, C Nelson, A W Kinkel. Gas chromatographic determination of bevantolol in plasma.
Journal of chromatography.
1984 Jun; 308(?):345-9. doi:
10.1016/s0021-9673(01)87565-8. [PMID: 6146636] - D C Warltier, G J Gross, G J Jesmok, H L Brooks, H F Hardman. Protection of ischemic myocardium: comparison of effects of propranolol, bevantolol and N-dimethyl propranolol on infarct size following coronary artery occlusion in anesthetized dogs.
Cardiology.
1980; 66(3):133-46. doi:
10.1159/000170859. [PMID: 6105914]