Telbivudine (BioDeep_00000033312)
human metabolite blood metabolite Chemicals and Drugs
代谢物信息卡片
1-[(2S,4R,5S)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-methyl-1,2,3,4-tetrahydropyrimidine-2,4-dione
化学式: C10H14N2O5 (242.0903)
中文名称: 替比夫定
谱图信息:
最多检出来源 Homo sapiens(urine) 85.71%
分子结构信息
SMILES: CC1=CN(C(=O)NC1=O)C2CC(C(O2)CO)O
InChI: InChI=1S/C10H14N2O5/c1-5-3-12(10(16)11-9(5)15)8-2-6(14)7(4-13)17-8/h3,6-8,13-14H,2,4H2,1H3,(H,11,15,16)/t6-,7+,8+/m1/s1
描述信息
Telbivudine is only found in individuals that have used or taken this drug. It is a synthetic thymidine nucleoside analog with specific activity against the hepatitis B virus. Telbivudine is orally administered, with good tolerance, lack of toxicity and no dose-limiting side effects.Telbivudine 5–triphosphate inhibits HBV DNA polymerase (reverse transcriptase) by competing with the natural substrate, thymidine 5–triphosphate. This leads to the chain termination of DNA synthesis, thereby inhibiting viral replication. Incorporation of telbivudine 5–triphosphate into viral DNA also causes DNA chain termination, resulting in inhibition of HBV replication. Telbivudine inhibits anticompliment or second-strand DNA.
J - Antiinfectives for systemic use > J05 - Antivirals for systemic use > J05A - Direct acting antivirals > J05AF - Nucleoside and nucleotide reverse transcriptase inhibitors
C471 - Enzyme Inhibitor > C1589 - Reverse Transcriptase Inhibitor > C97452 - Nucleoside Reverse Transcriptase Inhibitor
D004791 - Enzyme Inhibitors > D019384 - Nucleic Acid Synthesis Inhibitors
D000890 - Anti-Infective Agents > D000998 - Antiviral Agents
C254 - Anti-Infective Agent > C281 - Antiviral Agent
Telbivudine (Epavudine), an orally active thymidine nucleoside analog, is a potent antiviral inhibitor of hepatitis B virus (HBV) replication[1].
同义名列表
23 个代谢物同义名
1-[(2S,4R,5S)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-methyl-1,2,3,4-tetrahydropyrimidine-2,4-dione; 1-(2-Deoxy-beta-L-erythropentafuranosyl)-5-methyl-2,4(1H,3H)-pyrimidinedione; 1-(2-Deoxy-beta-L-ribofuranosyl)-5-methyluracil; 1-(2-Deoxy-b-L-ribofuranosyl)-5-methyluracil; 1-(2-Deoxy-β-L-ribofuranosyl)-5-methyluracil; beta-L-2-Deoxythymidine; beta L 2 Deoxythymidine; Β-L-2-deoxythymidine; b-L-2-Deoxythymidine; 2-Deoxy-L-thymidine; Beta-L-Thymidine; L-Deoxythymidine; ABBR LDT; b-L-Thymidine; Β-L-thymidine; Telbivudine; L-Thymidine; Telbivudin; Epavudine; Tyzeka; L-DT; LDT; NV 02B
数据库引用编号
10 个数据库交叉引用编号
- ChEBI: CHEBI:63624
- PubChem: 159269
- HMDB: HMDB0015394
- DrugBank: DB01265
- ChEMBL: CHEMBL374731
- Wikipedia: Telbivudine
- MeSH: Telbivudine
- chemspider: 140081
- CAS: 3424-98-4
- medchemexpress: HY-B0017
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
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BMC pharmacology & toxicology.
2015 Dec; 16(?):38. doi:
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Scientific reports.
2015 Nov; 5(?):17123. doi:
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The Journal of general virology.
2015 Nov; 96(11):3302-3312. doi:
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Journal of pharmaceutical and biomedical analysis.
2015 Oct; 114(?):127-32. doi:
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Advances in therapy.
2015 Aug; 32(8):727-41. doi:
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Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society.
2015 Aug; 21(8):1066-75. doi:
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Journal of viral hepatitis.
2015 Jul; 22(7):574-80. doi:
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Antiviral research.
2015 Jun; 118(?):10-9. doi:
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Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology.
2015 Jun; 23(6):407-11. doi:
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The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases.
2015 May; 19(3):291-5. doi:
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Medicine.
2015 Apr; 94(15):e646. doi:
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Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban.
2015 Apr; 35(2):230-234. doi:
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The Journal of international medical research.
2015 Apr; 43(2):161-72. doi:
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2015 Apr; 37(3):459-61. doi:
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World journal of gastroenterology.
2015 Feb; 21(8):2504-9. doi:
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Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology.
2015 Jan; 23(1):9-12. doi:
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Journal of Ayub Medical College, Abbottabad : JAMC.
2015 Jan; 27(1):241-2. doi:
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Journal of viral hepatitis.
2014 Dec; 21(12):873-81. doi:
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Scandinavian journal of gastroenterology.
2014 Dec; 49(12):1456-64. doi:
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Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association.
2014 Nov; 20(6):350-5. doi:
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Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology.
2014 Oct; 61(2):199-203. doi:
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Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology.
2014 Aug; 22(8):573-6. doi:
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Immunology letters.
2014 Jul; 160(1):65-71. doi:
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European journal of gastroenterology & hepatology.
2014 Apr; 26(4):396-403. doi:
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Transplant infectious disease : an official journal of the Transplantation Society.
2014 Apr; 16(2):295-303. doi:
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Journal of gastroenterology and hepatology.
2014 Mar; 29(3):428-34. doi:
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Journal of gastroenterology and hepatology.
2014 Mar; 29(3):568-75. doi:
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Liver international : official journal of the International Association for the Study of the Liver.
2014 Feb; 34 Suppl 1(?):146-53. doi:
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Alimentary pharmacology & therapeutics.
2014 Jan; 39(1):35-46. doi:
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Acta medica Indonesiana.
2014 Jan; 46(1):38-43. doi:
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Gastroenterology.
2014 Jan; 146(1):138-146.e5. doi:
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Journal of medical virology.
2013 Nov; 85(11):1907-12. doi:
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Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research.
2013 Oct; 33(10):612-8. doi:
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Viral immunology.
2013 Oct; 26(5):336-42. doi:
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World journal of gastroenterology.
2013 Sep; 19(33):5575-80. doi:
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Antimicrobial agents and chemotherapy.
2013 Sep; 57(9):4128-33. doi:
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Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology.
2013 Aug; 21(8):570-4. doi:
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Chinese medical journal.
2013 Jun; 126(12):2333-6. doi:
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Journal of medical virology.
2013 Jun; 85(6):996-1004. doi:
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Journal of viral hepatitis.
2013 Jun; 20(6):422-9. doi:
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Journal of viral hepatitis.
2013 Apr; 20(4):e37-46. doi:
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Journal of viral hepatitis.
2013 Apr; 20 Suppl 1(?):18-26. doi:
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Journal of viral hepatitis.
2013 Apr; 20 Suppl 1(?):58-64. doi:
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Journal of viral hepatitis.
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