Sertaconazole (BioDeep_00000033302)

   

human metabolite blood metabolite Chemicals and Drugs


代谢物信息卡片


1-{2-[(7-chloro-1-benzothiophen-3-yl)methoxy]-2-(2,4-dichlorophenyl)ethyl}-1H-imidazole

化学式: C20H15Cl3N2OS (435.997063)
中文名称: 舍他康唑
谱图信息: 最多检出来源 Ailuropoda melanoleuca(urine) 9.09%

分子结构信息

SMILES: C1=CC2=C(C(=C1)Cl)SC=C2COC(CN3C=CN=C3)C4=C(C=C(C=C4)Cl)Cl
InChI: InChI=1S/C20H15Cl3N2OS/c21-14-4-5-16(18(23)8-14)19(9-25-7-6-24-12-25)26-10-13-11-27-20-15(13)2-1-3-17(20)22/h1-8,11-12,19H,9-10H2

描述信息

Sertaconazole is only found in individuals that have used or taken this drug. Sertaconazole nitrate is an antifungal medication of the imidazole class. It is available as a cream to treat skin infections such as athletes foot. [Wikipedia]Sertaconazole interacts with 14-alpha demethylase, a cytochrome P-450 enzyme necessary to convert lanosterol to ergosterol. As ergosterol is an essential component of the fungal cell membrane, inhibition of its synthesis results in increased cellular permeability causing leakage of cellular contents. Sertaconazole may also inhibit endogenous respiration, interact with membrane phospholipids, inhibit the transformation of yeasts to mycelial forms, inhibit purine uptake, and impair triglyceride and/or phospholipid biosynthesis.
G - Genito urinary system and sex hormones > G01 - Gynecological antiinfectives and antiseptics > G01A - Antiinfectives and antiseptics, excl. combinations with corticosteroids > G01AF - Imidazole derivatives
D - Dermatologicals > D01 - Antifungals for dermatological use > D01A - Antifungals for topical use > D01AC - Imidazole and triazole derivatives
D000890 - Anti-Infective Agents > D000935 - Antifungal Agents
C254 - Anti-Infective Agent > C514 - Antifungal Agent

同义名列表

11 个代谢物同义名

1-{2-[(7-chloro-1-benzothiophen-3-yl)methoxy]-2-(2,4-dichlorophenyl)ethyl}-1H-imidazole; Sertaconazole mononitrate; Sertaconazole nitrate; sertaconazole; Ginedermofix; Dermoseptic; Mykosert; Dermofix; Demofix; Ertaczo; Zalain



数据库引用编号

8 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

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代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Ruolan Liu, Qiong Li, Siyuan Qin, Ling Qiao, Mei Yang, Shanshan Liu, Edouard C Nice, Wei Zhang, Canhua Huang, Shaojiang Zheng, Wei Gao. Sertaconazole-repurposed nanoplatform enhances lung cancer therapy via CD44-targeted drug delivery. Journal of experimental & clinical cancer research : CR. 2023 Jul; 42(1):188. doi: 10.1186/s13046-023-02766-2. [PMID: 37507782]
  • Romain Marteau, Séverine Ravez, Darius Mazhari Dorooee, Hind Bouchaoui, Karine Porte, Jean-Christophe Devedjian, Patricia Melnyk, David Devos, Raphaël Frédérick, Jamal El Bakali. Repositioning of FDA-Approved antifungal agents to interrogate Acyl-CoA synthetase long chain family member 4 (ACSL4) in ferroptosis. Biochemical pharmacology. 2022 Oct; 204(?):115239. doi: 10.1016/j.bcp.2022.115239. [PMID: 36075462]
  • Maha M Abou El-Alamin, Maha A Sultan, Mostafa A Atia, Hassan Y Aboul-Enein. Novel Application of Pentabromobenzyl Column for Simultaneous Determination of Eight Antifungal Drugs Using High-performance Liquid Chromatography. Combinatorial chemistry & high throughput screening. 2020; 23(10):991-1001. doi: 10.2174/1386207323666200220114818. [PMID: 32077818]
  • Naser Tavakoli, Somayeh Taymouri, Anahita Saeidi, Vajihe Akbari. Thermosensitive hydrogel containing sertaconazole loaded nanostructured lipid carriers for potential treatment of fungal keratitis. Pharmaceutical development and technology. 2019 Sep; 24(7):891-901. doi: 10.1080/10837450.2019.1616755. [PMID: 31062987]
  • Yuanyuan Wang, Lulu Pang, Manying Wu, Ning Ou. A validated LC-MS/MS method for determination of sertaconazole nitrate in human plasma. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2009 Dec; 877(31):4047-50. doi: 10.1016/j.jchromb.2009.09.032. [PMID: 19889586]
  • Jamie D Croxtall, Greg L Plosker. Sertaconazole: a review of its use in the management of superficial mycoses in dermatology and gynaecology. Drugs. 2009; 69(3):339-59. doi: 10.2165/00003495-200969030-00009. [PMID: 19275277]
  • Rudy Susilo, Hans C Korting, Wolfgang Greb, Uwe Phillip Strauss. Nail penetration of sertaconazole with a sertaconazole-containing nail patch formulation. American journal of clinical dermatology. 2006; 7(4):259-62. doi: 10.2165/00128071-200607040-00007. [PMID: 16901186]
  • J Agut, M Moren, M Rego, A Sacristán, J A Ortiz. Pharmacokinetic evaluation of labelled sertaconazole after dermal application. Arzneimittel-Forschung. 1992 May; 42(5A):748-51. doi: NULL. [PMID: 1627198]
  • M Farré, B Ugena, J M Badenas, M Márquez, P Roset, J A Ortiz. Pharmacokinetics and tolerance of sertaconazole in man after repeated percutaneous administration. Arzneimittel-Forschung. 1992 May; 42(5A):752-4. doi: NULL. [PMID: 1627199]
  • A Romero, F Villamayor, M T Grau, A Sacristán, J A Ortiz. Chronic toxicity studies of sertaconazole after oral administration to rats and ferrets. Arzneimittel-Forschung. 1992 May; 42(5A):732-8. doi: NULL. [PMID: 1627194]