Pemirolast (BioDeep_00000033273)

   

human metabolite blood metabolite


代谢物信息卡片


9-methyl-3-(2H-1,2,3,4-tetrazol-5-yl)-4H-pyrido[1,2-a]pyrimidin-4-one

化学式: C10H8N6O (228.07595579999997)
中文名称: 吡嘧司特
谱图信息: 最多检出来源 Homo sapiens(blood) 28.19%

分子结构信息

SMILES: CC1=CC=CN2C(=O)C(=CN=C12)C1=NNN=N1
InChI: InChI=1S/C10H8N6O/c1-6-3-2-4-16-9(6)11-5-7(10(16)17)8-12-14-15-13-8/h2-5H,1H3,(H,12,13,14,15)

描述信息

Pemirolast potassium is a slightly yellow powder that is soluble in water. It is a mast cell stabilizer that acts as an antiallergic agent. As an ophthalmic aqueous sterile solution, pemirolast is used for the prevention of itching of the eyes caused by allergies such as hay fever, and allergic conjunctivitis. Pemirolast is potentially useful for prophylaxis of pulmonary hypersensitivity reactions to drugs such as paclitaxel.
C78273 - Agent Affecting Respiratory System > C29712 - Anti-asthmatic Agent > C29714 - Mast Cell Stabilizer
D018377 - Neurotransmitter Agents > D018494 - Histamine Agents > D006633 - Histamine Antagonists

同义名列表

9 个代谢物同义名

9-methyl-3-(2H-1,2,3,4-tetrazol-5-yl)-4H-pyrido[1,2-a]pyrimidin-4-one; 9-Methyl-3-(1H-tetrazol-5-yl)-4H-pyrido(1,2-a)pyrimidin-4-one; Pemirolast potassium salt; Pemiroplast potassium; Pemirolast potassium; pemirolast; Alamast; Pemirox; 9-TBX



数据库引用编号

8 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

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代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

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文献列表

  • Tadafumi Tamura. Olopatadine ophthalmic solution suppresses substance P release in the conjunctivitis models. Asia Pacific allergy. 2012 Apr; 2(2):115-21. doi: 10.5415/apallergy.2012.2.2.115. [PMID: 22701861]
  • Samia Yazid, Egle Solito, Helen Christian, Simon McArthur, Nicolas Goulding, Roderick Flower. Cromoglycate drugs suppress eicosanoid generation in U937 cells by promoting the release of Anx-A1. Biochemical pharmacology. 2009 Jun; 77(12):1814-26. doi: 10.1016/j.bcp.2009.03.010. [PMID: 19428336]
  • Tomohito Gohda, Chisei Ra, Chieko Hamada, Toshinao Tsuge, Hiroshi Kawachi, Yasuhiko Tomino. Suppressive activity of pemirolast potassium, an antiallergic drug, on glomerulonephritis. Studies in glomerulonephritis model rats and in patients with chronic glomerulonephritis concurrently affected by allergic rhinitis. Arzneimittel-Forschung. 2008; 58(1):18-23. doi: 10.1055/s-0031-1296461. [PMID: 18368946]
  • Hideaki Yahata, Mami Saito, Toshiaki Sendo, Yoshinori Itoh, Mayako Uchida, Toshio Hirakawa, Hitoo Nakano, Ryozo Oishi. Prophylactic effect of pemirolast, an antiallergic agent, against hypersensitivity reactions to paclitaxel in patients with ovarian cancer. International journal of cancer. 2006 May; 118(10):2636-8. doi: 10.1002/ijc.21680. [PMID: 16353140]
  • Mayumi Kunitomo, Hirokuni Otsuka. Comparison of antigen-induced leukotriene and histamine release from nasal scrapings in allergic rhinitis. Rhinology. 2005 Sep; 43(3):199-204. doi: NULL. [PMID: 16218513]
  • Yoshinori Itoh, Toshiaki Sendo, Toshio Hirakawa, Shinya Takasaki, Takeshi Goromaru, Hitoo Nakano, Ryozo Oishi. Pemirolast potently attenuates paclitaxel hypersensitivity reactions through inhibition of the release of sensory neuropeptides in rats. Neuropharmacology. 2004 May; 46(6):888-94. doi: 10.1016/j.neuropharm.2003.11.018. [PMID: 15033348]
  • T Hasegawa, K Takagi, M Nadai, Y Ogura, T Nabeshima. Kinetic interaction between theophylline and a newly developed anti-allergic drug, pemirolast potassium. European journal of clinical pharmacology. 1994; 46(1):55-8. doi: 10.1007/bf00195916. [PMID: 8005187]
  • Y Yanagihara, H Kasai, S Matsui, K Ninomiya. Immunopharmacological studies on TBX, a new antiallergic drug (3). Inhibitory effects on histamine release from lung fragments and bronchoconstriction in guinea pigs. Japanese journal of pharmacology. 1989 Sep; 51(1):83-92. doi: 10.1254/jjp.51.83. [PMID: 2478743]
  • H Cheng, K A Pittman, K A Dandekar. Liquid chromatographic determination of 9-methyl-3-(1H-tetrazol-5-yl)-4H-pyrido[1,2-a]pyrimidin-4-one in human plasma with fluorescence detection. Journal of pharmaceutical sciences. 1987 Dec; 76(12):918-9. doi: 10.1002/jps.2600761216. [PMID: 2894450]