Benzonatate (BioDeep_00000033269)

   

human metabolite blood metabolite Chemicals and Drugs


代谢物信息卡片


2-[2-[2-[2-[2-[2-[2-[2-(2-Methoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethyl 4-butylaminobenzoic acid

化学式: C30H53NO11 (603.3618428)
中文名称: 苯佐那酯
谱图信息: 最多检出来源 Homo sapiens(blood) 28.13%

分子结构信息

SMILES: CCCCNC1=CC=C(C=C1)C(=O)OCCOCCOCCOCCOCCOCCOCCOCCOCCOC
InChI: InChI=1S/C30H53NO11/c1-3-4-9-31-29-7-5-28(6-8-29)30(32)42-27-26-41-25-24-40-23-22-39-21-20-38-19-18-37-17-16-36-15-14-35-13-12-34-11-10-33-2/h5-8,31H,3-4,9-27H2,1-2H3

描述信息

Benzonatate is a non-narcotic oral antitussive (cough suppressant) drug which works by anesthetizing the tissues of the lungs and pleura responsible for the cough reflex. It is chemically related to other ester anesthetics such as procaine. It has an anesthetic (numbing) action similar to that of benzocaine and numbs the stretch sensors in the lungs. It is the stretching of these sensors with breathing that causes the cough. It was approved by the FDA in 1958.
R - Respiratory system > R05 - Cough and cold preparations > R05D - Cough suppressants, excl. combinations with expectorants
C78273 - Agent Affecting Respiratory System > C66917 - Antitussive Agent
D019141 - Respiratory System Agents > D000996 - Antitussive Agents
D002491 - Central Nervous System Agents

同义名列表

20 个代谢物同义名

2-[2-[2-[2-[2-[2-[2-[2-(2-Methoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethyl 4-butylaminobenzoic acid; 2-[2-[2-[2-[2-[2-[2-[2-(2-Methoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethyl 4-butylaminobenzoate; 4-(Butylamino)benzoic acid 3,6,9,12,15,18,21,24,27-nonaoxaoctacos-1-yl ester; 2,5,8,11,14,17,20,23,26-Nonaoxaoctacosan-28-yl p-(butylamino)benzoic acid; 4-(Butylamino)benzoate 3,6,9,12,15,18,21,24,27-nonaoxaoctacos-1-yl ester; 2,5,8,11,14,17,20,23,26-Nonaoxaoctacosan-28-yl p-(butylamino)benzoate; 2,5,8,11,14,17,20,23,26-nonaoxaoctacosan-28-yl 4-(butylamino)benzoate; 3,6,9,12,15,18,21,24,27-Nonaoxaoctacosyl 4-butylaminobenzoic acid; p-Butylaminobenzoic acid omega-O-methylnonaethyleneglycol ester; Nonaethyleneglycol monomethyl ether p-N-butylaminobenzoic acid; 3,6,9,12,15,18,21,24,27-Nonaoxaoctacosyl 4-butylaminobenzoate; p-Butylaminobenzoate omega-O-methylnonaethyleneglycol ester; Nonaethyleneglycol monomethyl ether p-N-butylaminobenzoate; Benzonatic acid; Tessalon perles; Benzononatine; Benzonatatum; Benzonatato; Benzonatate; Tessalon



数据库引用编号

8 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

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INOH(0)

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1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

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文献列表

  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Jiayu Man, Feifei Jiao, Yiya Wang, Yueqing Gu, Li Ding, Chang Shu. Determination of benzonatate and its metabolite in human plasma by HPLC-MS/MS: A preliminary pharmacokinetic study in healthy Chinese volunteers after oral administration of benzonatate soft capsule. Journal of pharmaceutical and biomedical analysis. 2019 Sep; 173(?):134-143. doi: 10.1016/j.jpba.2019.05.030. [PMID: 31129533]
  • Steve Teo, Madhav Paranjpe, Marie Mckeon, Peter Mann, Sophie Lee, Richard LaRock, Tom Brown. The Antitussive Benzonatate Is Not Tumorigenic in Rodent Carcinogenicity Studies. Toxicologic pathology. 2018 08; 46(6):683-692. doi: 10.1177/0192623318789130. [PMID: 30033829]
  • Steve Teo, Wannie Madraymootoo, Emily Dakoulas, Rohan Kulkarni, Marie McKeon. Genotoxicity assessment of the novel antitussive agent Benzonatate and its major metabolite. Mutation research. Genetic toxicology and environmental mutagenesis. 2018 May; 829-830(?):19-25. doi: 10.1016/j.mrgentox.2018.03.007. [PMID: 29704989]
  • Daniel J Warner, Hongming Chen, Louis-David Cantin, J Gerry Kenna, Simone Stahl, Clare L Walker, Tobias Noeske. Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification. Drug metabolism and disposition: the biological fate of chemicals. 2012 Dec; 40(12):2332-41. doi: 10.1124/dmd.112.047068. [PMID: 22961681]
  • Bassam Estfan, Declan Walsh. The cough from hell: diazepam for intractable cough in a patient with renal cell carcinoma. Journal of pain and symptom management. 2008 Nov; 36(5):553-8. doi: 10.1016/j.jpainsymman.2007.12.007. [PMID: 18440768]
  • B I Crouch, K A Knick, D J Crouch, K S Matsumura, D E Rollins. Benzonatate overdose associated with seizures and arrhythmias. Journal of toxicology. Clinical toxicology. 1998; 36(7):713-8. doi: 10.3109/15563659809162620. [PMID: 9865240]
  • J A Cohan, T J Manning, L Lukash, C Long, K R Ziminski, S E Conradi. Two fatalities resulting from Tessalon (benzonatate). Veterinary and human toxicology. 1986 Dec; 28(6):543-4. doi: NULL. [PMID: 3788039]
  • P Thorén, B Oberg. Studies on the endoanesthetic effects of lidocaine and benzonatate on non-medullated nerve endings in the left ventricle. Acta physiologica Scandinavica. 1981 Jan; 111(1):51-8. doi: 10.1111/j.1748-1716.1981.tb06704.x. [PMID: 7223452]
  • ". NEW AND non-official drugs: benzonatate. Journal of the American Medical Association. 1959 Aug; 170(16):1927-8. doi: ". [PMID: 13672794]