Meropenem (BioDeep_00000033261)

human metabolite blood metabolite Chemicals and Drugs

代谢物信息卡片

(4R,5S,6S)-3-{[(3S,5S)-5-(dimethylcarbamoyl)pyrrolidin-3-yl]sulfanyl}-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid

化学式: C17H25N3O5S (383.15148400000004)
中文名称: 美罗培南
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC1C2C(C(=O)N2C(=C1SC3CC(NC3)C(=O)N(C)C)C(=O)O)C(C)O
InChI: InChI=1S/C17H25N3O5S/c1-7-12-11(8(2)21)16(23)20(12)13(17(24)25)14(7)26-9-5-10(18-6-9)15(22)19(3)4/h7-12,18,21H,5-6H2,1-4H3,(H,24,25)/t7-,8-,9+,10+,11-,12-/m1/s1

描述信息

Meropenem is only found in individuals that have used or taken this drug.It is a broad-spectrum carbapenem antibiotic. It is active against Gram-positive and Gram-negative bacteria. The bactericidal activity of meropenem results from the inhibition of cell wall synthesis. Meropenem readily penetrates the cell wall of most Gram-positive and Gram-negative bacteria to reach penicillin-binding- protein (PBP) targets and interfere with the synthesis of the vital cell wall components, which leads to cell death. Its strongest affinities are toward PBPs 2, 3 and 4 of Escherichia coli and Pseudomonas aeruginosa; and PBPs 1, 2 and 4 of Staphylococcus aureus.
J - Antiinfectives for systemic use > J01 - Antibacterials for systemic use > J01D - Other beta-lactam antibacterials > J01DH - Carbapenems
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D013845 - Thienamycins
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D047090 - beta-Lactams
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D007769 - Lactams
C254 - Anti-Infective Agent > C258 - Antibiotic > C260 - Beta-Lactam Antibiotic
Meropenem (SM 7338) is a carbapenem antibiotic with broad-spectrum antibacterial activity. Meropenem has activity against susceptible and resistant N. gonorrhoeae (MIC value of 0.02-0.06 mg/mL), H. influenzae (MIC value of 0.03-0.12 mg/mL), and H. ducreyi (MIC value of 0.015-0.12 mg/mL)[1][2].

同义名列表

17 个代谢物同义名

(4R,5S,6S)-3-{[(3S,5S)-5-(dimethylcarbamoyl)pyrrolidin-3-yl]sulfanyl}-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid; (4R,5S,6S)-3-{[(3S,5S)-5-(dimethylcarbamoyl)pyrrolidin-3-yl]thio}-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid; (4R,5S,6S)-3-{[(3S,5S)-5-(dimethylcarbamoyl)pyrrolidin-3-yl]thio}-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate; (1R,5S,6S)-2-[(3S,5S)-5-DIMETHYLAMINOCARBONYLPYRROLIDIN-3-ylthio]-6-[(R)-1-hydroxyethyl]-1-methylcarbapen-2-em-3-carboxylIC ACID; (1R,5S,6S)-2-[(3S,5S)-5-DIMETHYLAMINOCARBONYLPYRROLIDIN-3-ylthio]-6-[(R)-1-hydroxyethyl]-1-methylcarbapen-2-em-3-carboxylate; 3-(5-Dimethylcarbamoylpyrrolidin-3-ylthio)-6-(1-hydroxyethyl)-4-methyl-7-oxo-1-azabicyclo(3.2.0)hept-2-ene-2-carboxylic acid; Meropenem anhydrous; Antibiotic SM 7338; Merrem i.v.; Meropenemum; Meropenem; Meronem; Merrem; Penem; Ronem; MEPM; SM 7338

数据库引用编号

13 个数据库交叉引用编号

ChEBI: CHEBI:43968
ChEBI: CHEBI:6770
PubChem: 441130
HMDB: HMDB0014898
DrugBank: DB00760
ChEMBL: CHEMBL127
Wikipedia: Meropenem
MeSH: Meropenem
chemspider: 389924
CAS: 119478-56-7
CAS: 96036-03-2
RefMet: Meropenem
medchemexpress: HY-13678

分类词条

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

9606 - Homo sapiens: -

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

文献列表

Guoxiu Xiang, Zhiwei Zhao, Shebin Zhang, Yimei Cai, Yuting He, Jianming Zeng, Cha Chen, Bin Huang. Porin deficiency or plasmid copy number increase mediated carbapenem-resistant Escherichia coli resistance evolution. Emerging microbes & infections. 2024 Dec; 13(1):2352432. doi: 10.1080/22221751.2024.2352432. [PMID: 38712634]
Elin Helset, Vesa Cheng, Hilde Sporsem, Christian Thorstensen, Ingvild Nordøy, Karianne Wiger Gammelsrud, Gorm Hanssen, Erica Ponzi, Jeffrey Lipman, Elisabeth von der Lippe. Meropenem pharmacokinetic/pharmacodynamic target attainment and clinical response in ICU patients: A prospective observational study. Acta anaesthesiologica Scandinavica. 2024 Apr; 68(4):502-511. doi: 10.1111/aas.14376. [PMID: 38286568]
Xi Qin, Yali Wu, Ya Zhao, Shangshang Qin, Qiuru Ji, Jinhao Jia, Mengqi Huo, Xiaoyu Zhao, Qing Ma, Xiaoyan Wang, Xiaofei Chen, Hui Zhang, Mingliang Zhang, Liuqing Yang, Weixia Li, Jinfa Tang. Revealing active constituents within traditional Chinese Medicine used for treating bacterial pneumonia, with emphasis on the mechanism of baicalein against multi-drug resistant Klebsiella pneumoniae. Journal of ethnopharmacology. 2024 Mar; 321(?):117488. doi: 10.1016/j.jep.2023.117488. [PMID: 38008277]
M Cem Şirin, Yasemin Cezaroğlu, E Sesli Çetin, Buket Arıdoğan, Diğdem Trak, Yasin Arslan. Antibacterial and antibiofilm efficacy of colistin & meropenem conjugated silver nanoparticles against Escherichia coli and Klebsiella pneumoniae. Journal of basic microbiology. 2023 Dec; 63(12):1397-1411. doi: 10.1002/jobm.202300440. [PMID: 37821405]
Yu-Hang Yan, Ting-Ting Zhang, Rong Li, Si-Yao Wang, Liu-Liu Wei, Xin-Yue Wang, Kai-Rong Zhu, Shan-Rui Li, Guo-Qing Liang, Zeng-Bao Yang, Ling-Ling Yang, Shangshang Qin, Guo-Bo Li. Discovery of 2-Aminothiazole-4-carboxylic Acids as Broad-Spectrum Metallo-β-lactamase Inhibitors by Mimicking Carbapenem Hydrolysate Binding. Journal of medicinal chemistry. 2023 Oct; 66(19):13746-13767. doi: 10.1021/acs.jmedchem.3c01189. [PMID: 37791640]
Saumya Singh, Taru Verma, Balaram Khamari, Eswarappa Pradeep Bulagonda, Dipankar Nandi, Siva Umapathy. Antimicrobial Resistance Studies Using Raman Spectroscopy on Clinically Relevant Bacterial Strains. Analytical chemistry. 2023 08; 95(30):11342-11351. doi: 10.1021/acs.analchem.3c01453. [PMID: 37463121]
Doris Yoong Wen Di, Guangxiang Cao, Chuanqing Zhong, Tao Yan. Diversity of blaPOM in carbapenem-resistant opportunistic pathogenic Pseudomonas otitidis in municipal wastewater. Journal of water and health. 2023 May; 21(5):560-570. doi: 10.2166/wh.2023.255. [PMID: 37254905]
Miroslava Kačániová, Nenad L Vukovic, Natália Čmiková, Lucia Galovičová, Marianna Schwarzová, Veronika Šimora, Przemysław Łukasz Kowalczewski, Maciej Ireneusz Kluz, Czeslaw Puchalski, Ladislav Bakay, Milena D Vukic. Salvia sclarea Essential Oil Chemical Composition and Biological Activities. International journal of molecular sciences. 2023 Mar; 24(6):. doi: 10.3390/ijms24065179. [PMID: 36982252]
Wei Zhang, Chun-Yu Yan, Shu-Rui Li, Ting-Ting Fan, Shan-Shan Cao, Bin Cui, Meng-Ying Li, Bo-Yuan Fan, Bo Ji, Li Wang, Fei Cui, Jia Cui, Lei Wang, Yue Guan, Jing-Wen Wang. Efficacy and safety of piperacillin-tazobactam compared with meropenem in treating complicated urinary tract infections including acute pyelonephritis due to extended-spectrum β-lactamase-producing Enterobacteriaceae. Frontiers in cellular and infection microbiology. 2023; 13(?):1093842. doi: 10.3389/fcimb.2023.1093842. [PMID: 37207190]
Rael J Too, George C Gitao, Lilly C Bebora, Dixie F Mollenkopf, Samuel M Kariuki, Thomas E Wittum. Frequency and diversity of carbapenemase-producing Enterobacterales recovered from untreated wastewater impacted by selective media containing cefotaxime and meropenem in Ohio, USA. PloS one. 2023; 18(2):e0281909. doi: 10.1371/journal.pone.0281909. [PMID: 36812188]
Murugan Thulasi Meenu, Grace Kaul, Abdul Akhir, Manjulika Shukla, Kokkuvayil Vasu Radhakrishnan, Sidharth Chopra. Developing the Natural Prenylflavone Artocarpin from Artocarpus hirsutus as a Potential Lead Targeting Pathogenic, Multidrug-Resistant Staphylococcus aureus, Persisters and Biofilms with No Detectable Resistance. Journal of natural products. 2022 10; 85(10):2413-2423. doi: 10.1021/acs.jnatprod.2c00621. [PMID: 36222797]
C Campo-Beleño, R A Villamizar-Gallardo, L E López-Jácome, E E González, S Muñoz-Carranza, B Franco, R Morales-Espinosa, R Coria-Jimenez, R Franco-Cendejas, M Hernández-Durán, R Lara-Martínez, L F Jiménez-García, A M Fernández-Presas, R García-Contreras. Biologically synthesized silver nanoparticles as potent antibacterial effective against multidrug-resistant Pseudomonas aeruginosa. Letters in applied microbiology. 2022 Sep; 75(3):680-688. doi: 10.1111/lam.13759. [PMID: 35687297]
Kshipra Rajpoot, Shiv Kumar Prajapati, Akanksha Malaiya, Richa Jain, Aakanchha Jain. Meropenem-Loaded Nanostructured Lipid Carriers For Skin and Soft Tissue Infection Caused by Staphylococcus aureus: Formulation, Design, and Evaluation. AAPS PharmSciTech. 2022 Aug; 23(7):241. doi: 10.1208/s12249-022-02381-y. [PMID: 36008695]
Christina König, Jörn Grensemann, Patrick Czorlich, Eckhard Schlemm, Stefan Kluge, Sebastian G Wicha. A dosing nomograph for cerebrospinal fluid penetration of meropenem applied by continuous infusion in patients with nosocomial ventriculitis. Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases. 2022 Jul; 28(7):1022.e9-1022.e16. doi: 10.1016/j.cmi.2022.02.017. [PMID: 35182756]
Passara Maimongkol, Wanlika Yonwises, Suvaporn Anugulruengkitt, Jiratchaya Sophonphan, Wanchai Treyaprasert, Noppadol Wacharachaisurapol. Therapeutic drug monitoring of meropenem and pharmacokinetic-pharmacodynamic target assessment in critically ill pediatric patients from a prospective observational study. International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases. 2022 Jul; 120(?):96-102. doi: 10.1016/j.ijid.2022.04.052. [PMID: 35489632]
Kiran Patil, Amin Pathan, Sukanta Naik, Vineet Zope, Rajesh Chavan, Ravindra Yeole. Simultaneous determination of novel β-lactamase inhibitor WCK 4234 and Meropenem in dog plasma by LC-MS/MS and its application to preclinical pharmacokinetic study. Biomedical chromatography : BMC. 2022 Jul; 36(7):e5377. doi: 10.1002/bmc.5377. [PMID: 35347720]
Tatjana Van Der Heggen, Evelyn Dhont, Jef Willems, Ingrid Herck, Joris R Delanghe, Veronique Stove, Alain G Verstraete, Sophie Vanhaesebrouck, Peter De Paepe, Pieter A J G De Cock. Suboptimal Beta-Lactam Therapy in Critically Ill Children: Risk Factors and Outcome. Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies. 2022 Jul; 23(7):e309-e318. doi: 10.1097/pcc.0000000000002951. [PMID: 35426861]
Taylor Abbey, Alesia Vialichka, Michele Jurkovic, Mark Biagi, Eric Wenzler. Activity of Omadacycline Alone and in Combination against Carbapenem-Nonsusceptible Acinetobacter baumannii with Varying Minocycline Susceptibility. Microbiology spectrum. 2022 06; 10(3):e0054222. doi: 10.1128/spectrum.00542-22. [PMID: 35647655]
Jinhua Lan, Zheng Wu, Xipei Wang, Yifan Wang, Fen Yao, Bo-Xin Zhao, Yirong Wang, Jingchun Chen, Chunbo Chen. Population Pharmacokinetics Analysis and Dosing Simulations Of Meropenem in Critically Ill Patients with Pulmonary Infection. Journal of pharmaceutical sciences. 2022 06; 111(6):1833-1842. doi: 10.1016/j.xphs.2022.01.015. [PMID: 35090867]
Nadheema Hammood Hussein, Sawsan Mohammed Kareem, Sanaa Noori Hussein Al-Kakei, Buthainah Mohammed Taha. The predominance of Klebsiella pneumoniae carbapenemase (KPC-type) gene among high-level carbapenem-resistant Klebsiella pneumoniae isolates in Baghdad, Iraq. Molecular biology reports. 2022 Jun; 49(6):4653-4658. doi: 10.1007/s11033-022-07314-3. [PMID: 35471622]
Viviane Chaiben, Carolina Hikari Yamada, João Paulo Telles, Ana Paula de Andrade, Lavinia Nery Villa Stangler Arend, Victoria Stadler Tasca Ribeiro, Leticia Ramos Dantas, Paula Hansen Suss, Felipe Francisco Tuon. A carbapenem-resistant Acinetobacter baumannii outbreak associated with a polymyxin shortage during the COVID pandemic: an in vitro and biofilm analysis of synergy between meropenem, gentamicin and sulbactam. The Journal of antimicrobial chemotherapy. 2022 05; 77(6):1676-1684. doi: 10.1093/jac/dkac102. [PMID: 35368079]
Shahbaz Ahmad, Farooq Ali, Sadaf Anwar Qureshi, Bibi Uzma, Qismat Shakeela, Muhammad Shehryar Sabir, Sajjad Ahmad, Ijazul Haq, Atia Rasheed, Shehzad Ahmed, Muhammad Farooq. The evaluation of antibiotic susceptibility pattern and associated risk factors of UTI in tertiary care hospital of Peshawar. Pakistan journal of pharmaceutical sciences. 2022 May; 35(3(Special)):897-903. doi: NULL. [PMID: 35791585]
David Busse, Philipp Simon, Lisa Schmitt, David Petroff, Christoph Dorn, Arne Dietrich, Markus Zeitlinger, Wilhelm Huisinga, Robin Michelet, Hermann Wrigge, Charlotte Kloft. Comparative Plasma and Interstitial Tissue Fluid Pharmacokinetics of Meropenem Demonstrate the Need for Increasing Dose and Infusion Duration in Obese and Non-obese Patients. Clinical pharmacokinetics. 2022 05; 61(5):655-672. doi: 10.1007/s40262-021-01070-6. [PMID: 34894344]
Haiwei Cao, Lei Yin, Haihuan Cao, Haiyang Guo, Wenbo Ren, Yanyan Li, Jing Huang. A sensitive and selective HPLC-MS3 method for therapeutic drug monitoring of meropenem and its validation by comparison with HPLC-MS2 methods. Journal of separation science. 2022 May; 45(10):1683-1692. doi: 10.1002/jssc.202200064. [PMID: 35247934]
Sareh Razzazzadeh, Ilad Alavi Darazam, Mohammadreaza Hajiesmaeili, Jamshid Salamzadeh, Arash Mahboubi, Ehsan Sadeghnezhad, Zahra Sahraei. Investigation of pharmacokinetic and clinical outcomes of various meropenem regimens in patients with ventilator-associated pneumonia and augmented renal clearance. European journal of clinical pharmacology. 2022 May; 78(5):823-829. doi: 10.1007/s00228-022-03291-5. [PMID: 35171317]
George G Zhanel, Marianna Pozdirca, Alyssa R Golden, Courtney K Lawrence, Sheryl Zelenitsky, Liam Berry, Frank Schweizer, Denice Bay, Heather Adam, Michael A Zhanel, Philippe Lagacé-Wiens, Andrew Walkty, Neal Irfan, Kurt Naber, Joseph P Lynch, James A Karlowsky. Sulopenem: An Intravenous and Oral Penem for the Treatment of Urinary Tract Infections Due to Multidrug-Resistant Bacteria. Drugs. 2022 Apr; 82(5):533-557. doi: 10.1007/s40265-022-01688-1. [PMID: 35294769]
Claudia Garcia Messiano, Ronaldo Morales Junior, Gabriela Otofuji Pereira, Elson Mendes da Silva Junior, David de Souza Gomez, Silvia Regina Cavani Jorge Santos. Therapeutic Target Attainment of 3-Hour Extended Infusion of Meropenem in Patients With Septic Burns. Clinical therapeutics. 2022 04; 44(4):624-629. doi: 10.1016/j.clinthera.2022.02.007. [PMID: 35260257]
Gabriele Bianco, Matteo Boattini, Sara Comini, Roberto Casale, Marco Iannaccone, Rossana Cavallo, Cristina Costa. Occurrence of multi-carbapenemases producers among carbapenemase-producing Enterobacterales and in vitro activity of combinations including cefiderocol, ceftazidime-avibactam, meropenem-vaborbactam, and aztreonam in the COVID-19 era. European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology. 2022 Apr; 41(4):573-580. doi: 10.1007/s10096-022-04408-5. [PMID: 35061145]
Dhakrit Rungkitwattanakul, Amy L Ives, Nicole G Harriott, Sarah Pan-Chen, Lan Duong. Comparative incidence of acute kidney injury in patients on vancomycin therapy in combination with cefepime, piperacillin-tazobactam or meropenem. Journal of chemotherapy (Florence, Italy). 2022 Apr; 34(2):103-109. doi: 10.1080/1120009x.2021.1965334. [PMID: 34424136]
S Hasan Radhi, S A Kamal, N Mohammed Sahi, H J Hussein. Assessment of Antibacterial Efficacy of Callistemon viminalis (Sol. ex Gaertn.) G. Don against Some Isolates Obtained from Urinary Tract Infections. Archives of Razi Institute. 2022 Apr; 77(2):891-897. doi: 10.22092/ari.2022.357125.1981. [PMID: 36284981]
Haiwei Cao, Yi Jiang, Shaomin Wang, Haihuan Cao, Yanyan Li, Jing Huang. Dried Plasma Spot Based LC-MS/MS Method for Monitoring of Meropenem in the Blood of Treated Patients. Molecules (Basel, Switzerland). 2022 Mar; 27(6):. doi: 10.3390/molecules27061991. [PMID: 35335353]
Suzanne L Parker, Steven C Wallis, Cheryl Fourie, Melissa Lassig-Smith, Therese Starr, Avinash Chikatamarla, Tavey Dorofaeff, Mark D Chatfield, Jeffrey Lipman, Jason A Roberts. Evaluation of low-volume plasma sampling for the analysis of meropenem in clinical samples. Analytical and bioanalytical chemistry. 2022 Mar; 414(6):2155-2162. doi: 10.1007/s00216-021-03851-1. [PMID: 34981148]
Gabriele Arcari, Alessandra Oliva, Federica Sacco, Federica Maria Di Lella, Giammarco Raponi, Dario Tomolillo, Ambrogio Curtolo, Mario Venditti, Alessandra Carattoli. Interplay between Klebsiella pneumoniae producing KPC-31 and KPC-3 under treatment with high dosage meropenem: a case report. European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology. 2022 Mar; 41(3):495-500. doi: 10.1007/s10096-021-04388-y. [PMID: 34988712]
Kiyoko Fujita, Iichiro Takata, Ippei Yoshida, Hajime Takashima, Hiroyuki Sugiyama. TP0586532, a non-hydroxamate LpxC inhibitor, reduces LPS release and IL-6 production both in vitro and in vivo. The Journal of antibiotics. 2022 03; 75(3):136-145. doi: 10.1038/s41429-021-00498-z. [PMID: 34987187]
Raouaa Maaroufi, Olfa Dziri, Linda Hadjadj, Seydina M Diene, Jean-Marc Rolain, Chedly Chouchani. Detection by Whole-Genome Sequencing of a Novel Metallo-β-Lactamase Produced by Wautersiella falsenii Causing Urinary Tract Infection in Tunisia. Polish journal of microbiology. 2022 Feb; 71(1):73-81. doi: 10.33073/pjm-2022-010. [PMID: 35635163]
Ali Jabareen, Laila Nassar, Marina Karasik, Edna Efrati, Amir Hadash, Imad Kassis, Daniel Kurnik. Individual Meropenem Clearance in Infants on ECMO and CVVHDF is Difficult to Predict: A Case Report and Review of the Literature. The Pediatric infectious disease journal. 2022 02; 41(2):117-120. doi: 10.1097/inf.0000000000003354. [PMID: 34966143]
Kiyoko Fujita, Iichiro Takata, Ippei Yoshida, Hirotoshi Okumura, Katsumasa Otake, Hajime Takashima, Hiroyuki Sugiyama. TP0586532, a non-hydroxamate LpxC inhibitor, has in vitro and in vivo antibacterial activities against Enterobacteriaceae. The Journal of antibiotics. 2022 02; 75(2):98-107. doi: 10.1038/s41429-021-00486-3. [PMID: 34837061]
Hadrien Winiszewski, Cyrielle Despres, Marc Puyraveau, Jennifer Lagoutte-Renosi, Damien Montange, Guillaume Besch, Sebastien Pili Floury, Claire Chaignat, Guylaine Labro, Lucie Vettoretti, Anne-Laure Clairet, Gilles Capellier, Berengère Vivet, Gael Piton. β-lactam dosing at the early phase of sepsis: Performance of a pragmatic protocol for target concentration achievement in a prospective cohort study. Journal of critical care. 2022 02; 67(?):141-146. doi: 10.1016/j.jcrc.2021.10.023. [PMID: 34768176]
Mitchell S Buckley, Ivan A Komerdelj, Paul A D'Alessio, Pooja Rangan, Sumit K Agarwal, Nicole C Tinta, Brandon K Martinez, Delia S Ziadat, Melanie J Yerondopoulos, Emir Kobic, Sandra L Kane-Gill. Vancomycin with concomitant piperacillin/tazobactam vs. cefepime or meropenem associated acute kidney injury in the critically ill: A multicenter propensity score-matched study. Journal of critical care. 2022 02; 67(?):134-140. doi: 10.1016/j.jcrc.2021.10.018. [PMID: 34768175]
Chongmei Tian, Mengyu Xing, Liping Fu, Yaping Zhao, Xueyu Fan, Siwei Wang. Emergence of uncommon KL38-OCL6-ST220 carbapenem-resistant Acinetobacter pittii strain, co-producing chromosomal NDM-1 and OXA-820 carbapenemases. Frontiers in cellular and infection microbiology. 2022; 12(?):943735. doi: 10.3389/fcimb.2022.943735. [PMID: 36034705]
Marie Griemsmann, Denis Grote-Koska, Markus Cornberg, Julius J Schmidt, Benjamin Maasoumy. Plasma and ascites pharmacokinetics of meropenem in patients with decompensated cirrhosis and spontaneous bacterial peritonitis. Journal of hepatology. 2022 01; 76(1):230-233. doi: 10.1016/j.jhep.2021.07.015. [PMID: 34310999]
Mohammad Sistanizad, Rezvan Hassanpour, Elham Pourheidar. Are Antibiotics Appropriately Dosed in Critically Ill Patients with Augmented Renal Clearance? A Narrative Review. International journal of clinical practice. 2022; 2022(?):1867674. doi: 10.1155/2022/1867674. [PMID: 35685541]
Chongmei Tian, Mengyu Xing, Yaping Zhao, Xueyu Fan, Yongfeng Bai, Liping Fu, Siwei Wang. Whole genome sequencing of OXA-232-producing wzi93-KL112-O1 carbapenem-resistant Klebsiella pneumoniae in human bloodstream infection co-harboring chromosomal ISEcp1-based bla CTX-M-15 and one rmpA2-associated virulence plasmid. Frontiers in cellular and infection microbiology. 2022; 12(?):984479. doi: 10.3389/fcimb.2022.984479. [PMID: 36250056]
Ieva Bartuseviciene, Vaidas Vicka, Alvita Vickiene, Lidija Tetianec, Marius Dagys, Donata Ringaitiene, Andrius Klimasauskas, Jurate Sipylaite. Conceptual model of adding antibiotics to dialysate fluid during renal replacement therapy. Scientific reports. 2021 12; 11(1):23836. doi: 10.1038/s41598-021-03450-1. [PMID: 34903805]
Ahmed S Fayed, Rania M Youssif, Nahla N Salama, Eman S Elzanfaly, Hassan A M Hendawy. Utility of Silver-nanoparticles for Nano Spectrofluorimetric Determination of Meropenem and Ertapenem: Bio-analytical Validation. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. 2021 Dec; 262(?):120077. doi: 10.1016/j.saa.2021.120077. [PMID: 34175763]
Liming Song, Yan Bai, Baoheng Ren, Yongsheng Wu, Fan He, Qingyuan Zhou. Meropenem improves inflammation, stress indexes and hepatic-renal function of rats with septic shock. Minerva medica. 2021 Dec; 112(6):825-826. doi: 10.23736/s0026-4806.20.07224-9. [PMID: 33464228]
Sofie Colman, Sofie Dhaese, Veronique Stove, Jan J De Waele, Alain G Verstraete. Pilot study of oral fluid and plasma meropenem and piperacillin concentrations in the intensive care unit. Clinica chimica acta; international journal of clinical chemistry. 2021 Dec; 523(?):72-76. doi: 10.1016/j.cca.2021.09.005. [PMID: 34508687]
Samit Ganguly, Andrea N Edginton, Jacqueline G Gerhart, Michael Cohen-Wolkowiez, Rachel G Greenberg, Daniel Gonzalez. Physiologically Based Pharmacokinetic Modeling of Meropenem in Preterm and Term Infants. Clinical pharmacokinetics. 2021 12; 60(12):1591-1604. doi: 10.1007/s40262-021-01046-6. [PMID: 34155614]
Anna Olsson, Marcus Hong, Hissa Al-Farsi, Christian G Giske, Pernilla Lagerbäck, Thomas Tängdén. Interactions of Polymyxin B in Combination with Aztreonam, Minocycline, Meropenem, and Rifampin against Escherichia coli Producing NDM and OXA-48-Group Carbapenemases. Antimicrobial agents and chemotherapy. 2021 11; 65(12):e0106521. doi: 10.1128/aac.01065-21. [PMID: 34516251]
Michael Paal, Christina Scharf, Ann Katrin Denninger, Luis Ilia, Charlotte Kloft, Nikolaus Kneidinger, Uwe Liebchen, Sebastian Michel, Christian Schneider, Sebastian Schröpf, Carina Schuster, Michael Vogeser, Ferdinand Weinelt, Johannes Zander, Michael Zoller, Ines Schroeder. Target Site Pharmacokinetics of Meropenem: Measurement in Human Explanted Lung Tissue by Bronchoalveolar Lavage, Microdialysis, and Homogenized Lung Tissue. Antimicrobial agents and chemotherapy. 2021 11; 65(12):e0156421. doi: 10.1128/aac.01564-21. [PMID: 34570645]
Isabella Westermann, Silke Gastine, Carsten Müller, Wiebke Rudolph, Frank Peters, Frank Bloos, Mathias Pletz, Stefan Hagel. Population pharmacokinetics and probability of target attainment in patients with sepsis under renal replacement therapy receiving continuous infusion of meropenem: Sustained low-efficiency dialysis and continuous veno-venous haemodialysis. British journal of clinical pharmacology. 2021 11; 87(11):4293-4303. doi: 10.1111/bcp.14846. [PMID: 33818823]
Li Peng, Xinyu Wang, Hongwan Dang. Simultaneous determination of meropenem and imipenem in rat plasma by LC-MS/MS and its application to a pharmacokinetic study. Biomedical chromatography : BMC. 2021 Nov; 35(11):e5185. doi: 10.1002/bmc.5185. [PMID: 34060114]
Murugan Thulasi Meenu, Grace Kaul, Manjulika Shukla, Kokkuvayil Vasu Radhakrishnan, Sidharth Chopra. Cudraflavone C from Artocarpus hirsutus as a Promising Inhibitor of Pathogenic, Multidrug-Resistant S. aureus, Persisters, and Biofilms: A New Insight into a Rational Explanation of Traditional Wisdom. Journal of natural products. 2021 10; 84(10):2700-2708. doi: 10.1021/acs.jnatprod.1c00578. [PMID: 34546736]
Arthur Hosmann, Lavinia Ritscher, Heinz Burgmann, Valentin Al Jalali, Beatrix Wulkersdorfer, Michael Wölfl-Duchek, Maria Sanz Codina, Walter Jäger, Stefan Poschner, Walter Plöchl, Andrea Reinprecht, Karl Rössler, Andreas Gruber, Markus Zeitlinger. Meropenem concentrations in brain tissue of neurointensive care patients exceed CSF levels. The Journal of antimicrobial chemotherapy. 2021 10; 76(11):2914-2922. doi: 10.1093/jac/dkab286. [PMID: 34392352]
Jazmin D Lee, Brett H Heintz, Hilary J Mosher, Daniel J Livorsi, Jason A Egge, Brian C Lund. Risk of Acute Kidney Injury and Clostridioides difficile Infection With Piperacillin/Tazobactam, Cefepime, and Meropenem With or Without Vancomycin. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 2021 10; 73(7):e1579-e1586. doi: 10.1093/cid/ciaa1902. [PMID: 33382398]
Yuichi Ichimura, Natsumi Kudoh, Takashi Murabe, Takumi Akao, Sho Watanuki, Takanao Suzuki, Toshihide Saito, Masako Oda, Hiroshi Saitoh. Inhibitory effects of indoxyl sulfate and creatinine on the renal transport of meropenem and biapenem in rats. Drug metabolism and pharmacokinetics. 2021 Oct; 40(?):100406. doi: 10.1016/j.dmpk.2021.100406. [PMID: 34352708]
Mohammad Yousef Memar, Mina Yekani, Hadi Ghanbari, Edris Nabizadeh, Sepideh Zununi Vahed, Solmaz Maleki Dizaj, Simin Sharifi. Antimicrobial and antibiofilm activities of meropenem loaded-mesoporous silica nanoparticles against carbapenem-resistant Pseudomonas aeruginosa. Journal of biomaterials applications. 2021 10; 36(4):605-612. doi: 10.1177/08853282211003848. [PMID: 33722086]
Victoria Lima-Rogel, Leticia Olguín-Mexquitic, Ingrid Kühn-Córdova, Tania Correa-López, Melissa Romano-Aguilar, María Del Carmen Romero-Méndez, Susanna Edith Medellín-Garibay, Silvia Romano-Moreno. Optimizing Meropenem Therapy for Severe Nosocomial Infections in Neonates. Journal of pharmaceutical sciences. 2021 Oct; 110(10):3520-3526. doi: 10.1016/j.xphs.2021.05.019. [PMID: 34089712]
José Antonio Hernández-Ramos, José Manuel Caro-Telle, Miguel Ángel Bruni-Montero, Dolores Canales-Siguero, José Miguel Ferrari-Piquero. Interaction between valproic acid and meropenem or ertapenem in patients with epilepsy: clinical relevance and results from pharmaceutical intervention. Farmacia hospitalaria : organo oficial de expresion cientifica de la Sociedad Espanola de Farmacia Hospitalaria. 2021 09; 45(6):335-339. doi: NULL. [PMID: 34806574]
Casin Le, Camila Pimentel, Marisel R Tuttobene, Tomas Subils, Brent Nishimura, German M Traglia, Federico Perez, Krisztina M Papp-Wallace, Robert A Bonomo, Marcelo E Tolmasky, Maria Soledad Ramirez. Interplay between Meropenem and Human Serum Albumin on Expression of Carbapenem Resistance Genes and Natural Competence in Acinetobacter baumannii. Antimicrobial agents and chemotherapy. 2021 09; 65(10):e0101921. doi: 10.1128/aac.01019-21. [PMID: 34280015]
Sarah Van Vooren, Jan J De Waele, Jerina Boelens, Michael Polet, Veronique Stove, Lynn Vanhaecke, Alain G Verstraete. Development and validation of a liquid chromatography high-resolution mass spectrometry orbitrap method for the sensitive quantification of amoxicillin, piperacillin, tazobactam and meropenem in human faeces. Analytica chimica acta. 2021 Sep; 1177(?):338760. doi: 10.1016/j.aca.2021.338760. [PMID: 34482897]
Matthew W Bjergum, Erin F Barreto, Marc H Scheetz, Andrew D Rule, Paul J Jannetto. Stability and Validation of a High-Throughput LC-MS/MS Method for the Quantification of Cefepime, Meropenem, and Piperacillin and Tazobactam in Serum. The journal of applied laboratory medicine. 2021 09; 6(5):1202-1212. doi: 10.1093/jalm/jfab036. [PMID: 34086904]
Luana Bojko, Gustavo de Paula Ripka, Laura Mattana Dionísio, Celso Luiz Borges, Danielle Cristyane Kalva Borato, Mariane de Faria Moss. Drug dosing using estimated glomerular filtration rate: Misclassification due to metamizole interference in a creatinine assay. Annals of clinical biochemistry. 2021 09; 58(5):474-480. doi: 10.1177/00045632211020029. [PMID: 34006123]
Abdullah Tarık Aslan, Tural Pashayev, Osman Dağ, Murat Akova. Comparison of teicoplanin versus vancomycin in combination with piperacillin-tazobactam or meropenem for the risk of acute kidney injury. European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology. 2021 Sep; 40(9):1953-1961. doi: 10.1007/s10096-021-04258-7. [PMID: 33884515]
Uwe Liebchen, Hanna Salletmeier, Simon Kallee, Christina Scharf, Lucas Huebner, Alexandra Weber, Michael Zoller. Optimal loading dose of meropenem before continuous infusion in critically ill patients: a simulation study. Scientific reports. 2021 08; 11(1):17211. doi: 10.1038/s41598-021-96744-3. [PMID: 34446780]
Salvatore Lucio Cutuli, Flavio De Maio, Gennaro De Pascale, Domenico Luca Grieco, Francesca Romana Monzo, Simone Carelli, Eloisa Sofia Tanzarella, Gabriele Pintaudi, Edoardo Piervincenzi, Laura Cascarano, Rikardo Xhemalaj, Maurizio Sanguinetti, Brunella Posteraro, Teresa Spanu, Massimo Antonelli. COVID-19 influences lung microbiota dynamics and favors the emergence of rare infectious diseases: A case report of Hafnia Alvei pneumonia. Journal of critical care. 2021 08; 64(?):173-175. doi: 10.1016/j.jcrc.2021.04.008. [PMID: 33957578]
Zhi-Qiang Wang, Zhi-Liang Guo, Hao Feng, Cheng Fu, Guang-Yuan Zhao, Ke Ma, Lan Zhu, Gang Chen. Treatment of Donor-derived Carbapenem-resistant Klebsiella pneumoniae Infection after Renal Transplantation with Tigecycline and Extended-infusion Meropenem. Current medical science. 2021 Aug; 41(4):770-776. doi: 10.1007/s11596-021-2397-z. [PMID: 34403102]
Renata Černá Pařízková, Jiřina Martínková, Eduard Havel, Petr Šafránek, Milan Kaška, David Astapenko, Jan Bezouška, Jaroslav Chládek, Vladimír Černý. Impact of cumulative fluid balance on the pharmacokinetics of extended infusion meropenem in critically ill patients with sepsis. Critical care (London, England). 2021 07; 25(1):251. doi: 10.1186/s13054-021-03680-9. [PMID: 34274013]
Adrien Contejean, Caroline Charlier, Jean-Marc Treluyer, Solen Kernéis, Laurent Chouchana. A worldwide pharmacovigilance database analysis to assess the risk of acute kidney injury in patients receiving teicoplanin in association with piperacillin, cefepime or meropenem. The Journal of antimicrobial chemotherapy. 2021 07; 76(8):2221-2223. doi: 10.1093/jac/dkab144. [PMID: 34008026]
Dušan Krnáč, Katarína Reiffová, Boris Rolinski. A new HPLC-MS/MS analytical method for quantification of tazobactam, piperacillin, and meropenem in human plasma. Journal of separation science. 2021 Jul; 44(14):2744-2753. doi: 10.1002/jssc.202100067. [PMID: 33988308]
Yibo Fei, Shengyuan Wu, Yuanyuan Wang, Fuming Shen, Guorong Fan. A fast and high-sensitivity liquid chromatography-tandem mass spectrometry method combined with in vivo microdialysis for quantification of meropenem in rabbits with sepsis under the simultaneous infusion of total parenteral nutrition: Application to a pharmacokinetic study. Biomedical chromatography : BMC. 2021 Jul; 35(7):e5100. doi: 10.1002/bmc.5100. [PMID: 33624854]
Nhu T Q Nguyen, Emmanuelle Gras, Nguyen D Tran, Nhi N Y Nguyen, Hanh T H Lam, William J Weiss, Thien N M Doan, Binh An Diep. Pseudomonas aeruginosa Ventilator-Associated Pneumonia Rabbit Model for Preclinical Drug Development. Antimicrobial agents and chemotherapy. 2021 06; 65(7):e0272420. doi: 10.1128/aac.02724-20. [PMID: 33972247]
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Rezvan Hassanpour, Shadi Ziaie, Farzad Kobarfard, Mehran Kouchek, Mirmohammad Miri, Azadeh Ahmadi Koomleh, Seyedpouzhia Shojaei, Sara Salarian, Elham Pourheidar, Fatemeh Nezarat, Mohammad Sistanizad. Evaluation of pharmacokinetic and pharmacodynamic parameters of meropenem in critically ill patients with acute kidney disease. European journal of clinical pharmacology. 2021 Jun; 77(6):831-840. doi: 10.1007/s00228-020-03062-0. [PMID: 33409684]
Wei Wei Tan, Kevin M Watt, Felix Boakye-Agyeman, Michael Cohen-Wolkowiez, Yee Hui Mok, Chee Fu Yung, Yoke Hwee Chan. Optimal Dosing of Meropenem in a Small Cohort of Critically Ill Children Receiving Continuous Renal Replacement Therapy. Journal of clinical pharmacology. 2021 06; 61(6):744-754. doi: 10.1002/jcph.1798. [PMID: 33314163]
W G D Wickramasingha, S Jayasinghe, D N Karunaratne, E W M A Ekanayake, V Liyanapathirana, V Karunaratne. Antibacterial and synergistic activity of 6β-hydroxy-3-oxolup-20(29)-en-28-oic acid (6β-hydroxy betunolic acid) isolated from Schumacheria castaneifolia vahl. Bioorganic & medicinal chemistry. 2021 05; 38(?):116142. doi: 10.1016/j.bmc.2021.116142. [PMID: 33892286]
Zhengwu Shen, Wei Xu, Jingfeng Yu, Lixia Chen, Jinghua Zhang, Sihan Sheng, Xun Dong, Hongzhu Bian. Synthesis and in vitro antibacterial activity of new aminothiazole-oximepiperidone cephalosporins. Bioorganic & medicinal chemistry letters. 2021 05; 40(?):127928. doi: 10.1016/j.bmcl.2021.127928. [PMID: 33705899]
M Kächele, F Keller. [Pharmacokinetics and pharmacodynamics in extracorporeal renal replacement therapy]. Medizinische Klinik, Intensivmedizin und Notfallmedizin. 2021 May; 116(4):295-300. doi: 10.1007/s00063-020-00654-7. [PMID: 32047978]
Matthew S Sussman, Michelle B Mulder, Emily L Ryon, Eva M Urrechaga, Gabriel A Lama, Amritpal Bahga, Sarah A Eidelson, Howard M Lieberman, Carl I Schulman, Nicholas Namias, Kenneth G Proctor. Acute Kidney Injury Risk in Patients Treated with Vancomycin Combined with Meropenem or Cefepime. Surgical infections. 2021 May; 22(4):415-420. doi: 10.1089/sur.2020.105. [PMID: 32783764]
Madiha Zaman, Humaira Majeed Khan, Muhammad Usman, Muhammad Imran Khokhar, Huma Rasheed, Mateen Abbas, Rizwan Rasul Khan, Rabia Saleem. Population pharmacokinetics of meropenem among post-operative patients in Pakistan. International journal of clinical pharmacology and therapeutics. 2021 May; 59(5):398-408. doi: 10.5414/cp203790. [PMID: 33480841]
Sophie Rakete, Carina Schuster, Michael Paal, Michael Vogeser. An isotope-dilution LC-MS/MS method for the simultaneous quantification of meropenem and its open-ring metabolite in serum. Journal of pharmaceutical and biomedical analysis. 2021 Apr; 197(?):113944. doi: 10.1016/j.jpba.2021.113944. [PMID: 33588299]
Sonya C Tang Girdwood, Peter H Tang, Mark E Murphy, Andrea R Chamberlain, Laura A Benken, Rhonda L Jones, Erin M Stoneman, Jennifer M Kaplan, Alexander A Vinks. Demonstrating Feasibility of an Opportunistic Sampling Approach for Pharmacokinetic Studies of β-Lactam Antibiotics in Critically Ill Children. Journal of clinical pharmacology. 2021 04; 61(4):565-573. doi: 10.1002/jcph.1773. [PMID: 33111331]
Kathrin Rothe, Susanne Feihl, Jochen Schneider, Fabian Wallnöfer, Milena Wurst, Marina Lukas, Matthias Treiber, Tobias Lahmer, Markus Heim, Michael Dommasch, Birgit Waschulzik, Alexander Zink, Christiane Querbach, Dirk H Busch, Roland M Schmid, Gerhard Schneider, Christoph D Spinner. Rates of bacterial co-infections and antimicrobial use in COVID-19 patients: a retrospective cohort study in light of antibiotic stewardship. European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology. 2021 Apr; 40(4):859-869. doi: 10.1007/s10096-020-04063-8. [PMID: 33140176]
Selina Schießer, Florian Hitzenbichler, Martin G Kees, Alexander Kratzer, Matthias Lubnow, Bernd Salzberger, Frieder Kees, Christoph Dorn. Measurement of Free Plasma Concentrations of Beta-Lactam Antibiotics: An Applicability Study in Intensive Care Unit Patients. Therapeutic drug monitoring. 2021 04; 43(2):264-270. doi: 10.1097/ftd.0000000000000827. [PMID: 33086362]
Akosua A Agyeman, Kate E Rogers, Jessica R Tait, Phillip J Bergen, Carl M Kirkpatrick, Steven C Wallis, Jürgen B Bulitta, David L Paterson, Jeffrey Lipman, Roger L Nation, Jason A Roberts, Cornelia B Landersdorfer. Evaluation of Meropenem-Ciprofloxacin Combination Dosage Regimens for the Pharmacokinetics of Critically Ill Patients With Augmented Renal Clearance. Clinical pharmacology and therapeutics. 2021 04; 109(4):1104-1115. doi: 10.1002/cpt.2191. [PMID: 33550617]
Makoto Kai, Ryota Tanaka, Yosuke Suzuki, Koji Goto, Yoshifumi Ohchi, Norihisa Yasuda, Ryosuke Tatsuta, Takaaki Kitano, Hiroki Itoh. Simultaneous quantification of plasma levels of 12 antimicrobial agents including carbapenem, anti-methicillin-resistant Staphylococcus aureus agent, quinolone and azole used in intensive care unit using UHPLC-MS/MS method. Clinical biochemistry. 2021 Apr; 90(?):40-49. doi: 10.1016/j.clinbiochem.2021.01.012. [PMID: 33539809]
J Petersson, C G Giske, E Eliasson. Poor Correlation between Meropenem and Piperacillin Plasma Concentrations and Delivered Dose of Continuous Renal Replacement Therapy. Antimicrobial agents and chemotherapy. 2021 03; 65(4):. doi: 10.1128/aac.02029-20. [PMID: 33495227]
Aun Raza, Jared A Miles, Fekade Bruck Sime, Benjamin P Ross, Jason A Roberts, Amirali Popat, Tushar Kumeria, James R Falconer. PLGA encapsulated γ-cyclodextrin-meropenem inclusion complex formulation for oral delivery. International journal of pharmaceutics. 2021 Mar; 597(?):120280. doi: 10.1016/j.ijpharm.2021.120280. [PMID: 33540004]
Ying Wang, Zhichao Du, Yongdong Chen, Yugang Liu, Zhitang Yang. Meta-analysis: combination of meropenem vs ceftazidime and amikacin for empirical treatment of cancer patients with febrile neutropenia. Medicine. 2021 Feb; 100(8):e24883. doi: 10.1097/md.0000000000024883. [PMID: 33663117]
Fabrizio Di Maida, Lorenzo Viola, Luca Lambertini, Andrea Mari, Jessica Mencarini, Beatrice Borchi, Marco Carini, Lorenzo Zammarchi, Andrea Minervini. A rare urinary JC virus reactivation after long-term therapy with rituximab. International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases. 2021 Feb; 103(?):447-449. doi: 10.1016/j.ijid.2020.11.194. [PMID: 33278620]
Andreas Körtge, Jolanta Majcher-Peszynska, Benjamin Heskamp, Reinhold Wasserkort, Steffen Mitzner. Antibiotics Removal by Continuous Venovenous Hemofiltration with a Novel Asymmetric Triacetate Membrane Hemofilter: An in vitro Study. Blood purification. 2021; 50(6):899-905. doi: 10.1159/000513417. [PMID: 33631754]
Qiong-Dan Hu, Nan Mao, Xin-Chun Huang, Ding-Guo Chen, Qiong Zhang. Identification of Complex Pneumonia during the Outbreak of COVID-19: Bacterial Pneumonia Combined with Acute Eosinophilic Pneumonia in Patients with Maintenance Hemodialysis. Blood purification. 2021 ; 50(1):132-136. doi: 10.1159/000509789. [PMID: 32721968]
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Amy Legg, Melanie Halford, Kate McCarthy. Plasma concentrations resulting from continuous infusion of meropenem in a community-based outpatient program: A case series. American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists. 2020 Dec; 77(24):2074-2080. doi: 10.1093/ajhp/zxaa319. [PMID: 33274740]
Santosh K Maurya, Akhilesh Kumar Maurya, Nidhi Mishra, Hifzur R Siddique. Virtual screening, ADME/T, and binding free energy analysis of anti-viral, anti-protease, and anti-infectious compounds against NSP10/NSP16 methyltransferase and main protease of SARS CoV-2. Journal of receptor and signal transduction research. 2020 Dec; 40(6):605-612. doi: 10.1080/10799893.2020.1772298. [PMID: 32476594]
Ensieh Vahedi, Mostafa Ghanei, Ali Ghazvini, Hossein Azadi, Morteza Izadi, Yunes Panahi, Saeid Fathi, Mahmood Salesi, Seyed Hassan Saadat, Amir Hossein Ghazale, Mohammad Rezapour, Abolfazl Mozafari, Nahid Zand, Mohammadreza Raesi Parsaei, Mohammad Hossein Ranjkesh, Ramezan Jafari, Fatemeh Movaseghi, Enayat Darabi. The clinical value of two combination regimens in the Management of Patients Suffering from Covid-19 pneumonia: a single centered, retrospective, observational study. Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences. 2020 Dec; 28(2):507-516. doi: 10.1007/s40199-020-00353-w. [PMID: 32562159]
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