Adefovir Dipivoxil (BioDeep_00000033257)
human metabolite blood metabolite Chemicals and Drugs
代谢物信息卡片
[({[2-(6-amino-9H-purin-9-yl)ethoxy]methyl}({[(2,2-dimethylpropanoyl)oxy]methoxy})phosphoryl)oxy]methyl 2,2-dimethylpropanoate
化学式: C20H32N5O8P (501.1988402)
中文名称: 阿德福韦酯
谱图信息:
最多检出来源 Homo sapiens(blood) 96.88%
分子结构信息
SMILES: CC(C)(C)C(=O)OCOP(=O)(COCCN1C=NC2=C(N)N=CN=C12)OCOC(=O)C(C)(C)C
InChI: InChI=1S/C20H32N5O8P/c1-19(2,3)17(26)30-11-32-34(28,33-12-31-18(27)20(4,5)6)13-29-8-7-25-10-24-14-15(21)22-9-23-16(14)25/h9-10H,7-8,11-13H2,1-6H3,(H2,21,22,23)
描述信息
Adefovir Dipivoxil is only found in individuals that have used or taken this drug.Adefovir dipivoxil, previously called bis-POM PMEA, with trade names Preveon and Hepsera, is an orally-administered nucleotide analog reverse transcriptase inhibitor (ntRTI) used for treatment of hepatitis B. It is a failed treatment for HIV. [Wikipedia]Adefovir dipivoxil is a prodrug of adefovir. Adefovir is an acyclic nucleotide analog of adenosine monophosphate which is phosphorylated to the active metabolite adefovir diphosphate by cellular kinases. Adefovir diphosphate inhibits HBV DNA polymerase (reverse transcriptase) by competing with the natural substrate deoxyadenosine triphosphate and by causing DNA chain termination after its incorporation into viral DNA. The inhibition constant (Ki) for adefovir diphosphate for HBV DNA polymerase was 0.1 μM. Adefovir diphosphate is a weak inhibitor of human DNA polymerases alpha and gamma with Ki values of 1.18 μM and 0.97μM, respectively.
J - Antiinfectives for systemic use > J05 - Antivirals for systemic use > J05A - Direct acting antivirals > J05AF - Nucleoside and nucleotide reverse transcriptase inhibitors
C471 - Enzyme Inhibitor > C1589 - Reverse Transcriptase Inhibitor > C97452 - Nucleoside Reverse Transcriptase Inhibitor
D000890 - Anti-Infective Agents > D000998 - Antiviral Agents > D018894 - Reverse Transcriptase Inhibitors
D004791 - Enzyme Inhibitors > D019384 - Nucleic Acid Synthesis Inhibitors
C254 - Anti-Infective Agent > C281 - Antiviral Agent
Adefovir dipivoxil, an adenosine analogue, is an oral proagent of the nucleoside reverse transcriptase inhibitor Adefovir. Adefovir dipivoxil inhibits both the wild type and HBV Lamivudine-resistant strains[1][2]. Adefovir dipivoxil shows anti-orthopoxvirus activity.
同义名列表
14 个代谢物同义名
[({[2-(6-amino-9H-purin-9-yl)ethoxy]methyl}({[(2,2-dimethylpropanoyl)oxy]methoxy})phosphoryl)oxy]methyl 2,2-dimethylpropanoate; 9-(2-((-Bis((pivaloyloxy)methoxy)phosphinyl)methoxy)ethyl)adenine; Adefovir Dipivoxil; Adefovir depivoxil; Adefovir pivoxil; Adefovirdipivoxl; Bis-pom pmea; ADEFOVIR; Preveon; Hepsera; GS-840; PMEA; ADV; GS 0840
数据库引用编号
9 个数据库交叉引用编号
- ChEBI: CHEBI:31175
- PubChem: 60871
- HMDB: HMDB0014856
- DrugBank: DB00718
- ChEMBL: CHEMBL922
- Wikipedia: Adefovir
- chemspider: 54855
- CAS: 142340-99-6
- medchemexpress: HY-B0255
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
1 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(1)
- Adefovir Dipivoxil Metabolism Pathway:
Adefovir + Adenosine triphosphate ⟶ Adefovir Monophosphate + Adenosine diphosphate
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Shady M Abd El-Halim, Ghada A Abdelbary, Maha M Amin, Mohamed Y Zakaria, Hesham A Shamsel-Din, Ahmed B Ibrahim. Stabilized oral nanostructured lipid carriers of Adefovir Dipivoxil as a potential liver targeting: Estimation of liver function panel and uptake following intravenous injection of radioiodinated indicator.
Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences.
2020 Dec; 28(2):517-532. doi:
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Journal of clinical pharmacy and therapeutics.
2020 Aug; 45(4):722-728. doi:
10.1111/jcpt.13154. [PMID: 32406123] - Qian Xiang, Zhiyan Liu, Yanyan Yu, Hanxu Zhang, Qiufen Xie, Guangyan Mu, Jianhua Zhang, Xinan Cen, Yimin Cui. Osteomalacia and renal failure due to Fanconi syndrome caused by long-term low-dose Adefovir Dipivoxil: a case report.
BMC pharmacology & toxicology.
2020 06; 21(1):43. doi:
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Chinese journal of integrative medicine.
2020 May; 26(5):330-338. doi:
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Clinical pharmacology and therapeutics.
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Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association.
2014 Nov; 20(6):350-5. doi:
10.4103/1319-3767.145320. [PMID: 25434315] - Sha Liao, Shi-Yong Fan, Qin Liu, Chang-Kun Li, Jia Chen, Jing-Lai Li, Zhi-Wei Zhang, Zhen-Qing Zhang, Bo-Hua Zhong, Jian-Wei Xie. In vitro evaluation of 9-(2-phosphonylmethoxyethyl)adenine ester analogues, a series of anti-HBV structures with improved plasma stability and liver release.
Archives of pharmacal research.
2014 Nov; 37(11):1416-25. doi:
10.1007/s12272-013-0300-6. [PMID: 24338503] - Jingyu Jin, Fei Sun, Gang Wang, Jinshui Yang, Gui Luo, Hua Ma, Zheng Zhao, Lixia Feng, Yanyan Wang, Wei Zhao, Jianglin Zhang, Jian Zhu, Feng Huang. [The clinical characteristics of 26 cases of hypophosphatemia osteomalacia misdiagnosed as spondyloarthritis].
Zhonghua nei ke za zhi.
2014 Nov; 53(11):847-51. doi:
NULL. [PMID: 25586353] - M R Khan, M S Chowdhury, M Saha, S M Roknuzzaman, M Mahmuduzzaman, A R Miah, P K Roy, M A Raihan, K M Rahman. Efficacy of adefovir dipivoxil therapy in patients with chronic hepatitis B viral infection.
Mymensingh medical journal : MMJ.
2014 Oct; 23(4):715-9. doi:
. [PMID: 25481590] - Ying Ge, Deming Li, Yunming Fan, Haihong Yang, Wei Lyu, Hongwei Fan, Baotong Zhou, Xiaoqing Liu, Zhengyin Liu. [Tenofovir rescue therapy for chronic hepatitis B patients after suboptimal response to treatment with lamivudine plus adefovir dipivoxil].
Zhonghua nei ke za zhi.
2014 Sep; 53(9):697-700. doi:
. [PMID: 25511401] - Shilpa Chokshi, Helen Cooksley, Antonio Riva, Sandra Phillips, Roger Williams, Anuj Gaggar, Nikolai V Naoumov. Identification of serum cytokine profiles associated with HBeAg seroconversion following antiviral treatment interruption.
Viral immunology.
2014 Jun; 27(5):235-44. doi:
10.1089/vim.2014.0022. [PMID: 24797262] - Mio Tanaka, Fumitaka Suzuki, Yuya Seko, Tasuku Hara, Yusuke Kawamura, Hitomi Sezaki, Tetsuya Hosaka, Norio Akuta, Masahiro Kobayashi, Yoshiyuki Suzuki, Satoshi Saitoh, Yasuji Arase, Kenji Ikeda, Mariko Kobayashi, Hiromitsu Kumada. Renal dysfunction and hypophosphatemia during long-term lamivudine plus adefovir dipivoxil therapy in patients with chronic hepatitis B.
Journal of gastroenterology.
2014 Mar; 49(3):470-80. doi:
10.1007/s00535-013-0779-0. [PMID: 23525978] - Li-Na Zhu, Li-Jun Mou, Ying Hu, Jia-Xi Chen. Fanconi syndrome caused by low-dose adefovir dipivoxil.
Saudi medical journal.
2014 Mar; 35(3):309-13. doi:
NULL. [PMID: 24623213] - Hong Peng, Junying Liu, Min Yang, Shiwen Tong, Wenwei Yin, Hui Tang, Peng Hu, Huaidong Hu, Hong Ren. Efficacy of lamivudine combined with adefovir dipivoxil versus entecavir monotherapy in patients with hepatitis B-associated decompensated cirrhosis: A meta-analysis.
Journal of clinical pharmacology.
2014 Feb; 54(2):189-200. doi:
10.1002/jcph.181. [PMID: 24105676] - Minran Li, Hongli Xi, Qinhuan Wang, Fengqin Hou, Na Huo, Xiaxia Zhang, Fang Li, Xiaoyuan Xu. Kinetics of serum HBsAg in Chinese patients with chronic HBV infection with long-term adefovir dipivoxil treatment.
Chinese medical journal.
2014; 127(11):2101-4. doi:
NULL. [PMID: 24890161] - Yongbin Zeng, Dezhong Li, Wei Wang, Mingkuan Su, Jinpiao Lin, Huijuan Chen, Ling Jiang, Jing Chen, Bin Yang, Qishui Ou. Establishment of real time allele specific locked nucleic acid quantitative PCR for detection of HBV YIDD (ATT) mutation and evaluation of its application.
PloS one.
2014; 9(2):e90029. doi:
10.1371/journal.pone.0090029. [PMID: 24587198] - Min-Ran Li, Hong-Li Xi, Qin-Huan Wang, Feng-Qin Hou, Na Huo, Xia-Xia Zhang, Fang Li, Xiao-Yuan Xu. Kinetics and prediction of HBsAg loss during long-term therapy with nucleos(t)ide analogues of different potency in patients with chronic hepatitis B.
PloS one.
2014; 9(6):e98476. doi:
10.1371/journal.pone.0098476. [PMID: 24905586] - Hiroyuki Eguchi, Munehisa Tsuruta, Junichi Tani, Reiichiro Kuwahara, Yuji Hiromatsu. Hypophosphatemic osteomalacia due to drug-induced Fanconi's syndrome associated with adefovir dipivoxil treatment for hepatitis B.
Internal medicine (Tokyo, Japan).
2014; 53(3):233-7. doi:
10.2169/internalmedicine.53.1213. [PMID: 24492692] - Jihan Huang, Yaping Zhang, Xiaohui Huang, Lujin Li, Yunfei Li, Kun Wang, Juan Yang, Yingchun He, Yinghua Lv, Qingshan Zheng. Population pharmacokinetics of adefovir dipivoxil tablets in healthy Chinese volunteers.
International journal of clinical pharmacology and therapeutics.
2014 Jan; 52(1):8-14. doi:
10.5414/cp201928. [PMID: 24219967] - Zhenzhen Deng, Chunjiang Wang, Zuojun Li, Bing Li, Shikun Liu. Peginterferon alpha versus other antiviral regimes for Chinese HBeAg-positive chronic hepatitis B patients.
Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences.
2013 Dec; 38(12):1193-207. doi:
10.3969/j.issn.1672-7347.2013.12.001. [PMID: 24384957] - Jiang-Shan Lian, Lin-Yan Zeng, Jian-Yang Chen, Hong-Yu Jia, Yi-Min Zhang, Dai-Rong Xiang, Liang Yu, Jian-Hua Hu, Ying-Feng Lu, Ling Zheng, Lan-Juan Li, Yi-Da Yang. De novo combined lamivudine and adefovir dipivoxil therapy vs entecavir monotherapy for hepatitis B virus-related decompensated cirrhosis.
World journal of gastroenterology.
2013 Oct; 19(37):6278-83. doi:
10.3748/wjg.v19.i37.6278. [PMID: 24115827] - Fu-Yi Xie, Qi Sun, Wei Chen. [The clinical significance of hepatitis B virus large surface protein in the diagnosis and treatment of patients with hepatitis B].
Zhonghua shi yan he lin chuang bing du xue za zhi = Zhonghua shiyan he linchuang bingduxue zazhi = Chinese journal of experimental and clinical virology.
2013 Aug; 27(4):280-2. doi:
NULL. [PMID: 24579475] - C Wu, H Zhang, Y Qian, L Wang, X Gu, Z Dai. Hypophosphatemic osteomalacia and renal Fanconi syndrome induced by low-dose adefovir dipivoxil: a case report and literature review suggesting ethnic predisposition.
Journal of clinical pharmacy and therapeutics.
2013 Aug; 38(4):321-6. doi:
10.1111/jcpt.12050. [PMID: 23590583] - Shamsunder Dodiya, Sandip Chavhan, Aruna Korde, Krutika K Sawant. Solid lipid nanoparticles and nanosuspension of adefovir dipivoxil for bioavailability improvement: formulation, characterization, pharmacokinetic and biodistribution studies.
Drug development and industrial pharmacy.
2013 May; 39(5):733-43. doi:
10.3109/03639045.2012.694889. [PMID: 22690834] - Mi Sung Park, Beom Kyung Kim, Kyung Sik Kim, Ja Kyung Kim, Seung Up Kim, Jun Yong Park, Do Young Kim, Oidov Baartarkhuu, Kwang Hyub Han, Chae Yoon Chon, Sang Hoon Ahn. Antiviral efficacies of currently available rescue therapies for multidrug-resistant chronic hepatitis B.
Clinical and molecular hepatology.
2013 Mar; 19(1):29-35. doi:
10.3350/cmh.2013.19.1.29. [PMID: 23593607] - H Wang, Y Y Ji, G B Yao, X Y Ma, Q Xie, H Y Pang, S M Wu, J Li, C W Chen, X W Xu, E L Gu. Two years efficiency of lamivudine and adefovir dipivoxil combined therapy in chronic hepatitis B patients.
European review for medical and pharmacological sciences.
2013 Mar; 17(5):636-43. doi:
NULL. [PMID: 23543447] - Takashi Kumada, Hidenori Toyoda, Toshifumi Tada, Seiki Kiriyama, Makoto Tanikawa, Yasuhiro Hisanaga, Akira Kanamori, Takurou Niinomi, Satoshi Yasuda, Yusuke Andou, Kenta Yamamoto, Junko Tanaka. Effect of nucleos(t)ide analogue therapy on hepatocarcinogenesis in chronic hepatitis B patients: a propensity score analysis.
Journal of hepatology.
2013 Mar; 58(3):427-33. doi:
10.1016/j.jhep.2012.10.025. [PMID: 23123221] - Sun Jae Lee, Hyung Joon Yim, Seong Gyu Hwang, Yeon Seok Seo, Ji Hoon Kim, Eileen L Yoon, Joong Min Lee, Bo Hyun Kim, Sang Jong Park, Young Min Park, Hong Soo Kim, Se Hwan Lee, Sang Hoon Ahn, Jeong Il Lee, Jin Woo Lee, In Hee Kim, Hyung Soo Kim, Sun Pyo Hong. Treatment of lamivudine-resistant chronic hepatitis B infection: a multicenter retrospective study.
Scandinavian journal of gastroenterology.
2013 Feb; 48(2):196-204. doi:
10.3109/00365521.2012.722671. [PMID: 23194375] - Benny S P Fok, Stephen Gardner, Steve Piscitelli, Shuguang Chen, Tanya T W Chu, Jones C M Chan, Brian Tomlinson. Pharmacokinetic properties of single-dose lamivudine/adefovir dipivoxil fixed-dose combination in healthy Chinese male volunteers.
Clinical therapeutics.
2013 Jan; 35(1):68-76. doi:
10.1016/j.clinthera.2012.12.001. [PMID: 23274144] - Jie Wang, Jun-Ping Shi, Jing Wu, Xiao-Xiao Huang, Meng-Fei Zhu, Guo-Qiang Lou. [Genotypes and evolution characteristics of three patients with poor response to initial treatment of Lamivudine and Adefovir dipivoxil for hepatitis].
Zhonghua shi yan he lin chuang bing du xue za zhi = Zhonghua shiyan he linchuang bingduxue zazhi = Chinese journal of experimental and clinical virology.
2012 Dec; 26(6):474-6. doi:
". [PMID: 23627034] - Yuan Gao, Jing Gao, Ziling Liu, Hongliang Kan, Hui Zu, Wanjin Sun, Jianjun Zhang, Shuai Qian. Coformer selection based on degradation pathway of drugs: a case study of adefovir dipivoxil-saccharin and adefovir dipivoxil-nicotinamide cocrystals.
International journal of pharmaceutics.
2012 Nov; 438(1-2):327-35. doi:
10.1016/j.ijpharm.2012.09.027. [PMID: 22989978] - Kevin T Chaung, Nghiem B Ha, Huy N Trinh, Ruel T Garcia, Huy A Nguyen, Khanh K Nguyen, Gabriel Garcia, Aijaz Ahmed, Emmet B Keeffe, Mindie H Nguyen. High frequency of recurrent viremia after hepatitis B e antigen seroconversion and consolidation therapy.
Journal of clinical gastroenterology.
2012 Nov; 46(10):865-70. doi:
10.1097/mcg.0b013e31825ceed9. [PMID: 22941429] - Pan Zhao, Chunya Wang, Lili Huang, Dongping Xu, Tanshi Li. Comparison of rescue strategies in lamivudine-resistant patients with chronic hepatitis B.
Antiviral research.
2012 Nov; 96(2):100-4. doi:
10.1016/j.antiviral.2012.08.008. [PMID: 22960601] - Li-yan Chen, Li-ying Zhu, Bao-shan Yang, Man-ru Bi, Bing-zhu Yan, Wei Wang, Ying-ji Ma. Regulatory T-cell responses in chronic hepatitis B patients treated with nucleos(t)ide analogs compared with healthy subjects and untreated infected individuals.
Hepato-gastroenterology.
2012 Nov; 59(120):2582-6. doi:
10.5754/hge12287. [PMID: 22626879] - M L Cuestas, V L Mathet, J R Oubiña. Specific primer sets used to amplify by PCR the hepatitis B virus overlapping S/Pol region select different viral variants.
Journal of viral hepatitis.
2012 Oct; 19(10):754-6. doi:
10.1111/j.1365-2893.2012.01614.x. [PMID: 22967107] - Bin Zhu, Zhen-ni Zhu, Jun-zhong Wang, Shun-mei Huang, Xue-mei Feng, An-yi Li, Dong-liang Yang, Bao-ju Wang. [Assessment of mitochondrial toxicity induced by zidovudine and adefovir dipivoxil in rats].
Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology.
2012 Oct; 20(10):794-7. doi:
10.3760/cma.j.issn.1007-3418.2012.10.018. [PMID: 23207344] - E Cholongitas, T Vasiliadis, N Antoniadis, I Goulis, V Papanikolaou, E Akriviadis. Hepatitis B prophylaxis post liver transplantation with newer nucleos(t)ide analogues after hepatitis B immunoglobulin discontinuation.
Transplant infectious disease : an official journal of the Transplantation Society.
2012 Oct; 14(5):479-87. doi:
10.1111/j.1399-3062.2012.00741.x. [PMID: 22624695] - Meng-Fei Zhu, Jian-Cheng Qian, Lu Lu, Feng-Le Yan, Jun-Ping Shi, Guo-Qiang Lou. [Three-year efficacy and side effect of adefovir dipivoxil for the treatment of the old patients with chronic hepatitis B virus infection].
Zhonghua shi yan he lin chuang bing du xue za zhi = Zhonghua shiyan he linchuang bingduxue zazhi = Chinese journal of experimental and clinical virology.
2012 Oct; 26(5):379-81. doi:
NULL. [PMID: 23547463] - Yu Jin Kim, Seung Woon Paik, Dong Hyun Sinn, Geum-Youn Gwak, Moon Seok Choi, Joon Hyeok Lee, Kwang Cheol Koh, Byung Chul Yoo. Viral response at 6 months is associated with treatment outcome of adefovir add-on therapy for lamivudine-resistance.
Journal of gastroenterology and hepatology.
2012 Sep; 27(9):1454-60. doi:
10.1111/j.1440-1746.2011.07050.x. [PMID: 22168753] - Y F Jiang, B He, J Ma, N-P Li, G-Z Gong, D Cheng. Comparison of the antiviral effects of entecavir and adefovir dipivoxil in chronic HBV infection: a randomized control trial.
Acta gastro-enterologica Belgica.
2012 Sep; 75(3):316-21. doi:
NULL. [PMID: 23082701] - Stephanos J Hadziyannis, Vassilios Sevastianos, Irene Rapti, Dimitrios Vassilopoulos, Emilia Hadziyannis. Sustained responses and loss of HBsAg in HBeAg-negative patients with chronic hepatitis B who stop long-term treatment with adefovir.
Gastroenterology.
2012 Sep; 143(3):629-636.e1. doi:
10.1053/j.gastro.2012.05.039. [PMID: 22659218] - Hsin-Wu Lai, Chiu-Chun Chang, Tan-Hsia Chen, Ming-Chang Tsai, Tzy-Yen Chen, Chun-Che Lin. Safety and efficacy of adefovir therapy for lamivudine-resistant hepatitis B virus infection in renal transplant recipients.
Journal of the Formosan Medical Association = Taiwan yi zhi.
2012 Aug; 111(8):439-44. doi:
10.1016/j.jfma.2011.05.010. [PMID: 22939662] - Ai-rong Hu, Su-wen Jiang, Ling Li, Shi-xiong Ding, Yao-ren Hu, Xiao-yue Liang. [Clinical analysis of hepatitis B virus mutations related to adefovir dipivoxil among patients with chronic hepatitis B virus infection in eastern Zhejiang province].
Zhonghua yi xue za zhi.
2012 Jul; 92(27):1878-81. doi:
NULL. [PMID: 23134956] - Si-Hai Zhao, En-Qi Liu, Da-Xin Cheng, Ya-Feng Li, Yan-Li Wang, Yu-Long Chen, Wen-Tao Sun, Xi-Cai Yan, Shuang-Suo Dang. Comparison of entecavir and adefovir for the treatment of chronic hepatitis B.
The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases.
2012 Jul; 16(4):366-72. doi:
10.1016/j.bjid.2012.06.016. [PMID: 22846126] - Xiaoxi Li, Chunxiu Zhong, Shuling Yang, Rong Fan, Jie Peng, Yabing Guo, Jian Sun, Jinlin Hou. [Influence of adefovir dipivoxil or telbivudine monotherapy on renal function of patients with chronic hepatitis B].
Nan fang yi ke da xue xue bao = Journal of Southern Medical University.
2012 Jun; 32(6):826-9. doi:
NULL. [PMID: 22699063] - N Gara, X Zhao, M T Collins, W H Chong, D E Kleiner, T Jake Liang, M G Ghany, J H Hoofnagle. Renal tubular dysfunction during long-term adefovir or tenofovir therapy in chronic hepatitis B.
Alimentary pharmacology & therapeutics.
2012 Jun; 35(11):1317-25. doi:
10.1111/j.1365-2036.2012.05093.x. [PMID: 22506503] - Elisabetta Pagani, Valentina Pasquetto, Chiara Cemin, Patrizia Rossi, Marina Crovatto, Graziella Gava, Martina Felder, Hartwig P Huemer, Clara Larcher. Evaluation of a 'home-made' method to determine viral genotype and characterize mutations conferring drug resistance in chronic hepatitis B patients.
Le infezioni in medicina.
2012 Jun; 20(2):88-92. doi:
NULL. [PMID: 22767306] - Juan Wang, Yanjun Cai, Huifan Ji, Junyan Feng, Desalegn Admassu Ayana, Junqi Niu, Yanfang Jiang. Serum IL-33 levels are associated with liver damage in patients with chronic hepatitis B.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research.
2012 Jun; 32(6):248-53. doi:
10.1089/jir.2011.0109. [PMID: 22304300] - I Mederacke, C Yurdaydin, A Großhennig, A Erhardt, Y Cakaloglu, K Yalcin, S Gurel, S Zeuzem, K Zachou, C Chatzikyrkou, H Bozkaya, G N Dalekos, M P Manns, H Wedemeyer. Renal function during treatment with adefovir plus peginterferon alfa-2a vs either drug alone in hepatitis B/D co-infection.
Journal of viral hepatitis.
2012 Jun; 19(6):387-95. doi:
10.1111/j.1365-2893.2011.01560.x. [PMID: 22571900] - Yong-fang Jiang, Jing Ma, Bo He, Nai-ping Li, Wei Tang, Guo-zhong Gong. [The therapeutic effect of Anluohuaxian capsule combined with adefovir dipivoxil on patients with chronic hepatitis B and influence on hepatic histology].
Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology.
2012 May; 20(5):344-7. doi:
10.3760/cma.j.issn.1007-3418.2012.05.008. [PMID: 22971278] - Jung Won Jeon, Hyun Phil Shin, Joung Il Lee, Kwang Ro Joo, Jae Myung Cha, Jae Jun Park, Jun Uk Lim, Kyuseong Lim, Sunyong Kim. Efficacy of entecavir and adefovir combination therapy for patients with lamivudine- and entecavir-resistant chronic hepatitis B.
Digestive diseases and sciences.
2012 May; 57(5):1358-65. doi:
10.1007/s10620-011-1988-0. [PMID: 22134785] - Fen-zhi Ji, Lei Wang, Bao-hua Yang, Jing-jie Zhao, Feng Liu, Yan Xue, Tao Li. [Clinical characteristics and effect of secondary individualized therapy in chronic hepatitis B patients infected with the rtA181 mutation hepatitis B virus].
Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology.
2012 Apr; 20(4):280-4. doi:
10.3760/cma.j.issn.1007-3418.2012.04.011. [PMID: 22964149] - S-T Law, K K Li, Y Y Ho. Nephrotoxicity, including acquired Fanconi's syndrome, caused by adefovir dipivoxil - is there a safe dose?.
Journal of clinical pharmacy and therapeutics.
2012 Apr; 37(2):128-31. doi:
10.1111/j.1365-2710.2011.01278.x. [PMID: 21714795] - Julien Dupouey, René Gerolami, Caroline Solas, Philippe Colson. Hepatitis B virus variant with the a194t substitution within reverse transcriptase before and under adefovir and tenofovir therapy.
Clinics and research in hepatology and gastroenterology.
2012 Apr; 36(2):e26-8. doi:
10.1016/j.clinre.2012.01.003. [PMID: 22342116] - Xiao-Zhong Fu, Yu Ou, Jian-Ying Pei, Ying Liu, Jing Li, Wen Zhou, Yan-Yu Lan, Ai-Min Wang, Yong-Lin Wang. Synthesis, anti-HBV activity and renal cell toxicity evaluation of mixed phosphonate prodrugs of adefovir.
European journal of medicinal chemistry.
2012 Mar; 49(?):211-8. doi:
10.1016/j.ejmech.2012.01.013. [PMID: 22305613] - YongFa Chen, Ting Ju. Comparative meta-analysis of adefovir dipivoxil monotherapy and combination therapy of adefovir dipivoxil and lamivudine for lamivudine-resistant chronic hepatitis B.
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases.
2012 Mar; 16(3):e152-8. doi:
10.1016/j.ijid.2011.11.006. [PMID: 22226087] - Mauro Viganò, Pietro Lampertico. Clinical implications of HBsAg quantification in patients with chronic hepatitis B.
Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association.
2012 Mar; 18(2):81-6. doi:
10.4103/1319-3767.93805. [PMID: 22421711] - Xiao-Yong Zheng, Ri-Bao Wei, Li Tang, Ping Li, Xiao-Dong Zheng. Meta-analysis of combined therapy for adult hepatitis B virus-associated glomerulonephritis.
World journal of gastroenterology.
2012 Feb; 18(8):821-32. doi:
10.3748/wjg.v18.i8.821. [PMID: 22371643]