Pentosan Polysulfate (BioDeep_00000033254)
human metabolite blood metabolite Chemicals and Drugs
代谢物信息卡片
[(2R,3R,4S,5R)-2-Hydroxy-5-{[(2S,3R,4S,5R)-5-hydroxy-3,4-bis(sulphooxy)oxan-2-yl]oxy}-4-(sulphooxy)oxan-3-yl]oxidanesulphonic acid
化学式: C10H18O21S4 (601.9223458)
中文名称:
谱图信息:
最多检出来源 Homo sapiens(blood) 80%
分子结构信息
SMILES: C1C(C(C(C(O1)OC2COC(C(C2OS(=O)(=O)O)OS(=O)(=O)O)O)OS(=O)(=O)O)OS(=O)(=O)O)O
InChI: InChI=1S/C10H18O21S4/c11-3-1-26-10(8(31-35(22,23)24)5(3)28-32(13,14)15)27-4-2-25-9(12)7(30-34(19,20)21)6(4)29-33(16,17)18/h3-12H,1-2H2,(H,13,14,15)(H,16,17,18)(H,19,20,21)(H,22,23,24)/t3-,4-,5+,6+,7-,8-,9-,10+/m1/s1
描述信息
Pentosan Polysulfate is only found in individuals that have used or taken this drug. It is a sulfated pentosyl polysaccharide with heparin-like properties. [PubChem]Pentosan polysulfate is a polymer of xylose hydrogen sulfate and contains two sulfate groups per carbohydrate monomer. It binds Fibroblast growth factors (FGFs) as well as other heparin-binding growth factors. It has been shown to interact also with the heparin-binding site of FGFR-1. It inhibits the growth of SW13 adrenocortical cells transfected with FGF-4 and tumorigenicity of MCF-7 breast carcinoma cells transfected with FGF-1 or FGF-4.
Cartrophen-Vet is a 100mg/ml formulation of Pentosan polysulphate that has been used in Australia since the early 1990s. It is produced by Biopharm Australia , a subsidiary of R-Biopharm, Germany.; Pentosan polysulfate sodium is a low molecular weight heparin-like compound. It has anticoagulant and fibrinolytic effects. Pentosan polysulfate is found in garden onion, fig, and tamarind.
C78275 - Agent Affecting Blood or Body Fluid > C263 - Anticoagulant Agent
D006401 - Hematologic Agents > D000925 - Anticoagulants
同义名列表
47 个代谢物同义名
[(2R,3R,4S,5R)-2-Hydroxy-5-{[(2S,3R,4S,5R)-5-hydroxy-3,4-bis(sulphooxy)oxan-2-yl]oxy}-4-(sulphooxy)oxan-3-yl]oxidanesulphonic acid; [(2S,3R,4S,5R)-5-hydroxy-2-{[(3R,4S,5R,6R)-6-hydroxy-4,5-bis(sulfooxy)oxan-3-yl]oxy}-4-(sulfooxy)oxan-3-yl]oxidanesulfonic acid; [(2R,3R,4S,5R)-2-Hydroxy-5-{[(2S,3R,4S,5R)-5-hydroxy-3,4-bis(sulphooxy)oxan-2-yl]oxy}-4-(sulphooxy)oxan-3-yl]oxidanesulphonate; [(2R,3R,4S,5R)-2-Hydroxy-5-{[(2S,3R,4S,5R)-5-hydroxy-3,4-bis(sulfooxy)oxan-2-yl]oxy}-4-(sulfooxy)oxan-3-yl]oxidanesulfonate; Sodium, pentosan polysulphate; Polyester, pentosane sulfuric; Polysulphate sodium, pentosan; Sulfuric polyester, pentosane; Polyester, pentosan sulfuric; Polysulfate sodium, pentosan; Sulfuric polyester, pentosan; Sodium, pentosan polysulfate; Pentosane sulfuric polyester; Pentosan polysulphate sodium; Pentosan polysulphuric acid; Pentosan Polysulfate Sodium; Pentosan sulfuric polyester; Pentosan polysulfuric acid; Pentosan polysulphate; Polysulfate, pentosan; Pentosan Polysulfate; Sulfate, polypentose; Polypentose sulfate; Xylan, polysulfated; Polysulfated xylan; Sulfate, xylan; Xylan sulfate; 946, HOE-bay; SP 54, Tavan; 54, Tavan SP; HOE-bay-946; SP54, Xylan; HOE bay 946; Tavan SP 54; HOE-bay 946; Xylan SP54; Fibrocid; Hemoclar; BAY-946; Elmiron; HOE-946; BAY 946; HOE 946; SP-54; SP 54; PZ 68; PZ-68
数据库引用编号
13 个数据库交叉引用编号
- ChEBI: CHEBI:184555
- PubChem: 37720
- HMDB: HMDB0014824
- DrugBank: DB00686
- ChEMBL: CHEMBL4073796
- Wikipedia: Pentosan polysulfate
- MeSH: Pentosan Sulfuric Polyester
- foodb: FDB019140
- chemspider: 34595
- CAS: 2763886-11-7
- CAS: 11096-31-4
- CAS: 39432-58-1
- CAS: 37300-21-3
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Gerd Bendas. Pentosan Polysulfate-A 'Better Heparin' as Potential Medication for the Treatment of SARS-CoV-2 Infections?.
Thrombosis and haemostasis.
2022 Jun; 122(6):870. doi:
10.1055/a-1815-2142. [PMID: 35373312] - Sabrina Bertini, Anna Alekseeva, Stefano Elli, Isabel Pagani, Serena Zanzoni, Giorgio Eisele, Ravi Krishnan, Klaus P Maag, Christian Reiter, Dominik Lenhart, Rudolf Gruber, Edwin A Yates, Elisa Vicenzi, Annamaria Naggi, Antonella Bisio, Marco Guerrini. Pentosan Polysulfate Inhibits Attachment and Infection by SARS-CoV-2 In Vitro: Insights into Structural Requirements for Binding.
Thrombosis and haemostasis.
2022 06; 122(6):984-997. doi:
10.1055/a-1807-0168. [PMID: 35322395] - Pavitra Solanki, Mohd Danish Ansari, Anjali, Iram Khan, Rao Nargis Jahan, Nikita, Jayamanti Pandit, Mohd Aqil, Farhan J Ahmad, Yasmin Sultana. Repurposing pentosan polysulfate sodium as hyaluronic acid linked polyion complex nanoparticles for the management of osteoarthritis: A potential approach.
Medical hypotheses.
2021 Dec; 157(?):110713. doi:
10.1016/j.mehy.2021.110713. [PMID: 34710749] - Yung-Hsiang Chen, Wen-Chi Chen, Kao-Sung Tsai, Po-Len Liu, Ming-Yen Tsai, Tzu-Chun Lin, Shih-Chieh Yu, Huey-Yi Chen. Efficacy of Frankincense and Myrrha in Treatment of Acute Interstitial Cystitis/Painful Bladder Syndrome.
Chinese journal of integrative medicine.
2020 Jul; 26(7):519-526. doi:
10.1007/s11655-020-3216-2. [PMID: 32279153] - Lei Lin, Yanlei Yu, Fuming Zhang, Ke Xia, Xing Zhang, Robert J Linhardt. Bottom-up and top-down profiling of pentosan polysulfate.
The Analyst.
2019 Aug; 144(16):4781-4786. doi:
10.1039/c9an01006h. [PMID: 31287456] - Ima Indirayani, Aida Kalok, Nik A Nik Ismail, Shamsul A Shah, Pei S Lim, Nor A Mohamed Ismail, Abdul G Nur Azurah, Mohd Hashim Omar, Mohamad N Shafiee. Sodium pentosan polysulfate efficacy as thromboprophylaxis agent in high-risk women following gynecological surgery.
The journal of obstetrics and gynaecology research.
2018 Aug; 44(8):1458-1465. doi:
10.1111/jog.13686. [PMID: 29845672] - Laura L Giusto, Patricia M Zahner, Daniel A Shoskes. An evaluation of the pharmacotherapy for interstitial cystitis.
Expert opinion on pharmacotherapy.
2018 07; 19(10):1097-1108. doi:
10.1080/14656566.2018.1491968. [PMID: 29972328] - Mona Mozafari, Sami El Deeb, Friederike Krull, Robert Wildgruber, Gerhard Weber, Christian G Reiter, Hermann Wätzig. Interaction of albumins and heparinoids investigated by affinity capillary electrophoresis and free flow electrophoresis.
Electrophoresis.
2018 02; 39(4):569-580. doi:
10.1002/elps.201700202. [PMID: 29131355] - Ping Chen, Yang Yuan, Tianying Zhang, Bo Xu, Qing Gao, Tianjun Guan. Pentosan polysulfate ameliorates apoptosis and inflammation by suppressing activation of the p38 MAPK pathway in high glucose‑treated HK‑2 cells.
International journal of molecular medicine.
2018 Feb; 41(2):908-914. doi:
10.3892/ijmm.2017.3290. [PMID: 29207166] - Caroline Sanden, Michiko Mori, Prajakta Jogdand, Jimmie Jönsson, Ravi Krishnan, Xiangdong Wang, Jonas S Erjefält. Broad Th2 neutralization and anti-inflammatory action of pentosan polysulfate sodium in experimental allergic rhinitis.
Immunity, inflammation and disease.
2017 09; 5(3):300-309. doi:
10.1002/iid3.164. [PMID: 28497614] - C V Rao. Therapeutic Potential of Human Chorionic Gonadotropin Against Painful Bladder Syndrome/Interstitial Cystitis.
Reproductive sciences (Thousand Oaks, Calif.).
2016 11; 23(11):1451-1458. doi:
10.1177/1933719116639139. [PMID: 27004802] - Mareike Delille, Laura Fröhlich, Ralf S Müller, Katrin Hartmann, Roswitha Dorsch. Efficacy of intravesical pentosan polysulfate sodium in cats with obstructive feline idiopathic cystitis.
Journal of feline medicine and surgery.
2016 06; 18(6):492-500. doi:
10.1177/1098612x15588934. [PMID: 26116618] - Zhengrong Guan, Sean T Singletary, Haword Cha, Justin P Van Beusecum, Anthony K Cook, Jennifer S Pollock, David M Pollock, Edward W Inscho. Pentosan polysulfate preserves renal microvascular P2X1 receptor reactivity and autoregulatory behavior in DOCA-salt hypertensive rats.
American journal of physiology. Renal physiology.
2016 Mar; 310(6):F456-65. doi:
10.1152/ajprenal.00110.2015. [PMID: 26697978] - Péter Hardi, Tibor Nagy, Gábor Fazekas, Endre Arató, Gábor Menyhei, György Sétáló, Mónika Vecsernyés, Örs Pintér, Ildikó Takács, Noémi Bohonyi, Gábor Jancsó. Sodium Pentosan Polysulfate Reduced Renal Ischemia-Reperfusion-Induced Oxidative Stress and Inflammatory Responses in an Experimental Animal Model.
Journal of vascular research.
2016; 53(3-4):230-242. doi:
10.1159/000452246. [PMID: 27889777] - Calogera M Simonaro, Shunji Tomatsu, Tracy Sikora, Francyne Kubaski, Michael Frohbergh, Johana M Guevara, Raymond Y Wang, Moin Vera, Jennifer L Kang, Lachlan J Smith, Edward H Schuchman, Mark E Haskins. Pentosan Polysulfate: Oral Versus Subcutaneous Injection in Mucopolysaccharidosis Type I Dogs.
PloS one.
2016; 11(4):e0153136. doi:
10.1371/journal.pone.0153136. [PMID: 27064989] - William M Mendenhall, Randal H Henderson, Joseph A Costa, Bradford S Hoppe, Roi Dagan, Curtis M Bryant, Romaine C Nichols, Christopher R Williams, Stephanie E Harris, Nancy P Mendenhall. Hemorrhagic radiation cystitis.
American journal of clinical oncology.
2015 Jun; 38(3):331-6. doi:
10.1097/coc.0000000000000016. [PMID: 24322335] - V Pirgozliev, S P Rose, T Pellny, A M Amerah, M Wickramasinghe, M Ulker, M Rakszegi, Z Bedo, P R Shewry, A Lovegrove. Energy utilization and growth performance of chickens fed novel wheat inbred lines selected for different pentosan levels with and without xylanase supplementation.
Poultry science.
2015 Feb; 94(2):232-9. doi:
10.3382/ps/peu059. [PMID: 25595480] - Tatsufumi Nakamura, Katsuya Satoh, Taku Fukuda, Ikuo Kinoshita, Yoshihiro Nishiura, Kunihiko Nagasato, Atsushi Yamauchi, Yasufumi Kataoka, Tadahiro Nakamura, Hitoshi Sasaki, Kenji Kumagai, Masami Niwa, Mitsuru Noguchi, Hideki Nakamura, Noriyuki Nishida, Atsushi Kawakami. Pentosan polysulfate treatment ameliorates motor function with increased serum soluble vascular cell adhesion molecule-1 in HTLV-1-associated neurologic disease.
Journal of neurovirology.
2014 Jun; 20(3):269-77. doi:
10.1007/s13365-014-0244-8. [PMID: 24671717] - Michael Frohbergh, Yi Ge, Fanli Meng, Nesrin Karabul, Alexander Solyom, Alon Lai, James Iatridis, Edward H Schuchman, Calogera M Simonaro. Dose responsive effects of subcutaneous pentosan polysulfate injection in mucopolysaccharidosis type VI rats and comparison to oral treatment.
PloS one.
2014; 9(6):e100882. doi:
10.1371/journal.pone.0100882. [PMID: 24964042] - Edward H Schuchman, Yi Ge, Alon Lai, Yury Borisov, Meghan Faillace, Efrat Eliyahu, Xingxuan He, James Iatridis, Helen Vlassara, Gary Striker, Calogera M Simonaro. Pentosan polysulfate: a novel therapy for the mucopolysaccharidoses.
PloS one.
2013; 8(1):e54459. doi:
10.1371/journal.pone.0054459. [PMID: 23365668] - Takafumi Sunaga, Namgil Oh, Kenji Hosoya, Satoshi Takagi, Masahiro Okumura. Inhibitory effects of pentosan polysulfate sodium on MAP-kinase pathway and NF-κB nuclear translocation in canine chondrocytes in vitro.
The Journal of veterinary medical science.
2012 Jun; 74(6):707-11. doi:
10.1292/jvms.11-0511. [PMID: 22214865] - Abdullah Kutlar, Kenneth I Ataga, Lillian McMahon, Joanna Howard, Frederic Galacteros, Ward Hagar, Elliott Vichinsky, Anthony T W Cheung, Neil Matsui, Stephen H Embury. A potent oral P-selectin blocking agent improves microcirculatory blood flow and a marker of endothelial cell injury in patients with sickle cell disease.
American journal of hematology.
2012 May; 87(5):536-9. doi:
10.1002/ajh.23147. [PMID: 22488107] - Enrico Lupia, Feng Zheng, Fabrizio Grosjean, Ivan Tack, Sophie Doublier, Sharon J Elliot, Helen Vlassara, Gary E Striker. Pentosan polysulfate inhibits atherosclerosis in Watanabe heritable hyperlipidemic rabbits: differential modulation of metalloproteinase-2 and -9.
Laboratory investigation; a journal of technical methods and pathology.
2012 Feb; 92(2):236-45. doi:
10.1038/labinvest.2011.154. [PMID: 22042083] - Jin Wu, Tian-jun Guan, Shirong Zheng, Fabrizio Grosjean, Weicheng Liu, Huabao Xiong, Ronald Gordon, Helen Vlassara, Gary E Striker, Feng Zheng. Inhibition of inflammation by pentosan polysulfate impedes the development and progression of severe diabetic nephropathy in aging C57B6 mice.
Laboratory investigation; a journal of technical methods and pathology.
2011 Oct; 91(10):1459-71. doi:
10.1038/labinvest.2011.93. [PMID: 21808238] - Erinn McMillan, Mabunatu Roberts, Vasant M Doctor. Effect of in-vitro addition of sulfated xylans, glucosans or chondroitins on the prothrombin time of human plasma and on the enhancement of activation of glutamic plasminogen by tissue plasminogen activator.
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis.
2011 Apr; 22(3):221-6. doi:
10.1097/mbc.0b013e328343f8fe. [PMID: 21346556] - Zhengrong Guan, Barry S Fuller, Tatsuo Yamamoto, Anthony K Cook, Jennifer S Pollock, Edward W Inscho. Pentosan polysulfate treatment preserves renal autoregulation in ANG II-infused hypertensive rats via normalization of P2X1 receptor activation.
American journal of physiology. Renal physiology.
2010 May; 298(5):F1276-84. doi:
10.1152/ajprenal.00743.2009. [PMID: 20200092] - C Persu, V Cauni, S Gutue, Irina Blaj, V Jinga, P Geavlete. From interstitial cystitis to chronic pelvic pain.
Journal of medicine and life.
2010 Apr; 3(2):167-74. doi:
NULL. [PMID: 20968203] - Kenji Kumagai, Susumu Shirabe, Noriaki Miyata, Masakazu Murata, Atsushi Yamauchi, Yasuhumi Kataoka, Masami Niwa. Sodium pentosan polysulfate resulted in cartilage improvement in knee osteoarthritis--an open clinical trial.
BMC clinical pharmacology.
2010 Mar; 10(?):7. doi:
10.1186/1472-6904-10-7. [PMID: 20346179] - Mária A Deli, Szilvia Veszelka, Boglárka Csiszár, Andrea Tóth, Agnes Kittel, Mária Csete, Aron Sipos, Anikó Szalai, Lívia Fülöp, Botond Penke, Csongor S Abrahám, Masami Niwa. Protection of the blood-brain barrier by pentosan against amyloid-β-induced toxicity.
Journal of Alzheimer's disease : JAD.
2010; 22(3):777-94. doi:
10.3233/jad-2010-100759. [PMID: 20847411] - Y Mathison Natera, H J Finol, Z Quero, R González, J González. [Pentosan polysulfate sodium prevents kidney morphological changes and albuminuria in rats with type 1 diabetes].
Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia.
2010; 30(6):639-45. doi:
10.3265/nefrologia.pre2010.jul.10543. [PMID: 21113213] - Noriaki Miyata, Kenji Kumagai, Makoto Osaki, Masakazu Murata, Masato Tomita, Akira Hozumi, Yoshihiro Nozaki, Masami Niwa. Pentosan reduces osteonecrosis of femoral head in SHRSP.
Clinical and experimental hypertension (New York, N.Y. : 1993).
2010; 32(8):511-6. doi:
10.3109/10641963.2010.496511. [PMID: 21091356] - Jason Sea, Joel M H Teichman. Paediatric painful bladder syndrome/interstitial cystitis: diagnosis and treatment.
Drugs.
2009; 69(3):279-96. doi:
10.2165/00003495-200969030-00004. [PMID: 19275272] - Abhishek Seth, Joel M H Teichman. What's new in the diagnosis and management of painful bladder syndrome/interstitial cystitis?.
Current urology reports.
2008 Sep; 9(5):349-57. doi:
10.1007/s11934-008-0061-9. [PMID: 18702917] - Jukka Sairanen, Kristina Hotakainen, Teuvo L J Tammela, Ulf-Håkan Stenman, Mirja Ruutu. Urinary epidermal growth factor and interleukin-6 levels in patients with painful bladder syndrome/interstitial cystitis treated with cyclosporine or pentosan polysulfate sodium.
Urology.
2008 Apr; 71(4):630-3. doi:
10.1016/j.urology.2007.11.055. [PMID: 18387391] - T E Dawson, J Jamison. Intravesical treatments for painful bladder syndrome/ interstitial cystitis.
The Cochrane database of systematic reviews.
2007 Oct; ?(4):CD006113. doi:
10.1002/14651858.cd006113.pub2. [PMID: 17943887] - Jordan Dimitrakov, Kurt Kroenke, William D Steers, Charles Berde, David Zurakowski, Michael R Freeman, Jeffrey L Jackson. Pharmacologic management of painful bladder syndrome/interstitial cystitis: a systematic review.
Archives of internal medicine.
2007 Oct; 167(18):1922-9. doi:
10.1001/archinte.167.18.1922. [PMID: 17923590] - Rohan Shahani, Cathy Streutker, Brendan Dickson, Robert J Stewart. Ketamine-associated ulcerative cystitis: a new clinical entity.
Urology.
2007 May; 69(5):810-2. doi:
10.1016/j.urology.2007.01.038. [PMID: 17482909] - Steven C Budsberg, Mary Sarah Bergh, Lisa R Reynolds, Heather K Streppa. Evaluation of pentosan polysulfate sodium in the postoperative recovery from cranial cruciate injury in dogs: a randomized, placebo-controlled clinical trial.
Veterinary surgery : VS.
2007 Apr; 36(3):234-44. doi:
10.1111/j.1532-950x.2007.00256.x. [PMID: 17461948] - C Lowell Parsons. The role of the urinary epithelium in the pathogenesis of interstitial cystitis/prostatitis/urethritis.
Urology.
2007 Apr; 69(4 Suppl):9-16. doi:
10.1016/j.urology.2006.03.084. [PMID: 17462486] - Mahadevan Rajasekaran, Paul Stein, C Lowell Parsons. Toxic factors in human urine that injure urothelium.
International journal of urology : official journal of the Japanese Urological Association.
2006 Apr; 13(4):409-14. doi:
10.1111/j.1442-2042.2006.01301.x. [PMID: 16734860] - Deborah R Erickson, Mostafa Sheykhnazari, Veer P Bhavanandan. Molecular size affects urine excretion of pentosan polysulfate.
The Journal of urology.
2006 Mar; 175(3 Pt 1):1143-7. doi:
10.1016/s0022-5347(05)00319-8. [PMID: 16469641] - Tongyao Liu, Ciaran D Scallan, George J Broze, Susanna Patarroyo-White, Glenn F Pierce, Kirk W Johnson. Improved coagulation in bleeding disorders by Non-Anticoagulant Sulfated Polysaccharides (NASP).
Thrombosis and haemostasis.
2006 Jan; 95(1):68-76. doi:
10.1160/th05-05-0361. [PMID: 16543964] - Jukka Sairanen, Teuvo L J Tammela, Mikael Leppilahti, Markku Multanen, Ilkka Paananen, Kari Lehtoranta, Mirja Ruutu. Cyclosporine A and pentosan polysulfate sodium for the treatment of interstitial cystitis: a randomized comparative study.
The Journal of urology.
2005 Dec; 174(6):2235-8. doi:
10.1097/01.ju.0000181808.45786.84. [PMID: 16280777] - M Simon, R H McClanahan, J F Shah, T Repko, N B Modi. Metabolism of [3H]pentosan polysulfate sodium (PPS) in healthy human volunteers.
Xenobiotica; the fate of foreign compounds in biological systems.
2005 Aug; 35(8):775-84. doi:
10.1080/00498250500230586. [PMID: 16278190] - C Lowell Parsons, Robert A Greene, Maurice Chung, Edward J Stanford, Gita Singh. Abnormal urinary potassium metabolism in patients with interstitial cystitis.
The Journal of urology.
2005 Apr; 173(4):1182-5. doi:
10.1097/01.ju.0000148361.82074.77. [PMID: 15758737] - Sarbjinder S Sandhu, Miles Goldstraw, Christopher R J Woodhouse. The management of haemorrhagic cystitis with sodium pentosan polysulphate.
BJU international.
2004 Oct; 94(6):845-7. doi:
10.1111/j.1464-410x.2004.05044.x. [PMID: 15476520] - Felix Grases, Bernat Isern, Joan Perelló, Antonia Costa-Bauzá. The role of glycoproteins in calcium oxalate crystal development.
BJU international.
2004 Jul; 94(1):177-81. doi:
10.1111/j.1464-4096.2004.04877.x. [PMID: 15217456] - NULL. NTP technical report on the toxicology and carcinogenesis studies of Elmiron (Cas No. 37319-17-8) in F344/N rats and B6C3F1 mice (Gavage Studies).
National Toxicology Program technical report series.
2004 May; ?(512):7-289. doi:
NULL. [PMID: 15213766] - G R Sant, K J Propert, P M Hanno, D Burks, D Culkin, A C Diokno, C Hardy, J R Landis, R Mayer, R Madigan, E M Messing, K Peters, T C Theoharides, J Warren, A J Wein, W Steers, J W Kusek, L M Nyberg. A pilot clinical trial of oral pentosan polysulfate and oral hydroxyzine in patients with interstitial cystitis.
The Journal of urology.
2003 Sep; 170(3):810-5. doi:
10.1097/01.ju.0000083020.06212.3d. [PMID: 12913705] - S J Elliot, B H Zorn, D G McLeod, J W Moul, L Nyberg, L J Striker, G E Striker. Pentosan polysulfate decreases prostate smooth muscle proliferation and extracellular matrix turnover.
Prostate cancer and prostatic diseases.
2003; 6(2):138-42. doi:
10.1038/sj.pcan.4500632. [PMID: 12806372] - Slawomir Mucha, Gabriela Melen-Mucha, Tomasz Stepien, Andrzej Godlewski, Henryk Stepien. Effects of pentosan polysulfate sodium on the estrogen-induced pituitary prolactinoma in Fischer 344 rats.
Oncology reports.
2002 Nov; 9(6):1385-9. doi:
10.3892/or.9.6.1385. [PMID: 12375053] - Tatsuya Nakatani, Keiichi Ishii, Yukio Yoneda, Sadanori Kamikawa, Toshinao Kanazawa, Toshikado Sugimoto, Hartmut Osswald. The preventive effect of sodium pentosan polysulfate against renal stone formation in hyperoxaluric rats.
Urological research.
2002 Oct; 30(5):329-35. doi:
10.1007/s00240-002-0271-4. [PMID: 12389123] - Provash C Sadhukhan, Marie-Blanche Tchetgen, Raymond R Rackley, Sandip P Vasavada, Louis Liou, Sudip K Bandyopadhyay. Sodium pentosan polysulfate reduces urothelial responses to inflammatory stimuli via an indirect mechanism.
The Journal of urology.
2002 Jul; 168(1):289-92. doi:
NULL. [PMID: 12050558] - Andis Klegeris, Edith A Singh, Patrick L McGeer. Effects of C-reactive protein and pentosan polysulphate on human complement activation.
Immunology.
2002 Jul; 106(3):381-8. doi:
10.1046/j.1365-2567.2002.01425.x. [PMID: 12100726] - Jaime Herrera-Acosta, Edilia Tapia, Laura G Sánchez-Lozada, Martha Franco, Liliane J Striker, Gary E Striker, Iturbe Bernardo Rodríguez. Restoration of glomerular haemodynamics and renal injury independent of arterial hypertension in rats with subtotal renal ablation.
Journal of hypertension. Supplement : official journal of the International Society of Hypertension.
2002 Jun; 20(3):S29-35. doi:
NULL. [PMID: 12184053] - C J Fuller, P Ghosh, A R S Barr. Plasma and synovial fluid concentrations of calcium pentosan polysulphate achieved in the horse following intramuscular injection.
Equine veterinary journal.
2002 Jan; 34(1):61-4. doi:
10.2746/042516402776181123. [PMID: 11822373] - Norma A Bobadilla, Ivan Tack, Edilia Tapia, Laura G Sánchez-Lozada, José Santamaría, Fabiola Jiménez, Liliane J Striker, Gary E Striker, Jaime Herrera-Acosta. Pentosan polysulfate prevents glomerular hypertension and structural injury despite persisting hypertension in 5/6 nephrectomy rats.
Journal of the American Society of Nephrology : JASN.
2001 Oct; 12(10):2080-2087. doi:
10.1681/asn.v12102080. [PMID: 11562406] - J F Metts. Interstitial cystitis: urgency and frequency syndrome.
American family physician.
2001 Oct; 64(7):1199-206. doi:
NULL. [PMID: 11601802] - A Dart, N Perkins, Dowling, T Batterham, C Livingston, D Hodgson. The effect of three different doses of sodium pentosan polysulphate on haematological and haemostatic variables in adult horses.
Australian veterinary journal.
2001 Sep; 79(9):624-7. doi:
10.1111/j.1751-0813.2001.tb10784.x. [PMID: 11702935] - B Schirm, H Benend, H Wätzig. Improvements in pentosan polysulfate sodium quality assurance using fingerprint electropherograms.
Electrophoresis.
2001 Apr; 22(6):1150-62. doi:
10.1002/1522-2683()22:6<1150::aid-elps1150>3.0.co;2-5. [PMID: 11358141] - M Demir, O Iqbal, B Untch, D A Hoppensteadt, B S Gaikwad, J Fareed. Ecarin clotting time is sensitive to heparinoids: comparison of two different techniques.
Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis.
2001 Jan; 7(1):38-43. doi:
10.1177/107602960100700109. [PMID: 11190903] - D J Schaeffer, V S Krylov. Anti-HIV activity of extracts and compounds from algae and cyanobacteria.
Ecotoxicology and environmental safety.
2000 Mar; 45(3):208-27. doi:
10.1006/eesa.1999.1862. [PMID: 10702339] - S B Schwedler, N Bobadilla, L J Striker, C A Vaamonde, J Herrera-Acosta, G E Striker. Pentosan polysulfate treatment reduces cyclosporine-induced nephropathy in salt-depleted rats.
Transplantation.
1999 Nov; 68(10):1583-8. doi:
10.1097/00007890-199911270-00025. [PMID: 10589959] - T Nishino, A Fukuda, T Nagumo, M Fujihara, E Kaji. Inhibition of the generation of thrombin and factor Xa by a fucoidan from the brown seaweed Ecklonia kurome.
Thrombosis research.
1999 Oct; 96(1):37-49. doi:
10.1016/s0049-3848(99)00060-2. [PMID: 10554083] - J Giedrojć, M Klimiuk, P Radziwon, J Kłoczko, M Bielawiec, H K Breddin. Comparative study on the in vitro and in vivo activities of heparinoids derivative investigated on the animal model.
Journal of cardiovascular pharmacology.
1999 Sep; 34(3):340-5. doi:
10.1097/00005344-199909000-00004. [PMID: 10470990] - A L Russell. Glycoaminoglycan (GAG) deficiency in protective barrier as an underlying, primary cause of ulcerative colitis, Crohn's disease interstitial cystitis and possibly Reiter's syndrome.
Medical hypotheses.
1999 Apr; 52(4):297-301. doi:
10.1054/mehy.1997.0652. [PMID: 10465666] - P Ghosh. The pathobiology of osteoarthritis and the rationale for the use of pentosan polysulfate for its treatment.
Seminars in arthritis and rheumatism.
1999 Feb; 28(4):211-67. doi:
10.1016/s0049-0172(99)80021-3. [PMID: 10073500] - S J Elliot, L J Striker, W G Stetler-Stevenson, T A Jacot, G E Striker. Pentosan polysulfate decreases proliferation and net extracellular matrix production in mouse mesangial cells.
Journal of the American Society of Nephrology : JASN.
1999 Jan; 10(1):62-8. doi:
10.1681/asn.v10162. [PMID: 9890310] - D Senthil, M M Malini, P Varalakshmi. Sodium pentosan polysulphate--a novel inhibitor of urinary risk factors and enzymes in experimental urolithiatic rats.
Renal failure.
1998 Jul; 20(4):573-80. doi:
10.3109/08860229809045149. [PMID: 9713875] - K S Kilgore, K B Naylor, E J Tanhehco, J L Park, E A Booth, R A Washington, B R Lucchesi. The semisynthetic polysaccharide pentosan polysulfate prevents complement-mediated myocardial injury in the rabbit perfused heart.
The Journal of pharmacology and experimental therapeutics.
1998 Jun; 285(3):987-94. doi:
NULL. [PMID: 9618399] - J L Marshall, A Wellstein, J Rae, R J DeLap, K Phipps, J Hanfelt, M K Yunmbam, J X Sun, K L Duchin, M J Hawkins. Phase I trial of orally administered pentosan polysulfate in patients with advanced cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research.
1997 Dec; 3(12 Pt 1):2347-54. doi:
NULL. [PMID: 9815633] - C E Orme, R C Harris, D J Marlin, J Hurley. Metabolic adaptation to fat-supplemented diet by the thoroughbred horse.
The British journal of nutrition.
1997 Sep; 78(3):443-58. doi:
10.1079/bjn19970162. [PMID: 9306885] - P Hwang, B Auclair, D Beechinor, M Diment, T R Einarson. Efficacy of pentosan polysulfate in the treatment of interstitial cystitis: a meta-analysis.
Urology.
1997 Jul; 50(1):39-43. doi:
10.1016/s0090-4295(97)00110-6. [PMID: 9218016] - C E Orme, R C Harris. A comparison of the lipolytic and anticoagulative properties of heparin and pentosan polysulphate in the thoroughbred horse.
Acta physiologica Scandinavica.
1997 Feb; 159(2):179-85. doi:
10.1046/j.1365-201x.1997.504239000.x. [PMID: 9055947] - J W Barrington, T P Stephenson. Pentosanpolysulphate for interstitial cystitis.
International urogynecology journal and pelvic floor dysfunction.
1997; 8(5):293-5. doi:
10.1007/bf02765487. [PMID: 9557994] - J P Chippaux, V S Rakotonirina, A Rakotonirina, G Dzikouk. [Drug or plant substances which antagonize venoms or potentiate antivenins].
Bulletin de la Societe de pathologie exotique (1990).
1997; 90(4):282-5. doi:
". [PMID: 9479470] - C Zenjari, Y Boilly-Marer, X Desbiens, M Oudghir, H Hondermarck, B Boilly. Experimental evidence for FGF-1 control of blastema cell proliferation during limb regeneration of the amphibian Pleurodeles waltl.
The International journal of developmental biology.
1996 Oct; 40(5):965-71. doi:
". [PMID: 8946244] - J W Barrington, S Fulford, L Fraylin, R Fish, M Shelley, T P Stephenson. Reduction of urinary basic fibroblast growth factor using pentosan polysulphate sodium.
British journal of urology.
1996 Jul; 78(1):54-6. doi:
10.1046/j.1464-410x.1996.05710.x. [PMID: 8795400] - A Wellstein, F Czubayko. Inhibition of fibroblast growth factors.
Breast cancer research and treatment.
1996; 38(1):109-19. doi:
10.1007/bf01803789. [PMID: 8825128] - S L Shyng, S Lehmann, K L Moulder, D A Harris. Sulfated glycans stimulate endocytosis of the cellular isoform of the prion protein, PrPC, in cultured cells.
The Journal of biological chemistry.
1995 Dec; 270(50):30221-9. doi:
10.1074/jbc.270.50.30221. [PMID: 8530433] - S Nishio. [Role of glycosaminoglycans relating to formation of urolithiasis].
Nihon Hinyokika Gakkai zasshi. The japanese journal of urology.
1995 Nov; 86(11):1597-609. doi:
10.5980/jpnjurol1989.86.1597. [PMID: 8551701] - R B Simmons, G R Newton, V M Doctor. Effect of sulfated xylans during the interaction of [125I]-thrombin with antithrombin III or heparin cofactor II of human plasma.
European journal of drug metabolism and pharmacokinetics.
1995 Jan; 20(1):73-7. doi:
10.1007/bf03192291. [PMID: 7588997] - S Ebisuno, Y Kohjimoto, M Tamura, T Ohkawa. Adhesion of calcium oxalate crystals to Madin-Darby canine kidney cells and some effects of glycosaminoglycans or cell injuries.
European urology.
1995; 28(1):68-73. doi:
10.1159/000475023. [PMID: 8521899] - K Suzuki, R Tsugawa. Analysis of glycosaminoglycans induced in newly formed calcium oxalate crystals using an undiluted urine system.
Scanning microscopy.
1995; 9(4):1089-95; discussion 1095. doi:
NULL. [PMID: 8819890] - Z Khaled, D Rideout, K R O'Driscoll, D Petrylak, A Cacace, R Patel, L C Chiang, S Rotenberg, C A Stein. Effects of suramin-related and other clinically therapeutic polyanions on protein kinase C activity.
Clinical cancer research : an official journal of the American Association for Cancer Research.
1995 Jan; 1(1):113-22. doi:
". [PMID: 9815893] - K E Goad, M K Horne, H R Gralnick. Pentosan-induced thrombocytopenia: support for an immune complex mechanism.
British journal of haematology.
1994 Dec; 88(4):803-8. doi:
10.1111/j.1365-2141.1994.tb05120.x. [PMID: 7529541] - C J Jackson, I Giles, A Knop, A Nethery, L Schrieber. Sulfated polysaccharides are required for collagen-induced vascular tube formation.
Experimental cell research.
1994 Dec; 215(2):294-302. doi:
10.1006/excr.1994.1345. [PMID: 7526991] - P S Braddock, D E Hu, T P Fan, I J Stratford, A L Harris, R Bicknell. A structure-activity analysis of antagonism of the growth factor and angiogenic activity of basic fibroblast growth factor by suramin and related polyanions.
British journal of cancer.
1994 May; 69(5):890-8. doi:
10.1038/bjc.1994.172. [PMID: 7514028] - M M Smith, P Ghosh, Y Numata, M K Bansal. The effects of orally administered calcium pentosan polysulfate on inflammation and cartilage degradation produced in rabbit joints by intraarticular injection of a hyaluronate-polylysine complex.
Arthritis and rheumatism.
1994 Jan; 37(1):125-36. doi:
10.1002/art.1780370118. [PMID: 7510481] - G Lüdecke, K Unsicker. HOE-BAY 946 has distinct effects on spontaneous and FGF induced proliferation of epithelial and neuroblastoma cell lines.
Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft.
1994 Jan; 176(1):33-8. doi:
10.1016/s0940-9602(11)80411-5. [PMID: 8304589] - T Kälble, F Amelung, K Möhring, G Staehler. Prevention of colon tumors following urinary diversion by antagonizing of nitrosamines or separation of feces and urine?.
Investigative urology (Berlin, Germany).
1994; 5(?):239-43. doi:
NULL. [PMID: 7536521] - B Fellström, U Backman, B Danielson, B Wikström. Treatment of renal calcium stone disease with the synthetic glycosaminoglycan pentosan polysulphate.
World journal of urology.
1994; 12(1):52-4. doi:
10.1007/bf00182052. [PMID: 7516780] - F Grases, M Kroupa, A Costa-Bauzá. Studies on calcium oxalate monohydrate crystallization: influence of inhibitors.
Urological research.
1994; 22(1):39-43. doi:
10.1007/bf00431547. [PMID: 7521089] - H P Klöcking, W Schunk, G Merkmann, C Giessmann, H Knoll, S Borgmann. A natural rubber drainage tube with antithrombogenic lumen surface.
Thrombosis research.
1993 Dec; 72(6):501-7. doi:
10.1016/0049-3848(93)90110-a. [PMID: 7510427] - J M Pluda, L E Shay, A Foli, S Tannenbaum, P J Cohen, B R Goldspiel, D Adamo, M R Cooper, S Broder, R Yarchoan. Administration of pentosan polysulfate to patients with human immunodeficiency virus-associated Kaposi's sarcoma.
Journal of the National Cancer Institute.
1993 Oct; 85(19):1585-92. doi:
10.1093/jnci/85.19.1585. [PMID: 7692072] - B W Parker, S M Swain, G Zugmaier, R L DeLap, M E Lippman, A Wellstein. Detectable inhibition of heparin-binding growth factor activity in sera from patients treated with pentosan polysulfate.
Journal of the National Cancer Institute.
1993 Jul; 85(13):1068-73. doi:
10.1093/jnci/85.13.1068. [PMID: 7685831] - K Subha, P Varalakshmi. Effect of sodium pentosan polysulphate on tissue lipids in control and glycollate treated rats.
Pharmacological research.
1993 May; 27(4):289-97. doi:
10.1006/phrs.1993.1029. [PMID: 7690133] - K Subha, P Varalakshmi. Alterations in some risk factors and urinary enzymes in urolithiatic rats treated with sodium pentosan polysulphate.
Biochemistry and molecular biology international.
1993 Feb; 29(2):271-80. doi:
. [PMID: 7684293] - G Zugmaier, M E Lippman, A Wellstein. Inhibition by pentosan polysulfate (PPS) of heparin-binding growth factors released from tumor cells and blockage by PPS of tumor growth in animals.
Journal of the National Cancer Institute.
1992 Nov; 84(22):1716-24. doi:
10.1093/jnci/84.22.1716. [PMID: 1279186]