Lymecycline (BioDeep_00000033212)

   

human metabolite blood metabolite Chemicals and Drugs


代谢物信息卡片


(2S)-6-[({[(4S,4aS,5aS,6S,12aS)-4-(dimethylamino)-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracen-2-yl]formamido}methyl)amino]-2-aminohexanoic acid

化学式: C29H38N4O10 (602.2587808)
中文名称: 四环素亚甲赖氨酸
谱图信息: 最多检出来源 Homo sapiens(blood) 90.91%

分子结构信息

SMILES: CC1(C2CC3C(C(=O)C(=C(C3(C(=O)C2=C(C4=C1C=CC=C4O)O)O)O)C(=O)NCNCCCCC(C(=O)O)N)N(C)C)O
InChI: InChI=1S/C29H38N4O10/c1-28(42)13-7-6-9-17(34)18(13)22(35)19-14(28)11-15-21(33(2)3)23(36)20(25(38)29(15,43)24(19)37)26(39)32-12-31-10-5-4-8-16(30)27(40)41/h6-7,9,14-16,21,31,34,36-37,42-43H,4-5,8,10-12,30H2,1-3H3,(H,32,39)(H,40,41)/t14-,15-,16-,21-,28+,29-/m0/s1

描述信息

Lymecycline is only found in individuals that have used or taken this drug. It is a tetracycline with a 7-chloro substitution.Lymecycline inhibits cell growth by inhibiting translation. It binds to the 30S ribosomal subunit and prevents the amino-acyl tRNA from binding to the A site of the ribosome. The binding is reversible in nature. Lymecycline is lipophilic and can easily pass through the cell membrane or passively diffuses through porin channels in the bacterial membrane. Cells become resistant to lymecycline by at least two mechanisms: efflux and ribosomal protection. In efflux, a resistance gene encodes a membrane protein that actively pumps lymecycline out of the cell. This is the mechanism of action of the tetracycline resistance gene on the artificial plasmid pBR322. In ribosomal protection, a resistance gene encodes a protein which binds to the ribosome and prevents lymecycline from acting on the ribosome.
J - Antiinfectives for systemic use > J01 - Antibacterials for systemic use > J01A - Tetracyclines > J01AA - Tetracyclines
C784 - Protein Synthesis Inhibitor > C1595 - Tetracycline Antibiotic
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents
C254 - Anti-Infective Agent > C258 - Antibiotic

同义名列表

16 个代谢物同义名

(2S)-6-[({[(4S,4aS,5aS,6S,12aS)-4-(dimethylamino)-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracen-2-yl]formamido}methyl)amino]-2-aminohexanoic acid; (+)-N-(5-Amino-5-carboxypentylaminomethyl)-4-dimethylamino-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxonaphthacene-2-carboxamide; N6-((4-(Dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenecarboxamido)methyl)lysine; N(2)-(((+)-5-Amino-5-carboxypentylamino)methyl)tetracycline; Tetracycline-L-methylene lysine; Tetracycline-L-methylenelysine; Chlortetracyclinium chloride; N-Lysinomethyltetracycline; 7-Chlorotetracycline; Chlorotetracycline; Chlortetracycline; Chlortetracyclin; Lymecyclinum; Limeciclina; Lymecycline; CLTC



数据库引用编号

9 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

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1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • A Lauhio, Y T Konttinen, T Salo, H Tschesche, J Lähdevirta, F Woessner, L M Golub, T Sorsa. Placebo-controlled study of the effects of three-month lymecycline treatment on serum matrix metalloproteinases in reactive arthritis. Annals of the New York Academy of Sciences. 1994 Sep; 732(?):424-6. doi: 10.1111/j.1749-6632.1994.tb24774.x. [PMID: 7978828]
  • A Lauhio, M Leirisalo-Repo, J Lähdevirta, P Saikku, H Repo. Double-blind, placebo-controlled study of three-month treatment with lymecycline in reactive arthritis, with special reference to Chlamydia arthritis. Arthritis and rheumatism. 1991 Jan; 34(1):6-14. doi: 10.1002/art.1780340103. [PMID: 1670621]
  • M Bjellerup, B Ljunggren. Double blind cross-over studies on phototoxicity to three tetracycline derivatives in human volunteers. Photo-dermatology. 1987 Dec; 4(6):281-7. doi: NULL. [PMID: 3127815]
  • A Schreiner, A Digranes. Pharmacokinetics of lymecycline and doxycycline in serum and suction blister fluid. Chemotherapy. 1985; 31(4):261-5. doi: 10.1159/000238345. [PMID: 4028871]
  • G Sjölin-Forsberg, J Hermansson. Comparative bioavailability of tetracycline and lymecycline. British journal of clinical pharmacology. 1984 Oct; 18(4):529-33. doi: 10.1111/j.1365-2125.1984.tb02500.x. [PMID: 6487493]
  • L Forslin, D Danielson, J Kjellander, V Falk. Antibiotic treatment of acute salpingitis. A study of plasma concentrations of two tetracyclines (doxycycline and lymecycline). Acta obstetricia et gynecologica Scandinavica. 1982; 61(1):59-64. doi: 10.3109/00016348209156953. [PMID: 7090752]
  • S Ericsson, H Gnarpe. Lymecycline or doxycycline for treatment of urinary-tract infections: a comparison of attained urine concentrations. Microbios. 1978; 20(80):95-8. doi: NULL. [PMID: 732594]
  • C Ekedahl, S E Holm, A M Bergholm. Penetration of antibiotics into the normal and diseased maxillary sinus mucosa. Scandinavian journal of infectious diseases. Supplementum. 1978; ?(14):279-84. doi: NULL. [PMID: 100874]
  • R R Bailey. Tetracylines continue to be prescribed for patients with renal failure. The New Zealand medical journal. 1976 Nov; 84(575):373-4. doi: NULL. [PMID: 1071152]
  • J L WHITBY, H J BLACK. COMPARISON OF LYMECYCLINE WITH TETRACYCLINE HYDROCHLORIDE. British medical journal. 1964 Dec; 2(5423):1491-5. doi: 10.1136/bmj.2.5423.1491. [PMID: 14214184]
  • M PARRAVICINI. [COMPARISON OF BLOOD LEVELS AND URINARY EXCRETION OF TETRACYCLINE-L METHYLENE-LYSINE AND OF DEMETHYLCHLORTETRACYCLINE HYDROCHLORIDE ADMINISTERED TO HUMANS BY ORAL ROUTE]. La Riforma medica. 1964 Jun; 78(?):712-5. doi: NULL. [PMID: 14172594]