Idoxuridine (BioDeep_00000033211)

human metabolite blood metabolite Chemicals and Drugs Antibiotics

代谢物信息卡片

1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-iodo-1,2,3,4-tetrahydropyrimidine-2,4-dione

化学式: C9H11IN2O5 (353.9712706)
中文名称: 5-碘-2-脱氧尿苷
谱图信息: 最多检出来源 Homo sapiens(blood) 96.15%

分子结构信息

SMILES: C1C(C(OC1N2C=C(C(=O)NC2=O)I)CO)O
InChI: InChI=1S/C9H11IN2O5/c10-4-2-12(9(16)11-8(4)15)7-1-5(14)6(3-13)17-7/h2,5-7,13-14H,1,3H2,(H,11,15,16)/t5-,6+,7+/m0/s1

描述信息

Idoxuridine is only found in individuals that have used or taken this drug. It is an analog of deoxyuridine that inhibits viral DNA synthesis. The drug is used as an antiviral agent. [PubChem]Idoxuridine acts as an antiviral agent by inhibiting viral replication by substituting itself for thymidine in viral DNA. This in turn inhibits thymidylate phosphorylase and viral DNA polymerases from properly functioning. The effect of Idoxuridine results in the inability of the virus to reproduce or to infect/destroy tissue.
J - Antiinfectives for systemic use > J05 - Antivirals for systemic use > J05A - Direct acting antivirals > J05AB - Nucleosides and nucleotides excl. reverse transcriptase inhibitors
D - Dermatologicals > D06 - Antibiotics and chemotherapeutics for dermatological use > D06B - Chemotherapeutics for topical use > D06BB - Antivirals
S - Sensory organs > S01 - Ophthalmologicals > S01A - Antiinfectives > S01AD - Antivirals
D004791 - Enzyme Inhibitors > D019384 - Nucleic Acid Synthesis Inhibitors
D000890 - Anti-Infective Agents > D000998 - Antiviral Agents
C274 - Antineoplastic Agent > C798 - Radiosensitizing Agent
Idoxuridine (5-Iodo-2′-deoxyuridine, 5-IUdR, IdUrd) is an iodinated thymidine analogue that competitively inhibits phosphorylases. Idoxuridine can inhibit viral activity, particularly viral eye infections, including herpes simplex keratitis, by inhibiting DNA polymerase and affecting viral replication. Idoxuridine against feline herpesvirus has the IC50 value of 4.3 μM[1]. Idoxuridine shows anti-orthopoxvirus activity.

同义名列表

62 个代谢物同义名

1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-iodo-1,2,3,4-tetrahydropyrimidine-2,4-dione; 1-(2-Deoxy-beta-D-ribofuranosyl)-5-iodouracil; 1-beta-D-2-Deoxyribofuranosyl-5-iodouracil; 1-(2-Deoxy-b-D-ribofuranosyl)-5-iodouracil; 1-(2-Deoxy-β-D-ribofuranosyl)-5-iodouracil; 1beta-D-2-Deoxyribofuranosyl-5-iodouracil; 1-Β-D-2-deoxyribofuranosyl-5-iodouracil; 1-b-D-2-Deoxyribofuranosyl-5-iodouracil; 1Β-D-2-deoxyribofuranosyl-5-iodouracil; 1b-D-2-Deoxyribofuranosyl-5-iodouracil; Idoxuridine, radical ion (1-); Idoxuridine, radical ion (+1); 5-Iodouracil deoxyriboside; (+)-5-Iodo-2-deoxyuridine; Idoxuridine, 131I labeled; Idoxuridine, 131I-labeled; Idoxuridine, 123I labeled; Idoxuridine, 123I-labeled; Idoxuridine, 125I labeled; Idoxuridine, 125I-labeled; 123I-labeled idoxuridine; 131I-labeled idoxuridine; 125I-labeled idoxuridine; Idoxuridine, 3H-labeled; Idoxuridine, 3H labeled; 3H-Labeled idoxuridine; 5-Iodo-2-deoxyuridine; 5 Iodo 2 deoxyuridine; 2-Deoxy-5-iodouridine; 5-Iododeoxyuridine; Liquifilm, herplex; 5 Iododeoxyuridine; Herplex liquifilm; Iododeoxyuridine; Iododeoxyridine; SK And F-14287; Joddeoxiuridin; ABBR idu; Allergan 211; Allergan 201; Idossuridina; Idoxuridinum; Iodoxuridine; idoxuridine; Idoxuridina; Idoxuridin; Oftan-idu; Oftan idu; OftanIDU; Kerecide; Dendrid; Herplex; Stoxil; 5IUDR; IDUR; 5IDU; IUDR; ID2; IdU; 5-Iodo-2′-deoxyuridine; 5-IUdR; IdUrd

数据库引用编号

11 个数据库交叉引用编号

ChEBI: CHEBI:147675
PubChem: 5905
HMDB: HMDB0014394
DrugBank: DB00249
ChEMBL: CHEMBL788
Wikipedia: Idoxuridine
MeSH: Idoxuridine
KNApSAcK: C00008801
chemspider: 5694
CAS: 54-42-2
medchemexpress: HY-B0307

分类词条

Pyrimidine 2'-deoxyribonucleosides

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

9606 - Homo sapiens: -

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

文献列表

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