Hydroxylansoprazole (BioDeep_00000033176)
human metabolite Endogenous blood metabolite
代谢物信息卡片
化学式: C16H14F3N3O3S (385.0707930000001)
中文名称: 5-羟基兰索拉唑
谱图信息:
最多检出来源 Homo sapiens(blood) 97.83%
分子结构信息
SMILES: CC1=C(C=CN=C1CS(=O)C2=NC3=C(N2)C=C(C=C3)O)OCC(F)(F)F
InChI: InChI=1S/C16H14F3N3O3S/c1-9-13(20-5-4-14(9)25-8-16(17,18)19)7-26(24)15-21-11-3-2-10(23)6-12(11)22-15/h2-6,23H,7-8H2,1H3,(H,21,22)
描述信息
Hydroxylansoprazole is only found in individuals that have used or taken Lansoprazole. Hydroxylansoprazole is a metabolite of Lansoprazole. Hydroxylansoprazole belongs to the family of Sulfinylbenzimidazoles. These are polycyclic aromatic compounds containing a sulfinyl group attached at the position 2 of a benzimidazole moiety.
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相关代谢途径
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代谢反应
0 个相关的代谢反应过程信息。
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1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Jenny Beebe, Sophia Josephraj, Chao J Wang, Jacob Danielson, Qingbin Cui, Caoqinglong Huang, Lincoln Barlow, Ryan H Zhang, Taolan Zhang, Harikrishna Nakshatri, Zizheng Dong, Xiaohong Li, Jing-Yuan Liu, Jian-Ting Zhang. Therapeutic Activity of the Lansoprazole Metabolite 5-Hydroxy Lansoprazole Sulfide in Triple-Negative Breast Cancer by Inhibiting the Enoyl Reductase of Fatty Acid Synthase.
Journal of medicinal chemistry.
2022 10; 65(20):13681-13691. doi:
10.1021/acs.jmedchem.2c00642. [PMID: 36257066] - Mustafa Tugrul Goktas, Ragip Ozgur Karaca, Said Kalkisim, Lokman Cevik, Levent Kilic, Ali Akdogan, Melih O Babaoglu, Atilla Bozkurt, Leif Bertilsson, Umit Yasar. Decreased Activity and Genetic Polymorphisms of CYP2C19 in Behçet's Disease.
Basic & clinical pharmacology & toxicology.
2017 Oct; 121(4):266-271. doi:
10.1111/bcpt.12710. [PMID: 27875029] - Dan Zhang, Yanan Zhang, Man Liu, Xiaolin Wang, Man Yang, Jing Han, Huichen Liu. Pharmacokinetics of lansoprazole and its main metabolites after single and multiple intravenous doses in healthy Chinese subjects.
European journal of drug metabolism and pharmacokinetics.
2013 Sep; 38(3):209-15. doi:
10.1007/s13318-012-0115-8. [PMID: 23229306] - Ersin Gumus, Ozgur Karaca, Melih O Babaoglu, Gökhan Baysoy, Necati Balamtekin, Hulya Demir, Nuray Uslu, Atilla Bozkurt, Aysel Yuce, Umit Yasar. Evaluation of lansoprazole as a probe for assessing cytochrome P450 2C19 activity and genotype-phenotype correlation in childhood.
European journal of clinical pharmacology.
2012 May; 68(5):629-36. doi:
10.1007/s00228-011-1151-z. [PMID: 22076562] - Dan Zhang, Xiaolin Wang, Man Yang, Guocai Wang, Huichen Liu. Effects of CYP2C19 polymorphism on the pharmacokinetics of lansoprazole and its main metabolites in healthy Chinese subjects.
Xenobiotica; the fate of foreign compounds in biological systems.
2011 Jun; 41(6):511-7. doi:
10.3109/00498254.2011.559556. [PMID: 21521077] - Min Song, Xuan Gao, Taijun Hang, Aidong Wen. Simultaneous determination of lansoprazole and its metabolites 5'-hydroxy lansoprazole and lansoprazole sulphone in human plasma by LC-MS/MS: application to a pharmacokinetic study in healthy volunteers.
Journal of pharmaceutical and biomedical analysis.
2008 Dec; 48(4):1181-6. doi:
10.1016/j.jpba.2008.08.034. [PMID: 18945568] - Tsukasa Uno, Norio Yasui-Furukori, Takenori Takahata, Kazunobu Sugawara, Tomonori Tateishi. Lack of significant effect of grapefruit juice on the pharmacokinetics of lansoprazole and its metabolites in subjects with different CYP2C19 genotypes.
Journal of clinical pharmacology.
2005 Jun; 45(6):690-4. doi:
10.1177/0091270005275430. [PMID: 15901751] - Tsukasa Uno, Norio Yasui-Furukori, Takenori Takahata, Kazunobu Sugawara, Tomonori Tateishi. Determination of lansoprazole and two of its metabolites by liquid-liquid extraction and automated column-switching high-performance liquid chromatography: application to measuring CYP2C19 activity.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2005 Feb; 816(1-2):309-14. doi:
10.1016/j.jchromb.2004.11.052. [PMID: 15664363] - M Miura, H Tada, N Yasui-Furukori, T Uno, K Sugawara, T Tateishi, T Suzuki. Pharmacokinetic differences between the enantiomers of lansoprazole and its metabolite, 5-hydroxylansoprazole, in relation to CYP2C19 genotypes.
European journal of clinical pharmacology.
2004 Nov; 60(9):623-8. doi:
10.1007/s00228-004-0809-1. [PMID: 15448955]