6-O-Desmethyldonepezil (BioDeep_00000033163)

   

human metabolite Endogenous blood metabolite


代谢物信息卡片


2-[(1-benzylpiperidin-4-yl)methyl]-6-hydroxy-5-methoxy-2,3-dihydro-1H-inden-1-one

化学式: C23H27NO3 (365.1990832)
中文名称: 6-O-去甲基多奈哌齐
谱图信息: 最多检出来源 Mus musculus(blood) 24%

分子结构信息

SMILES: COC1=C(C=C2C(=C1)CC(C2=O)CC3CCN(CC3)CC4=CC=CC=C4)O
InChI: InChI=1S/C23H27NO3/c1-27-22-13-18-12-19(23(26)20(18)14-21(22)25)11-16-7-9-24(10-8-16)15-17-5-3-2-4-6-17/h2-6,13-14,16,19,25H,7-12,15H2,1H3

描述信息

6-O-Desmethyldonepezil is only found in individuals that have used or taken Donepezil. 6-O-Desmethyldonepezil is a metabolite of Donepezil. 6-o-desmethyldonepezil belongs to the family of Indanones. These are compounds containing an indane ring bearing a ketone group.

同义名列表

4 个代谢物同义名

2-[(1-benzylpiperidin-4-yl)methyl]-6-hydroxy-5-methoxy-2,3-dihydro-1H-inden-1-one; 2-[(1-benzylpiperidin-4-yl)methyl]-6-hydroxy-5-methoxy-2,3-dihydroinden-1-one; 6-O-Desmethyl Donepezil; 6-O-Desmethyldonepezil



数据库引用编号

5 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Jan Bures, Ilja Tacheci, Jaroslav Kvetina, Vera Radochova, Lukas Prchal, Darina Kohoutova, Martin Valis, Martin Novak, Rafael Dolezal, Marcela Kopacova, Stanislav Rejchrt, Vit Sestak, Veronika Knoblochova, Eva Peterova, Jana Zdarova Karasova. The Impact of Dextran Sodium Sulfate-Induced Gastrointestinal Injury on the Pharmacokinetic Parameters of Donepezil and Its Active Metabolite 6-O-desmethyldonepezil, and Gastric Myoelectric Activity in Experimental Pigs. Molecules (Basel, Switzerland). 2021 Apr; 26(8):. doi: 10.3390/molecules26082160. [PMID: 33918638]
  • Chae Bin Lee, Jee Sun Min, Soon Uk Chae, Hye Min Kim, Jun Hee Jang, In Ho Jung, Yu Fen Zheng, Jong Hoon Ryu, Soo Kyung Bae. Simultaneous determination of donepezil, 6-O-desmethyl donepezil and spinosin in beagle dog plasma using liquid chromatography‒tandem mass spectrometry and its application to a drug-drug interaction study. Journal of pharmaceutical and biomedical analysis. 2020 Jan; 178(?):112919. doi: 10.1016/j.jpba.2019.112919. [PMID: 31654856]
  • Francesca Groppa, Alessandra Coin, Giovanni De Rosa, Serena Granziera, Chiara Alexopoulos, Maria Valentina Pamio, Roberto Padrini. Monitoring Plasma Levels of Donepezil, 5-O-Desmethyl-Donepezil, 6-O-Desmethyl-Donepezil, and Donepezil-N-Oxide by a Novel HPLC Method in Patients With Alzheimer Disease. Therapeutic drug monitoring. 2016 Feb; 38(1):108-13. doi: 10.1097/ftd.0000000000000246. [PMID: 26349080]
  • Yun Ju Chae, Hong Joon Lee, Ji Hyun Jeon, In-Beom Kim, Jin-Sung Choi, Ki-Wug Sung, Sang June Hahn. Effects of donepezil on hERG potassium channels. Brain research. 2015 Feb; 1597(?):77-85. doi: 10.1016/j.brainres.2014.11.057. [PMID: 25498859]
  • Arshad H Khuroo, Sanjay J Gurule, Tausif Monif, Dipanjan Goswami, Arabinda Saha, Santosh K Singh. ESI-MS/MS stability-indicating bioanalytical method development and validation for simultaneous estimation of donepezil, 5-desmethyl donepezil and 6-desmethyl donepezil in human plasma. Biomedical chromatography : BMC. 2012 May; 26(5):636-49. doi: 10.1002/bmc.1709. [PMID: 22120680]
  • Nageswara Rao Pilli, Jaswanth Kumar Inamadugu, Neeraja Kondreddy, Vijaya Kumari Karra, Rajasekhar Damaramadugu, J V L N Seshagiri Rao. A rapid and sensitive LC-MS/MS method for quantification of donepezil and its active metabolite, 6-o-desmethyl donepezil in human plasma and its pharmacokinetic application. Biomedical chromatography : BMC. 2011 Aug; 25(8):943-51. doi: 10.1002/bmc.1552. [PMID: 21154884]
  • Bhavin N Patel, Naveen Sharma, Mallika Sanyal, Pranav S Shrivastav. Quantitation of donepezil and its active metabolite 6-O-desmethyl donepezil in human plasma by a selective and sensitive liquid chromatography-tandem mass spectrometric method. Analytica chimica acta. 2008 Nov; 629(1-2):145-57. doi: 10.1016/j.aca.2008.09.048. [PMID: 18940331]