N-Palmitoylglycine (BioDeep_00000032801)

 

Secondary id: BioDeep_00000600772

human metabolite PANOMIX_OTCML-2023 Endogenous


代谢物信息卡片


2-(Hexadecanoylamino)acetic acid

化学式: C18H35NO3 (313.26168000000007)
中文名称: N-棕榈酰甘氨酸
谱图信息: 最多检出来源 Homo sapiens(feces) 2.26%

Reviewed

Last reviewed on 2024-09-13.

Cite this Page

N-Palmitoylglycine. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/n-palmitoylglycine (retrieved 2024-11-10) (BioDeep RN: BioDeep_00000032801). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: CCCCCCCCCCCCCCCC(=O)NCC(=O)O
InChI: InChI=1S/C18H35NO3/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-17(20)19-16-18(21)22/h2-16H2,1H3,(H,19,20)(H,21,22)

描述信息

Palmitoylglycine is an acylglycine with C-16 fatty acid group as the acyl moiety. Acylglycines 1 possess a common amidoacetic acid moiety and are normally minor metabolites of fatty acids. Elevated levels of certain acylglycines appear in the urine and blood of patients with various fatty acid oxidation disorders. They are normally produced through the action of glycine N-acyltransferase which is an enzyme that catalyzes the chemical reaction: acyl-CoA + glycine ↔ CoA + N-acylglycine.
Palmitoylglycine is an acylglycine with C-16 fatty acid group as the acyl moiety.
Palmitoylglycine (N-palmitoyl glycine), an endogenous lipid that acts as a modulator of calcium influx and nitric oxide (NO) production in sensory neurons[1].

同义名列表

17 个代谢物同义名

2-(Hexadecanoylamino)acetic acid; N-(Carboxymethyl)octadecanamide; 2-(Hexadecanoylamino)acetate; 2-Hexadecanamidoacetic acid; N-(1-Oxooctadecyl)-glycine; N-Ethanoyl-hexadecanamide; 2-Hexadecanamidoacetate; N-palmitoyl glycine; Hexadecanoylglycine; N-Palmitoylglycine; Glycine steatamide; Glycine stearamide; N-Stearoylglycine; Palmitoylglycine; Elmiric acid; Elmirate; PALGLY



数据库引用编号

10 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

2 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • James R Foster, Shohta Ueno, Mao Xiang Chen, Jenni Harvey, Simon J Dowell, Andrew J Irving, Andrew J Brown. N-Palmitoylglycine and other N-acylamides activate the lipid receptor G2A/GPR132. Pharmacology research & perspectives. 2019 12; 7(6):e00542. doi: 10.1002/prp2.542. [PMID: 31768260]
  • Heather B Bradshaw, Siham Raboune, Jennifer L Hollis. Opportunistic activation of TRP receptors by endogenous lipids: exploiting lipidomics to understand TRP receptor cellular communication. Life sciences. 2013 Mar; 92(8-9):404-9. doi: 10.1016/j.lfs.2012.11.008. [PMID: 23178153]
  • Yumiko Yamano, Kazuhito Tsuboi, Yuki Hozaki, Kiyohiro Takahashi, Xing-Hua Jin, Natsuo Ueda, Akimori Wada. Lipophilic amines as potent inhibitors of N-acylethanolamine-hydrolyzing acid amidase. Bioorganic & medicinal chemistry. 2012 Jun; 20(11):3658-65. doi: 10.1016/j.bmc.2012.03.065. [PMID: 22542283]
  • Douglas McHugh, Sherry S J Hu, Neta Rimmerman, Ana Juknat, Zvi Vogel, J Michael Walker, Heather B Bradshaw. N-arachidonoyl glycine, an abundant endogenous lipid, potently drives directed cellular migration through GPR18, the putative abnormal cannabidiol receptor. BMC neuroscience. 2010 Mar; 11(?):44. doi: 10.1186/1471-2202-11-44. [PMID: 20346144]
  • Heather B Bradshaw, Sung Ha Lee, Douglas McHugh. Orphan endogenous lipids and orphan GPCRs: a good match. Prostaglandins & other lipid mediators. 2009 Sep; 89(3-4):131-4. doi: 10.1016/j.prostaglandins.2009.04.006. [PMID: 19379823]
  • Heather B Bradshaw, Neta Rimmerman, Sherry S-J Hu, Sumner Burstein, J Michael Walker. Novel endogenous N-acyl glycines identification and characterization. Vitamins and hormones. 2009; 81(?):191-205. doi: 10.1016/s0083-6729(09)81008-x. [PMID: 19647113]
  • Neta Rimmerman, Heather B Bradshaw, H Velocity Hughes, Jay Shih-Chieh Chen, Sherry Shu-Jung Hu, Douglas McHugh, Eivind Vefring, Jan A Jahnsen, Eric L Thompson, Kim Masuda, Benjamin F Cravatt, Sumner Burstein, Michael R Vasko, Anne L Prieto, David K O'Dell, J Michael Walker. N-palmitoyl glycine, a novel endogenous lipid that acts as a modulator of calcium influx and nitric oxide production in sensory neurons. Molecular pharmacology. 2008 Jul; 74(1):213-24. doi: 10.1124/mol.108.045997. [PMID: 18424551]
  • Karolina M Pajerowska-Mukhtar, M Shahid Mukhtar, Nicolas Guex, Vincentius A Halim, Sabine Rosahl, Imre E Somssich, Christiane Gebhardt. Natural variation of potato allene oxide synthase 2 causes differential levels of jasmonates and pathogen resistance in Arabidopsis. Planta. 2008 Jul; 228(2):293-306. doi: 10.1007/s00425-008-0737-x. [PMID: 18431595]
  • Massimo Maffei, Simone Bossi, Dieter Spiteller, Axel Mithöfer, Wilhelm Boland. Effects of feeding Spodoptera littoralis on lima bean leaves. I. Membrane potentials, intracellular calcium variations, oral secretions, and regurgitate components. Plant physiology. 2004 Apr; 134(4):1752-62. doi: 10.1104/pp.103.034165. [PMID: 15051862]