Tetrahydropyridine (BioDeep_00000327885)
代谢物信息卡片
1,2,3,4-tetrahydropyridine
化学式: C5H9N (83.0735)
中文名称: 1,2,3,4-四氢吡啶
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1=CNCCC1
InChI: InChI=1S/C5H9N/c1-2-4-6-5-3-1/h2,4,6H,1,3,5H2
数据库引用编号
5 个数据库交叉引用编号
- ChEBI: CHEBI:47859
- PubChem: 10176084
- MeSH: Pyrrolidines
- CAS: 37497-65-7
- PMhub: MS000114742
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Tanvi Patel, Kimberly McBennett, Senthilkumar Sankararaman, Teresa Schindler, Krithika Sundaram, Nori Mercuri Minich, Sindhoosha Malay, Katherine Kutney. Impact of elexacaftor/tezacaftor/ivacaftor on lipid and fat-soluble vitamin levels and association with body mass index.
Pediatric pulmonology.
2024 Mar; 59(3):734-742. doi:
10.1002/ppul.26823. [PMID: 38179878] - Kevin Lonabaugh, Galvin Li, Rhonda List, Reyna Huang, Amber James, Andrew Barros, Lindsay Somerville, Dana Albon. Real world study on elexacaftor-tezacaftor-ivacaftor impact on cholesterol levels in adults with cystic fibrosis.
Pharmacotherapy.
2024 Mar; 44(3):231-240. doi:
10.1002/phar.2903. [PMID: 38143243] - Houfu Leng, Anna Katharina Simon, Nicole J Horwood. Blocking glycosphingolipid production alters autophagy in osteoclasts and improves myeloma bone disease.
Autophagy.
2023 Sep; ?(?):1-3. doi:
10.1080/15548627.2023.2208931. [PMID: 37771244] - Kacper Piotr Kaminski, Lucien Bovet, Aurore Hilfiker, Helene Laparra, Joanne Schwaar, Nicolas Sierro, Gerhard Lang, Damien De Palo, Philippe Alexandre Guy, Csaba Laszlo, Simon Goepfert, Nikolai V Ivanov. Suppression of pyrrolidine ring biosynthesis and its effects on gene expression and subsequent accumulation of anatabine in leaves of tobacco (N. tabacum L.).
BMC genomics.
2023 Sep; 24(1):516. doi:
10.1186/s12864-023-09588-8. [PMID: 37667170] - Swati Pant, Mohan Gupta, Tulika Anthwal, Monika Chauhan, Sumitra Nain. Neuroprotective effects of novel pyrrolidine-2-one derivatives on scopolamine-induced cognitive impairment in mice: Behavioral and biochemical analysis.
Pharmacology, biochemistry, and behavior.
2023 Jul; ?(?):173602. doi:
10.1016/j.pbb.2023.173602. [PMID: 37453560] - Hannah M Parks, Maris A Cinelli, Matthew A Bedewitz, Josh M Grabar, Steven M Hurney, Kevin D Walker, A Daniel Jones, Cornelius S Barry. Redirecting tropane alkaloid metabolism reveals pyrrolidine alkaloid diversity in Atropa belladonna.
The New phytologist.
2023 03; 237(5):1810-1825. doi:
10.1111/nph.18651. [PMID: 36451537] - Aeyaz Ahmad Bhat, Iqubal Singh, Nitin Tandon, Runjhun Tandon. Structure activity relationship (SAR) and anticancer activity of pyrrolidine derivatives: Recent developments and future prospects (A review).
European journal of medicinal chemistry.
2023 Jan; 246(?):114954. doi:
10.1016/j.ejmech.2022.114954. [PMID: 36481599] - Hao Chen, Pei Hua, Dane Huang, Yuting Zhang, Huihao Zhou, Jun Xu, Qiong Gu. Discovery of Spiro[pyrrolidine-3,3'-oxindole] LXRβ Agonists for the Treatment of Osteoporosis.
Journal of medicinal chemistry.
2023 01; 66(1):752-765. doi:
10.1021/acs.jmedchem.2c01661. [PMID: 36539349] - Xi-Yang Tang, Jia-Xing Zeng, Xiao-Xing Wang, Wan-Yi Xu, Peng-Cheng Zhao, Cai-Lian Fan, Zhi-Hong Yao, Xin-Sheng Yao, Yi Dai. Chemical and metabolic profiling of Codonopsis Radix extract with an integrated strategy using ultra-high-performance liquid chromatography coupled with mass spectrometry.
Journal of separation science.
2023 Jan; 46(2):e2200723. doi:
10.1002/jssc.202200723. [PMID: 36401831] - Xiyang Tang, Cailian Fan, Jiaxing Zeng, Pengcheng Zhao, Xiaoxing Wang, Wanjun Cai, Ting Li, Yi Dai, Zhihong Yao, Xinsheng Yao. Targeted isolation and identification of bioactive pyrrolidine alkaloids from Codonopsis pilosula using characteristic fragmentation-assisted mass spectral networking.
Chinese journal of natural medicines.
2022 Dec; 20(12):948-960. doi:
10.1016/s1875-5364(22)60216-4. [PMID: 36549808] - Jyh-Jou Chen, Yen-Cheng Chiu, Pei-Lun Lee, Hung-Da Tung, Hung-Chih Chiu, Shih-Chieh Chien, Pin-Nan Cheng. Real-world effectiveness and safety of sofosbuvir/velpatasvir and glecaprevir/pibrentasvir for genotype 6 chronic hepatitis C.
Journal of the Formosan Medical Association = Taiwan yi zhi.
2022 Nov; 121(11):2265-2272. doi:
10.1016/j.jfma.2022.04.020. [PMID: 35581112] - K Kemenes, E Hidvégi, L Szabó, Á Kerner, G Süvegh. Metabolism of the synthetic cathinone alpha-pyrrolidinoisohexanophenone in humans using UHPLC-MS-QToF.
Journal of analytical toxicology.
2022 Oct; ?(?):. doi:
10.1093/jat/bkac085. [PMID: 36287060] - Ming-Jin Huang, Jun-Chi Wang, Shou-Mao Shen, Jian-Yong Si, Yue-Wei Guo. Stereochemical insights into neuroprotective alkaloids from the aerial parts of Emilia sonchifolia.
Fitoterapia.
2022 Oct; 162(?):105267. doi:
10.1016/j.fitote.2022.105267. [PMID: 35961597] - Lei Wang, Xinghong Wu, Ge Yang, Nan Hu, Zijian Zhao, Lei Zhao, Shengyu Li. Cannabidiol Alleviates the Damage to Dopaminergic Neurons in 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine-Induced Parkinson's Disease Mice Via Regulating Neuronal Apoptosis and Neuroinflammation.
Neuroscience.
2022 08; 498(?):64-72. doi:
10.1016/j.neuroscience.2022.06.036. [PMID: 35792194] - Rhythm Shukla, Francesca Lavore, Sourav Maity, Maik G N Derks, Chelsea R Jones, Bram J A Vermeulen, Adéla Melcrová, Michael A Morris, Lea Marie Becker, Xiaoqi Wang, Raj Kumar, João Medeiros-Silva, Roy A M van Beekveld, Alexandre M J J Bonvin, Joseph H Lorent, Moreno Lelli, James S Nowick, Harold D MacGillavry, Aaron J Peoples, Amy L Spoering, Losee L Ling, Dallas E Hughes, Wouter H Roos, Eefjan Breukink, Kim Lewis, Markus Weingarth. Teixobactin kills bacteria by a two-pronged attack on the cell envelope.
Nature.
2022 08; 608(7922):390-396. doi:
10.1038/s41586-022-05019-y. [PMID: 35922513] - Duncan Richards, Helen Millns, Louise Cookson, Mary Ann Lukas. An observational, non-interventional study for the follow-up of patients with amyloidosis who received miridesap followed by dezamizumab in a phase 1 study.
Orphanet journal of rare diseases.
2022 07; 17(1):259. doi:
10.1186/s13023-022-02405-7. [PMID: 35810311] - Ahmad Fariz Malvi Zamzam Zein, Catur Setiya Sulistiyana, Wilson Matthew Raffaello, Arief Wibowo, Raymond Pranata. Sofosbuvir with daclatasvir and the outcomes of patients with COVID-19: a systematic review and meta-analysis with GRADE assessment.
Postgraduate medical journal.
2022 Jul; 98(1161):509-514. doi:
10.1136/postgradmedj-2021-140287. [PMID: 34103373] - Eunjin Hong, Lisa M Almond, Peter S Chung, Adupa P Rao, Paul M Beringer. Physiologically-Based Pharmacokinetic-Led Guidance for Patients With Cystic Fibrosis Taking Elexacaftor-Tezacaftor-Ivacaftor With Nirmatrelvir-Ritonavir for the Treatment of COVID-19.
Clinical pharmacology and therapeutics.
2022 06; 111(6):1324-1333. doi:
10.1002/cpt.2585. [PMID: 35292968] - Edward P Stern, Lauren V Host, Ivy Wanjiku, K Jane Escott, Peter S Gilmour, Rachel Ochiel, Robert Unwin, Aine Burns, Voon H Ong, Helen Cadiou, Aidan G O'Keeffe, Christopher P Denton. Zibotentan in systemic sclerosis-associated chronic kidney disease: a phase II randomised placebo-controlled trial.
Arthritis research & therapy.
2022 06; 24(1):130. doi:
10.1186/s13075-022-02818-6. [PMID: 35650639] - Michelle T Martin, Nicole Waring, Ammara Naveed. High Real-World Sustained Virologic Response Rate with Glecaprevir/Pibrentasvir at a Racially Diverse Urban Academic Medical Center.
Gut and liver.
2022 05; 16(3):489-492. doi:
10.5009/gnl210499. [PMID: 35145046] - Takeshi Hatanaka, Satoru Kakizaki, Takuya Kaburagi, Naoto Saito, Sachi Nakano, Yoichi Hazama, Sachiko Yoshida, Yoko Hachisu, Yoshiki Tanaka, Teruo Yoshinaga, Kenji Kashiwabara, Atsushi Naganuma, Yuichi Yamazaki, Toshio Uraoka, Shigeo Nagashima, Masaharu Takahashi, Tsutomu Nishizawa, Kazumoto Murata, Hiroaki Okamoto. Chronic Infection with Hepatitis C Virus Subtype 1g in a Japanese Patient Successfully Treated with Glecaprevir/Pibrentasvir.
Internal medicine (Tokyo, Japan).
2022 May; 61(10):1537-1543. doi:
10.2169/internalmedicine.8673-21. [PMID: 34897154] - Yue Qiao, Yang Zhang, Zhenrui Qiao, Wenya He, Yingda Chen, Depu Song, Guohao Wang, Ning Guo, Lulian Shao, Zhiyong Tian, Qiang Wang, Lin Yan, Hai Qian. Discovery of (S)-N-(3-isopropylphenyl)-2-(5-phenylthiazol-2-yl)pyrrolidine-1-carboxamide as potent and brain-penetrant TRPV1 antagonist.
European journal of medicinal chemistry.
2022 Apr; 233(?):114191. doi:
10.1016/j.ejmech.2022.114191. [PMID: 35263708] - Yining Wang, Pengfei Li, Marla Lavrijsen, Yang Li, Zhongren Ma, Maikel P Peppelenbosch, Mirza S Baig, Qiuwei Pan. Differing pan-coronavirus antiviral potency of boceprevir and GC376 in vitro despite discordant molecular docking predictions.
Archives of virology.
2022 Apr; 167(4):1125-1130. doi:
10.1007/s00705-022-05369-y. [PMID: 35171357] - Y Ding, Y Liu, Y Qu, M Lin, F Dong, Y Li, L Cao, S Lin. Efficacy and safety of combination therapy with vildagliptin and metformin vs. metformin monotherapy for Type 2 Diabetes Mellitus therapy: a meta-analysis.
European review for medical and pharmacological sciences.
2022 04; 26(8):2802-2817. doi:
10.26355/eurrev_202204_28611. [PMID: 35503625] - Daiana S Sánchez, Lilian K Fischer Sigel, Alejandro Balestracci, Cristina Ibarra, María M Amaral, Claudia Silberstein. Eliglustat prevents Shiga toxin 2 cytotoxic effects in human renal tubular epithelial cells.
Pediatric research.
2022 04; 91(5):1121-1129. doi:
10.1038/s41390-021-01622-3. [PMID: 34155339] - Amanda Mathis, David Collins, Sylvia Dobo, Dennis M Walling, William P Sheridan, Ray Taylor. Pharmacokinetics and Safety of the Nucleoside Analog Antiviral Drug Galidesivir Administered to Healthy Adult Subjects.
Clinical pharmacology in drug development.
2022 04; 11(4):467-474. doi:
10.1002/cpdd.1037. [PMID: 35182042] - Jennifer M Hobbs, Rebecca T DeRienz, Daniel D Baker, Morgan R Shuttleworth, Maneesha Pandey. Fatal Intoxication by the Novel Cathinone 4-Fluoro-3-methyl-α-PVP.
Journal of analytical toxicology.
2022 Mar; 46(3):e101-e104. doi:
10.1093/jat/bkac003. [PMID: 35020879] - Lone W Madsen, Peer B Christensen, Janne F Hansen, Birgit T Røge, Dorte K Holm, Sandra Dröse, Anne Øvrehus. Four Weeks Treatment with Glecaprevir/Pibrentasvir + Ribavirin-A Randomized Controlled Clinical Trial.
Viruses.
2022 03; 14(3):. doi:
10.3390/v14030614. [PMID: 35337021] - Hong Li, Yi Liang, Xuejing Song, Wu-Sha Liu-Huo, Wen Chen, Chao Tang, Lizhi Zhao, Xue Bai. Efficacy and safety of vernakalant for cardioversion of recent-onset atrial fibrillation: A protocol for systematic review and meta-analysis.
Medicine.
2022 Mar; 101(10):e29038. doi:
10.1097/md.0000000000029038. [PMID: 35451413] - Nuria Saiz, Lisbeth Herrera-Castillo, Esther Isorna, María Jesús Delgado, Marta Conde-Sieira, José Luis Soengas, Nuria de Pedro. REV-ERBα Agonist SR9009 Promotes a Negative Energy Balance in Goldfish.
International journal of molecular sciences.
2022 Mar; 23(6):. doi:
10.3390/ijms23062921. [PMID: 35328345] - Valeria Pingitore, Macarena Martínez-Bailén, Ana T Carmona, Zuzana Mészáros, Natalia Kulik, Kristýna Slámová, Vladimír Křen, Pavla Bojarová, Inmaculada Robina, Antonio J Moreno-Vargas. Discovery of human hexosaminidase inhibitors by in situ screening of a library of mono- and divalent pyrrolidine iminosugars.
Bioorganic chemistry.
2022 03; 120(?):105650. doi:
10.1016/j.bioorg.2022.105650. [PMID: 35144103] - Kenichi Umehara, Yumi Cleary, Stephen Fowler, Neil Parrott, Dietrich Tuerck. Accelerating Clinical Development of Idasanutlin through a Physiologically Based Pharmacokinetic Modeling Risk Assessment for CYP450 Isoenzyme-Related Drug-Drug Interactions.
Drug metabolism and disposition: the biological fate of chemicals.
2022 03; 50(3):214-223. doi:
10.1124/dmd.121.000720. [PMID: 34937801] - Brittany A Wright, Natalie K Ketchen, Leah N Rasmussen, Alyssa R Bartels, Sachinkumar B Singh. Impact of elexacaftor/tezacaftor/ivacaftor on vitamin D absorption in cystic fibrosis patients.
Pediatric pulmonology.
2022 03; 57(3):655-657. doi:
10.1002/ppul.25781. [PMID: 34859619] - Max C Petersen, Lauren Begnel, Michael Wallendorf, Marina Litvin. Effect of elexacaftor-tezacaftor-ivacaftor on body weight and metabolic parameters in adults with cystic fibrosis.
Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society.
2022 03; 21(2):265-271. doi:
10.1016/j.jcf.2021.11.012. [PMID: 34862121] - Antoine Poli, Caroline Schmitt, Boualem Moulouel, Arienne Mirmiran, Neila Talbi, Sophie Rivière, Diane Cerutti, Isabelle Bouchoule, Anthony Faivre, Vincent Grobost, Claire Douillard, Francis Duchêne, Valeria Fiorentino, Thierry Dupré, Hana Manceau, Katell Peoc'h, Hervé Puy, Thibaud Lefebvre, Laurent Gouya. Givosiran in acute intermittent porphyria: A personalized medicine approach.
Molecular genetics and metabolism.
2022 03; 135(3):206-214. doi:
10.1016/j.ymgme.2022.01.002. [PMID: 35058124] - Nashaat T Nashed, Annie Aniana, Rodolfo Ghirlando, Sai Chaitanya Chiliveri, John M Louis. Modulation of the monomer-dimer equilibrium and catalytic activity of SARS-CoV-2 main protease by a transition-state analog inhibitor.
Communications biology.
2022 03; 5(1):160. doi:
10.1038/s42003-022-03084-7. [PMID: 35233052] - Yoomin Jeon, Nora Lee, Seungjae Baek, JaeDuk Choi, Stanford Jhee, Howard Lee. A Randomized, Double-Blind, Placebo- and Active-Controlled, Escalating Single-Dose Study to Evaluate the Safety, Tolerability, Pharmacokinetic, and Pharmacodynamic Profiles of Subcutaneous Eflapegrastim in Healthy Japanese and Caucasian Subjects.
Drugs in R&D.
2022 Mar; 22(1):71-87. doi:
10.1007/s40268-021-00379-8. [PMID: 34993933] - Aung Naing, John D Powderly, John J Nemunaitis, Jason J Luke, Aaron S Mansfield, Wells A Messersmith, Solmaz Sahebjam, Patricia M LoRusso, Ignacio Garrido-Laguna, Lance Leopold, Ryan Geschwindt, Kai Ding, Michael Smith, Jordan D Berlin. Exploring the safety, effect on the tumor microenvironment, and efficacy of itacitinib in combination with epacadostat or parsaclisib in advanced solid tumors: a phase I study.
Journal for immunotherapy of cancer.
2022 03; 10(3):. doi:
10.1136/jitc-2021-004223. [PMID: 35288468] - Akari Kaba, Shigeyoshi Yamanaga, Yuji Hidaka, Mariko Toyoda, Masayuki Kashima, Yoshi Takekuma, Akito Inadome, Hiroshi Yokomizo, Akira Miyata. Glecaprevir/Pibrentasvir and Renal Dysfunction in Deceased Donor Renal Transplantation: A Case Report.
Transplantation proceedings.
2022 Mar; 54(2):549-551. doi:
10.1016/j.transproceed.2021.12.028. [PMID: 35120765] - Naoya Kitamura, Michael Dominic Sacco, Chunlong Ma, Yanmei Hu, Julia Alma Townsend, Xiangzhi Meng, Fushun Zhang, Xiujun Zhang, Mandy Ba, Tommy Szeto, Adis Kukuljac, Michael Thomas Marty, David Schultz, Sara Cherry, Yan Xiang, Yu Chen, Jun Wang. Expedited Approach toward the Rational Design of Noncovalent SARS-CoV-2 Main Protease Inhibitors.
Journal of medicinal chemistry.
2022 02; 65(4):2848-2865. doi:
10.1021/acs.jmedchem.1c00509. [PMID: 33891389] - Sara Mobarak, Mehdi Salasi, Ahmad Hormati, Javad Khodadadi, Masood Ziaee, Farshid Abedi, Azadeh Ebrahimzadeh, Zohreh Azarkar, Fariborz Mansour-Ghanaei, Farahnaz Joukar, Sara Yeganeh, Tofigh Yaghubi Kalurazi, Mohammadreza Naghipour, Zeinab Mehrabi, Amir Reza Bahadori, Shoeleh Yaghoubi, Rohollah Moslemi, Hamideh Abbaspour Kasgari, Hafez Fakheri, Minoo Moghimi, Amir Mohammad Shabani, Zahra Nekoukar, Farhang Babamahmoodi, Ali Reza Davoudi Badabi, Lotfollah Davoodi, Mehdi Hassaniazad, Elham Barahimi, Abdolali Tousi, Anahita Sadeghi, Hadiseh Hosamirudsari, Ali Ali Asgari, Mohammad Abdollahi, Amir Anushiravani, Minoosh Shabani, Shervin Shokouhi, Nasim Khajavirad, Mohammadreza Salehi, Seyed Ali Dehghan Manshadi, Hashem Mousavi, Farnaz Zolfaghari, Elmira Azimi, Aida Zeinali, Elham Akbarpour, Dorsa Merat, Gholamali Eslami, Sajedeh Mousaviasl, Sara Sayar, Esmat Radmanesh, Mona Ebrahimzadeh, Zahra Arizavi, Saeed Jelvay, Shokrollah Salmanzadeh, Hani Esmaeilian, Morteza Mobarak, Jalal Karimi, Zahra Poormontaseri, Nasrollah Hasooni Bahrini, Atefeh Bonyadi, Fatemeh Dehghani, Hadi Mirzaei, Masoome Noori Jangi, Hossein Pourmasoomi, Lili Rezaie Keikhaie, Mahdi Afshari, Alireza Nateghi Baygi, Helia Nateghi Baygi, Jacob Levi, Kaitlyn McCann, Hannah Wentzel, Bryony Simmons, Andrew Hill, Shahin Merat. Evaluation of the effect of sofosbuvir and daclatasvir in hospitalized COVID-19 patients: a randomized double-blind clinical trial (DISCOVER).
The Journal of antimicrobial chemotherapy.
2022 02; 77(3):758-766. doi:
10.1093/jac/dkab433. [PMID: 34849957] - Xuanting Wang, Carolina Q Sacramento, Steffen Jockusch, Otávio Augusto Chaves, Chuanjuan Tao, Natalia Fintelman-Rodrigues, Minchen Chien, Jairo R Temerozo, Xiaoxu Li, Shiv Kumar, Wei Xie, Dinshaw J Patel, Cindy Meyer, Aitor Garzia, Thomas Tuschl, Patrícia T Bozza, James J Russo, Thiago Moreno L Souza, Jingyue Ju. Combination of antiviral drugs inhibits SARS-CoV-2 polymerase and exonuclease and demonstrates COVID-19 therapeutic potential in viral cell culture.
Communications biology.
2022 02; 5(1):154. doi:
10.1038/s42003-022-03101-9. [PMID: 35194144] - Núria Nadal-Gratacós, Esther Lleixà, Mónica Gibert-Serramià, Roger Estrada-Tejedor, Xavier Berzosa, Xavier Batllori, David Pubill, Jordi Camarasa, Elena Escubedo, Raúl López-Arnau. Neuropsychopharmacology of Emerging Drugs of Abuse: meta- and para-Halogen-Ring-Substituted α-PVP ("flakka") Derivatives.
International journal of molecular sciences.
2022 Feb; 23(4):. doi:
10.3390/ijms23042226. [PMID: 35216339] - Ashutosh Wechalekar, Gunnar Antoni, Wasfi Al Azzam, Mats Bergström, Swethajit Biswas, Chao Chen, Joseph Cheriyan, Matthew Cleveland, Louise Cookson, Paul Galette, Robert L Janiczek, Raymond Y Kwong, Mary Ann Lukas, Helen Millns, Duncan Richards, Ian Schneider, Scott D Solomon, Jens Sörensen, James Storey, Douglas Thompson, Guus van Dongen, Danielle J Vugts, Anders Wall, Gerhard Wikström, Rodney H Falk. Pharmacodynamic evaluation and safety assessment of treatment with antibodies to serum amyloid P component in patients with cardiac amyloidosis: an open-label Phase 2 study and an adjunctive immuno-PET imaging study.
BMC cardiovascular disorders.
2022 02; 22(1):49. doi:
10.1186/s12872-021-02407-6. [PMID: 35152886] - Ismail Celik, Meryem Erol, Zekeriya Duzgun. In silico evaluation of potential inhibitory activity of remdesivir, favipiravir, ribavirin and galidesivir active forms on SARS-CoV-2 RNA polymerase.
Molecular diversity.
2022 Feb; 26(1):279-292. doi:
10.1007/s11030-021-10215-5. [PMID: 33765239] - Mahmoud El-Bendary, Sherief Abd-Elsalam, Tamer Elbaz, Wafaa El-Akel, Ahmed Cordie, Tamer Elhadidy, Hatem Elalfy, Khaled Farid, Mohamed Elegezy, Adel El-Badrawy, Mustafa Neamatallah, Mohamed Abd Elghafar, Marwa Salama, Mohamed AbdAllah, Mahmoud Essam, Mostafa El-Shazly, Gamal Esmat. Efficacy of combined Sofosbuvir and Daclatasvir in the treatment of COVID-19 patients with pneumonia: a multicenter Egyptian study.
Expert review of anti-infective therapy.
2022 02; 20(2):291-295. doi:
10.1080/14787210.2021.1950532. [PMID: 34225541] - Jing Qian, Xiao-Hong Wang, Ben-Zhong Wei, Guo-Xiong Zhou, Shun-Xing Zhu, Chun Liu. Therapeutic effects of salidroside vs pyrrolidine dithiocarbamate against severe acute pancreatitis in rat.
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan.
2022 02; 42(1):49-57. doi:
10.19852/j.cnki.jtcm.20210707.002. [PMID: 35322632] - Martine Gehin, Jolanta Wierdak, Giancarlo Sabattini, Patricia N Sidharta, Jasper Dingemanse. Effect of gastric pH and of a moderate CYP3A4 inducer on the pharmacokinetics of daridorexant, a dual orexin receptor antagonist.
British journal of clinical pharmacology.
2022 02; 88(2):810-819. doi:
10.1111/bcp.15029. [PMID: 34371524] - Katharina Habler, Anne-Sophie Kalla, Michael Rychlik, Mathias Bruegel, Daniel Teupser, Susanne Nährig, Michael Vogeser, Michael Paal. Isotope dilution LC-MS/MS quantification of the cystic fibrosis transmembrane conductance regulator (CFTR) modulators ivacaftor, lumacaftor, tezacaftor, elexacaftor, and their major metabolites in human serum.
Clinical chemistry and laboratory medicine.
2022 01; 60(1):82-91. doi:
10.1515/cclm-2021-0724. [PMID: 34668357] - Shinji Nakamura, Masahiro Kamaura, Yuichiro Akao, Natsuko Nakamura, Atsushi Mizukami, Akihiko Goto, Naoki Furuyama, Nobuo Cho, Shizuo Kasai. Discovery of phenylpyrrolidine derivatives as a novel class of retinol binding protein 4 (RBP4) reducers.
Bioorganic & medicinal chemistry.
2022 01; 54(?):116553. doi:
10.1016/j.bmc.2021.116553. [PMID: 34953340] - Danny Galleguillos, Qian Wang, Noam Steinberg, Asifa Zaidi, Gaurav Shrivastava, Kamaldeep Dhami, Gour C Daskhan, Edward N Schmidt, Zoë Dworsky-Fried, Fabrizio Giuliani, Matthew Churchward, Christopher Power, Kathryn Todd, Anna Taylor, Matthew S Macauley, Simonetta Sipione. Anti-inflammatory role of GM1 and other gangliosides on microglia.
Journal of neuroinflammation.
2022 Jan; 19(1):9. doi:
10.1186/s12974-021-02374-x. [PMID: 34991625] - Felicitas Wagener, Sven Guddat, Christian Görgens, Yiannis S Angelis, Michael Petrou, Andreas Lagojda, Dirk Kühne, Mario Thevis. Investigations into the elimination profiles and metabolite ratios of micro-dosed selective androgen receptor modulator LGD-4033 for doping control purposes.
Analytical and bioanalytical chemistry.
2022 Jan; 414(2):1151-1162. doi:
10.1007/s00216-021-03740-7. [PMID: 34734312] - Christopher A Jones, Fred K Hoehler, Valeria Frangione, Gilbert Ledesma, Paul P Wisman, Clarence Jones. Safety and Efficacy of the FLECTOR (Diclofenac Epolamine) Topical System in Children with Minor Soft Tissue Injuries: A Phase IV Non-randomized Clinical Trial.
Clinical drug investigation.
2022 Jan; 42(1):43-51. doi:
10.1007/s40261-021-01101-x. [PMID: 34826122] - Charlotte Cutler, Daniel Leigh White, Marjaana Viljanto. In vitro metabolism of the REV-ERB agonist SR-9009 and subsequent detection of metabolites in associated routine equine plasma and urine doping control samples.
Drug testing and analysis.
2022 Jan; 14(1):169-174. doi:
10.1002/dta.3124. [PMID: 34224639] - Einat B Vitner, Roy Avraham, Boaz Politi, Sharon Melamed, Tomer Israely. Elevation in sphingolipid upon SARS-CoV-2 infection: possible implications for COVID-19 pathology.
Life science alliance.
2022 01; 5(1):. doi:
10.26508/lsa.202101168. [PMID: 34764206] - Ilaria Mastrorosa, Massimo Tempestilli, Stefania Notari, Patrizia Lorenzini, Gabriele Fabbri, Elisabetta Grilli, Rita Bellagamba, Alessandra Vergori, Stefania Cicalini, Adriana Ammassari, Chiara Agrati, Andrea Antinori. Association of Sofosbuvir and Daclatasvir Plasma Trough Concentrations with Patient-, Treatment-, and Disease-Related Factors Among HIV/HCV-Coinfected Persons.
European journal of drug metabolism and pharmacokinetics.
2022 Jan; 47(1):135-142. doi:
10.1007/s13318-021-00725-w. [PMID: 34623616] - Kerstin Stein, Albrecht Stoehr, Hartwig Klinker, Gerlinde Teuber, Uwe Naumann, Christine John, Renate Heyne, Yvonne Serfert, Claus Niederau, Stefan Zeuzem, Thomas Berg, Johannes Wiegand. Hepatitis C therapy with grazoprevir/elbasvir and glecaprevir/pibrentasvir in patients with advanced chronic kidney disease: data from the German Hepatitis C-Registry (DHC-R).
European journal of gastroenterology & hepatology.
2022 01; 34(1):76-83. doi:
10.1097/meg.0000000000001923. [PMID: 32956186] - Ray Taylor, Richard Bowen, James F Demarest, Michael DeSpirito, Airn Hartwig, Helle Bielefeldt-Ohmann, Dennis M Walling, Amanda Mathis, Yarlagadda S Babu. Activity of Galidesivir in a Hamster Model of SARS-CoV-2.
Viruses.
2021 12; 14(1):. doi:
10.3390/v14010008. [PMID: 35062212] - Ji Su Yang, Naeun Yoon, Mingyu Kong, Byung Hwa Jung, Hyunbeom Lee, Jinyoung Park. USP14 Regulates Cancer Cell Growth in a Fatty Acid Synthase-Independent Manner.
International journal of molecular sciences.
2021 Dec; 22(24):. doi:
10.3390/ijms222413437. [PMID: 34948233] - Ken Ogasawara, Rebecca N Wood-Horrall, Mark Thomas, Michael Thomas, Liangang Liu, Mary Liu, Yongjun Xue, Sekhar Surapaneni, Leonidas N Carayannopoulos, Simon Zhou, Maria Palmisano, Gopal Krishna. Impact of fedratinib on the pharmacokinetics of transporter probe substrates using a cocktail approach.
Cancer chemotherapy and pharmacology.
2021 12; 88(6):941-952. doi:
10.1007/s00280-021-04346-7. [PMID: 34477937] - Mahmoud Abdo, Ahmed Rabiee, Zeinab Abdellatif, Shereen Abdel Alem, Ahmed Moustafa. Impact of sustained virological response on metabolic disorders in diabetic chronic hepatitis C virus patients after treatment with generic sofosbuvir and daclatasvir.
European journal of gastroenterology & hepatology.
2021 12; 33(12):1588-1594. doi:
10.1097/meg.0000000000001903. [PMID: 32804853] - Seigo Ito, Hiroyuki Nakashima, Takuya Ishikiriyama, Masahiro Nakashima, Akira Yamagata, Toshihiko Imakiire, Manabu Kinoshita, Shuhji Seki, Hiroo Kumagai, Naoki Oshima. Effects of a CCR2 antagonist on macrophages and Toll-like receptor 9 expression in a mouse model of diabetic nephropathy.
American journal of physiology. Renal physiology.
2021 12; 321(6):F757-F770. doi:
10.1152/ajprenal.00191.2021. [PMID: 34719947] - Sherif Abbass, Ehab Kamal, Mohsen Salama, Tary Salman, Alyaa Sabry, Wael Abdel-Razek, Sherine Helmy, Ahmed Abdelgwad, Neamt Sakr, Mohamed Elgazzar, Mohamed Einar, Mahmoud Farouk, Mounir Saif, Ismail Shehab, Eman El-Hosieny, Mai Mansour, Doaa Mahdi, El-Sayed Tharwa, Mostafa Salah, Ola Elrouby, Imam Waked. Efficacy and safety of sofosbuvir plus daclatasvir or ravidasvir in patients with COVID-19: A randomized controlled trial.
Journal of medical virology.
2021 12; 93(12):6750-6759. doi:
10.1002/jmv.27264. [PMID: 34379337] - Mio Iijima, Shota Takemi, Sayaka Aizawa, Takafumi Sakai, Ichiro Sakata. The suppressive effect of REVERBs on ghrelin and GOAT transcription in gastric ghrelin-producing cells.
Neuropeptides.
2021 Dec; 90(?):102187. doi:
10.1016/j.npep.2021.102187. [PMID: 34450431] - Shizuo Yamada, Junko Chimoto, Mizuki Shiho, Takashi Okura, Kana Morikawa, Satomi Kagota, Kazumasa Shinozuka. Muscarinic receptor binding activity in rat tissues by vibegron and prediction of its receptor occupancy levels in the human bladder.
International journal of urology : official journal of the Japanese Urological Association.
2021 Dec; 28(12):1298-1303. doi:
10.1111/iju.14696. [PMID: 34545632] - Yumei Ren, Yongbin Yan, Lei Zhen, Caihong Cao, Quan Wang, Yingying Zhang, Shan Zhu. Zhike Pingchuan Granule suppresses interleukin (IL)-6 or the medium of M2 macrophages induced apoptosis in human bronchial epithelial cells.
Bioengineered.
2021 12; 12(1):7694-7703. doi:
10.1080/21655979.2021.1982309. [PMID: 34608825] - Nesrine Baatallah, Ahmad Elbahnsi, Jean-Paul Mornon, Benoit Chevalier, Iwona Pranke, Nathalie Servel, Renaud Zelli, Jean-Luc Décout, Aleksander Edelman, Isabelle Sermet-Gaudelus, Isabelle Callebaut, Alexandre Hinzpeter. Pharmacological chaperones improve intra-domain stability and inter-domain assembly via distinct binding sites to rescue misfolded CFTR.
Cellular and molecular life sciences : CMLS.
2021 Dec; 78(23):7813-7829. doi:
10.1007/s00018-021-03994-5. [PMID: 34714360] - Ozlem Delen, Yesim H Uz. Protective effect of pyrrolidine dithiocarbamate against methotrexate-induced testicular damage.
Human & experimental toxicology.
2021 Dec; 40(12_suppl):S164-S177. doi:
10.1177/09603271211035674. [PMID: 34340576] - Tyler W E Steele, Zachary Spires, Charles B Jones, Richard A Glennon, Małgorzata Dukat, Jose M Eltit. Non-conserved residues dictate dopamine transporter selectivity for the potent synthetic cathinone and psychostimulant MDPV.
Neuropharmacology.
2021 12; 200(?):108820. doi:
10.1016/j.neuropharm.2021.108820. [PMID: 34619165] - Chong Li, Guangchi Sun, Binglin Chen, Lei Xu, Yangfan Ye, Jinyan He, Zhongyuan Bao, Pengzhan Zhao, Zong Miao, Lin Zhao, Jingming Hu, Yongping You, Ning Liu, Honglu Chao, Jing Ji. Nuclear receptor coactivator 4-mediated ferritinophagy contributes to cerebral ischemia-induced ferroptosis in ischemic stroke.
Pharmacological research.
2021 12; 174(?):105933. doi:
10.1016/j.phrs.2021.105933. [PMID: 34634471] - Thomas J F Angenoorth, Stevan Stankovic, Marco Niello, Marion Holy, Simon D Brandt, Harald H Sitte, Julian Maier. Interaction Profiles of Central Nervous System Active Drugs at Human Organic Cation Transporters 1-3 and Human Plasma Membrane Monoamine Transporter.
International journal of molecular sciences.
2021 Nov; 22(23):. doi:
10.3390/ijms222312995. [PMID: 34884800] - Dahu Liang, Jie Shen, Yuanwei Jia, Min Dai, Xianghong Li, Lixiang Zhou, Weijia Wang, Bin Yang, Jing Shao, Yan Jiang, Haitang Xie, Hua Sun. Pharmacokinetic Properties of S-oxiracetam After Single and Multiple Intravenous Infusions in Healthy Volunteers.
European journal of drug metabolism and pharmacokinetics.
2021 Nov; 46(6):793-805. doi:
10.1007/s13318-021-00718-9. [PMID: 34549388] - Noriyuki Akutsu, Shigeru Sasaki, Takeshi Matsui, Hirofumi Akashi, Kazuhiko Yonezawa, Keisuke Ishigami, Masayuki Tsujisaki, Hiroyuki Isshiki, Atsushi Yawata, Satoshi Yamaoka, Toshihiro Ban, Takeya Adachi, Seiya Nakahara, Hideyasu Takagi, Kohei Nakachi, Katsunori Tanaka, Takehiro Hirano, Itaru Yamamoto, Hiroyuki Kaneto, Kohei Wagatsuma, Yasunao Numata, Hiroshi Nakase. Association of the Low-density Lipoprotein Cholesterol/High-density Lipoprotein Cholesterol Ratio with Glecaprevir-pibrentasvir Treatment.
Internal medicine (Tokyo, Japan).
2021 Nov; 60(21):3369-3376. doi:
10.2169/internalmedicine.7098-21. [PMID: 34024854] - Benjamin Berger, Clemens Muehlan, Gernot Klein, Jasper Dingemanse. Pharmacokinetics of daridorexant, a dual orexin receptor antagonist, are not affected by renal impairment.
Clinical and translational science.
2021 11; 14(6):2132-2138. doi:
10.1111/cts.13079. [PMID: 34121345] - Abdullahi Tsanni. African scientists race to test COVID drugs - but face major hurdles.
Nature.
2021 11; 599(7883):25-27. doi:
10.1038/d41586-021-02995-5. [PMID: 34732862] - Courtney Gearlds, Jessica Brooke Bouldin, Mariah McKinney, Shannon Schreiner, Stacy D Brown, Brooks B Pond. Pharmacokinetics of Synthetic Cathinones Found in Bath Salts in Mouse Brain and Plasma Using High-Pressure Liquid Chromatography-Tandem Mass Spectrometry.
European journal of drug metabolism and pharmacokinetics.
2021 Nov; 46(6):771-778. doi:
10.1007/s13318-021-00712-1. [PMID: 34427910] - Rama Dey-Rao, George R Smith, Uddhav Timilsina, Zackary Falls, Ram Samudrala, Spyridon Stavrou, Thomas Melendy. A fluorescence-based, gain-of-signal, live cell system to evaluate SARS-CoV-2 main protease inhibition.
Antiviral research.
2021 11; 195(?):105183. doi:
10.1016/j.antiviral.2021.105183. [PMID: 34626674] - Sonia Younas, Hamid Mukhtar, Umar Farooq Gohar, Abdullah Alsrhani, Badr Alzahrani, Kashaf Junaid, Muhammad Usman Qamar, Hasan Ejaz. Diagnostic approach to elucidate the efficacy and side effects of direct-acting antivirals in HCV infected patients.
Journal of infection in developing countries.
2021 10; 15(10):1489-1496. doi:
10.3855/jidc.12912. [PMID: 34780372] - Wayne Vuong, Conrad Fischer, Muhammad Bashir Khan, Marco J van Belkum, Tess Lamer, Kurtis D Willoughby, Jimmy Lu, Elena Arutyunova, Michael A Joyce, Holly A Saffran, Justin A Shields, Howard S Young, James A Nieman, D Lorne Tyrrell, M Joanne Lemieux, John C Vederas. Improved SARS-CoV-2 Mpro inhibitors based on feline antiviral drug GC376: Structural enhancements, increased solubility, and micellar studies.
European journal of medicinal chemistry.
2021 Oct; 222(?):113584. doi:
10.1016/j.ejmech.2021.113584. [PMID: 34118724] - João Paulo Almirão de Jesus, Letícia Cristina Assis, Alexandre Alves de Castro, Elaine Fontes Ferreira da Cunha, Eugenie Nepovimova, Kamil Kuca, Teodorico de Castro Ramalho, Felipe de Almeida La Porta. Effect of drug metabolism in the treatment of SARS-CoV-2 from an entirely computational perspective.
Scientific reports.
2021 10; 11(1):19998. doi:
10.1038/s41598-021-99451-1. [PMID: 34620963] - Zhengyuan Zhou, Michael R Zalutsky, Satish K Chitneni. Fluorine-18 Labeling of the MDM2 Inhibitor RG7388 for PET Imaging: Chemistry and Preliminary Evaluation.
Molecular pharmaceutics.
2021 10; 18(10):3871-3881. doi:
10.1021/acs.molpharmaceut.1c00531. [PMID: 34523337] - Jun-Yan Jiang, Dai-Jiang Liu, Mao-Xia Liu. The protective effect of NF-κB signaling pathway inhibitor PDTC on mice with chronic atrophic gastritis.
Scandinavian journal of gastroenterology.
2021 10; 56(10):1131-1139. doi:
10.1080/00365521.2021.1953130. [PMID: 34310252] - Chih-Cheng Lai, Chien-Ming Chao, Po-Ren Hsueh. Clinical efficacy of antiviral agents against coronavirus disease 2019: A systematic review of randomized controlled trials.
Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi.
2021 Oct; 54(5):767-775. doi:
10.1016/j.jmii.2021.05.011. [PMID: 34253490] - Benjamin Berger, Jasper Dingemanse, Giancarlo Sabattini, Stéphane Delahaye, Urs Duthaler, Clemens Muehlan, Stephan Krähenbühl. Effect of Liver Cirrhosis on the Pharmacokinetics, Metabolism, and Tolerability of Daridorexant, A Novel Dual Orexin Receptor Antagonist.
Clinical pharmacokinetics.
2021 10; 60(10):1349-1360. doi:
10.1007/s40262-021-01028-8. [PMID: 34002356] - Daryl U Nnani, Alesa Campbell, Maria Ajaimy, Omar Saeed, Snehal R Patel, Sana Ahmed, Jay A Graham, Ulrich P Jorde. Effect of glecaprevir/pibrentasvir on weight-adjusted tacrolimus trough/dose ratios in heart and kidney transplant recipients.
Transplant infectious disease : an official journal of the Transplantation Society.
2021 Oct; 23(5):e13716. doi:
10.1111/tid.13716. [PMID: 34407270] - Yun-Sook Lim, Lap P Nguyen, Gun-Hee Lee, Sung-Geun Lee, Kwang-Soo Lyoo, Bumseok Kim, Soon B Hwang. Asunaprevir, a Potent Hepatitis C Virus Protease Inhibitor, Blocks SARS-CoV-2 Propagation.
Molecules and cells.
2021 Sep; 44(9):688-695. doi:
10.14348/molcells.2021.0076. [PMID: 34518443] - Richard Jennemann, Martina Volz, Felix Bestvater, Claudia Schmidt, Karsten Richter, Sylvia Kaden, Johannes Müthing, Hermann-Josef Gröne, Roger Sandhoff. Blockade of Glycosphingolipid Synthesis Inhibits Cell Cycle and Spheroid Growth of Colon Cancer Cells In Vitro and Experimental Colon Cancer Incidence In Vivo.
International journal of molecular sciences.
2021 Sep; 22(19):. doi:
10.3390/ijms221910539. [PMID: 34638879] - Amit Goel, Dharmendra S Bhadauria, Anupma Kaul, Abhai Verma, Prachi Tiwari, Sumit Rungta, Praveer Rai, Amit Gupta, Rakesh Aggarwal. Acute hepatitis C treatment in advanced renal failure using 8 weeks of pan-genotypic daclatasvir and reduced-dose sofosbuvir.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.
2021 09; 36(10):1867-1871. doi:
10.1093/ndt/gfaa187. [PMID: 33097949] - Michal Kopczynski, Izabela Rumienczyk, Maria Kulecka, Małgorzata Statkiewicz, Kazimiera Pysniak, Zuzanna Sandowska-Markiewicz, Urszula Wojcik-Trechcinska, Krzysztof Goryca, Karolina Pyziak, Eliza Majewska, Magdalena Masiejczyk, Katarzyna Wojcik-Jaszczynska, Tomasz Rzymski, Karol Bomsztyk, Jerzy Ostrowski, Michal Mikula. Selective Extracellular Signal-Regulated Kinase 1/2 (ERK1/2) Inhibition by the SCH772984 Compound Attenuates In Vitro and In Vivo Inflammatory Responses and Prolongs Survival in Murine Sepsis Models.
International journal of molecular sciences.
2021 Sep; 22(19):. doi:
10.3390/ijms221910204. [PMID: 34638546] - Abolghasem Jouyban, Mir Ali Farajzadeh, Fariba Khodadadeian, Maryam Khoubnasabjafari, Mohammad Reza Afshar Mogaddam. Development of a deep eutectic solvent-based ultrasound-assisted homogenous liquid-liquid microextraction method for simultaneous extraction of daclatasvir and sofosbuvir from urine samples.
Journal of pharmaceutical and biomedical analysis.
2021 Sep; 204(?):114254. doi:
10.1016/j.jpba.2021.114254. [PMID: 34256327] - Fangjun Yu, Zhigang Wang, Tianpeng Zhang, Xun Chen, Haiman Xu, Fei Wang, Lianxia Guo, Min Chen, Kaisheng Liu, Baojian Wu. Deficiency of intestinal Bmal1 prevents obesity induced by high-fat feeding.
Nature communications.
2021 09; 12(1):5323. doi:
10.1038/s41467-021-25674-5. [PMID: 34493722] - Muhammad Wasif Saif, Carlos R Becerra, Marwan G Fakih, Weijing Sun, Lazar Popovic, Smitha Krishnamurthi, Thomas J George, Michelle A Rudek, Dale R Shepard, Jiri Skopek, Vladimir Sramek, Bojan Zaric, Ikuo Yamamiya, Karim A Benhadji, Kensuke Hamada, Yaohua He, Lee Rosen. A phase I, open-label study evaluating the safety and pharmacokinetics of trifluridine/tipiracil in patients with advanced solid tumors and varying degrees of renal impairment.
Cancer chemotherapy and pharmacology.
2021 09; 88(3):485-497. doi:
10.1007/s00280-021-04308-z. [PMID: 34097100] - Friederike A Sandbaumhüter, Claudia Gittel, M Paula Larenza-Menzies, Regula Theurillat, Wolfgang Thormann, Christina Braun. Stereoselective methadone disposition after administration of racemic methadone to anesthetized Shetland ponies assessed by capillary electrophoresis.
Electrophoresis.
2021 09; 42(17-18):1826-1831. doi:
10.1002/elps.202100115. [PMID: 33978252] - Pramod K Mistry, Elena Lukina, Hadhami Ben Turkia, Suma P Shankar, Hagit Baris Feldman, Marwan Ghosn, Atul Mehta, Seymour Packman, Heather Lau, Milan Petakov, Sarit Assouline, Manisha Balwani, Sumita Danda, Evgueniy Hadjiev, Andres Ortega, Meredith C Foster, Sebastiaan J M Gaemers, M Judith Peterschmitt. Clinical outcomes after 4.5 years of eliglustat therapy for Gaucher disease type 1: Phase 3 ENGAGE trial final results.
American journal of hematology.
2021 09; 96(9):1156-1165. doi:
10.1002/ajh.26276. [PMID: 34161616] - Tahira Naqvi, Asif Amin, Shujat Ali, Mohsin Y Lone, Nadeem Bashir, Shafi U Khan, Thet T Htar, Masood Ahmad Rizvi. In vitro and In silico Evaluation of Structurally Diverse Benzyl-pyrrolidine-3-ol Analogues as Apoptotic Agents via Caspase Activation.
Acta chimica Slovenica.
2021 Sep; 68(3):667-682. doi:
NULL. [PMID: 34897536] - Xing Zhao, Li-Ya Wang, Jia-Meng Li, Li-Mei Peng, Chun-Yan Tang, Xiang-Jun Zha, Kai Ke, Ming-Bo Yang, Bai-Hai Su, Wei Yang. Redox-Mediated Artificial Non-Enzymatic Antioxidant MXene Nanoplatforms for Acute Kidney Injury Alleviation.
Advanced science (Weinheim, Baden-Wurttemberg, Germany).
2021 09; 8(18):e2101498. doi:
10.1002/advs.202101498. [PMID: 34272933] - Monika D Scuron, Brittany L Fay, Andrew J Connell, Julian Oliver, Paul A Smith. The PI3Kδ inhibitor parsaclisib ameliorates pathology and reduces autoantibody formation in preclinical models of systemic lupus erythematosus and Sjӧgren's syndrome.
International immunopharmacology.
2021 Sep; 98(?):107904. doi:
10.1016/j.intimp.2021.107904. [PMID: 34214886] - Vinciane Saint-Criq, Yiting Wang, Livia Delpiano, JinHeng Lin, David N Sheppard, Michael A Gray. Extracellular phosphate enhances the function of F508del-CFTR rescued by CFTR correctors.
Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society.
2021 09; 20(5):843-850. doi:
10.1016/j.jcf.2021.04.013. [PMID: 34020896] - Ken Ogasawara, Jeanelle Kam, Mark Thomas, Liangang Liu, Mary Liu, Yongjun Xue, Sekhar Surapaneni, Leonidas N Carayannopoulos, Simon Zhou, Maria Palmisano, Gopal Krishna. Effects of strong and moderate CYP3A4 inducers on the pharmacokinetics of fedratinib in healthy adult participants.
Cancer chemotherapy and pharmacology.
2021 09; 88(3):369-377. doi:
10.1007/s00280-021-04292-4. [PMID: 34019108]
