Kinetensin 1-8 (BioDeep_00000032781)

   

human metabolite Endogenous


代谢物信息卡片


(2S)-2-{[(2S)-2-({[(2S)-1-[(2S)-2-{[(2S)-2-{[(2S)-2-{[(2S)-2-{[(2S,3S)-2-amino-1-hydroxy-3-methylpentylidene]amino}-1-hydroxypropylidene]amino}-5-carbamimidamido-1-hydroxypentylidene]amino}-5-carbamimidamido-1-hydroxypentylidene]amino}-3-(1H-imidazol-5-yl)propanoyl]pyrrolidin-2-yl](hydroxy)methylidene}amino)-1-hydroxy-3-(4-hydroxyphenyl)propylidene]amino}-3-phenylpropanoate

化学式: C50H74N16O10 (1058.5773543999999)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CCC(C)C(C(=O)NC(C)C(=O)NC(CCCN=C(N)N)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC1=CN=CN1)C(=O)N2CCCC2C(=O)NC(CC3=CC=C(C=C3)O)C(=O)NC(CC4=CC=CC=C4)C(=O)O)N
InChI: InChI=1S/C50H74N16O10/c1-4-28(2)40(51)46(73)60-29(3)41(68)61-34(13-8-20-57-49(52)53)42(69)62-35(14-9-21-58-50(54)55)43(70)64-37(25-32-26-56-27-59-32)47(74)66-22-10-15-39(66)45(72)63-36(23-31-16-18-33(67)19-17-31)44(71)65-38(48(75)76)24-30-11-6-5-7-12-30/h5-7,11-12,16-19,26-29,34-40,67H,4,8-10,13-15,20-25,51H2,1-3H3,(H,56,59)(H,60,73)(H,61,68)(H,62,69)(H,63,72)(H,64,70)(H,65,71)(H,75,76)(H4,52,53,57)(H4,54,55,58)/t28-,29-,34-,35-,36-,37-,38-,39-,40-/m0/s1

描述信息

Kinetensin 1-8 is a fraction of kinetensin with only an Ile-Ala-Arg-Arg-His-Pro-Tyr-Phe peptide chain. Kinetensin is a nonapeptide, originally isolated from pepsin-treated plasma that shares some sequence homology with the C-terminal end of neurotensin, serum albumin, and angiotensin. It is a potent histamine releaser in rodents and may serve as an inflammatory mediator.
Kinetensin 1-8 is a fraction of Kinetensin with only Ile-Ala-Arg-Arg-His-Pro-Tyr-Phe peptide chain.

同义名列表

16 个代谢物同义名

(2S)-2-{[(2S)-2-({[(2S)-1-[(2S)-2-{[(2S)-2-{[(2S)-2-{[(2S)-2-{[(2S,3S)-2-amino-1-hydroxy-3-methylpentylidene]amino}-1-hydroxypropylidene]amino}-5-carbamimidamido-1-hydroxypentylidene]amino}-5-carbamimidamido-1-hydroxypentylidene]amino}-3-(1H-imidazol-5-yl)propanoyl]pyrrolidin-2-yl](hydroxy)methylidene}amino)-1-hydroxy-3-(4-hydroxyphenyl)propylidene]amino}-3-phenylpropanoate; (2S)-2-[(2S)-2-{[(2S)-1-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-[(2S,3S)-2-amino-3-methylpentanamido]propanamido]-5-carbamimidamidopentanamido]-5-carbamimidamidopentanamido]-3-(1H-imidazol-4-yl)propanoyl]pyrrolidin-2-yl]formamido}-3-(4-hydroxyphenyl)propanamido]-3-phenylpropanoic acid; L-Isoleucyl-L-alanyl-L-arginyl-L-arginyl-L-histidyl-L-prolyl-L-tyrosyl-L-phenylalanine; Isoleucyl-alanyl-arginyl-arginyl-histidyl-prolyl-tyrosyl-prolyl-tyrosyl-phenylalanine; L-Ile-L-ala-L-arg-L-arg-L-his-L-pro-L-tyr-L-phe; Ile-ala-arg-arg-his-pro-tyr-pro-tyr-phe; H-Ile-ala-arg-arg-his-pro-tyr-phe-OH; Ile-ala-arg-arg-his-pro-tyr-phe; Histamine-releasing peptide; (Des-leu9)-kinetensin; Kinetensin-(1-8); I-a-R-R-H-p-y-F; Kinetensin 1-8; 1-8-Kinetensin; IARRHPYF; KT(1-8)



数据库引用编号

6 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

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1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • David E Cochrane, Robert E Carraway, Lisa A Miller, Ross S Feldberg, Harry Bernheim. Histamine releasing peptide (HRP) has proinflammatory effects and is present at sites of inflammation. Biochemical pharmacology. 2003 Jul; 66(2):331-42. doi: 10.1016/s0006-2952(03)00251-x. [PMID: 12826276]
  • M Rosa-Fraile, A Sampedro, J Varela, M Garcia-Peña, G Gimenez-Gallego. Identification of a peptide from mammal albumins responsible for enhanced pigment production by group B streptococci. Clinical and diagnostic laboratory immunology. 1999 May; 6(3):425-6. doi: 10.1128/cdli.6.3.425-426.1999. [PMID: 10225848]
  • D E Cochrane, R E Carraway, R S Feldberg, W Boucher, J M Gelfand. Stimulated rat mast cells generate histamine-releasing peptide from albumin. Peptides. 1993 Mar; 14(2):117-23. doi: 10.1016/0196-9781(93)90018-c. [PMID: 7683397]
  • R E Carraway, D E Cochrane, W Boucher, S P Mitra. Structures of histamine-releasing peptides formed by the action of acid proteases on mammalian albumin(s). Journal of immunology (Baltimore, Md. : 1950). 1989 Sep; 143(5):1680-4. doi: NULL. [PMID: 2474609]
  • G E Levin, D N Baron. Leucocyte intracellular pH in patients with the metabolic acidosis of renal failure. Clinical science and molecular medicine. 1977 Mar; 52(3):325-8. doi: 10.1042/cs0520325. [PMID: 14806]