3-Methylene-indolenine (BioDeep_00000032149)

   

human metabolite Endogenous Toxin


代谢物信息卡片


3-Methyleneindolenine, conjugate acid

化学式: C9H7N (129.0578462)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C=C1C=NC2=CC=CC=C12
InChI: InChI=1S/C9H7N/c1-7-6-10-9-5-3-2-4-8(7)9/h2-6H,1H2

描述信息

3-Methylene-indolenine is an electrophilic molecule produced by the action of cytochrome P450 2F1 on 3-methylindole (3MI). 3-Methylindole (3MI) is a naturally occurring pulmonary toxin that requires metabolic activation. In particular, 3MI-induced pneumotoxicity arises from cytochrome P-450-catalyzed dehydrogenation of 3MI to an electrophilic methylene imine (3-methyleneindolenine), which covalently binds to cellular macromolecules. Members of the CYP2F gene subfamily are selectively expressed in lung tissues and have been implicated as important catalysts in the formation of reactive intermediates from several pneumotoxic chemicals. (PMID: 10383923) [HMDB]
3-Methylene-indolenine is an electrophilic molecule produced by the action of cytochrome P450 2F1 on 3-methylindole (3MI). 3-Methylindole (3MI) is a naturally occurring pulmonary toxin that requires metabolic activation. In particular, 3MI-induced pneumotoxicity arises from cytochrome P-450-catalyzed dehydrogenation of 3MI to an electrophilic methylene imine (3-methyleneindolenine), which covalently binds to cellular macromolecules. Members of the CYP2F gene subfamily are selectively expressed in lung tissues and have been implicated as important catalysts in the formation of reactive intermediates from several pneumotoxic chemicals. (PMID: 10383923).

同义名列表

5 个代谢物同义名

3-Methyleneindolenine, conjugate acid; 3-methylidene-3H-indole; 3-Methylene-indolenine; 3-Methylene-3H-indole; 3-Methyleneindolenine



数据库引用编号

6 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(5)

BioCyc(0)

PlantCyc(0)

代谢反应

55 个相关的代谢反应过程信息。

Reactome(55)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

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文献列表

  • Anika E Wagner, Gerald Rimbach. Ascorbigen: chemistry, occurrence, and biologic properties. Clinics in dermatology. 2009 Mar; 27(2):217-24. doi: 10.1016/j.clindermatol.2008.01.012. [PMID: 19168003]
  • Guy H Loneragan, Paul S Morley, John J Wagner, Gary L Mason, Garold S Yost, Mike A Thoren, Thomas E Wittum, Tammy M Bray. Effects of feeding aspirin and supplemental vitamin E on plasma concentrations of 3-methylindole, 3-methyleneindolenine-adduct concentrations in blood and pulmonary tissues, lung lesions, and growth performance in feedlot cattle. American journal of veterinary research. 2002 Dec; 63(12):1641-7. doi: 10.2460/ajvr.2002.63.1641. [PMID: 12492277]
  • Guy H Loneragan, Paul S Morley, John J Wagner, Gary L Mason, Garold S Yost, Mike A Thoren, Joni Triantis. Time-dependent changes in plasma concentrations of 3-methylindole and blood concentrations of 3-methyleneindolenine-adduct in feedlot cattle. American journal of veterinary research. 2002 Apr; 63(4):591-7. doi: 10.2460/ajvr.2002.63.591. [PMID: 11939325]
  • J K Kaster, G S Yost. Production and characterization of specific antibodies: utilization to predict organ- and species-selective pneumotoxicity of 3-methylindole. Toxicology and applied pharmacology. 1997 Apr; 143(2):324-37. doi: 10.1006/taap.1996.8092. [PMID: 9144449]
  • G Cury. [Action of 'myelauxins', substances capable of accelerating granulocytic hematopoiesis, in vivo in rabbits]. Comptes rendus des seances de la Societe de biologie et de ses filiales. 1978; 172(1):47-51. doi: NULL. [PMID: 150901]