Deoxyhypusine (BioDeep_00000031789)

   

human metabolite Endogenous


代谢物信息卡片


(2S)-2-amino-6-[(4-aminobutyl)amino]hexanoic acid

化学式: C10H23N3O2 (217.179)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(not specific) 4.31%

分子结构信息

SMILES: C(CCNCCCCN)CC(C(=O)O)N
InChI: InChI=1S/C10H23N3O2/c11-6-2-4-8-13-7-3-1-5-9(12)10(14)15/h9,13H,1-8,11-12H2,(H,14,15)/t9-/m0/s1

描述信息

Deoxyhypusine is an amino acid derivative of the unusual amino acid known as hypusine. It is a substrate of Deoxyhypusine synthase which catalyzes the cleavage of the polyamine spermidine and transfer of its 4-aminobutyl moiety to the ε-amino group of one specific lysine residue of the eIF-5A precursor to form deoxyhypusine and 1,3-diaminopropane. By the addition of a hydroxyl group to the deoxyhypusine residue deoxyhypusine hydroxylase mediates the formation of hypusine. [HMDB]
Deoxyhypusine is an amino acid derivative of the unusual amino acid known as hypusine. It is a substrate of deoxyhypusine synthase which catalyzes the cleavage of the polyamine spermidine and transfer of its 4-aminobutyl moiety to the ε-amino group of one specific lysine residue of the eIF-5A precursor to form deoxyhypusine and 1,3-diaminopropane. By the addition of a hydroxyl group to the deoxyhypusine residue, deoxyhypusine hydroxylase mediates the formation of hypusine (Wikipedia).

同义名列表

6 个代谢物同义名

(2S)-2-amino-6-[(4-aminobutyl)amino]hexanoic acid; (2S)-2-Amino-6-[(4-aminobutyl)amino]hexanoate; N(6)-(4-Aminobutyl)-L-lysine; N6-(4-Aminobutyl)-L-lysine; N(6)-(4-Aminobutyl)lysine; Deoxyhypusine



数据库引用编号

7 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

2 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Jigang Han, Dilip K Lakshman, Leny C Galvez, Sharmila Mitra, Peter Stephen Baenziger, Amitava Mitra. Transgenic expression of lactoferrin imparts enhanced resistance to head blight of wheat caused by Fusarium graminearum. BMC plant biology. 2012 Mar; 12(?):33. doi: 10.1186/1471-2229-12-33. [PMID: 22405032]
  • Jan-Willem de Kraker, Jonathan Gershenzon. From amino acid to glucosinolate biosynthesis: protein sequence changes in the evolution of methylthioalkylmalate synthase in Arabidopsis. The Plant cell. 2011 Jan; 23(1):38-53. doi: 10.1105/tpc.110.079269. [PMID: 21205930]
  • Bernhard Maier, Sarah A Tersey, Raghavendra G Mirmira. Hypusine: a new target for therapeutic intervention in diabetic inflammation. Discovery medicine. 2010 Jul; 10(50):18-23. doi: . [PMID: 20670594]
  • Sven Sehlmeyer, Linzhu Wang, Dorothee Langel, David G Heckel, Hoda Mohagheghi, Georg Petschenka, Dietrich Ober. Flavin-dependent monooxygenases as a detoxification mechanism in insects: new insights from the arctiids (lepidoptera). PloS one. 2010 May; 5(5):e10435. doi: 10.1371/journal.pone.0010435. [PMID: 20454663]
  • Michael Saeftel, Ramadan Salem Sarite, Tujo Njuguna, Ulrike Holzgrabe, Daniela Ulmer, Achim Hoerauf, Annette Kaiser. Piperidones with activity against Plasmodium falciparum. Parasitology research. 2006 Aug; 99(3):281-6. doi: 10.1007/s00436-006-0173-4. [PMID: 16550432]
  • Zizheng Dong, Randy J Arnold, Youyun Yang, Myung Hee Park, Petra Hrncirova, Yehia Mechref, Milos V Novotny, Jian-Ting Zhang. Modulation of differentiation-related gene 1 expression by cell cycle blocker mimosine, revealed by proteomic analysis. Molecular & cellular proteomics : MCP. 2005 Jul; 4(7):993-1001. doi: 10.1074/mcp.m500044-mcp200. [PMID: 15855174]
  • Tzann-Wei Wang, Chun-Guang Zhang, Wendy Wu, Linda M Nowack, Ewa Madey, John E Thompson. Antisense suppression of deoxyhypusine synthase in tomato delays fruit softening and alters growth and development. Plant physiology. 2005 Jul; 138(3):1372-82. doi: 10.1104/pp.105.060194. [PMID: 15951486]
  • Yoon Lee, Hyun-Kyung Kim, Hyo-Eun Park, Myung Hee Park, Young Ae Joe. Effect of N1-guanyl-1,7-diaminoheptane, an inhibitor of deoxyhypusine synthase, on endothelial cell growth, differentiation and apoptosis. Molecular and cellular biochemistry. 2002 Aug; 237(1-2):69-76. doi: 10.1023/a:1016535217038. [PMID: 12236588]
  • T W Wang, L Lu, D Wang, J E Thompson. Isolation and characterization of senescence-induced cDNAs encoding deoxyhypusine synthase and eucaryotic translation initiation factor 5A from tomato. The Journal of biological chemistry. 2001 May; 276(20):17541-9. doi: 10.1074/jbc.m008544200. [PMID: 11278418]