Sibutramine (BioDeep_00000003176)

 

Secondary id: BioDeep_00000406021

human metabolite blood metabolite Chemicals and Drugs


代谢物信息卡片


N-1-(1-(4-Chlorophenyl)cyclobutyl)-3-methylbutyl-N,N-dimethylamine HCL

化学式: C17H26ClN (279.1753666)
中文名称: 盐酸西布曲明, 西布曲明
谱图信息: 最多检出来源 Homo sapiens(blood) 0.55%

分子结构信息

SMILES: CC(C)CC(C1(CCC1)c1ccc(cc1)Cl)N(C)C
InChI: InChI=1S/C17H26ClN/c1-13(2)12-16(19(3)4)17(10-5-11-17)14-6-8-15(18)9-7-14/h6-9,13,16H,5,10-12H2,1-4H3

描述信息

Sibutramine (trade name Meridia in the USA, Reductil in Europe and other countries), usually as sibutramide hydrochloride monohydrate, is an orally administered agent for the treatment of obesity. It is a centrally acting stimulant chemically related to amphetamines. Sibutramine is classified as a Schedule IV controlled substance in the United States. In October 2010, Sibutramine was withdrawn from Canadian and U.S. markets due to concerns that the drug increases the risk of heart attack and stroke in patients with a history of heart disease.
A - Alimentary tract and metabolism > A08 - Antiobesity preparations, excl. diet products > A08A - Antiobesity preparations, excl. diet products > A08AA - Centrally acting antiobesity products
D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D000928 - Antidepressive Agents
D019440 - Anti-Obesity Agents > D001067 - Appetite Depressants
C78272 - Agent Affecting Nervous System > C29728 - Anorexiant

同义名列表

11 个代谢物同义名

N-1-(1-(4-Chlorophenyl)cyclobutyl)-3-methylbutyl-N,N-dimethylamine HCL; {1-[1-(4-chlorophenyl)cyclobutyl]-3-methylbutyl}dimethylamine; mono-Desmethylsibutramine; Sibutramine hydrochloride; Di-desmethylsibutramine; Didesmethylsibutramine; sibutramine; Butramin; (R)-DDMS; Reductil; Meridia



数据库引用编号

16 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Paola Dos Santos da Rocha, Sarah Lam Orué, Daniel Ferreira Leite, Priscilla Pereira de Toledo Espindola, Nadla Soares Cassemiro, Denise Brentan da Silva, Carlos Alexandre Carollo, Valéria Nunes-Souza, Luiza Antas Rabelo, Jaqueline Ferreira Campos, Letícia Miranda Fernandes Estevinho, Edson Lucas Dos Santos, Kely de Picoli Souza. Beneficial Effects of Bauhinia rufa Leaves on Oxidative Stress, Prevention, and Treatment of Obesity in High-Fat Diet-Fed C57BL/6 Mice. Oxidative medicine and cellular longevity. 2022; 2022(?):8790810. doi: 10.1155/2022/8790810. [PMID: 36466091]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Ping Hung Boris Wong, Joanna E Harnett, David Clases, Nial J Wheate. An Analysis for Adulteration and Contamination of Over-the-Counter Weight-Loss Products. AAPS PharmSciTech. 2021 Feb; 22(3):78. doi: 10.1208/s12249-021-01946-7. [PMID: 33604777]
  • A M Sukhanova, I B Perova, A S Koshechkina, E V Rylina, E V Tumolskaya, G M Rodionova. [Development and validation of methodology of quantitative determination of sibutramine in dietary supplements by high performance liquid chromatography]. Voprosy pitaniia. 2020 ; 89(6):123-129. doi: 10.24411/0042-8833-2020-10085. [PMID: 33476505]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Carina de Souza Anselmo, Bernardo Fonseca Matias, Vinicius Figueiredo Sardela, Ana Ferreira Ribeiro, Isabelle Karine da Costa Nunes, Valéria Pereira de Sousa, Henrique Marcelo Gualberto Pereira. Development of a liquid chromatography Q Exactive high resolution mass spectrometry method by the Box-Behnken design for the investigation of sibutramine urinary metabolites. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2019 Sep; 1125(?):121726. doi: 10.1016/j.jchromb.2019.121726. [PMID: 31362180]
  • Vinicius Figueiredo Sardela, Carina de Souza Anselmo, Isabelle Karine da Costa Nunes, Gabriel Reis Alves Carneiro, Gustavo Ramalho Cardoso Dos Santos, Aline Reis de Carvalho, Bruna de Jesus Labanca, Daniely Silva Oliveira, William Dias Ribeiro, Amanda Lessa Dutra de Araujo, Monica Costa Padilha, Cleverton Kleiton Freitas de Lima, Valeria Pereira de Sousa, Francisco Radler de Aquino Neto, Henrique Marcelo Gualberto Pereira. Zebrafish (Danio rerio) water tank model for the investigation of drug metabolism: Progress, outlook, and challenges. Drug testing and analysis. 2018 Nov; 10(11-12):1657-1669. doi: 10.1002/dta.2523. [PMID: 30341930]
  • Eun Chae Gong, Satya Chea, Anand Balupuri, Nam Sook Kang, Young-Won Chin, Young Hee Choi. Enzyme Kinetics and Molecular Docking Studies on Cytochrome 2B6, 2C19, 2E1, and 3A4 Activities by Sauchinone. Molecules (Basel, Switzerland). 2018 Mar; 23(3):. doi: 10.3390/molecules23030555. [PMID: 29498658]
  • Karine Maria Martins Bezerra Carvalho, Tiago Sousa de Melo, Karina Moura de Melo, Ana Luiza Gomes Quinderé, Francisca Tuelly Bandeira de Oliveira, Ana Flávia Seraine Custódio Viana, Paulo Iury Gomes Nunes, Josiane da Silva Quetz, Daniel de Araújo Viana, Armenio André de Carvalho Almeida da Silva, Alexandre Havt, Said Gonçalves da Cruz Fonseca, Mariana Helena Chaves, Vietla Satyanarayana Rao, Flávia Almeida Santos. Amyrins from Protium heptaphyllum Reduce High-Fat Diet-Induced Obesity in Mice via Modulation of Enzymatic, Hormonal And Inflammatory Responses. Planta medica. 2017 Feb; 83(3-04):285-291. doi: 10.1055/s-0042-114222. [PMID: 27525508]
  • T S de Melo, P R Lima, K M M B Carvalho, T M Fontenele, F R N Solon, A R Tomé, T L G de Lemos, S G da Cruz Fonseca, F A Santos, V S Rao, M G R de Queiroz. Ferulic acid lowers body weight and visceral fat accumulation via modulation of enzymatic, hormonal and inflammatory changes in a mouse model of high-fat diet-induced obesity. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. 2017 Jan; 50(1):e5630. doi: 10.1590/1414-431x20165630. [PMID: 28076453]
  • Antonio De Vincentis, Claudio Pedone, Umberto Vespasiani-Gentilucci, Antonio Picardi, Giuseppe Derosa, Pamela Maffioli, Amirhossein Sahebkar. Effect of Sibutramine on Plasma C-Reactive Protein, Leptin and Adipon ectin Concentrations: A Systematic Review and Meta-Analysis of Randomized Contr olled Trials. Current pharmaceutical design. 2017; 23(6):870-878. doi: 10.2174/1381612822666161006122934. [PMID: 27719651]
  • Belqes Abdullah Mohammad Al-Tahami, Ab Aziz Al-Safi Ismail, Zulkefli Sanip, Zurkurnai Yusoff, Tg Muzaffar Tm Shihabudin, Taran Singh Pall Singh, Aida Hanum Ghulam Rasool. Metabolic and Inflammatory Changes with Orlistat and Sibutramine Treatment in Obese Malaysian Subjects. Journal of Nippon Medical School = Nippon Ika Daigaku zasshi. 2017; 84(3):125-132. doi: 10.1272/jnms.84.125. [PMID: 28724846]
  • Manlio F Márquez, Jorge Rafael Gómez-Flores, Jesús A González-Hermosillo, Teresita de Jesús Ruíz-Siller, Manuel Cárdenas. [Role of the sympathetic nervous system in vasovagal syncope and rationale for beta-blockers and norepinephrine transporter inhibitors]. Medwave. 2016 12; 16(Suppl4):e6824. doi: 10.5867/medwave.2016.6824. [PMID: 28055999]
  • Phyllis Wilson, Claude Masse. Detection of Synthetic Drugs as Adulterants in Natural and Herbal Slimming Products by LC-ESI-MS/MS with Polarity Switching. Journal of AOAC International. 2016 Jul; 99(4):929-940. doi: 10.5740/jaoacint.15-0295. [PMID: 27143234]
  • Florence van Hunsel, Bastiaan J Venhuis, Peter H J Keizers, Agnes Kant. A 'natural' weight loss product containing sibutramine. Drug testing and analysis. 2016 Mar; 8(3-4):311-4. doi: 10.1002/dta.1925. [PMID: 27072843]
  • Naoko Yoshida, Midori Numano, Yoko Nagasaka, Kaori Ueda, Hirohito Tsuboi, Tsuyoshi Tanimoto, Kazuko Kimura. Study on health hazards through medicines purchased on the Internet: a cross-sectional investigation of the quality of anti-obesity medicines containing crude drugs as active ingredients. BMC complementary and alternative medicine. 2015 Dec; 15(1):430. doi: 10.1186/s12906-015-0955-2. [PMID: 26637485]
  • Neirivaldo Cavalcante da Silva, Ricardo Saldanha Honorato, Maria Fernanda Pimentel, Salvador Garrigues, Maria Luisa Cervera, Miguel de la Guardia. Near Infrared Spectroscopy Detection and Quantification of Herbal Medicines Adulterated with Sibutramine. Journal of forensic sciences. 2015 Sep; 60(5):1199-205. doi: 10.1111/1556-4029.12884. [PMID: 26260573]
  • Belqes Abdullah Mohammad Al-Tahami, Ab Aziz Al-Safi Ismail, Yvonne Tee Get Bee, Siti Azima Awang, Wan Rimei Salha Wan Abdul Rani, Zulkefli Sanip, Aida Hanum Ghulam Rasool. The effects of anti-obesity intervention with orlistat and sibutramine on microvascular endothelial function. Clinical hemorheology and microcirculation. 2015; 59(4):323-34. doi: 10.3233/ch-131765. [PMID: 24002121]
  • Ciska van der Schoor, Hester Magdalena Oberholzer, Megan Jean Bester, Mia-Jeanne van Rooy. The effect of sibutramine, a serotonin-norepinephrine reuptake inhibitor, on platelets and fibrin networks of male Sprague-Dawley rats: a descriptive study. Ultrastructural pathology. 2014 Dec; 38(6):399-405. doi: 10.3109/01913123.2014.946635. [PMID: 25191960]
  • S A Winther, N Finer, A M Sharma, C Torp-Pedersen, C Andersson. Association of anemia with the risk of cardiovascular adverse events in overweight/obese patients. International journal of obesity (2005). 2014 Mar; 38(3):432-7. doi: 10.1038/ijo.2013.111. [PMID: 23774460]
  • In Cheol Hwang, Ji Young Park, Hong Yup Ahn, Kyoung Kon Kim, Heuy Sun Suh, Ki Dong Ko, Kyoung-Ah Kim. Effects of CYP3A5, CYP2C19, and CYP2B6 on the clinical efficacy and adverse outcomes of sibutramine therapy: a crucial role for the CYP2B6*6 allele. Clinica chimica acta; international journal of clinical chemistry. 2014 Jan; 428(?):77-81. doi: 10.1016/j.cca.2013.11.007. [PMID: 24262967]
  • Caroline Mathon, Anita Ankli, Eike Reich, Stefan Bieri, Philippe Christen. Screening and determination of sibutramine in adulterated herbal slimming supplements by HPTLC-UV densitometry. Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment. 2014; 31(1):15-20. doi: 10.1080/19440049.2013.861934. [PMID: 24215519]
  • Ekaterini Koiou, Konstantinos Tziomalos, Ilias Katsikis, Dimitrios Delkos, Elena A Tsourdi, Dimitrios Panidis. Disparate effects of pharmacotherapy on plasma plasminogen activator inhibitor-1 levels in women with the polycystic ovary syndrome. Hormones (Athens, Greece). 2013 Oct; 12(4):559-66. doi: 10.14310/horm.2002.1444. [PMID: 24457404]
  • M Baretić. Obesity drug therapy. Minerva endocrinologica. 2013 Sep; 38(3):245-54. doi: ". [PMID: 24126545]
  • Robert S Sheldon, Debbie Ritchie, Maureen McRae, Satish Raj. Norepinephrine transport inhibition for treatment of vasovagal syncope. Journal of cardiovascular electrophysiology. 2013 Jul; 24(7):799-803. doi: 10.1111/jce.12111. [PMID: 23444896]
  • Henri Roukoz, David G Benditt. NET-NET: are norepinephrine transport inhibitors a potentially useful therapy for vasovagal syncope?. Journal of cardiovascular electrophysiology. 2013 Jul; 24(7):804-5. doi: 10.1111/jce.12136. [PMID: 23574151]
  • Hester Magdalena Oberholzer, Ciska Van Der Schoor, Etheresia Pretorius. The effect of sibutramine on platelet morphology of Spraque-Dawley rats fed a high energy diet. Microscopy research and technique. 2013 Jun; 76(6):653-7. doi: 10.1002/jemt.22214. [PMID: 23576325]
  • Dhananjay D Shinde, Ho-Sook Kim, Jae-Seok Choi, Wei Pan, Soo Kyung Bae, Chang-Woo Yeo, Ji-Hong Shon, Dong-Hyun Kim, Jae Gook Shin. Different effects of clopidogrel and clarithromycin on the enantioselective pharmacokinetics of sibutramine and its active metabolites in healthy subjects. Journal of clinical pharmacology. 2013 May; 53(5):550-8. doi: 10.1002/jcph.69. [PMID: 23381968]
  • Wei Pan, Soo-Kyung Bae, Eon-Jeong Shim, Sung-Eun Park, Sang-Seop Lee, Soo-Jin Park, Chang-Woo Yeo, Hong-Hao Zhou, Ji-Hong Shon, Jae-Gook Shin. Effects of clopidogrel and clarithromycin on the disposition of sibutramine and its active metabolites M1 and M2 in relation to CYP2B6*6 polymorphism. Xenobiotica; the fate of foreign compounds in biological systems. 2013 Feb; 43(2):211-8. doi: 10.3109/00498254.2012.706722. [PMID: 22830954]
  • V Pavlik, J Fajfrova, L Slovacek, E Drahokoupilova. The role of sibutramine in weight reduction. Bratislavske lekarske listy. 2013; 114(3):155-7. doi: 10.4149/bll_2013_034. [PMID: 23406184]
  • B Ozdemir, I Sahin, H Kapucu, O Celbis, Y Karakoc, S Erdogan, Y Onal. How safe is the use of herbal weight-loss products sold over the internet?. Human & experimental toxicology. 2013 Jan; 32(1):101-6. doi: 10.1177/0960327112436407. [PMID: 22354083]
  • L Trigueros, S Peña, A V Ugidos, E Sayas-Barberá, J A Pérez-Álvarez, E Sendra. Food ingredients as anti-obesity agents: a review. Critical reviews in food science and nutrition. 2013; 53(9):929-42. doi: 10.1080/10408398.2011.574215. [PMID: 23768185]
  • C Schroeder, J Jordan. Norepinephrine transporter function and human cardiovascular disease. American journal of physiology. Heart and circulatory physiology. 2012 Dec; 303(11):H1273-82. doi: 10.1152/ajpheart.00492.2012. [PMID: 23023867]
  • Yang Li, Hong Zhang, Jiangtao Hu, Feng Xue, Yongxin Li, Chengjun Sun. A GC-EI-MS-MS method for simultaneous determination of seven adulterants in slimming functional foods. Journal of chromatographic science. 2012 Nov; 50(10):928-33. doi: 10.1093/chromsci/bms092. [PMID: 22732254]
  • Joanna Suliburska, Paweł Bogdański, Monika Szulińska, Danuta Pupek-Musialik. Short-term effects of sibutramine on mineral status and selected biochemical parameters in obese women. Biological trace element research. 2012 Nov; 149(2):163-70. doi: 10.1007/s12011-012-9425-6. [PMID: 22539020]
  • T Klein, H G Niessen, C Ittrich, E Mayoux, H-P Mueller, S Cheetham, D Stiller, J Kassubek, M Mark. Evaluation of body fat composition after linagliptin treatment in a rat model of diet-induced obesity: a magnetic resonance spectroscopy study in comparison with sibutramine. Diabetes, obesity & metabolism. 2012 Nov; 14(11):1050-3. doi: 10.1111/j.1463-1326.2012.01629.x. [PMID: 22651241]
  • Hua Wang, Yongning Wu, Bin Guo, Wenjian Sun, Li Ding, Bo Chen. Quantification of low-polar small molecules using room temperature ionic liquids matrix-assisted desorption corona beam ionization. The Analyst. 2012 Sep; 137(17):3982-8. doi: 10.1039/c2an35508f. [PMID: 22814401]
  • Christos Vosnakis, Neoklis A Georgopoulos, Anastasia K Armeni, Efstathios Papadakis, Nikolaos D Roupas, Ilias Katsikis, Dimitrios Panidis. Sibutramine administration decreases serum anti-Müllerian hormone (AMH) levels in women with polycystic ovary syndrome. European journal of obstetrics, gynecology, and reproductive biology. 2012 Aug; 163(2):185-9. doi: 10.1016/j.ejogrb.2012.04.014. [PMID: 22579228]
  • H Wang, Y Wu, Y Zhao, W Sun, L Ding, B Guo, B Chen. Rapid screening of illicit additives in weight loss dietary supplements with desorption corona beam ionisation (DCBI) mass spectrometry. Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment. 2012 Aug; 29(8):1194-201. doi: 10.1080/19440049.2012.692395. [PMID: 22784191]
  • David C Guzmán, Ernestina H García, Gerardo B Mejía, Hugo J Olguín, Francisca T Jiménez, Erick B Soto, Daniel S Del Angel, Liliana C Aparicio. Effect of sibutramine on 5-hydroxyindole acetic acid levels and selected oxidative biomarkers on brain regions of female rats in the presence of zinc. Basic & clinical pharmacology & toxicology. 2012 May; 110(5):421-6. doi: 10.1111/j.1742-7843.2011.00829.x. [PMID: 22141426]
  • Pui Kin Lam, K S Leung, T W Wong, H H C Lee, M H Y Tang, T W L Mak. Serotonin syndrome following overdose of a non-prescription slimming product containing sibutramine: a case report. Human & experimental toxicology. 2012 Apr; 31(4):414-7. doi: 10.1177/0960327111431704. [PMID: 22249388]
  • L M De Carvalho, P A Cohen, C V Silva, A P L Moreira, T M Falcão, T R Dal Molin, G Zemolin, M Martini. A new approach to determining pharmacologic adulteration of herbal weight loss products. Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment. 2012; 29(11):1661-7. doi: 10.1080/19440049.2012.706834. [PMID: 22849359]
  • Ekaterini Koiou, Konstantinos Tziomalos, Ilias Katsikis, Eleni A Kandaraki, Emmanuil Kalaitzakis, Dimitrios Delkos, Christos Vosnakis, Dimitrios Panidis. Weight loss significantly reduces serum lipocalin-2 levels in overweight and obese women with polycystic ovary syndrome. Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology. 2012 Jan; 28(1):20-4. doi: 10.3109/09513590.2011.588745. [PMID: 21756081]
  • Jung-Woo Bae, Choon-Gon Jang, Seok-Young Lee. Effects of clopidogrel on the pharmacokinetics of sibutramine and its active metabolites. Journal of clinical pharmacology. 2011 Dec; 51(12):1704-11. doi: 10.1177/0091270010388651. [PMID: 21209232]
  • Jung-Woo Bae, Chang-Ik Choi, Choon-Gon Jang, Seok-Yong Lee. Simultaneous determination of sibutramine and its active metabolites in human plasma by LC-MS/MS and its application to a pharmacokinetic study. Biomedical chromatography : BMC. 2011 Nov; 25(11):1181-8. doi: 10.1002/bmc.1587. [PMID: 21294141]
  • Fernanda F Bellentani, Glaura S A Fernandes, Juliana E Perobelli, Enio S A Pacini, Luiz R A Kiguti, André S Pupo, Wilma D G Kempinas. Acceleration of sperm transit time and reduction of sperm reserves in the epididymis of rats exposed to sibutramine. Journal of andrology. 2011 Nov; 32(6):718-24. doi: 10.2164/jandrol.111.013466. [PMID: 21764897]
  • D M Abo-Elmatty, S A Zaitone. Topiramate induces weight loss and improves insulin sensitivity in dietary obese rats: comparison to sibutramine. European review for medical and pharmacological sciences. 2011 Oct; 15(10):1187-95. doi: . [PMID: 22165681]
  • G Derosa, P Maffioli, I Ferrari, I Palumbo, S Randazzo, A D'Angelo, A F G Cicero. Variation of inflammatory parameters after sibutramine treatment compared to placebo in type 2 diabetic patients. Journal of clinical pharmacy and therapeutics. 2011 Oct; 36(5):592-601. doi: 10.1111/j.1365-2710.2010.01217.x. [PMID: 21070297]
  • Jung-Won Choi, Jeong In Joo, Dong Hyun Kim, Xia Wang, Tae Seok Oh, Duk Kwon Choi, Jong Won Yun. Proteome changes in rat plasma in response to sibutramine. Proteomics. 2011 Apr; 11(7):1300-12. doi: 10.1002/pmic.201000664. [PMID: 21337517]
  • Giuseppe Derosa, Pamela Maffioli, Sibilla A T Salvadeo, Ilaria Ferrari, Alessia Gravina, Roberto Mereu, Angela D'Angelo, Ilaria Palumbo, Sabrina Randazzo, Arrigo F G Cicero. Effects of combination of sibutramine and L-carnitine compared with sibutramine monotherapy on inflammatory parameters in diabetic patients. Metabolism: clinical and experimental. 2011 Mar; 60(3):421-9. doi: 10.1016/j.metabol.2010.03.010. [PMID: 20423740]
  • Ekaterini Koiou, Konstantinos Tziomalos, Konstantinos Dinas, Ilias Katsikis, Emmanuil Kalaitzakis, Dimitrios Delkos, Eleni A Kandaraki, Dimitrios Panidis. The effect of weight loss and treatment with metformin on serum vaspin levels in women with polycystic ovary syndrome. Endocrine journal. 2011; 58(4):237-46. doi: 10.1507/endocrj.k10e-330. [PMID: 21325745]
  • Jae Yong Chung, Seong Bok Jang, Yoon Jung Lee, Min Soo Park, Kyungsoo Park. Effect of CYP2B6 genotype on the pharmacokinetics of sibutramine and active metabolites in healthy subjects. Journal of clinical pharmacology. 2011 Jan; 51(1):53-9. doi: 10.1177/0091270010362906. [PMID: 20350955]
  • Min Li, Bai Chang, Zhong Zhen, Pei-Jie Qin, Wen-Ke Liu, Xiao-Lin Tong. Hepatic PTP1B expression involvement in the effects of Chinese medicine formula xiao-gao-jiang-zhuo using an obese rat model. The American journal of Chinese medicine. 2011; 39(2):301-13. doi: 10.1142/s0192415x1100883x. [PMID: 21476207]
  • Qing-Wei Zhou, Qin-Mei Yang. [Moxibustion on the Governor Vessel for lung and kidney qi deficiency type in chronic obstructive pulmonary disease: a randomized controlled trial]. Zhongguo zhen jiu = Chinese acupuncture & moxibustion. 2011 Jan; 31(1):31-4. doi: NULL. [PMID: 21355151]
  • J Lennert Veerman, Jan J Barendregt, Megan Forster, Theo Vos. Cost-effectiveness of pharmacotherapy to reduce obesity. PloS one. 2011; 6(10):e26051. doi: 10.1371/journal.pone.0026051. [PMID: 22046255]
  • Ramazan Sari, Esin Eray, Sabahat Ozdem, Halide Akbas, Erkan Coban. Comparison of the effects of sibutramine versus sibutramine plus metformin in obese women. Clinical and experimental medicine. 2010 Sep; 10(3):179-84. doi: 10.1007/s10238-009-0080-y. [PMID: 19937362]
  • J Vaysse, S Balayssac, V Gilard, D Desoubdzanne, M Malet-Martino, R Martino. Analysis of adulterated herbal medicines and dietary supplements marketed for weight loss by DOSY 1H-NMR. Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment. 2010 Jul; 27(7):903-16. doi: 10.1080/19440041003705821. [PMID: 20437283]
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