Tetrahydroaldosterone-3-glucuronide (BioDeep_00000031466)

   

human metabolite Endogenous blood metabolite


代谢物信息卡片


(2S,3S,4R,5R,6R)-3,4,5-trihydroxy-6-{[(2S,14S,16S)-18-hydroxy-2-(2-hydroxyacetyl)-14-methyl-17-oxapentacyclo[14.2.1.0¹,⁵.0⁶,¹⁵.0⁹,¹⁴]nonadecan-11-yl]oxy}oxane-2-carboxylic acid

化学式: C27H40O11 (540.257049)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(blood) 10.51%

分子结构信息

SMILES: CC12CCC(CC1CCC3C2C4CC5(C3CCC5C(=O)CO)C(O4)O)OC6C(C(C(C(O6)C(=O)O)O)O)O
InChI: InChI=1S/C27H40O11/c1-26-7-6-12(36-24-21(32)19(30)20(31)22(38-24)23(33)34)8-11(26)2-3-13-14-4-5-15(16(29)10-28)27(14)9-17(18(13)26)37-25(27)35/h11-15,17-22,24-25,28,30-32,35H,2-10H2,1H3,(H,33,34)/t11?,12?,13?,14?,15-,17+,18?,19-,20+,21-,22+,24-,25?,26+,27?/m1/s1

描述信息

Tetrahydroaldosterone-3-glucuronide is a natural human metabolite of Tetrahydroaldosterone generated in the liver by UDP glucuonyltransferase. Glucuronidation is used to assist in the excretion of toxic substances, drugs or other substances that cannot be used as an energy source. Glucuronic acid is attached via a glycosidic bond to the substance, and the resulting glucuronide, which has a much higher water solubility than the original substance, is eventually excreted by the kidneys.
Tetrahydroaldosterone-3-glucuronide is a natural human metabolite of Tetrahydroaldosterone generated in the liver by UDP glucuonyltransferase.
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones

同义名列表

10 个代谢物同义名

(2S,3S,4R,5R,6R)-3,4,5-trihydroxy-6-{[(2S,14S,16S)-18-hydroxy-2-(2-hydroxyacetyl)-14-methyl-17-oxapentacyclo[14.2.1.0¹,⁵.0⁶,¹⁵.0⁹,¹⁴]nonadecan-11-yl]oxy}oxane-2-carboxylic acid; (3alpha,5beta,11beta)-11,18-Epoxy-18,21-dihydro-20-oxopregnan-3-yl-beta-delta-glucopyranosiduronic acid; 11beta,18-Epoxy-18,21-dihydroxy-20-oxo-5beta-pregnan-3alpha-yl beta-delta-glucopyranosiduronic acid; (3alpha,5beta,11beta)-11,18-Epoxy-18,21-dihydro-20-oxopregnan-3-yl-beta-D-glucopyranosiduronic acid; 11 beta,18-Epoxy-18,21-dihydroxy-20-oxo-5 beta-pregnan-3 alpha-yl beta-D-glucopyranosiduronic acid; 11beta,18-Epoxy-18,21-dihydroxy-20-oxo-5beta-pregnan-3alpha-yl beta-D-glucopyranosiduronic acid; Tetrahydroaldosterone 3 beta-glucosiduronic acid; Tetrahydroaldosterone-3-glucuronoside; Tetrahydroaldosterone-3-glucuronide; TA-ga



数据库引用编号

7 个数据库交叉引用编号

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代谢反应

0 个相关的代谢反应过程信息。

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1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • S Medina, F Ferreres, C García-Viguera, M N Horcajada, J Orduna, M Savirón, G Zurek, J M Martínez-Sanz, J I Gil, A Gil-Izquierdo. Non-targeted metabolomic approach reveals urinary metabolites linked to steroid biosynthesis pathway after ingestion of citrus juice. Food chemistry. 2013 Jan; 136(2):938-46. doi: 10.1016/j.foodchem.2012.09.004. [PMID: 23122147]
  • T Miyazaki, K Matsuzaki. Further characterization of urinary aldosterone metabolities in the rabbit by fast atom bombardment mass spectrometry. Endocrinologia japonica. 1990 Feb; 37(1):103-12. doi: 10.1507/endocrj1954.37.103. [PMID: 2384048]
  • P Marks, B Wilson, A Delassalle. Aldosterone studies in obese patients with hypertension. The American journal of the medical sciences. 1985 Jun; 289(6):224-8. doi: 10.1097/00000441-198506000-00003. [PMID: 3890539]
  • M Risk, O B Holland, H Brown. Rapid chromatographic purification of urinary steroid glucuronates for determination of aldosterone secretion rate. Journal of chromatography. 1984 Dec; 317(?):367-76. doi: 10.1016/s0021-9673(01)91676-0. [PMID: 6530444]
  • P Marks, R Vincent, B Wilson, A Delassale. Aldosterone in acromegaly. The American journal of the medical sciences. 1984 May; 287(3):16-9. doi: 10.1097/00000441-198405000-00005. [PMID: 6375368]
  • G T Griffing, T E Wilson, J C Melby. Altered fractional tetrahydroaldosterone excretion during pharmacological blockade and activation of the renin-aldosterone system. The Journal of clinical endocrinology and metabolism. 1982 Dec; 55(6):1217-21. doi: 10.1210/jcem-55-6-1217. [PMID: 6290525]
  • V R Mattox, A N Nelson. Determination of urinary tetrahydroaldosterone glucosiduronic acid by radioimmunoassay. Journal of steroid biochemistry. 1981 Mar; 14(3):243-9. doi: 10.1016/0022-4731(81)90132-1. [PMID: 7218790]
  • T P Jowett, J D Slater. A radioimmunoassay for the measurement of tetrahydroaldosterone 3-glucosiduronic acid in human plasma. Clinica chimica acta; international journal of clinical chemistry. 1981 Jan; 109(2):133-44. doi: 10.1016/0009-8981(81)90327-2. [PMID: 7193539]