Aldosterone 18-glucuronide (BioDeep_00000031457)

   

human metabolite Endogenous blood metabolite


代谢物信息卡片


(2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-{[(2S,14R,16R)-2-(2-hydroxyacetyl)-14-methyl-11-oxo-17-oxapentacyclo[14.2.1.0¹,⁵.0⁶,¹⁵.0⁹,¹⁴]nonadec-9-en-18-yl]oxy}oxane-2-carboxylic acid

化学式: C27H36O11 (536.2257506)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(blood) 90.91%

分子结构信息

SMILES: CC12CCC(=O)C=C1CCC3C2C4CC5(C3CCC5C(=O)CO)C(O4)OC6C(C(C(C(O6)C(=O)O)O)O)O
InChI: InChI=1S/C27H36O11/c1-26-7-6-12(29)8-11(26)2-3-13-14-4-5-15(16(30)10-28)27(14)9-17(18(13)26)36-25(27)38-24-21(33)19(31)20(32)22(37-24)23(34)35/h8,13-15,17-22,24-25,28,31-33H,2-7,9-10H2,1H3,(H,34,35)/t13?,14?,15-,17-,18?,19+,20+,21-,22+,24+,25?,26+,27?/m1/s1

描述信息

Aldosterone 18-glucuronide is a natural human metabolite of Aldosterone generated in the liver by UDP glucuonyltransferase. Glucuronidation is used to assist in the excretion of toxic substances, drugs or other substances that cannot be used as an energy source. Glucuronic acid is attached via a glycosidic bond to the substance, and the resulting glucuronide, which has a much higher water solubility than the original substance, is eventually excreted by the kidneys.
Aldosterone 18-glucuronide is a natural human metabolite of Aldosterone generated in the liver by UDP glucuonyltransferase.
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones

同义名列表

8 个代谢物同义名

(2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-{[(2S,14R,16R)-2-(2-hydroxyacetyl)-14-methyl-11-oxo-17-oxapentacyclo[14.2.1.0¹,⁵.0⁶,¹⁵.0⁹,¹⁴]nonadec-9-en-18-yl]oxy}oxane-2-carboxylic acid; 11beta,18-Epoxy-21-hydroxy-3,20-dioxopregn-4-en-18-yl-beta-delta-glucopyranosiduronic acid; 11beta,18-Epoxy-21-hydroxy-3,20-dioxopregn-4-en-18-yl-beta-D-glucopyranosiduronic acid; Aldosterone-18-delta-glucosiduronic acid; Aldosterone-18-D-glucosiduronic acid; Aldosterone-18-delta-glucuronoside; Aldosterone-18-D-glucuronoside; Aldosterone 18-glucuronide



数据库引用编号

7 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

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代谢反应

1 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(1)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Kathleen M Knights, Leanne K Winner, David J Elliot, Kushari Bowalgaha, John O Miners. Aldosterone glucuronidation by human liver and kidney microsomes and recombinant UDP-glucuronosyltransferases: inhibition by NSAIDs. British journal of clinical pharmacology. 2009 Sep; 68(3):402-12. doi: 10.1111/j.1365-2125.2009.03469.x. [PMID: 19740398]
  • S Fredersdorf, D H Endemann, A Luchner, D Heitzmann, C Ulucan, C Birner, P Schmid, B Stoelcker, M Resch, F Muders, G A J Riegger, J Weil. Increased aldosterone levels in a model of type 2 diabetes mellitus. Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association. 2009 Jan; 117(1):15-20. doi: 10.1055/s-2008-1073128. [PMID: 18726873]
  • Sven Diederich, Martin Bidlingmaier, Marcus Quinkler, Martin Reincke. [Diagnosis of primary hyperaldosteronism]. Medizinische Klinik (Munich, Germany : 1983). 2007 Jan; 102(1):16-21. doi: 10.1007/s00063-007-1002-y. [PMID: 17221347]
  • J Wacker, P Piel, S Lewicka, D Haack, P Vecsei, G Bastert. Increased aldosterone-18-glucuronide/tetrahydroaldosterone ratios in pregnancy. Endocrine research. 1995 Feb; 21(1-2):197-202. doi: 10.3109/07435809509030435. [PMID: 7588381]
  • H Witzgall, B Scherer, H H Lange, P C Weber. Does hormone analysis predict the antihypertensive response of basic medical treatment?. Herz. 1989 Jun; 14(3):197-203. doi: NULL. [PMID: 2661389]
  • A Iu Zaruba, A I Kutsenko, V V Kukharchuk, S V Mal'ginov, V P Masenko. [The efficacy of isolated ultrafiltration of the blood in patients with refractory heart failure]. Terapevticheskii arkhiv. 1989; 61(4):84-7. doi: NULL. [PMID: 2763201]
  • C E Gomez-Sanchez, J N Clore, H L Estep, C O Watlington. Effect of chronic adrenocorticotropin stimulation on the excretion of 18-hydroxycortisol and 18-oxocortisol. The Journal of clinical endocrinology and metabolism. 1988 Aug; 67(2):322-6. doi: 10.1210/jcem-67-2-322. [PMID: 2839536]
  • W Tenschert, R Maurer, H Vetter, W Vetter. Primary aldosteronism by carcinoma of the adrenal cortex. Klinische Wochenschrift. 1987 May; 65(9):428-32. doi: 10.1007/bf01715766. [PMID: 3298831]
  • G I Leslie. Ontogeny of aldosterone glucuronidation by the human newborn. Early human development. 1986 Dec; 14(3-4):179-86. doi: 10.1016/0378-3782(86)90179-9. [PMID: 3803264]
  • G Wambach, C Bleienheuft, G Bönner. Sodium loading raises urinary cortisol in man. Journal of endocrinological investigation. 1986 Jun; 9(3):257-9. doi: 10.1007/bf03348113. [PMID: 3020116]
  • E S Rom-Bugoslavskaia, I V Komarova. [Regulation of aldosterone secretion in thyrotoxicosis. Thyroid hormones as possible stimulators of the activity of the renin-angiotensin-aldosterone system]. Problemy endokrinologii. 1986 Mar; 32(2):13-6. doi: NULL. [PMID: 2424003]
  • S Lewicka, P Vecsei. Clinical significance of unconjugated 3 alpha,5 beta-tetrahydroaldosterone and 5 beta-dihydroaldosterone measured by radioimmunoassay. Clinical endocrinology. 1985 Feb; 22(2):123-33. doi: 10.1111/j.1365-2265.1985.tb01074.x. [PMID: 3987065]
  • C E Gomez-Sanchez, O B Holland, R Upcavage. Urinary free 19-nor-deoxycorticosterone and deoxycorticosterone in human hypertension. The Journal of clinical endocrinology and metabolism. 1985 Feb; 60(2):234-8. doi: 10.1210/jcem-60-2-234. [PMID: 3880766]
  • W Oelkers. Prolonged ACTH infusion suppresses aldosterone secretion in spite of high renin activity. Acta endocrinologica. 1985 Jan; 108(1):91-7. doi: 10.1530/acta.0.1080091. [PMID: 2982239]
  • W Nowaczynski, W J Oliver, J V Neel. Serum aldosterone and protein-binding variables in Yanomama Indians: a no-salt culture as compared to partially acculturated Guaymi Indians. Clinical physiology and biochemistry. 1985; 3(6):289-306. doi: NULL. [PMID: 3907928]
  • M Risk, O B Holland, H Brown. Rapid chromatographic purification of urinary steroid glucuronates for determination of aldosterone secretion rate. Journal of chromatography. 1984 Dec; 317(?):367-76. doi: 10.1016/s0021-9673(01)91676-0. [PMID: 6530444]
  • H Bauknecht, P Vecsei, H Endres, A Hettenbach. Urinary free 18-hydroxycorticosterone, plasma aldosterone, and urinary aldosterone metabolites in normal pregnancy. American journal of obstetrics and gynecology. 1982 Sep; 144(1):28-34. doi: 10.1016/0002-9378(82)90389-1. [PMID: 7114109]
  • S Abdelhamid, P Vecsei, D Haack, K H Gless, D Walb, P Fiegel, K Lichtwald. Elevated 'free' 18-hydroxy-corticosterone excretion as a possible indicator for early diagnosis of primary aldosteronism. Journal of steroid biochemistry. 1981 Sep; 14(9):913-20. doi: 10.1016/0022-4731(81)90240-5. [PMID: 7029142]
  • S P Wilkinson, P G Wheeler, T P Jowett, I K Smith, J Keenan, J D Slater, R Williams. Factors relating to aldosterone secretion rate, the excretions of aldosterone 18-glucuronide, and the plasma aldosterone concentration in cirrhosis. Clinical endocrinology. 1981 Apr; 14(4):355-62. doi: 10.1111/j.1365-2265.1981.tb00620.x. [PMID: 7021011]
  • C E Gomez-Sanchez, O B Holland. Urinary tetrahydroaldosterone and aldosterone-18-glucuronide excretion in white and black normal subjects and hypertensive patients. The Journal of clinical endocrinology and metabolism. 1981 Feb; 52(2):214-9. doi: 10.1210/jcem-52-2-214. [PMID: 7462387]