Beta-D-Glucopyranuronic acid (BioDeep_00000031436)

   

human metabolite Endogenous


代谢物信息卡片


(2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-(2-hydroxybenzoyloxy)oxane-2-carboxylic acid

化学式: C13H14O9 (314.06377940000004)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1=CC=C(C(=C1)C(=O)OC2C(C(C(C(O2)C(=O)O)O)O)O)O
InChI: InChI=1S/C13H14O9/c14-6-4-2-1-3-5(6)12(20)22-13-9(17)7(15)8(16)10(21-13)11(18)19/h1-4,7-10,13-17H,(H,18,19)/t7-,8-,9+,10-,13-/m0/s1

描述信息

Salicylacyl glucuronide is a natural human metabolite of acetylsilacylic acid generated in the liver by UDP glucuonyltransferase. Glucuronidation is used to assist in the excretion of toxic substances, drugs or other substances that cannot be used as an energy source. Glucuronic acid is attached via a glycosidic bond to the substance, and the resulting glucuronide, which has a much higher water solubility than the original substance, is eventually excreted by the kidneys. [HMDB]
Salicylacyl glucuronide is a natural human metabolite of acetylsilacylic acid generated in the liver by UDP glucuonyltransferase. Glucuronidation is used to assist in the excretion of toxic substances, drugs or other substances that cannot be used as an energy source. Glucuronic acid is attached via a glycosidic bond to the substance, and the resulting glucuronide, which has a much higher water solubility than the original substance, is eventually excreted by the kidneys.
D000893 - Anti-Inflammatory Agents > D000894 - Anti-Inflammatory Agents, Non-Steroidal > D012459 - Salicylates

同义名列表

15 个代谢物同义名

(2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-(2-hydroxybenzoyloxy)oxane-2-carboxylic acid; (2S,3S,4S,5R,6S)-3,4,5-Trihydroxy-6-(2-hydroxybenzoyl)oxyoxane-2-carboxylic acid; 1-(2-Hydroxybenzoate) beta-delta-glucopyranuronic acid; 1-(2-Hydroxybenzoate) beta-D-glucopyranuronic acid; Beta-D-Glucopyranuronic acid; b-D-Glucopyranuronic acid; Β-D-glucopyranuronic acid; 1-(2-Hydroxybenzoic acid; Salicyl acyl glucuronide; beta-D-Glucopyranuronate; Salicylacyl glucuronide; Β-D-glucopyranuronate; b-D-Glucopyranuronate; 1-(2-Hydroxybenzoate; Acyl sa glucuronide



数据库引用编号

5 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

2 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(2)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • J H Liu, R S Malone, H Stallings, P C Smith. Influence of renal failure in rats on the disposition of salicyl acyl glucuronide and covalent binding of salicylate to plasma proteins. The Journal of pharmacology and experimental therapeutics. 1996 Jul; 278(1):277-83. doi: NULL. [PMID: 8764361]
  • J H Liu, P C Smith. Direct analysis of salicylic acid, salicyl acyl glucuronide, salicyluric acid and gentisic acid in human plasma and urine by high-performance liquid chromatography. Journal of chromatography. B, Biomedical applications. 1996 Jan; 675(1):61-70. doi: 10.1016/0378-4347(95)00337-1. [PMID: 8634769]
  • R G Dickinson, P V Baker, A R King. Studies on the reactivity of acyl glucuronides--VII. Salicyl acyl glucuronide reactivity in vitro and covalent binding of salicylic acid to plasma protein of humans taking aspirin. Biochemical pharmacology. 1994 Feb; 47(3):469-76. doi: 10.1016/0006-2952(94)90177-5. [PMID: 8117314]
  • J J Shen, S Wanwimolruk, M S Roberts. Novel direct high-performance liquid chromatographic method for determination of salicylate glucuronide conjugates in human urine. Journal of chromatography. 1991 Apr; 565(1-2):309-20. doi: 10.1016/0378-4347(91)80392-p. [PMID: 1874875]
  • D K Patel, L J Notarianni, P N Bennett. Comparative metabolism of high doses of aspirin in man and rat. Xenobiotica; the fate of foreign compounds in biological systems. 1990 Aug; 20(8):847-54. doi: 10.3109/00498259009046898. [PMID: 2219967]