HYPOTHEMYCIN (BioDeep_00000311596)
代谢物信息卡片
化学式: C19H22O8 (378.1315)
中文名称:
谱图信息:
最多检出来源 Homo sapiens(general) 100%
分子结构信息
SMILES: CC1CC=CC(=O)C(C(CC2C(O2)C3=C(C(=CC(=C3)OC)O)C(=O)O1)O)O
InChI: InChI=1S/C19H22O8/c1-9-4-3-5-12(20)17(23)14(22)8-15-18(27-15)11-6-10(25-2)7-13(21)16(11)19(24)26-9/h3,5-7,9,14-15,17-18,21-23H,4,8H2,1-2H3/b5-3-/t9-,14-,15+,17+,18+/m0/s1
描述信息
A macrolide that is isolated from the cultured broth of Hypomyces subiculosus and shows antifungal activity and inhibits the growth of some human cancer cells.
D009676 - Noxae > D011042 - Poisons > D009183 - Mycotoxins
同义名列表
1 个代谢物同义名
数据库引用编号
7 个数据库交叉引用编号
- ChEBI: CHEBI:83275
- PubChem: 9929643
- PubChem: 73075931
- DrugBank: DB07905
- ChEMBL: CHEMBL471474
- PMhub: MS000083244
- MetaboLights: MTBLC83275
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
|---|
文献列表
- Ying Gao, Fang-Fang Duan, Lin Liu, Xiao-Gang Peng, Xiang-Gao Meng, Han-Li Ruan. Hypothemycin-Type Resorcylic Acid Lactones with Immunosuppressive Activities from a Podospora sp.
Journal of natural products.
2021 02; 84(2):483-494. doi:
10.1021/acs.jnatprod.0c01344. [PMID: 33544615] - Liangxiong Xu, Ping Wu, Jinghua Xue, Istvan Molnar, Xiaoyi Wei. Antifungal and Cytotoxic β-Resorcylic Acid Lactones from a Paecilomyces Species.
Journal of natural products.
2017 08; 80(8):2215-2223. doi:
10.1021/acs.jnatprod.7b00066. [PMID: 28749671] - Takeshi Iwasa, Toshiya Matsuzaki, Altankhuu Tungalagsuvd, Munkhsaikhan Munkhzaya, Mayila Yiliyasi, Takeshi Kato, Akira Kuwahara, Minoru Irahara. Prenatal undernutrition results in greater lipopolysaccharide-induced changes in hypothalamic TNF-α expression, but does not affect the equivalent changes in the serum levels of luteinizing hormone and testosterone, in adult male rats.
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience.
2016 Feb; 48(?):80-3. doi:
10.1016/j.ijdevneu.2015.12.001. [PMID: 26674468] - Liangxiong Xu, Jinghua Xue, Ping Wu, Duoduo Wang, Lijing Lin, Yueming Jiang, Xuewu Duan, Xiaoyi Wei. Antifungal activity of hypothemycin against Peronophythora litchii in vitro and in vivo.
Journal of agricultural and food chemistry.
2013 Oct; 61(42):10091-5. doi:
10.1021/jf4030882. [PMID: 24106914] - Hidesuke Fukazawa, Yoshimi Ikeda, Mari Fukuyama, Takeshi Suzuki, Hiroshi Hori, Toru Okuda, Yoshimasa Uehara. The resorcylic acid lactone hypothemycin selectively inhibits the mitogen-activated protein kinase kinase-extracellular signal-regulated kinase pathway in cells.
Biological & pharmaceutical bulletin.
2010; 33(2):168-73. doi:
10.1248/bpb.33.168. [PMID: 20118535] - Masahiko Isaka, Chotika Suyarnsestakorn, Morakot Tanticharoen, Palangpon Kongsaeree, Yodhathai Thebtaranonth. Aigialomycins A-E, new resorcylic macrolides from the marine mangrove fungus Aigialus parvus.
The Journal of organic chemistry.
2002 Mar; 67(5):1561-6. doi:
10.1021/jo010930g. [PMID: 11871887]
